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Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study / Alejandro Díaz Díaz ; Sossa Alarcón, María Camila ; Gutiérrez, Mónica Paola ; Becerra, Natalia ; Ortegon, Luz Yessenia ; David, María Camila ; Naranjo Vanegas, Melisa ; Friedrich, Gabriela ; Vásquez Hoyos, Pablo ; Mesa Rubio, María Lucía ; Navarro Ramirez, Luis Miguel ; Moreno Lopez, Sergio ; Baquero, Olga Lucía ; Marina Mejía, Luz ; Piñeros, Juan Gabriel ; Restrepo Gualteros, Sonia ; Álvarez Moreno, Carlos ; Gutierrez Tobar, Iván ; Camilo Mesa, Andrés ; Bachiller Tuta, William Ricardo ; Galvis Diaz, Clara Esperanza ; Africano, Martha ; Nieto, José Manuel ; Pérez Camacho, Paola Marsela ; Beltrán Arroyave, Claudia ; Vivas Trochez, Rosalba ; Gastesi, Irati ; Moraleda, Cinta ; Tagarro García, Alfredo ; Herrero, Blanca ; Calleja, Lourdes ; Grasa, Carlos ; Rodriguez, Paula ; Melendo, Susana ; Soriano Arandes, Antoni ; Gómez Pastrana, Irene ; García García, Sonsoles ; Fumado, Victoria ; Ramirez Varela, Andrea
Título : Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study Tipo de documento : documento electrónico Autores : Alejandro Díaz Díaz, Autor ; Sossa Alarcón, María Camila, Autor ; Gutiérrez, Mónica Paola, Autor ; Becerra, Natalia, Autor ; Ortegon, Luz Yessenia, Autor ; David, María Camila, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Piñeros, Juan Gabriel, Autor ; Restrepo Gualteros, Sonia, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez Tobar, Iván, Autor ; Camilo Mesa, Andrés, Autor ; Bachiller Tuta, William Ricardo, Autor ; Galvis Diaz, Clara Esperanza, Autor ; Africano, Martha, Autor ; Nieto, José Manuel, Autor ; Pérez Camacho, Paola Marsela, Autor ; Beltrán Arroyave, Claudia, Autor ; Vivas Trochez, Rosalba, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Herrero, Blanca, Autor ; Calleja, Lourdes, Autor ; Grasa, Carlos, Autor ; Rodriguez, Paula, Autor ; Melendo, Susana, Autor ; Soriano Arandes, Antoni, Autor ; Gómez Pastrana, Irene, Autor ; García García, Sonsoles, Autor ; Fumado, Victoria, Autor ; Ramirez Varela, Andrea, Autor Fecha de publicación : 2025 Títulos uniformes : International Journal of Collaborative Research on Internal Medicine & Public Health Idioma : Inglés (eng) Palabras clave : COVID-19 pediatrics inpatients cluster analysis SARS-CoV-2 variants Resumen : Objective To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study. Methods We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes. Results A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries. Conclusion Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies. Mención de responsabilidad : María Camila Sossa-Alarcón1*†, Mónica Paola Gutiérrez1†, Natalia Becerra1†,Luz Yessenia Ortegon1†, María Camila David1†,Melisa Naranjo vanegas2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24, Gabriela Friedrich 2,Pablo Vásquez-Hoyos3, María Lucía Mesa-Rubio1,Luis Miguel Navarro-Ramirez2Sergio Moreno-Lopez2, Olga Lucía Baquero4, Luz Marina Mejía5, Juan Gabriel Piñeros1,Sonia Restrepo-Gualteros1, Carlos Álvarez-Moreno6, Alejandro Díaz-Díaz7, Iván Gutierrez-Tobar8, Andrés Camilo Mesa9, William Ricardo Bachiller Tuta10,Clara Esperanza Galvis Diaz11, Martha Africano12, José Manuel Nieto13,Paola Marcela Pérez Camacho14, Claudia Beltrán-Arroyave15, Rosalba Vivas Trochez16,Irati Gastesi17, Cinta Moraleda17, Alfredo Tagarro García17,18, Blanca Herrero19,Lourdes Calleja19, Carlos Grasa20, Paula Rodriguez20, Susana Melendo21,Antoni Soriano-Arandes21, Irene Gómez Pastrana17, Sonsoles García García17,Victoria Fumado22 and Andrea Ramírez Varela23 on behalf of EPICO-Colombia and EPICO-AEP Referencia : Int J Public Health. 