4 búsqueda de la palabra clave 'C-reactive protein'

Biomarkers as a prognostic factor in COPD exacerbation: a cohort study / Jaime Alberto Gómez Rosero  

Público ISBD Título : Biomarkers as a prognostic factor in COPD exacerbation: a cohort study Tipo de documento : documento electrónico Autores : Jaime Alberto Gómez Rosero, Fecha de publicación : 2021 Títulos uniformes : COPD Idioma : Inglés (eng) Palabras clave : C-reactive protein  mean platelet volume  eosinophil count  neutrophil/lymphocyte ratio  morbidity and mortality Resumen : The acute exacerbations of COPD (AECOPD) are one of the main causes of hospitalization and morbimortality in the adult population. There are not many tools available to predict the clinical course of these patients during exacerbations. Our goal was to estimate the clinical utility of C Reactive Protein (CRP), Mean Platelet Volume (MPV), eosinophil count and neutrophil/lymphocyte ratio (NLR) as in-hospital prognostic factors in patients with AECOPD. A prospective cohort study was conducted in patients who consulted three reference hospitals in the city of Medellín for AECOPD and who required hospitalization between 2017 and 2020. A multivariate analysis was performed to estimate the effect of biomarkers in the two primary outcomes: the composite outcome of in-hospital death and/or admission to the ICU and hospital length-of-stay. A total of 610 patients with a median age of 74 years were included; 15% were admitted to the ICU and 3.9% died in the hospital. In the multivariate analysis adjusted for confounding variables, the only marker significantly associated with the risk of dying or being admitted to the ICU was the NLR > 5 (OR: 3; CI95%: 1.5; 6). Similarly, the NLR > 5 was also associated to a lower probability of being discharged alive from the institution (SHR: 0.73; CI95%: 0.57; 0.94) and, therefore, a longer hospital stay. It was found that a neutrophil/lymphocyte ratio greater than 5 is a strong predictor of mortality or ICU admissions and a longer hospital stay in patients hospitalized with AECOPD. Mención de responsabilidad : Jaime A. Gómez-Rosero, Camilo Cáceres-Galvis, Johana Ascuntar, Carlos Atencia, Carlos E. Vallejo & Fabián Jaimes Referencia : COPD. 2021 Jun;18(3):325-332. DOI (Digital Object Identifier) : 10.1080/15412555.2021.1922370 PMID : 33970730 En línea : https://www.tandfonline.com/doi/full/10.1080/15412555.2021.1922370 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5775 Biomarkers as a prognostic factor in COPD exacerbation: a cohort study [documento electrónico] / Jaime Alberto Gómez Rosero,  . - 2021. Obra : COPD Idioma : Inglés (eng) Palabras clave : C-reactive protein  mean platelet volume  eosinophil count  neutrophil/lymphocyte ratio  morbidity and mortality Resumen : The acute exacerbations of COPD (AECOPD) are one of the main causes of hospitalization and morbimortality in the adult population. There are not many tools available to predict the clinical course of these patients during exacerbations. Our goal was to estimate the clinical utility of C Reactive Protein (CRP), Mean Platelet Volume (MPV), eosinophil count and neutrophil/lymphocyte ratio (NLR) as in-hospital prognostic factors in patients with AECOPD. A prospective cohort study was conducted in patients who consulted three reference hospitals in the city of Medellín for AECOPD and who required hospitalization between 2017 and 2020. A multivariate analysis was performed to estimate the effect of biomarkers in the two primary outcomes: the composite outcome of in-hospital death and/or admission to the ICU and hospital length-of-stay. A total of 610 patients with a median age of 74 years were included; 15% were admitted to the ICU and 3.9% died in the hospital. In the multivariate analysis adjusted for confounding variables, the only marker significantly associated with the risk of dying or being admitted to the ICU was the NLR > 5 (OR: 3; CI95%: 1.5; 6). Similarly, the NLR > 5 was also associated to a lower probability of being discharged alive from the institution (SHR: 0.73; CI95%: 0.57; 0.94) and, therefore, a longer hospital stay. It was found that a neutrophil/lymphocyte ratio greater than 5 is a strong predictor of mortality or ICU admissions and a longer hospital stay in patients hospitalized with AECOPD. Mención de responsabilidad : Jaime A. Gómez-Rosero, Camilo Cáceres-Galvis, Johana Ascuntar, Carlos Atencia, Carlos E. Vallejo & Fabián Jaimes Referencia : COPD. 2021 Jun;18(3):325-332. DOI (Digital Object Identifier) : 10.1080/15412555.2021.1922370 PMID : 33970730 En línea : https://www.tandfonline.com/doi/full/10.1080/15412555.2021.1922370 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5775

