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Título : Biomarkers of pituitary carcinomas Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2016 Títulos uniformes : Expert Review of Endocrinology and Metabolism Idioma : Inglés (eng) Palabras clave : Angiogenesis Galectin-3 HIF-1 H-ras Ki-67 microRNA P27/KIP1 P53 pituitary carcinoma telomerase Resumen : Pituitary carcinoma is a rare tumor originating from adenohypophyseal cells. Currently, diverse pathogenetic mechanisms, i.e. de novo versus malignant transformation from pituitary adenoma, remain obscure and require further investigation. During the last two decades, scientific research added new horizons not only in regards to general tumor concepts but also in next generation biomarker armamentarium that sheds light on alternate pathways in carcinogenesis. Areas covered: In this review, the impact of apoptotic and proliferative markers, angiogenesis, telomerase activity, H-ras, HIF-1, HER-2/neu, Rb gene, and microRNAs in pathogenetic mechanisms of pituitary carcinomas were revised. Expert commentary: It is becoming increasingly important for the need of standardization of new biomarkers but also for better comprehension of the diverse pathways in tumorigenesis. This can only be accomplished by tapping into the continuously expanding spectrum of new biomarkers. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V Syro, Antonio Di Ieva, Michael D Cusimano, Kalman Kovacs Referencia : Expert Rev Endocrinol Metab. 2016 May;11(3):253-261. DOI (Digital Object Identifier) : 10.1080/17446651.2016.1179110 PMID : 30058931 En línea : https://www.tandfonline.com/doi/abs/10.1080/17446651.2016.1179110 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4611 Biomarkers of pituitary carcinomas [documento electrónico] / Luis Vicente Syro Moreno, . - 2016.
Obra : Expert Review of Endocrinology and Metabolism
Idioma : Inglés (eng)
Palabras clave : Angiogenesis Galectin-3 HIF-1 H-ras Ki-67 microRNA P27/KIP1 P53 pituitary carcinoma telomerase Resumen : Pituitary carcinoma is a rare tumor originating from adenohypophyseal cells. Currently, diverse pathogenetic mechanisms, i.e. de novo versus malignant transformation from pituitary adenoma, remain obscure and require further investigation. During the last two decades, scientific research added new horizons not only in regards to general tumor concepts but also in next generation biomarker armamentarium that sheds light on alternate pathways in carcinogenesis. Areas covered: In this review, the impact of apoptotic and proliferative markers, angiogenesis, telomerase activity, H-ras, HIF-1, HER-2/neu, Rb gene, and microRNAs in pathogenetic mechanisms of pituitary carcinomas were revised. Expert commentary: It is becoming increasingly important for the need of standardization of new biomarkers but also for better comprehension of the diverse pathways in tumorigenesis. This can only be accomplished by tapping into the continuously expanding spectrum of new biomarkers. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V Syro, Antonio Di Ieva, Michael D Cusimano, Kalman Kovacs Referencia : Expert Rev Endocrinol Metab. 2016 May;11(3):253-261. DOI (Digital Object Identifier) : 10.1080/17446651.2016.1179110 PMID : 30058931 En línea : https://www.tandfonline.com/doi/abs/10.1080/17446651.2016.1179110 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4611 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001109 AC-2016-090 Archivo digital Producción Científica Artículos científicos Disponible Microvessel density and VEGF expression in pituitaries of pregnant women / Jorge Hernando Donado Gómez ; Luis Vicente Syro Moreno
Título : Microvessel density and VEGF expression in pituitaries of pregnant women Tipo de documento : documento electrónico Autores : Jorge Hernando Donado Gómez, ; Luis Vicente Syro Moreno, Fecha de publicación : 2013 Títulos uniformes : Hormones Idioma : Inglés (eng) Palabras clave : Angiogenesis Immunohistochemistry Pituitary Pregnancy Vascular endothelial growth factor Resumen : Objective: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprol-actinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of non pregnant women who had no endocrine diseases. Design: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abor- tion or during post-partum were immunostained for CD-34 and VEGF using the streptavidin-biotin-peroxidase complex method. Results: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. Conclusion: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression. Mención de responsabilidad : Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W Scheithauer, Luis V Syro, Jorge H Donado, James E Tarara, Kalman Kovacs Referencia : Hormones. 2013;12(2):292-7. DOI (Digital Object Identifier) : 10.14310/horm.2002.1413 PMID : 23933698 En línea : https://link.springer.com/article/10.14310/horm.2002.1413 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3699 Microvessel density and VEGF expression in pituitaries of pregnant women [documento electrónico] / Jorge Hernando Donado Gómez, ; Luis Vicente Syro Moreno, . - 2013.
