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Twenty-five years of cancer gene therapy: Anti - Gene IGF-I approach / Beatriz Helena Aristizábal Bernal  

Público ISBD Título : Twenty-five years of cancer gene therapy: Anti - Gene IGF-I approach Tipo de documento : documento electrónico Autores : Beatriz Helena Aristizábal Bernal, Fecha de publicación : 2020 Títulos uniformes : British Journal of Cancer Research Idioma : Inglés (eng) Palabras clave : cancer gene therapy  IGF-I  antisense  triple helix  glioblastoma  CD 8 Resumen : IGF-I is one of the most important growth factors that is related to normal differentiation, and its overproduction in mature tissues is a sign of neoplastic processes, e.g. liver or brain malignant tumors. For this reason, IGF-I became an essential target for gene testing and therapeutic purpose. The development of a new medical domain in 1992/1993, called cancer gene therapy, followed by NIH and FDA approval in 1994, represents an important revolution in the treatment of malignant tumors. The new strategy, using anti-gene (antisense/triple helix) anti IGF-I technology, has shown promising results in clinical trials of malignant tumors derivatived of all three embryonic layers; in the case of tumor derivatived of neuroectodermal tissue – glioblastoma, the median survival of patients reached 21 months and, in some cases, up to three and four years. This strategy was also proven to be efficient in the treatment of mesodermal and endodermal tissue derivatives – cancers of colon, prostate and ovary. Mención de responsabilidad : Jerzy Trojan, Alexander Shevelev, Adama Ly, Yuexin Pan, Yajun Guo, Gabriela Quintero, Lia C. Upegui-Gonzalez, Maciej Bierwagen, Anna Junkiert, Ming X. Wei, Jerzy G. Hildebrand, Jean-C. Francois, Frederick Hor, Tatiana Castillo, Adis Ayala, Andrea Guzman, Jean-F. Cloix, Marie-Y. Ardourel, Piotr Jarocki, Marek Sierzega, Zbigniew Wolski, Cristiane Lafarge-Frayssinet, Beatriz H. Aristizabal, Pedro J. Penagos, Tadeusz Popiela, Heliodor Kasprzak, Ignacio Bricenio, Donald D. Anthony, Heber Siachoque, Alvaro Alvarez, Yu-Chun Lone, Annabelle Trojan En línea : https://makperiodicallibrary.com/britishjournalofcancerresearch/twenty-five-year [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5086 Twenty-five years of cancer gene therapy: Anti - Gene IGF-I approach [documento electrónico] / Beatriz Helena Aristizábal Bernal,  . - 2020. Obra : British Journal of Cancer Research Idioma : Inglés (eng) Palabras clave : cancer gene therapy  IGF-I  antisense  triple helix  glioblastoma  CD 8 Resumen : IGF-I is one of the most important growth factors that is related to normal differentiation, and its overproduction in mature tissues is a sign of neoplastic processes, e.g. liver or brain malignant tumors. For this reason, IGF-I became an essential target for gene testing and therapeutic purpose. The development of a new medical domain in 1992/1993, called cancer gene therapy, followed by NIH and FDA approval in 1994, represents an important revolution in the treatment of malignant tumors. The new strategy, using anti-gene (antisense/triple helix) anti IGF-I technology, has shown promising results in clinical trials of malignant tumors derivatived of all three embryonic layers; in the case of tumor derivatived of neuroectodermal tissue – glioblastoma, the median survival of patients reached 21 months and, in some cases, up to three and four years. This strategy was also proven to be efficient in the treatment of mesodermal and endodermal tissue derivatives – cancers of colon, prostate and ovary. Mención de responsabilidad : Jerzy Trojan, Alexander Shevelev, Adama Ly, Yuexin Pan, Yajun Guo, Gabriela Quintero, Lia C. Upegui-Gonzalez, Maciej Bierwagen, Anna Junkiert, Ming X. Wei, Jerzy G. Hildebrand, Jean-C. Francois, Frederick Hor, Tatiana Castillo, Adis Ayala, Andrea Guzman, Jean-F. Cloix, Marie-Y. Ardourel, Piotr Jarocki, Marek Sierzega, Zbigniew Wolski, Cristiane Lafarge-Frayssinet, Beatriz H. Aristizabal, Pedro J. Penagos, Tadeusz Popiela, Heliodor Kasprzak, Ignacio Bricenio, Donald D. Anthony, Heber Siachoque, Alvaro Alvarez, Yu-Chun Lone, Annabelle Trojan En línea : https://makperiodicallibrary.com/britishjournalofcancerresearch/twenty-five-year [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5086

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