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Factors associated with infection amongst paediatric patients with systemic lupus erythematosus treated in the intensive care unit / Mauricio Restrepo Escobar ; Ruth María Eraso Garnica  

Público ISBD Título : Factors associated with infection amongst paediatric patients with systemic lupus erythematosus treated in the intensive care unit Tipo de documento : documento electrónico Autores : Mauricio Restrepo Escobar, ; Ruth María Eraso Garnica, Fecha de publicación : 2019 Títulos uniformes : Lupus Idioma : Inglés (eng) Palabras clave : Childhood-onset systemic lupus erythematosus  paediatric intensive care unit  nosocomial infection  C-reactive protein  mortality Resumen : Objective: To identify determinants and outcomes associated with infection in paediatric systemic lupus erythematosus (SLE) patients at admission and during hospitalization in intensive care units (ICUs). Patients and methods: A retrospective cohort study of paediatric SLE patients admitted to two ICUs was conducted. Frequency and risk factors of infection as well as mortality were studied. Results: Seventy-three infection episodes amongst 55 patients were analysed. The median age was 14.4 years (IQR 12.5–16). The median SLEDAI was 16 (IQR 12–20). Twenty-nine episodes were documented at admission; the CRP was higher in these patients (6.58 versus 1.04 mg/dl, p Mención de responsabilidad : M Restrepo-Escobar, N A Ríos, L J Hernández-Zapata, M Velásquez, R Eraso Referencia : Lupus. 2019 Aug;28(9):1141-1147. DOI (Digital Object Identifier) : 10.1177/0961203319860194 PMID : 31256746 En línea : https://journals.sagepub.com/doi/abs/10.1177/0961203319860194 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4243 Factors associated with infection amongst paediatric patients with systemic lupus erythematosus treated in the intensive care unit [documento electrónico] / Mauricio Restrepo Escobar, ; Ruth María Eraso Garnica,  . - 2019. Obra : Lupus Idioma : Inglés (eng) Palabras clave : Childhood-onset systemic lupus erythematosus  paediatric intensive care unit  nosocomial infection  C-reactive protein  mortality Resumen : Objective: To identify determinants and outcomes associated with infection in paediatric systemic lupus erythematosus (SLE) patients at admission and during hospitalization in intensive care units (ICUs). Patients and methods: A retrospective cohort study of paediatric SLE patients admitted to two ICUs was conducted. Frequency and risk factors of infection as well as mortality were studied. Results: Seventy-three infection episodes amongst 55 patients were analysed. The median age was 14.4 years (IQR 12.5–16). The median SLEDAI was 16 (IQR 12–20). Twenty-nine episodes were documented at admission; the CRP was higher in these patients (6.58 versus 1.04 mg/dl, p Mención de responsabilidad : M Restrepo-Escobar, N A Ríos, L J Hernández-Zapata, M Velásquez, R Eraso Referencia : Lupus. 2019 Aug;28(9):1141-1147. DOI (Digital Object Identifier) : 10.1177/0961203319860194 PMID : 31256746 En línea : https://journals.sagepub.com/doi/abs/10.1177/0961203319860194 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4243

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C-reactive protein and the MASCC risk index identify high-risk patients with febrile neutropenia and hematologic neoplasms / Marcos Arango Barrientos ; Juan Felipe Combariza Vallejo  

