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Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis / Fabián Alberto Jaimes Barragán  

Público ISBD Título : Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2016 Títulos uniformes : Immunologic Research Idioma : Inglés (eng) Palabras clave : Sepsis  Colombian population  Infection  SNP  SIRS  Cytokines  Cross-sectional study Resumen : The aim of this study was to explore the association between some SNPs of the TNF, LTA, IL1B and IL10 genes with cytokine concentrations and clinical course in Colombian septic patients. We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs −308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; −511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and −1082(A/G) rs1800896, −819(C/T) rs1800871 and −592(C/A) rs1800872 of IL10. The association of theses SNPs with the following parameters was evaluated: (1) the presence of sepsis; (2) severity and clinical outcomes; (3) APACHE II and SOFA scores; and (4) procalcitonin, C-reactive protein, tumor necrosis factor, lymphotoxin alpha, interleukin 1 beta and interleukin 10 plasma concentrations. We found an association between the SNP LTA +252 with the development of sepsis [OR 1.29 (1.00–1.68)]; the SNP IL10 −1082 with sepsis severity [OR 0.53 (0.29–0.97)]; the TNF −308 with mortality [OR 0.33 (0.12–0.95)]; and the IL10 −592 and IL10 −1082 with admission to the intensive care unit (ICU) [OR 3.36 (1.57–7.18)] and [OR 0.18 (0.04–0.86)], respectively. None of the SNPs were associated with cytokine levels, procalcitonin and C-reactive protein serum concentrations, nor with APACHE II and SOFA scores. Our results suggest that these genetic variants play an important role in the development of sepsis and its clinical course. Mención de responsabilidad : Carolina Montoya-Ruiz, Fabián A Jaimes, Maria T Rugeles, Juan Álvaro López, Gabriel Bedoya, Paula A Velilla Referencia : Immunol Res. 2016 Dec;64(5-6):1168-1178. DOI (Digital Object Identifier) : 10.1007/s12026-016-8860-4 PMID : 27592234 En línea : https://link.springer.com/article/10.1007%2Fs12026-016-8860-4 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3977 Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis [documento electrónico] / Fabián Alberto Jaimes Barragán,  . - 2016. Obra : Immunologic Research Idioma : Inglés (eng) Palabras clave : Sepsis  Colombian population  Infection  SNP  SIRS  Cytokines  Cross-sectional study Resumen : The aim of this study was to explore the association between some SNPs of the TNF, LTA, IL1B and IL10 genes with cytokine concentrations and clinical course in Colombian septic patients. We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs −308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; −511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and −1082(A/G) rs1800896, −819(C/T) rs1800871 and −592(C/A) rs1800872 of IL10. The association of theses SNPs with the following parameters was evaluated: (1) the presence of sepsis; (2) severity and clinical outcomes; (3) APACHE II and SOFA scores; and (4) procalcitonin, C-reactive protein, tumor necrosis factor, lymphotoxin alpha, interleukin 1 beta and interleukin 10 plasma concentrations. We found an association between the SNP LTA +252 with the development of sepsis [OR 1.29 (1.00–1.68)]; the SNP IL10 −1082 with sepsis severity [OR 0.53 (0.29–0.97)]; the TNF −308 with mortality [OR 0.33 (0.12–0.95)]; and the IL10 −592 and IL10 −1082 with admission to the intensive care unit (ICU) [OR 3.36 (1.57–7.18)] and [OR 0.18 (0.04–0.86)], respectively. None of the SNPs were associated with cytokine levels, procalcitonin and C-reactive protein serum concentrations, nor with APACHE II and SOFA scores. Our results suggest that these genetic variants play an important role in the development of sepsis and its clinical course. Mención de responsabilidad : Carolina Montoya-Ruiz, Fabián A Jaimes, Maria T Rugeles, Juan Álvaro López, Gabriel Bedoya, Paula A Velilla Referencia : Immunol Res. 2016 Dec;64(5-6):1168-1178. DOI (Digital Object Identifier) : 10.1007/s12026-016-8860-4 PMID : 27592234 En línea : https://link.springer.com/article/10.1007%2Fs12026-016-8860-4 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3977

