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Maternal transfer of anti HPV 6 and 11 antibodies upon immunization with the 9-valent HPV vaccine / Ana María Guevara Zambrano
Título : Maternal transfer of anti HPV 6 and 11 antibodies upon immunization with the 9-valent HPV vaccine Tipo de documento : documento electrónico Autores : Ana María Guevara Zambrano, Fecha de publicación : 2019 Títulos uniformes : Human Vaccines & Immunotherapeutics Idioma : Inglés (eng) Palabras clave : Human papillomavirus 9vHPV vaccine recurrent respiratory papillomatosis clinical trial geometric mean titers (GMTs) Resumen : Background: This exploratory analysis was conducted to characterize the level of HPV types 6/11 antibodies in peripartum maternal blood and in cord blood of infants born to women who received 9-valent HPV (9vHPV) vaccine or quadrivalent HPV (qHPV) vaccine in a pivotal efficacy study (V503-001, NCT 00543543). Methods: A total of 21 mother-infant pairs had evaluable HPV 6/11 results available for analysis. HPV6/11 antibodies were assessed using competitive Luminex immunoassay. The distribution of the ratios of infant to mother anti-HPV antibodies (i.e., infant-anti-HPV/mother- anti-HPV) was summarized. Results: All mothers and infants were seropositive to HPV 6 and HPV 11. Anti-HPV 6/11 geometric mean titers (GMTs) in peripartum maternal blood and in cord blood of infant born to study participants were highly correlated. A 100% of infants born to seropositive mothers were also seropositive. The GMT ratios of peripartum maternal blood vs. those in cord blood were HPV 6: 1.23 [0.43, 3.49] and HPV 11: 1.29 [0.54, 3.07] in the 9vHPV vaccine group and HPV 6: 1.33 [0.41, 4.29] and HPV 11: 1.19 [0.45, 3.13] in the qHPV vaccine group, respectively. Conclusions: These results indicate that antibodies induced by the 9vHPV vaccine cross the placenta, which could potentially be beneficial against HPV6/11 infection and related disease such as recurrent respiratory papillomatosis. Mención de responsabilidad : Ana Maria Guevara, Eugenio Suarez, Alejandro Victoria, Hextan Ys Ngan, Angelica Lindén Hirschberg, Edison Fedrizzi, Oliver Bautista, Christine Shields, Amita Joshi, Alain Luxembourg Referencia : Hum Vaccin Immunother. 2019;15(1):141-145. DOI (Digital Object Identifier) : 10.1080/21645515.2018.1514227 PMID : 30261146 En línea : https://www.tandfonline.com/doi/abs/10.1080/21645515.2018.1514227?journalCode=kh [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4174 Maternal transfer of anti HPV 6 and 11 antibodies upon immunization with the 9-valent HPV vaccine [documento electrónico] / Ana María Guevara Zambrano, . - 2019.
Obra : Human Vaccines & Immunotherapeutics
Idioma : Inglés (eng)
Palabras clave : Human papillomavirus 9vHPV vaccine recurrent respiratory papillomatosis clinical trial geometric mean titers (GMTs) Resumen : Background: This exploratory analysis was conducted to characterize the level of HPV types 6/11 antibodies in peripartum maternal blood and in cord blood of infants born to women who received 9-valent HPV (9vHPV) vaccine or quadrivalent HPV (qHPV) vaccine in a pivotal efficacy study (V503-001, NCT 00543543). Methods: A total of 21 mother-infant pairs had evaluable HPV 6/11 results available for analysis. HPV6/11 antibodies were assessed using competitive Luminex immunoassay. The distribution of the ratios of infant to mother anti-HPV antibodies (i.e., infant-anti-HPV/mother- anti-HPV) was summarized. Results: All mothers and infants were seropositive to HPV 6 and HPV 11. Anti-HPV 6/11 geometric mean titers (GMTs) in peripartum maternal blood and in cord blood of infant born to study participants were highly correlated. A 100% of infants born to seropositive mothers were also seropositive. The GMT ratios of peripartum maternal blood vs. those in cord blood were HPV 6: 1.23 [0.43, 3.49] and HPV 11: 1.29 [0.54, 3.07] in the 9vHPV vaccine group and HPV 6: 1.33 [0.41, 4.29] and HPV 11: 1.19 [0.45, 3.13] in the qHPV vaccine group, respectively. Conclusions: These results indicate that antibodies induced by the 9vHPV vaccine cross the placenta, which could potentially be beneficial against HPV6/11 infection and related disease such as recurrent respiratory papillomatosis. Mención de responsabilidad : Ana Maria Guevara, Eugenio Suarez, Alejandro Victoria, Hextan Ys Ngan, Angelica Lindén Hirschberg, Edison Fedrizzi, Oliver Bautista, Christine Shields, Amita Joshi, Alain Luxembourg Referencia : Hum Vaccin Immunother. 2019;15(1):141-145. DOI (Digital Object Identifier) : 10.1080/21645515.2018.1514227 PMID : 30261146 En línea : https://www.tandfonline.com/doi/abs/10.1080/21645515.2018.1514227?journalCode=kh [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4174 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000788 AC-2018-075 Archivo digital Producción Científica Artículos científicos Disponible Antibody persistence and evidence of immune memory at 5 years following administration of the 9-valent HPV vaccine / Ana María Guevara Zambrano
