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Título : Pituitary ganglioneuroma: case report and literature review Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2014 Títulos uniformes : Journal of Cytology and Histology Idioma : Inglés (eng) Palabras clave : Electron microscopy ganglioneuroma. immunohistochemistry neuronal tumors pituitary neoplasms Resumen : We present a case of pituitary ganglioneuroma occurring in a 25 year old woman who presented with headache and hemianopsia. The histologic, immunohistochemical, and ultrastructural features of this tumor support the view that these rare hypothalamic-pituitary tumors are independently functioning neurohormonal units. Immunostaining is strongly positive for neuron-specific enolase (NSE) in all tumor cells and cell processes and for synaptophysin in a few cells and fibers. Few cells closely associated with tumor cells are positive for S100 protein. The cell processes are positive for neurofilament antigen. Ultrastructural analysis documents a spectacular neoplasm of neural derivation. The tumor consists of ganglion cells and areas of neuropil. The most typical tumor cells have relatively lucent spherical nucleus with large nucleolus, and abundant cytoplasm harbors compact sacks of RER membranes studded with ribosomes. Particular emphasis is given to the ultrastructural features which strongly support the functional relationship between the tumor components. It should be kept in mind that unusual and rare ganglionic tumors might show a progressive clinical course and needs surgical intervention as the major part of their treatment whereas ontogenetic and pathogenetic mechanisms taking part still need more work to enlighten pituitary neuronal tumorigenesis. Mención de responsabilidad : Aydin Sav, Luis V Syro, Fabio Rotondo, Bernd W Scheithauer,§, Humberto Uribe, Luis C Penagos, Eva Horvath and Kalman Kovacs Referencia : J Cytol Histol 2013;4(1):1-4. DOI (Digital Object Identifier) : 10.4172/2157-7099.1000203 Derechos de uso : CC BY En línea : https://www.omicsonline.org/pituitary-ganglioneuroma-case-report-and-literature- [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3776 Pituitary ganglioneuroma: case report and literature review [documento electrónico] / Luis Vicente Syro Moreno, . - 2014.
Obra : Journal of Cytology and Histology
Idioma : Inglés (eng)
Palabras clave : Electron microscopy ganglioneuroma. immunohistochemistry neuronal tumors pituitary neoplasms Resumen : We present a case of pituitary ganglioneuroma occurring in a 25 year old woman who presented with headache and hemianopsia. The histologic, immunohistochemical, and ultrastructural features of this tumor support the view that these rare hypothalamic-pituitary tumors are independently functioning neurohormonal units. Immunostaining is strongly positive for neuron-specific enolase (NSE) in all tumor cells and cell processes and for synaptophysin in a few cells and fibers. Few cells closely associated with tumor cells are positive for S100 protein. The cell processes are positive for neurofilament antigen. Ultrastructural analysis documents a spectacular neoplasm of neural derivation. The tumor consists of ganglion cells and areas of neuropil. The most typical tumor cells have relatively lucent spherical nucleus with large nucleolus, and abundant cytoplasm harbors compact sacks of RER membranes studded with ribosomes. Particular emphasis is given to the ultrastructural features which strongly support the functional relationship between the tumor components. It should be kept in mind that unusual and rare ganglionic tumors might show a progressive clinical course and needs surgical intervention as the major part of their treatment whereas ontogenetic and pathogenetic mechanisms taking part still need more work to enlighten pituitary neuronal tumorigenesis. Mención de responsabilidad : Aydin Sav, Luis V Syro, Fabio Rotondo, Bernd W Scheithauer,§, Humberto Uribe, Luis C Penagos, Eva Horvath and Kalman Kovacs Referencia : J Cytol Histol 2013;4(1):1-4. DOI (Digital Object Identifier) : 10.4172/2157-7099.1000203 Derechos de uso : CC BY En línea : https://www.omicsonline.org/pituitary-ganglioneuroma-case-report-and-literature- [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3776 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000351 AC-2014-017 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2014-017.pdfAdobe Acrobat PDFSilent somatotroph adenoma: a morphologic, immunohistochemical and electron microscopic study: a case report / Carlos Esteban Builes Montaño ; Luis Vicente Syro Moreno
Título : Silent somatotroph adenoma: a morphologic, immunohistochemical and electron microscopic study: a case report Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, ; Luis Vicente Syro Moreno, Fecha de publicación : 2012 Títulos uniformes : Journal of Medical Cases Idioma : Inglés (eng) Palabras clave : Electron microscopy histology immunohistochemistry pituitary adenoma endocrine silence Resumen : Pituitary adenoma, removed surgically from a 22 old young man with normal serum growth hormone level, and no evidence of acromegaly by histology, immunohistochemistry and electron microscopy was studied. Ultrastructurally the tumor cells were shown to correspond to sparsely granulated somatotrophs and immunohisto chemistry showed no, moderate, or little growth hormone. Clinically silent somatotroph adenomas so far are unresolved entities; although electron microscopy shows that they are consisted of sparsely granulated somatotrophs they do not secrete substantial amounts to raise growth hormone and IGF-1 blood levels. Further work is required to clarify the mechanisms accounting for the clinical and biochemical silence of these tumors. Mención de responsabilidad : Aydin Sav, Luis V Syro, Bernd W Scheithauer, Fabio Rotondo, Carlos A Builes, Eva Horvath, Kalman Kovacs Referencia : J Med Cases. 2012;3(1):43-8. DOI (Digital Object Identifier) : 10.4021/jmc416w Derechos de uso : CC BY-NC En línea : https://www.journalmc.org/index.php/JMC/article/view/416 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3612 Silent somatotroph adenoma: a morphologic, immunohistochemical and electron microscopic study: a case report [documento electrónico] / Carlos Esteban Builes Montaño, ; Luis Vicente Syro Moreno, . - 2012.