2025 Mar 18;70:1607246 DOI (Digital Object Identifier) : 10.3389/ijph.2025.1607246 PMID : 40170693 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11959304/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study [documento electrónico] / Alejandro Díaz Díaz, Autor ; Sossa Alarcón, María Camila, Autor ; Gutiérrez, Mónica Paola, Autor ; Becerra, Natalia, Autor ; Ortegon, Luz Yessenia, Autor ; David, María Camila, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Piñeros, Juan Gabriel, Autor ; Restrepo Gualteros, Sonia, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez Tobar, Iván, Autor ; Camilo Mesa, Andrés, Autor ; Bachiller Tuta, William Ricardo, Autor ; Galvis Diaz, Clara Esperanza, Autor ; Africano, Martha, Autor ; Nieto, José Manuel, Autor ; Pérez Camacho, Paola Marsela, Autor ; Beltrán Arroyave, Claudia, Autor ; Vivas Trochez, Rosalba, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Herrero, Blanca, Autor ; Calleja, Lourdes, Autor ; Grasa, Carlos, Autor ; Rodriguez, Paula, Autor ; Melendo, Susana, Autor ; Soriano Arandes, Antoni, Autor ; Gómez Pastrana, Irene, Autor ; García García, Sonsoles, Autor ; Fumado, Victoria, Autor ; Ramirez Varela, Andrea, Autor . - 2025.
Obra : International Journal of Collaborative Research on Internal Medicine & Public Health
Idioma : Inglés (eng)
Palabras clave : COVID-19 pediatrics inpatients cluster analysis SARS-CoV-2 variants Resumen : Objective To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study. Methods We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes. Results A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries. Conclusion Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies. Mención de responsabilidad : María Camila Sossa-Alarcón1*†, Mónica Paola Gutiérrez1†, Natalia Becerra1†,Luz Yessenia Ortegon1†, María Camila David1†,Melisa Naranjo vanegas2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24, Gabriela Friedrich 2,Pablo Vásquez-Hoyos3, María Lucía Mesa-Rubio1,Luis Miguel Navarro-Ramirez2Sergio Moreno-Lopez2, Olga Lucía Baquero4, Luz Marina Mejía5, Juan Gabriel Piñeros1,Sonia Restrepo-Gualteros1, Carlos Álvarez-Moreno6, Alejandro Díaz-Díaz7, Iván Gutierrez-Tobar8, Andrés Camilo Mesa9, William Ricardo Bachiller Tuta10,Clara Esperanza Galvis Diaz11, Martha Africano12, José Manuel Nieto13,Paola Marcela Pérez Camacho14, Claudia Beltrán-Arroyave15, Rosalba Vivas Trochez16,Irati Gastesi17, Cinta Moraleda17, Alfredo Tagarro García17,18, Blanca Herrero19,Lourdes Calleja19, Carlos Grasa20, Paula Rodriguez20, Susana Melendo21,Antoni Soriano-Arandes21, Irene Gómez Pastrana17, Sonsoles García García17,Victoria Fumado22 and Andrea Ramírez Varela23 on behalf of EPICO-Colombia and EPICO-AEP Referencia : Int J Public Health. 2025 Mar 18;70:1607246 DOI (Digital Object Identifier) : 10.3389/ijph.2025.1607246 PMID : 40170693 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11959304/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Aggression, micro-aggression, and abuse against health care providers during the COVID-19 pandemic. A Latin American Survey Tipo de documento : documento electrónico Autores : Andrés Felipe Miranda Arboleda, Fecha de publicación : 2022 Títulos uniformes : Current Problems in Cardiology Idioma : Inglés (eng) Palabras clave : COVID-19 aggression health personnel workplace violence Resumen : The COVID-19 pandemic has had tremendous consequences globally. Notably, increasing complaints of verbal and physical violence against health care providers have been reported. A cross-sectional electronic survey was conducted between January 11th and February 28th, 2022 to delineate the violent behavior against front-line health professionals in Latin America. A total of 3,544 participants from 19 countries were included. The 58.5% were women, 70.8% were physicians, 16% nurses, and 13.2% were other health team members. About 54.8% reported acts of abuse: 95.6% verbal abuse, 11.1% physical abuse, and 19.9% other types. Nearly half of those who