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Different responses of human mononuclear phagocyte populations to Mycobacterium tuberculosis / Héctor Ortega  

Público ISBD Título : Different responses of human mononuclear phagocyte populations to Mycobacterium tuberculosis Tipo de documento : documento electrónico Autores : Héctor Ortega, Fecha de publicación : 2014 Títulos uniformes : Tuberculosis Idioma : Inglés (eng) Palabras clave : Cell death  Cytokines  ESAT-6  Interferon gamma  Mononuclear phagocytes  Mycobacterium tuberculosis Resumen : Mycobacterium tuberculosis (Mtb) infects different populations of macrophages. Alveolar macrophages (AMs) are initially infected, and their response may contribute to controlling Mtb infection and dissemination. However, Mtb infection may disseminate to other tissues, infecting a wide variety of macrophages. Given the difficulty in obtaining AMs, monocyte-derived macrophages (MDMs) are used to model macrophage-mycobacteria interactions in humans. However, the response of other tissue macrophages to Mtb infection has been poorly explored. We have compared MDMs, AMs and splenic human macrophages (SMs) for their in vitro capacity to control Mtb growth, cytokine production, and induction of cell death in response to Mtb H37Rv, and the Colombian isolate UT205, and to the virulence factor ESAT-6. Significant differences in the magnitude of cell death and cytokine production depending mainly on the Mtb strain were observed; however, no major differences in the mycobacteriostatic/mycobacteriocidal activity were detected among the macrophage populations. Infection with the clinical isolate UT205 was associated with an increased cell death with membrane damage, particularly in IFNγ-treated SMs and H37Rv induced a higher production of cytokines compared to UT205. These results are concordant with the interpretation of a differential response to Mtb infection mainly depending upon the strain of Mtb. Mención de responsabilidad : Camilo Duque, Leonar Arroyo, Héctor Ortega, Franco Montúfar, Blanca Ortíz, Mauricio Rojas, Luis F Barrera Referencia : Tuberculosis (Edinb). 2014 Mar;94(2):111-22. DOI (Digital Object Identifier) : 10.1016/j.tube.2013.11.001 PMID : 24360327 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1472-9792(13)00196-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4549 Different responses of human mononuclear phagocyte populations to Mycobacterium tuberculosis [documento electrónico] / Héctor Ortega,  . - 2014. Obra : Tuberculosis Idioma : Inglés (eng) Palabras clave : Cell death  Cytokines  ESAT-6  Interferon gamma  Mononuclear phagocytes  Mycobacterium tuberculosis Resumen : Mycobacterium tuberculosis (Mtb) infects different populations of macrophages. Alveolar macrophages (AMs) are initially infected, and their response may contribute to controlling Mtb infection and dissemination. However, Mtb infection may disseminate to other tissues, infecting a wide variety of macrophages. Given the difficulty in obtaining AMs, monocyte-derived macrophages (MDMs) are used to model macrophage-mycobacteria interactions in humans. However, the response of other tissue macrophages to Mtb infection has been poorly explored. We have compared MDMs, AMs and splenic human macrophages (SMs) for their in vitro capacity to control Mtb growth, cytokine production, and induction of cell death in response to Mtb H37Rv, and the Colombian isolate UT205, and to the virulence factor ESAT-6. Significant differences in the magnitude of cell death and cytokine production depending mainly on the Mtb strain were observed; however, no major differences in the mycobacteriostatic/mycobacteriocidal activity were detected among the macrophage populations. Infection with the clinical isolate UT205 was associated with an increased cell death with membrane damage, particularly in IFNγ-treated SMs and H37Rv induced a higher production of cytokines compared to UT205. These results are concordant with the interpretation of a differential response to Mtb infection mainly depending upon the strain of Mtb. Mención de responsabilidad : Camilo Duque, Leonar Arroyo, Héctor Ortega, Franco Montúfar, Blanca Ortíz, Mauricio Rojas, Luis F Barrera Referencia : Tuberculosis (Edinb). 2014 Mar;94(2):111-22. DOI (Digital Object Identifier) : 10.1016/j.tube.2013.11.001 PMID : 24360327 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1472-9792(13)00196-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4549

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