Obra : Hormones
Idioma : Inglés (eng)
Palabras clave : Angiogenesis Immunohistochemistry Pituitary Pregnancy Vascular endothelial growth factor Resumen : Objective: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprol-actinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of non pregnant women who had no endocrine diseases. Design: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abor- tion or during post-partum were immunostained for CD-34 and VEGF using the streptavidin-biotin-peroxidase complex method. Results: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. Conclusion: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression. Mención de responsabilidad : Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W Scheithauer, Luis V Syro, Jorge H Donado, James E Tarara, Kalman Kovacs Referencia : Hormones. 2013;12(2):292-7. DOI (Digital Object Identifier) : 10.14310/horm.2002.1413 PMID : 23933698 En línea : https://link.springer.com/article/10.14310/horm.2002.1413 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3699 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000272 AC-2013-040 Archivo digital Producción Científica Artículos científicos Disponible
Título : Biomarkers of pituitary neoplasms Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2012 Títulos uniformes : Anticancer Research Idioma : Inglés (eng) Palabras clave : Angiogenesis apoptosis p53 p27 cox-2 folliculostellate cells galectin-3 hif-1alpha inflammation and tumor matrix metalloproteinases (MMPS) microarray microenvironment microvessel density (MVD) pituitary stem cells proliferative marker (ki-67) pituitary tumor-transforming gene (PTTG) topoisomerase-2-alpha tumor heterogeneity VEGF review Resumen : In a wide spectrum of tumors, cell proliferation, vascularity, apoptosis, cell adhesion, and cell-cycle progression may indicate tumor progression. In this review article, the literature regarding apoptotic markers and p53, as well as cyclooxygenase-2, galectin-3, and pituitary tumor transforming factor, proliferative markers, angiogenesis, including vascular endothelial growth factor and its receptor, pituitary tumor-transforming gene, microarrays, stem cells, and microenvironment and tumor heterogeneity are presented. Only a particular group of selected biomarkers show promise in differentiating pituitary tumors which will behave in an aggressive manner. Therefore, the most common and promising biomarkers and terms were analyzed, proposing the need for uniform design and application of methods and standardized criteria for the interpretation of results. The new spectrum of biomarkers may shed light upon the pathogenetic mechanisms and also may serve as standardized diagnostic tool for daily pathologic practice. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V. Syro, Bernd W. Scheithauer, and Kalman Kovacs Referencia : Anticancer Res. 2012; 32:(11)4639-54. En línea : http://ar.iiarjournals.org/content/32/11/4639.abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3635 Biomarkers of pituitary neoplasms [documento electrónico] / Luis Vicente Syro Moreno, . - 2012.
Obra : Anticancer Research
Idioma : Inglés (eng)
Palabras clave : Angiogenesis apoptosis p53 p27 cox-2 folliculostellate cells galectin-3 hif-1alpha inflammation and tumor matrix metalloproteinases (MMPS) microarray microenvironment microvessel density (MVD) pituitary stem cells proliferative marker (ki-67) pituitary tumor-transforming gene (PTTG) topoisomerase-2-alpha tumor heterogeneity VEGF review Resumen : In a wide spectrum of tumors, cell proliferation, vascularity, apoptosis, cell adhesion, and cell-cycle progression may indicate tumor progression. In this review article, the literature regarding apoptotic markers and p53, as well as cyclooxygenase-2, galectin-3, and pituitary tumor transforming factor, proliferative markers, angiogenesis, including vascular endothelial growth factor and its receptor, pituitary tumor-transforming gene, microarrays, stem cells, and microenvironment and tumor heterogeneity are presented. Only a particular group of selected biomarkers show promise in differentiating pituitary tumors which will behave in an aggressive manner. Therefore, the most common and promising biomarkers and terms were analyzed, proposing the need for uniform design and application of methods and standardized criteria for the interpretation of results. The new spectrum of biomarkers may shed light upon the pathogenetic mechanisms and also may serve as standardized diagnostic tool for daily pathologic practice. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V. Syro, Bernd W. Scheithauer, and Kalman Kovacs Referencia : Anticancer Res. 2012; 32:(11)4639-54. En línea : http://ar.iiarjournals.org/content/32/11/4639.abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3635 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000206 AC-2012-046 Archivo digital Producción Científica Artículos científicos Disponible
Título : Endoglin (CD105) : a review of its role in angiogenesis and tumor diagnosis, progression and therapy Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2011 Títulos uniformes : Anticancer Research Idioma : Inglés (eng) Palabras clave : Angiogenesis cancer CD105 endoglin tumor review Resumen : Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrate the potential of endoglin in tumor diagnosis, prognosis, and therapy. This review details the structure and function of endoglin, and investigates the role of endoglin in angiogenesis and tumor diagnosis, prognosis, and therapy. Mención de responsabilidad : Farshad Nassiri, Michael D Cusimano, Bernd W Scheithauer, Fabio Rotondo, Alessandra Fazio, George M Yousef, Luis V Syro, Kalman Kovacs, Ricardo V Lloyd Referencia : Anticancer Res. 2011 Jun;31(6):2283-90. PMID : 21737653 En línea : http://ar.iiarjournals.org/content/31/6/2283.full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3555 Endoglin (CD105) : a review of its role in angiogenesis and tumor diagnosis, progression and therapy [documento electrónico] / Luis Vicente Syro Moreno, . - 2011.