reported abuse experienced psychosomatic symptoms after the event, 56.2% considered changing their care tasks, and 33.6% considered quitting their profession. In a logistic regression model, nurses (odds ratio (OR) 1.90, p Mención de responsabilidad : Sebastián Garcia-Zamora, Laura Pulido, Andrés Felipe Miranda-Arboleda, Darío Eduardo Garcia, Gonzalo Perez, Mauricio Priotti, Diego X. Chango, Melisa Antoniolli, Ezequiel José Zaidel, Ricardo Lopez-Santi, Gustavo Vazquez, Rodrigo Nuñez-Mendez, Luz Teresa Cabral, Álvaro Sosa-Liprandi, Kiera Liblik, and Adrian Baranchuk Referencia : Curr Probl Cardiol. 2022 Oct;47(10):101296. DOI (Digital Object Identifier) : 10.1016/j.cpcardiol.2022.101296 PMID : 35779676 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0146-2806(22)00193-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Aggression, micro-aggression, and abuse against health care providers during the COVID-19 pandemic. A Latin American Survey [documento electrónico] / Andrés Felipe Miranda Arboleda, . - 2022.
Obra : Current Problems in Cardiology
Idioma : Inglés (eng)
Palabras clave : COVID-19 aggression health personnel workplace violence Resumen : The COVID-19 pandemic has had tremendous consequences globally. Notably, increasing complaints of verbal and physical violence against health care providers have been reported. A cross-sectional electronic survey was conducted between January 11th and February 28th, 2022 to delineate the violent behavior against front-line health professionals in Latin America. A total of 3,544 participants from 19 countries were included. The 58.5% were women, 70.8% were physicians, 16% nurses, and 13.2% were other health team members. About 54.8% reported acts of abuse: 95.6% verbal abuse, 11.1% physical abuse, and 19.9% other types. Nearly half of those who reported abuse experienced psychosomatic symptoms after the event, 56.2% considered changing their care tasks, and 33.6% considered quitting their profession. In a logistic regression model, nurses (odds ratio (OR) 1.90, p Mención de responsabilidad : Sebastián Garcia-Zamora, Laura Pulido, Andrés Felipe Miranda-Arboleda, Darío Eduardo Garcia, Gonzalo Perez, Mauricio Priotti, Diego X. Chango, Melisa Antoniolli, Ezequiel José Zaidel, Ricardo Lopez-Santi, Gustavo Vazquez, Rodrigo Nuñez-Mendez, Luz Teresa Cabral, Álvaro Sosa-Liprandi, Kiera Liblik, and Adrian Baranchuk Referencia : Curr Probl Cardiol. 2022 Oct;47(10):101296. DOI (Digital Object Identifier) : 10.1016/j.cpcardiol.2022.101296 PMID : 35779676 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0146-2806(22)00193-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001881 AC-2022-046 Archivo digital Producción Científica Artículos científicos Disponible 
Título : Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America Tipo de documento : documento electrónico Autores : Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America [documento electrónico] / Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Clinical characteristics of children with SARS-CoV-2 infection in a hospital in Latin America Tipo de documento : documento electrónico Autores : Laura Fernanda Niño Serna, ; Eliana López Barón, ; Isabel Cristina Maya Ángel, ; Carolina Tamayo Múnera, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatrics comorbidity inpatients pediatric intensive care unit Latin America COVID-19 Resumen : Objective: COVID-19 infections have shown a different behavior in children than in adults. The objective of this study was to describe the clinical characteristics and severity of SARS-CoV-2 infection in pediatric patients seen at a reference hospital in Colombia. Method: A descriptive, observational study in patients under the age of 18 years with a positive test for SARS-CoV-2 infection (RT-PCR or antigen) between April 2020 and March 2021. Multiple