Obra : Journal of Medical Cases
Idioma : Inglés (eng)
Palabras clave : Electron microscopy histology immunohistochemistry pituitary adenoma endocrine silence Resumen : Pituitary adenoma, removed surgically from a 22 old young man with normal serum growth hormone level, and no evidence of acromegaly by histology, immunohistochemistry and electron microscopy was studied. Ultrastructurally the tumor cells were shown to correspond to sparsely granulated somatotrophs and immunohisto chemistry showed no, moderate, or little growth hormone. Clinically silent somatotroph adenomas so far are unresolved entities; although electron microscopy shows that they are consisted of sparsely granulated somatotrophs they do not secrete substantial amounts to raise growth hormone and IGF-1 blood levels. Further work is required to clarify the mechanisms accounting for the clinical and biochemical silence of these tumors. Mención de responsabilidad : Aydin Sav, Luis V Syro, Bernd W Scheithauer, Fabio Rotondo, Carlos A Builes, Eva Horvath, Kalman Kovacs Referencia : J Med Cases. 2012;3(1):43-8. DOI (Digital Object Identifier) : 10.4021/jmc416w Derechos de uso : CC BY-NC En línea : https://www.journalmc.org/index.php/JMC/article/view/416 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3612 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000182 AC-2012-022 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2012-022.pdfAdobe Acrobat PDF
Título : Prolactin-producing pituitary adenoma associated with prolactin cell hyperplasia Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2002 Títulos uniformes : Endocrine Pathology Idioma : Inglés (eng) Palabras clave : Prolactin adenoma pituitary hyperplasia human electron microscopy immunohistochemistry Resumen : A 24-yr-old woman with amenorrhea, galactorrhea, hyperprolactinemia, and sellar mass underwent transsphenoidal surgery. Histologic, immunohistochemical, and electron microscopic investigation revealed a well-differentiated, sparsely granulated prolactin (PRL) cell adenoma of the pituitary showing conclusive PRL immunoreactivity. In the nontumorous adenohypophysis PRL cell hyperplasia was noted. Marked differences were evident between the neoplastic and hyperplastic areas. The tumor consisted of sparsely granulated PRL cells immunoreactive only for PRL. As demonstrated by immunoelectron microscopy, the hyperplastic are a comprised monohormonal sparsely granulated PRL cells as well as bihormonal mammosomatotrophs immunoreactive for both PRL and growth hormone. The MIB-1 index was higher whereas microvessel density was lower in the adenoma as compared with the hyperplastic area. In addition, the nontumorous area showed lymphocytic infiltration whereas inflammatory reaction was not seen in the adenoma. This case represents a rare association of a PRL cell adenoma and PRL cell hyperplasia. The fact that these two lesions were contiguous in the surgically removed material raises the possibility that hyperplasia can precede and transform into adenoma. Mención de responsabilidad : Sergio Vidal DVM, Eva Horvath PhD, Luis V. Syro MD, Humberto Uribe MD, Sandy Cohen RT & Kalman Kovacs MD, PhD Referencia : Endocr Pathol. Summer 2002;13(2):157-65. DOI (Digital Object Identifier) : 10.1385/EP:13:2:157 PMID : 12165665 En línea : https://link.springer.com/article/10.1385/EP:13:2:157 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4393 Prolactin-producing pituitary adenoma associated with prolactin cell hyperplasia [documento electrónico] / Luis Vicente Syro Moreno, . - 2002.
Obra : Endocrine Pathology
Idioma : Inglés (eng)
Palabras clave : Prolactin adenoma pituitary hyperplasia human electron microscopy immunohistochemistry Resumen : A 24-yr-old woman with amenorrhea, galactorrhea, hyperprolactinemia, and sellar mass underwent transsphenoidal surgery. Histologic, immunohistochemical, and electron microscopic investigation revealed a well-differentiated, sparsely granulated prolactin (PRL) cell adenoma of the pituitary showing conclusive PRL immunoreactivity. In the nontumorous adenohypophysis PRL cell hyperplasia was noted. Marked differences were evident between the neoplastic and hyperplastic areas. The tumor consisted of sparsely granulated PRL cells immunoreactive only for PRL. As demonstrated by immunoelectron microscopy, the hyperplastic are a comprised monohormonal sparsely granulated PRL cells as well as bihormonal mammosomatotrophs immunoreactive for both PRL and growth hormone. The MIB-1 index was higher whereas microvessel density was lower in the adenoma as compared with the hyperplastic area. In addition, the nontumorous area showed lymphocytic infiltration whereas inflammatory reaction was not seen in the adenoma. This case represents a rare association of a PRL cell adenoma and PRL cell hyperplasia. The fact that these two lesions were contiguous in the surgically removed material raises the possibility that hyperplasia can precede and transform into adenoma. Mención de responsabilidad : Sergio Vidal DVM, Eva Horvath PhD, Luis V. Syro MD, Humberto Uribe MD, Sandy Cohen RT & Kalman Kovacs MD, PhD Referencia : Endocr Pathol. Summer 2002;13(2):157-65. DOI (Digital Object Identifier) : 10.1385/EP:13:2:157 PMID : 12165665 En línea : https://link.springer.com/article/10.1385/EP:13:2:157 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4393 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000893 AC-2002-002 Archivo digital Producción Científica Artículos científicos Disponible