Público ISBD Título : C-reactive protein and the MASCC risk index identify high-risk patients with febrile neutropenia and hematologic neoplasms Tipo de documento : documento electrónico Autores : Marcos Arango Barrientos, ; Juan Felipe Combariza Vallejo, Fecha de publicación : 2014 Títulos uniformes : Supportive Care in Cancer Idioma : Inglés (eng) Palabras clave : Febrile neutropenia  C-reactive protein  hematologic neoplasms Resumen : Objective: The objective of this study is to assess the prognostic usefulness of the Multinational Association of Supportive Care in Cancer (MASCC) risk score in association with the value of C-reactive protein (CRP) to identify high-risk patients with febrile neutropenia and hematologic neoplasms. Methods: A retrospective cohort study in which the MASCC score and the CRP values were used to assess the mortality risk at 30 days among patients with febrile neutropenia and hematologic malignancies was performed. Results: Two hundred thiry-seven patients with febrile neutropenia were analyzed; the mortality rate within 30 days was 9 %. High-risk patients according to the MASCC score were significantly more likely to experience adverse outcomes, such as being transferred to the intensive care unit (RR 3.55; CI 95 % 2.73–6.62, p  Mención de responsabilidad : Juan F Combariza, Milton Lombana, Luis E Pino, Marcos Arango Referencia : Support Care Cancer. 2015 Apr;23(4):1009-13. DOI (Digital Object Identifier) : 10.1007/s00520-014-2454-2 PMID : 25270848 En línea : https://link.springer.com/article/10.1007%2Fs00520-014-2454-2 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3842 C-reactive protein and the MASCC risk index identify high-risk patients with febrile neutropenia and hematologic neoplasms [documento electrónico] / Marcos Arango Barrientos, ; Juan Felipe Combariza Vallejo,  . - 2014. Obra : Supportive Care in Cancer Idioma : Inglés (eng) Palabras clave : Febrile neutropenia  C-reactive protein  hematologic neoplasms Resumen : Objective: The objective of this study is to assess the prognostic usefulness of the Multinational Association of Supportive Care in Cancer (MASCC) risk score in association with the value of C-reactive protein (CRP) to identify high-risk patients with febrile neutropenia and hematologic neoplasms. Methods: A retrospective cohort study in which the MASCC score and the CRP values were used to assess the mortality risk at 30 days among patients with febrile neutropenia and hematologic malignancies was performed. Results: Two hundred thiry-seven patients with febrile neutropenia were analyzed; the mortality rate within 30 days was 9 %. High-risk patients according to the MASCC score were significantly more likely to experience adverse outcomes, such as being transferred to the intensive care unit (RR 3.55; CI 95 % 2.73–6.62, p  Mención de responsabilidad : Juan F Combariza, Milton Lombana, Luis E Pino, Marcos Arango Referencia : Support Care Cancer. 2015 Apr;23(4):1009-13. DOI (Digital Object Identifier) : 10.1007/s00520-014-2454-2 PMID : 25270848 En línea : https://link.springer.com/article/10.1007%2Fs00520-014-2454-2 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3842

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A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis / Gisela de la Rosa Echavez ; Clara María Arango Toro ; Carlos Ignacio Gómez Roldán ; Fabián Alberto Jaimes Barragán    

