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Título : Clinical biology of the pituitary adenoma Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2022 Títulos uniformes : Endocrine Reviews Idioma : Inglés (eng) Palabras clave : pituitary adenoma acromegaly prolactinoma Cushing’s disease aggressive pituitary tumor hypothalamus Resumen : All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of diverse behaviors and impact on health. To understand the clinical biology of these common yet often innocuous neoplasms, we review pituitary physiology, and adenoma epidemiology, pathophysiology, behavior, and clinical consequences. The anterior pituitary develops in response to a range of complex brain signals integrating with intrinsic ectodermal cell transcriptional events that together determine gland growth, cell type differentiation, and hormonal production, in turn maintaining optimal endocrine health. Pituitary adenomas occur in ten percent of the population; however, the overwhelming majority remain harmless during life. Triggered by somatic or germline mutations, disease-causing adenomas manifest pathogenic mechanisms that disrupt intra-pituitary signaling to promote benign cell proliferation associated with chromosomal instability. Cellular senescence acts as a mechanistic buffer protecting against malignant transformation, an extremely rare event. It is estimated that fewer than one thousandth of all pituitary adenomas cause clinically significant disease. Adenomas variably and adversely affect morbidity and mortality depending on cell type, hormone secretory activity, and growth behavior. For most clinically apparent adenomas, multimodal therapy controlling hormone secretion and adenoma growth lead to improved quality of life and normalized mortality. The clinical biology of pituitary adenomas and particularly their benign nature stands in marked contrast to other tumors of the endocrine system such as thyroid and neuroendocrine tumors. Mención de responsabilidad : Shlomo Melmed, Ursula B Kaiser, M Beatriz Lopes, Jerome Bertherat, Luis V Syro, Gerald Raverot, Martin Reincke, Gudmundur Johannsson, Albert Beckers, Maria Fleseriu, Andrea Giustina, John A H Wass, Ken K Y Ho Referencia : Endocr Rev. 2022 Apr 8;bnac010. DOI (Digital Object Identifier) : 10.1210/endrev/bnac010 PMID : 35395078 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/edrv/advance-article/doi/10.1210/endrev/bnac010/6565598 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6028 Clinical biology of the pituitary adenoma [documento electrónico] / Luis Vicente Syro Moreno, . - 2022.
Obra : Endocrine Reviews
Idioma : Inglés (eng)
Palabras clave : pituitary adenoma acromegaly prolactinoma Cushing’s disease aggressive pituitary tumor hypothalamus Resumen : All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of diverse behaviors and impact on health. To understand the clinical biology of these common yet often innocuous neoplasms, we review pituitary physiology, and adenoma epidemiology, pathophysiology, behavior, and clinical consequences. The anterior pituitary develops in response to a range of complex brain signals integrating with intrinsic ectodermal cell transcriptional events that together determine gland growth, cell type differentiation, and hormonal production, in turn maintaining optimal endocrine health. Pituitary adenomas occur in ten percent of the population; however, the overwhelming majority remain harmless during life. Triggered by somatic or germline mutations, disease-causing adenomas manifest pathogenic mechanisms that disrupt intra-pituitary signaling to promote benign cell proliferation associated with chromosomal instability. Cellular senescence acts as a mechanistic buffer protecting against malignant transformation, an extremely rare event. It is estimated that fewer than one thousandth of all pituitary adenomas cause clinically significant disease. Adenomas variably and adversely affect morbidity and mortality depending on cell type, hormone secretory activity, and growth behavior. For most clinically apparent adenomas, multimodal therapy controlling hormone secretion and adenoma growth lead to improved quality of life and normalized mortality. The clinical biology of pituitary adenomas and particularly their benign nature stands in marked contrast to other tumors of the endocrine system such as thyroid and neuroendocrine tumors. Mención de responsabilidad : Shlomo Melmed, Ursula B Kaiser, M Beatriz Lopes, Jerome Bertherat, Luis V Syro, Gerald Raverot, Martin Reincke, Gudmundur Johannsson, Albert Beckers, Maria Fleseriu, Andrea Giustina, John A H Wass, Ken K Y Ho Referencia : Endocr Rev. 2022 Apr 8;bnac010. DOI (Digital Object Identifier) : 10.1210/endrev/bnac010 PMID : 35395078 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/edrv/advance-article/doi/10.1210/endrev/bnac010/6565598 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6028 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001869 AC-2022-034 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-034Adobe Acrobat PDFPituitary society guidance: pituitary disease management and patient care recommendations during the COVID‐19 pandemic—an international perspective / Luis Vicente Syro Moreno
Título : Pituitary society guidance: pituitary disease management and patient care recommendations during the COVID‐19 pandemic—an international perspective Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2020 Títulos uniformes : Pituitary Idioma : Inglés (eng) Palabras clave : Acromegaly COVID-19 Cushing’s disease Pituitary disease and surgery Prolactinomas SARS-CoV-2 Resumen : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the viral strain that has caused the coronavirus disease 2019 (COVID-19) pandemic, has presented healthcare systems around the world with an unprecedented challenge. In locations with significant rates of viral transmission, social distancing measures and enforced 'lockdowns' are the new 'norm' as governments try to prevent healthcare services from being overwhelmed. However, with these measures have come important challenges for the delivery of existing services for other diseases and conditions. The clinical care of patients with pituitary disorders typically involves a multidisciplinary team, working in concert to deliver timely, often complex, disease investigation and management, including pituitary surgery. COVID-19 has brought about major disruption to such services, limiting access to care and opportunities for testing (both laboratory and radiological), and dramatically reducing the ability to safely undertake transsphenoidal surgery. In the absence of clinical trials to guide management of patients with pituitary disease during the COVID-19 pandemic, herein the Professional Education Committee of the Pituitary Society proposes guidance for continued safe management and care of this population. Mención de responsabilidad : Maria Fleseriu, Michael Buchfelder, Justin S. Cetas, Pouneh K. Fazeli, Susana M. Mallea-Gil, Mark Gurnell, Ann McCormack, Maria M. Pineyro, Luis V. Syro, Nicholas A. Tritos & Hani J. Marcus Referencia : Pituitary. 2020 Aug;23(4):327-337. DOI (Digital Object Identifier) : 10.1007/s11102-020-01059-7 PMID : 32556793 Derechos de uso : CC BY En línea : https://link.springer.com/article/10.1007/s11102-020-01059-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5121 Pituitary society guidance: pituitary disease management and patient care recommendations during the COVID‐19 pandemic—an international perspective [documento electrónico] / Luis Vicente Syro Moreno, . - 2020.