Título : Antibody persistence and evidence of immune memory at 5 years following administration of the 9-valent HPV vaccine Tipo de documento : documento electrónico Autores : Ana María Guevara Zambrano, Fecha de publicación : 2017 Títulos uniformes : Vaccine Idioma : Inglés (eng) Palabras clave : 9vHPV vaccine Clinical trial Human papillomavirus Immune memory Immunogenicity Resumen : Background: The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Vaccines that induce long-term protection are generally characterized by the generation of immune memory. The purpose of this report is to assess the persistence of HPV antibody response and existence of immune memory at 5 years post-vaccination. Methods:A subset of subjects (N = 150) who received 3 doses of 9vHPV vaccine at day 1, month 2 and month 6 in the pivotal efficacy study continued in a study extension and received a fourth dose of 9vHPV vaccine at month 60. Serum HPV antibody levels were measured pre-dose 4 and at 7 and 28 days post-dose 4 by competitive Luminex immunoassay. Adverse events were assessed using a vaccination report card. Results: HPV antibodies induced following the 3-dose series of 9vHPV vaccine in the base study persisted through month 60 with seropositivity rates ranging from 77.5% to 100%. Geometric mean titers at 1 week and 1 month post-dose 4 were 1.25–4.10 and 1.65–4.88-fold higher, respectively, than levels observed 1 month following the completion of the three-dose primary series. Seropositivity rates were >99% and 100% at 1 week and 1 month post-dose 4, respectively. The fourth dose of 9vHPV vaccine was generally well tolerated. Conclusions: A three-dose regimen of the 9vHPV vaccine induced persistent HPV antibody response through 5 years post-vaccination. Administration of a fourth dose resulted in a strong anamnestic response to all 9 vaccine types. These findings suggest that the efficacy of the 9vHPV vaccine will be long lasting Mención de responsabilidad : Ana Guevara, Robinson Cabello, Linn Woelber, Edson Duarte Moreira Jr, Elmar Joura, Olaf Reich, Christine Shields, Misoo C Ellison, Amita Joshi, Alain Luxembourg Referencia : Vaccine. 2017 Sep 5;35(37):5050-5057. DOI (Digital Object Identifier) : 10.1016/j.vaccine.2017.07.017 PMID : 28789851 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0264410X17309131 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4034 Antibody persistence and evidence of immune memory at 5 years following administration of the 9-valent HPV vaccine [documento electrónico] / Ana María Guevara Zambrano, . - 2017.
Obra : Vaccine
Idioma : Inglés (eng)
Palabras clave : 9vHPV vaccine Clinical trial Human papillomavirus Immune memory Immunogenicity Resumen : Background: The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Vaccines that induce long-term protection are generally characterized by the generation of immune memory. The purpose of this report is to assess the persistence of HPV antibody response and existence of immune memory at 5 years post-vaccination. Methods:A subset of subjects (N = 150) who received 3 doses of 9vHPV vaccine at day 1, month 2 and month 6 in the pivotal efficacy study continued in a study extension and received a fourth dose of 9vHPV vaccine at month 60. Serum HPV antibody levels were measured pre-dose 4 and at 7 and 28 days post-dose 4 by competitive Luminex immunoassay. Adverse events were assessed using a vaccination report card. Results: HPV antibodies induced following the 3-dose series of 9vHPV vaccine in the base study persisted through month 60 with seropositivity rates ranging from 77.5% to 100%. Geometric mean titers at 1 week and 1 month post-dose 4 were 1.25–4.10 and 1.65–4.88-fold higher, respectively, than levels observed 1 month following the completion of the three-dose primary series. Seropositivity rates were >99% and 100% at 1 week and 1 month post-dose 4, respectively. The fourth dose of 9vHPV vaccine was generally well tolerated. Conclusions: A three-dose regimen of the 9vHPV vaccine induced persistent HPV antibody response through 5 years post-vaccination. Administration of a fourth dose resulted in a strong anamnestic response to all 9 vaccine types. These findings suggest that the efficacy of the 9vHPV vaccine will be long lasting Mención de responsabilidad : Ana Guevara, Robinson Cabello, Linn Woelber, Edson Duarte Moreira Jr, Elmar Joura, Olaf Reich, Christine Shields, Misoo C Ellison, Amita Joshi, Alain Luxembourg Referencia : Vaccine. 2017 Sep 5;35(37):5050-5057. DOI (Digital Object Identifier) : 10.1016/j.vaccine.2017.07.017 PMID : 28789851 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0264410X17309131 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4034 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000630 AC-2017-019 Archivo digital Producción Científica Artículos científicos Disponible