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Gut microbiota alterations in critically ill older patients: a multicenter study / Adriana Giraldo Villa
Título : Gut microbiota alterations in critically ill older patients: a multicenter study Tipo de documento : documento electrónico Autores : Adriana Giraldo Villa, Fecha de publicación : 2022 Títulos uniformes : BMC Geriatrics Idioma : Inglés (eng) Palabras clave : Older adults Critically ill Gut microbiota ICU Sepsis Dysbiosis Resumen : Background: Aging generates changes in the gut microbiota, affecting its functionality. Little is known about gut microbiota in critically ill older adults. The objective of this study was to describe the profile of gut microbiota in a cohort of critically ill older adults. Methods: This observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients over 18 years old who were admitted to the intensive care unit were enrolled. Fecal microbiota profiles were determined from 155 individuals, over 60 years old (n = 72) and under 60 years old (n = 83). Gut microbiota was analyzed by sequencing the V3-V4 region of the 16S rRNA gene. Alpha and beta diversity, operational taxonomic units and the interaction of gut microbiota with variables under study were analyzed. Amplicon sequence variants (ASVs) specifically associated with age were recovered by including gender, discharge condition, BMI, ICU stay and antibiotics as covariates in a linear mixed model. Results: In older adults, sepsis, malnutrition, antibiotic prescription and severity (APACHE and SOFA scores) were higher than in the group under 60 years of age. Alpha diversity showed lower gut microbiota diversity in those over 60 years of age (p Mención de responsabilidad : Mesa Victoria, Valdés-Duque Beatriz Elena, Giraldo-Giraldo Nubia Amparo, Jailler-R Ana María, Giraldo-Villa Adriana, Acevedo-Castaño Irene, Yepes-M Mónica Alejandra, Barbosa-Barbosa Janeth & Agudelo-Ochoa Gloria María Referencia : BMC Geriatr. 2022 Apr 28;22(1):373. DOI (Digital Object Identifier) : 10.1186/s12877-022-02981-0 PMID : 35484500 Derechos de uso : CC BY En línea : https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-022-02981-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6025 Gut microbiota alterations in critically ill older patients: a multicenter study [documento electrónico] / Adriana Giraldo Villa, . - 2022.
Obra : BMC Geriatrics
Idioma : Inglés (eng)
Palabras clave : Older adults Critically ill Gut microbiota ICU Sepsis Dysbiosis Resumen : Background: Aging generates changes in the gut microbiota, affecting its functionality. Little is known about gut microbiota in critically ill older adults. The objective of this study was to describe the profile of gut microbiota in a cohort of critically ill older adults. Methods: This observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients over 18 years old who were admitted to the intensive care unit were enrolled. Fecal microbiota profiles were determined from 155 individuals, over 60 years old (n = 72) and under 60 years old (n = 83). Gut microbiota was analyzed by sequencing the V3-V4 region of the 16S rRNA gene. Alpha and beta diversity, operational taxonomic units and the interaction of gut microbiota with variables under study were analyzed. Amplicon sequence variants (ASVs) specifically associated with age were recovered by including gender, discharge condition, BMI, ICU stay and antibiotics as covariates in a linear mixed model. Results: In older adults, sepsis, malnutrition, antibiotic prescription and severity (APACHE and SOFA scores) were higher than in the group under 60 years of age. Alpha diversity showed lower gut microbiota diversity in those over 60 years of age (p Mención de responsabilidad : Mesa Victoria, Valdés-Duque Beatriz Elena, Giraldo-Giraldo Nubia Amparo, Jailler-R Ana María, Giraldo-Villa Adriana, Acevedo-Castaño Irene, Yepes-M Mónica Alejandra, Barbosa-Barbosa Janeth & Agudelo-Ochoa Gloria María Referencia : BMC Geriatr. 2022 Apr 28;22(1):373. DOI (Digital Object Identifier) : 10.1186/s12877-022-02981-0 PMID : 35484500 Derechos de uso : CC BY En línea : https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-022-02981-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6025 Reserva
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AC-2022-031Adobe Acrobat PDF Post-COVID-19 necrotizing pneumonia in patients on invasive mechanical ventilation / Alicia Inés Hidrón Botero