Obra : Pituitary
Idioma : Inglés (eng)
Palabras clave : Acromegaly COVID-19 Cushing’s disease Pituitary disease and surgery Prolactinomas SARS-CoV-2 Resumen : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the viral strain that has caused the coronavirus disease 2019 (COVID-19) pandemic, has presented healthcare systems around the world with an unprecedented challenge. In locations with significant rates of viral transmission, social distancing measures and enforced 'lockdowns' are the new 'norm' as governments try to prevent healthcare services from being overwhelmed. However, with these measures have come important challenges for the delivery of existing services for other diseases and conditions. The clinical care of patients with pituitary disorders typically involves a multidisciplinary team, working in concert to deliver timely, often complex, disease investigation and management, including pituitary surgery. COVID-19 has brought about major disruption to such services, limiting access to care and opportunities for testing (both laboratory and radiological), and dramatically reducing the ability to safely undertake transsphenoidal surgery. In the absence of clinical trials to guide management of patients with pituitary disease during the COVID-19 pandemic, herein the Professional Education Committee of the Pituitary Society proposes guidance for continued safe management and care of this population. Mención de responsabilidad : Maria Fleseriu, Michael Buchfelder, Justin S. Cetas, Pouneh K. Fazeli, Susana M. Mallea-Gil, Mark Gurnell, Ann McCormack, Maria M. Pineyro, Luis V. Syro, Nicholas A. Tritos & Hani J. Marcus Referencia : Pituitary. 2020 Aug;23(4):327-337. DOI (Digital Object Identifier) : 10.1007/s11102-020-01059-7 PMID : 32556793 Derechos de uso : CC BY En línea : https://link.springer.com/article/10.1007/s11102-020-01059-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5121 Reserva
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Título : Current status on histological classification in Cushing’s disease Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2015 Títulos uniformes : Pituitary Idioma : Inglés (eng) Palabras clave : Classification cushing’s disease diagnosis pathology pituitary tumor Resumen : Introduction: Managing Cushing’s disease remains a challenge. Surgery is the first option of treatment and it offers a high success rate. Even in cases where biochemical remission is not achieved, it is crucial to obtain surgical tissue for morphological diagnosis because the therapeutic approach can be modified according to the findings. Materials and Methods: A literature search was performed using PubMed for information regarding pathology and Cushing’s disease. Results: The histopathological features found in the pituitary gland of patients with Cushing’s disease are presented. Conclusion: Different subtypes of ACTH-producing pituitary tumors are recognized and characterized. The significance of finding a normal pituitary gland with or without Crooke’s changes is also discussed. Mención de responsabilidad : Luis V Syro, Fabio Rotondo, Michael D Cusimano, Antonio Di Ieva, Eva Horvath, Lina M Restrepo, Min Wong, Donald W Killinger, Harley Smyth, Kalman Kovacs Referencia : Pituitary. 2015 Apr;18(2):217-24. DOI (Digital Object Identifier) : 10.1007/s11102-014-0619-0 PMID : 25501318 En línea : https://link.springer.com/article/10.1007%2Fs11102-014-0619-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3873 Current status on histological classification in Cushing’s disease [documento electrónico] / Luis Vicente Syro Moreno, . - 2015.
Obra : Pituitary
Idioma : Inglés (eng)
Palabras clave : Classification cushing’s disease diagnosis pathology pituitary tumor Resumen : Introduction: Managing Cushing’s disease remains a challenge. Surgery is the first option of treatment and it offers a high success rate. Even in cases where biochemical remission is not achieved, it is crucial to obtain surgical tissue for morphological diagnosis because the therapeutic approach can be modified according to the findings. Materials and Methods: A literature search was performed using PubMed for information regarding pathology and Cushing’s disease. Results: The histopathological features found in the pituitary gland of patients with Cushing’s disease are presented. Conclusion: Different subtypes of ACTH-producing pituitary tumors are recognized and characterized. The significance of finding a normal pituitary gland with or without Crooke’s changes is also discussed. Mención de responsabilidad : Luis V Syro, Fabio Rotondo, Michael D Cusimano, Antonio Di Ieva, Eva Horvath, Lina M Restrepo, Min Wong, Donald W Killinger, Harley Smyth, Kalman Kovacs Referencia : Pituitary. 2015 Apr;18(2):217-24. DOI (Digital Object Identifier) : 10.1007/s11102-014-0619-0 PMID : 25501318 En línea : https://link.springer.com/article/10.1007%2Fs11102-014-0619-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3873 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000453 AC-2015-006 Archivo digital Producción Científica Artículos científicos Disponible