variables were studied, including demographic data, clinical characteristics, lab measurements, treatments administered, intensive care unit admission, and mortality. Results: A total of 361 patients were included of whom 196 (54%) were males. The median age was 3 years. Of all the patients, 65 (18%) were asymptomatic. The majority of patients had no comorbidities (n = 225, 76%). In those who were symptomatic (n = 296, 82%), the most frequent complaints were fever (n = 178, 60%), nasal congestion (n = 164, 55%) and cough (n = 149, 50%). Chest x-rays were normal in 73 patients (50%). When abnormalities were found, interstitial (29%) and alveolar (12%) patterns were the most prevalent. One hundred and fifty-seven children (53%) required general ward hospitalization, and 24 patients (8%) required pediatric intensive care admission. The global mortality was 0.8% (3 patients). Conclusions: The majority of cases were asymptomatic or mild. However, a significant percentage of patients required general ward admission, and some even required intensive care. The main symptom of COVID-19 infections in newborns was apnea. A second COVID-19 RT-PCR may be necessary to detect infections in critically ill patients with a high clinical suspicion of the disease if an initial test was negative. Mención de responsabilidad : Laura F. Niño-Serna, Eliana López-Barón, Isabel Cristina Maya Ángel and Carolina Tamayo-Múnera Referencia : Front Pediatr. 2022 Jun 9;10:921880. DOI (Digital Object Identifier) : 10.3389/fped.2022.921880 PMID : 35757135 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.921880/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Clinical characteristics of children with SARS-CoV-2 infection in a hospital in Latin America [documento electrónico] / Laura Fernanda Niño Serna, ; Eliana López Barón, ; Isabel Cristina Maya Ángel, ; Carolina Tamayo Múnera, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pediatrics comorbidity inpatients pediatric intensive care unit Latin America COVID-19 Resumen : Objective: COVID-19 infections have shown a different behavior in children than in adults. The objective of this study was to describe the clinical characteristics and severity of SARS-CoV-2 infection in pediatric patients seen at a reference hospital in Colombia. Method: A descriptive, observational study in patients under the age of 18 years with a positive test for SARS-CoV-2 infection (RT-PCR or antigen) between April 2020 and March 2021. Multiple variables were studied, including demographic data, clinical characteristics, lab measurements, treatments administered, intensive care unit admission, and mortality. Results: A total of 361 patients were included of whom 196 (54%) were males. The median age was 3 years. Of all the patients, 65 (18%) were asymptomatic. The majority of patients had no comorbidities (n = 225, 76%). In those who were symptomatic (n = 296, 82%), the most frequent complaints were fever (n = 178, 60%), nasal congestion (n = 164, 55%) and cough (n = 149, 50%). Chest x-rays were normal in 73 patients (50%). When abnormalities were found, interstitial (29%) and alveolar (12%) patterns were the most prevalent. One hundred and fifty-seven children (53%) required general ward hospitalization, and 24 patients (8%) required pediatric intensive care admission. The global mortality was 0.8% (3 patients). Conclusions: The majority of cases were asymptomatic or mild. However, a significant percentage of patients required general ward admission, and some even required intensive care. The main symptom of COVID-19 infections in newborns was apnea. A second COVID-19 RT-PCR may be necessary to detect infections in critically ill patients with a high clinical suspicion of the disease if an initial test was negative. Mención de responsabilidad : Laura F. Niño-Serna, Eliana López-Barón, Isabel Cristina Maya Ángel and Carolina Tamayo-Múnera Referencia : Front Pediatr. 