Obra : Anticancer Research
Idioma : Inglés (eng)
Palabras clave : Angiogenesis cancer CD105 endoglin tumor review Resumen : Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrate the potential of endoglin in tumor diagnosis, prognosis, and therapy. This review details the structure and function of endoglin, and investigates the role of endoglin in angiogenesis and tumor diagnosis, prognosis, and therapy. Mención de responsabilidad : Farshad Nassiri, Michael D Cusimano, Bernd W Scheithauer, Fabio Rotondo, Alessandra Fazio, George M Yousef, Luis V Syro, Kalman Kovacs, Ricardo V Lloyd Referencia : Anticancer Res. 2011 Jun;31(6):2283-90. PMID : 21737653 En línea : http://ar.iiarjournals.org/content/31/6/2283.full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3555 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000124 AC-2011-009 Archivo digital Producción Científica Artículos científicos Disponible
Título : Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2010 Títulos uniformes : Neoplasma Idioma : Inglés (eng) Palabras clave : immunohistochemistry endoglin CD34 microvascular density angiogenesis pituitary Resumen : Vascularization is a prerequisite of tumor growth, invasion and metastasis. In the present work, microvessel density was assessed by quantitating using two different endothelial cell biomarkers, endoglin (CD-105) and CD-34. Fifty endocrinologically active and 36 clinically nonfunctioning pituitary adenomas, all surgically resected, as well as 10 autopsy-derived normal adenohypophyses were investigated by immunohistochemistry. The results showed that in every pituitary adenoma type endoglin, an assumed biomarker of proliferating endothelial cells, immunostained fewer vessels than CD-34 which revealed immunopositivity in all capillaries. Differences in endoglin versus CD-34 immunoexpression indicate varying degrees of vascularity in pituitary adenoma subtypes. The low levels of endoglin immunoexpression in pituitary tumors exposed to long-acting somatostatin analogs and dopamine agonists are consistent with the view that these agents inhibit angiogenesis. Mención de responsabilidad : F Rotondo, S Sharma, B W Scheithauer, E Horvath, L V Syro, M Cusimano, F Nassiri, G M Yousef, K Kovacs Referencia : Neoplasma. 2010;57(6):590-3. DOI (Digital Object Identifier) : 10.4149/neo_2010_06_590 PMID : 20845998 En línea : http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&produ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4470 Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes [documento electrónico] / Luis Vicente Syro Moreno, . - 2010.
Obra : Neoplasma
Idioma : Inglés (eng)
Palabras clave : immunohistochemistry endoglin CD34 microvascular density angiogenesis pituitary Resumen : Vascularization is a prerequisite of tumor growth, invasion and metastasis. In the present work, microvessel density was assessed by quantitating using two different endothelial cell biomarkers, endoglin (CD-105) and CD-34. Fifty endocrinologically active and 36 clinically nonfunctioning pituitary adenomas, all surgically resected, as well as 10 autopsy-derived normal adenohypophyses were investigated by immunohistochemistry. The results showed that in every pituitary adenoma type endoglin, an assumed biomarker of proliferating endothelial cells, immunostained fewer vessels than CD-34 which revealed immunopositivity in all capillaries. Differences in endoglin versus CD-34 immunoexpression indicate varying degrees of vascularity in pituitary adenoma subtypes. The low levels of endoglin immunoexpression in pituitary tumors exposed to long-acting somatostatin analogs and dopamine agonists are consistent with the view that these agents inhibit angiogenesis. Mención de responsabilidad : F Rotondo, S Sharma, B W Scheithauer, E Horvath, L V Syro, M Cusimano, F Nassiri, G M Yousef, K Kovacs Referencia : Neoplasma. 2010;57(6):590-3. DOI (Digital Object Identifier) : 10.4149/neo_2010_06_590 PMID : 20845998 En línea : http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&produ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4470 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000970 AC-2010-060 Archivo digital Producción Científica Artículos científicos Disponible