Público ISBD Título : A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis Tipo de documento : documento electrónico Autores : Gisela de la Rosa Echavez, ; Clara María Arango Toro, ; Carlos Ignacio Gómez Roldán, ; Fabián Alberto Jaimes Barragán, Fecha de publicación : 2013 Títulos uniformes : BMC Anesthesiology Idioma : Inglés (eng) Palabras clave : Sensitivity  specificity  sepsis  latent class  C-reactive protein  procalcitonin  D-dimer Resumen : Background: Given the acknowledged problems in sepsis diagnosis, we use a novel way with the application of the latent class analysis (LCA) to determine the operative characteristics of C-reactive protein (CRP), D-dimer (DD) and Procalcitonin (PCT) as diagnostic tests for sepsis in patients admitted to hospital care with a presumptive infection. Methods: Cross-sectional study to determine the diagnostic accuracy of three biological markers against the gold standard of clinical definition of sepsis provided by an expert committee, and also against the likelihood of sepsis according to LCA. Patients were recruited in the emergency room within 24 hours of hospitalization and were follow-up daily until discharge. Results: Among 765 patients, the expert committee classified 505 patients (66%) with sepsis, 112 (15%) with infection but without sepsis and 148 (19%) without infection. The best cut-offs points for CRP, DD, and PCT were 7.8 mg/dl, 1616 ng/ml and 0.3 ng/ml, respectively; but, neither sensitivity nor specificity reach 70% for any biomarker. The LCA analysis with the same three tests identified a “cluster” of 187 patients with several characteristics suggesting a more severe condition as well as better microbiological confirmation. Assuming this subset of patients as the new prevalence of sepsis, the ROC curve analysis identified new cut-off points for the tests and suggesting a better discriminatory ability for PCT with a value of 2 ng/ml. Conclusions: Under a “classical” definition of sepsis three typical biomarkers (CRP, PCT and DD) are not capable enough to differentiate septic from non-septic patients in the ER. However, a higher level of PCT discriminates a selected group of patients with severe sepsis. Mención de responsabilidad : Fabián A Jaimes, Gisela D De La Rosa, Marta L Valencia, Clara M Arango, Carlos I Gomez, Alex Garcia, Sigifredo Ospina, Susana C Osorno, Adriana I Henao Referencia : BMC Anesthesiol. 2013 Sep 19;13(1):23. DOI (Digital Object Identifier) : 10.1186/1471-2253-13-23 PMID : 24050481 Derechos de uso : CC BY En línea : https://bmcanesthesiol.biomedcentral.com/articles/10.1186/1471-2253-13-23#Abs1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3689 A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis [documento electrónico] / Gisela de la Rosa Echavez, ; Clara María Arango Toro, ; Carlos Ignacio Gómez Roldán, ; Fabián Alberto Jaimes Barragán,  . - 2013. Obra : BMC Anesthesiology Idioma : Inglés (eng) Palabras clave : Sensitivity  specificity  sepsis  latent class  C-reactive protein  procalcitonin  D-dimer Resumen : Background: Given the acknowledged problems in sepsis diagnosis, we use a novel way with the application of the latent class analysis (LCA) to determine the operative characteristics of C-reactive protein (CRP), D-dimer (DD) and Procalcitonin (PCT) as diagnostic tests for sepsis in patients admitted to hospital care with a presumptive infection. Methods: Cross-sectional study to determine the diagnostic accuracy of three biological markers against the gold standard of clinical definition of sepsis provided by an expert committee, and also against the likelihood of sepsis according to LCA. Patients were recruited in the emergency room within 24 hours of hospitalization and were follow-up daily until discharge. Results: Among 765 patients, the expert committee classified 505 patients (66%) with sepsis, 112 (15%) with infection but without sepsis and 148 (19%) without infection. The best cut-offs points for CRP, DD, and PCT were 7.8 mg/dl, 1616 ng/ml and 0.3 ng/ml, respectively; but, neither sensitivity nor specificity reach 70% for any biomarker. The LCA analysis with the same three tests identified a “cluster” of 187 patients with several characteristics suggesting a more severe condition as well as better microbiological confirmation. Assuming this subset of patients as the new prevalence of sepsis, the ROC curve analysis identified new cut-off points for the tests and suggesting a better discriminatory ability for PCT with a value of 2 ng/ml. Conclusions: Under a “classical” definition of sepsis three typical biomarkers (CRP, PCT and DD) are not capable enough to differentiate septic from non-septic patients in the ER. However, a higher level of PCT discriminates a selected group of patients with severe sepsis. Mención de responsabilidad : Fabián A Jaimes, Gisela D De La Rosa, Marta L Valencia, Clara M Arango, Carlos I Gomez, Alex Garcia, Sigifredo Ospina, Susana C Osorno, Adriana I Henao Referencia : BMC Anesthesiol. 2013 Sep 19;13(1):23. DOI (Digital Object Identifier) : 10.1186/1471-2253-13-23 PMID : 24050481 Derechos de uso : CC BY En línea : https://bmcanesthesiol.biomedcentral.com/articles/10.1186/1471-2253-13-23#Abs1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3689

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