Título : Post-COVID-19 necrotizing pneumonia in patients on invasive mechanical ventilation Tipo de documento : documento electrónico Autores : Alicia Inés Hidrón Botero, Fecha de publicación : 2021 Títulos uniformes : Infectious Disease Reports Idioma : Inglés (eng) Palabras clave : necrotizing pneumonia critically ill COVID-19 mechanical ventilation pulmonary embolism Resumen : (1) Background: Few reports of necrotizing pneumonia in patients with COVID-19 have been published. We have observed an elevated incidence at two hospitals in our city, suggesting this complication is not uncommon, and may have been overlooked. (2) Methods: This article presents a retrospective, descriptive cohort study that was undertaken from 22 March 2020 to 15 June 2021 in two tertiary care hospitals in Medellín, Colombia. All adult patients admitted to the intensive care unit (ICU) for respiratory failure related to confirmed COVID-19, on invasive mechanical ventilation (IMV), with imaging or surgical findings documenting necrotizing pneumonia (NP) were included. (3) Results: Of 936 patients with COVID-19 that required IMV, 42 (4.5%) developed NP. Overall mortality was 57% and in-hospital mortality was 71%, occurring 15–79 days after COVID-19 diagnosis. NP was diagnosed at a median of 27 days after COVID-19 symptom onset and 15.5 days after initiation of IMV. Infections were polymicrobial in 52.4% of patients. Klebsiella pneumoniae (57%) and Pseudomonas aeruginosa (33%) were the most common etiologic agents. Pulmonary embolism (PE) was documented in 13 patients overall (31%), and in 50% of patients who underwent an angioCT. Drainage and/or surgical procedures were performed on 19 patients (45.2%) with a 75% mortality rate. (4) Conclusions: In our experience, NP is a relatively common, albeit neglected, complication in mechanically ventilated COVID-19 patients, possibly originating in poorly vascularized areas of lung parenchyma. Associated mortality is high. Although drainage procedures did not seem to favorably impact patient outcomes, diagnosis and treatment were late events in the overall disease course, suggesting that early recognition and timely treatment could have a positive impact on prognosis. Mención de responsabilidad : Alicia Hidron,William Quiceno, John J. Cardeño, Gustavo Roncancio and Cristian García Referencia : Infect Dis Rep. 2021 Sep 8;13(3):835-842. DOI (Digital Object Identifier) : 10.3390/idr13030075 PMID : 34563000 Derechos de uso : CC BY En línea : https://www.mdpi.com/2036-7449/13/3/75 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5854 Post-COVID-19 necrotizing pneumonia in patients on invasive mechanical ventilation [documento electrónico] / Alicia Inés Hidrón Botero, . - 2021.
Obra : Infectious Disease Reports
Idioma : Inglés (eng)
Palabras clave : necrotizing pneumonia critically ill COVID-19 mechanical ventilation pulmonary embolism Resumen : (1) Background: Few reports of necrotizing pneumonia in patients with COVID-19 have been published. We have observed an elevated incidence at two hospitals in our city, suggesting this complication is not uncommon, and may have been overlooked. (2) Methods: This article presents a retrospective, descriptive cohort study that was undertaken from 22 March 2020 to 15 June 2021 in two tertiary care hospitals in Medellín, Colombia. All adult patients admitted to the intensive care unit (ICU) for respiratory failure related to confirmed COVID-19, on invasive mechanical ventilation (IMV), with imaging or surgical findings documenting necrotizing pneumonia (NP) were included. (3) Results: Of 936 patients with COVID-19 that required IMV, 42 (4.5%) developed NP. Overall mortality was 57% and in-hospital mortality was 71%, occurring 15–79 days after COVID-19 diagnosis. NP was diagnosed at a median of 27 days after COVID-19 symptom onset and 15.5 days after initiation of IMV. Infections were polymicrobial in 52.4% of patients. Klebsiella pneumoniae (57%) and Pseudomonas aeruginosa (33%) were the most common etiologic agents. Pulmonary embolism (PE) was documented in 13 patients overall (31%), and in 50% of patients who underwent an angioCT. Drainage and/or surgical procedures were performed on 19 patients (45.2%) with a 75% mortality rate. (4) Conclusions: In our experience, NP is a relatively common, albeit neglected, complication in mechanically ventilated COVID-19 patients, possibly originating in poorly vascularized areas of lung parenchyma. Associated mortality is high. Although drainage procedures did not seem to favorably impact patient outcomes, diagnosis and treatment were late events in the overall disease course, suggesting that early recognition and timely treatment could have a positive impact on prognosis. Mención de responsabilidad : Alicia Hidron,William Quiceno, John J. Cardeño, Gustavo Roncancio and Cristian García Referencia : Infect Dis Rep. 2021 Sep 8;13(3):835-842. DOI (Digital Object Identifier) : 10.3390/idr13030075 PMID : 34563000 Derechos de uso : CC BY En línea : https://www.mdpi.com/2036-7449/13/3/75 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5854 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001792 AC-2021-104 Archivo digital Producción Científica Artículos científicos Disponible