2022 Jun 9;10:921880. DOI (Digital Object Identifier) : 10.3389/fped.2022.921880 PMID : 35757135 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.921880/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001874 AC-2022-039 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : Colangitis esclerosante asociada a infección severa por SARS-CoV-2 Otros títulos : Sclerosing cholangitis associated with severe infection by SARS-CoV-2 Tipo de documento : documento electrónico Autores : Luz Adriana Gómez Ramírez, ; Octavio Germán Muñoz Maya, Fecha de publicación : 2022 Títulos uniformes : Hepatología Idioma : Español (spa) Palabras clave : SARS-CoV-2 colangitis esclerosante secundaria enfermedad crítica COVID-19 ácido ursodesoxicólico trasplante Resumen : La colangitis esclerosante secundaria es una enfermedad poco prevalente, de etiología multifactorial y con una fisiopatología progresiva, caracterizada por obstrucción biliar y fibrosis. Entre las múltiples causas se destacan las siguientes: inmunomediada por IgG4, isquémica, infecciosa y relacionada a medicamentos. En el contexto de la pandemia por SARS-CoV-2, se han reportado algunas series de casos que determinan una asociación entre estas dos entidades. Se presenta el caso de una mujer en la octava década de la vida con infección por SARS-CoV-2 grave, que cursó con ictericia progresiva, perfil hepático con patrón colestásico, y hallazgos imagenológicos de colangitis esclerosante con vía biliar desestructurada de manera difusa, microcálculos y barro biliar. Se diagnosticó colangitis esclerosante secundaria a SARS-CoV-2 y se dio manejo con ácido ursodesoxicólico. Mención de responsabilidad : Natalia Torres-Vellojín, Juan Camilo Díaz-Duque, Luz Adriana Gómez-Ramírez, Octavio G. Muñoz-Maya Referencia : Hepatología ; 3(2): 225-232, 2022. DOI (Digital Object Identifier) : 10.52784/27112330.161 Derechos de uso : CC BY-NC-ND En línea : https://revistahepatologia.com/index.php/hepa/article/view/62 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Colangitis esclerosante asociada a infección severa por SARS-CoV-2 = Sclerosing cholangitis associated with severe infection by SARS-CoV-2 [documento electrónico] / Luz Adriana Gómez Ramírez, ; Octavio Germán Muñoz Maya, . - 2022.
Obra : Hepatología
Idioma : Español (spa)
Palabras clave : SARS-CoV-2 colangitis esclerosante secundaria enfermedad crítica COVID-19 ácido ursodesoxicólico trasplante Resumen : La colangitis esclerosante secundaria es una enfermedad poco prevalente, de etiología multifactorial y con una fisiopatología progresiva, caracterizada por obstrucción biliar y fibrosis. Entre las múltiples causas se destacan las siguientes: inmunomediada por IgG4, isquémica, infecciosa y relacionada a medicamentos. En el contexto de la pandemia por SARS-CoV-2, se han reportado algunas series de casos que determinan una asociación entre estas dos entidades. Se presenta el caso de una mujer en la octava década de la vida con infección por SARS-CoV-2 grave, que cursó con ictericia progresiva, perfil hepático con patrón colestásico, y hallazgos imagenológicos de colangitis esclerosante con vía biliar desestructurada de manera difusa, microcálculos y barro biliar. Se diagnosticó colangitis esclerosante secundaria a SARS-CoV-2 y se dio manejo con ácido ursodesoxicólico. Mención de responsabilidad : Natalia Torres-Vellojín, Juan Camilo Díaz-Duque, Luz Adriana Gómez-Ramírez, Octavio G. Muñoz-Maya Referencia : Hepatología ; 3(2): 225-232, 2022. DOI (Digital Object Identifier) : 10.52784/27112330.161 Derechos de uso : CC BY-NC-ND En línea : https://revistahepatologia.com/index.php/hepa/article/view/62 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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