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Enlace permanente de la investigaciónTrends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients / Fabián Juliao Baños ; Jorge Hernando Donado Gómez
Título : Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients Tipo de documento : documento electrónico Autores : Fabián Juliao Baños, ; Jorge Hernando Donado Gómez, Fecha de publicación : 2021 Títulos uniformes : Medicine (Baltimore) Idioma : Inglés (eng) Palabras clave : Colombians Crohn’s disease Epidemiology Hispanics Latinos Ulcerative colitis Resumen : The incidence of inflammatory bowel disease (IBD) is on the rise in Latin America. The aims of this study were to examine epidemiologic trends of IBD in Colombia by demographics, region, urbanicity, and to describe the IBD phenotype in a large well-characterized Colombian cohort. We used a national database of 33 million adults encompassing 97.6% of the Colombian population in order to obtain epidemiologic trends of IBD using International Classification of Diseases 10codes for adults with ulcerative colitis (UC) and Crohn disease (CD). We calculated the incidence and prevalence of UC and CD from 2010–2017 and examined epidemiologic trends by urbanicity, demographics, and region. We then examined the IBD phenotype (using Montreal Classification), prevalence of IBD-related surgeries, and types of IBD-medications prescribed to adult patients attending a regional IBD clinic in Medellin, Colombia between 2001 and 2017. The incidence of UC increased from 5.59/100,000 in 2010 to 6.3/100,000 in 2017 (relative risk [RR] 1.12, confidence interval (CI) (1.09–1.18), P Mención de responsabilidad : Juliao-Baños, Fabian MD; Kock, Joshua MD, MSc; Arrubla, Mateo MD; Calixto, Omar MD; Camargo, Joselyn MD; Cruz, Lina MD; Hurtado, Juan MD; Clavijo, Absalon MD; Donado, Jorge MD, MSc; Schwartz, Seth PhD; Abreu, Maria T. MD; Damas, Oriana M. MD Referencia : Medicine (Baltimore). 2021 Feb 19;100(7):e24729. DOI (Digital Object Identifier) : 10.1097/MD.0000000000024729 PMID : 33607817 Derechos de uso : CC BY-NC En línea : https://journals.lww.com/md-journal/Fulltext/2021/02190/Trends_in_the_epidemiolo [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5760 Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients [documento electrónico] / Fabián Juliao Baños, ; Jorge Hernando Donado Gómez, . - 2021.
Obra : Medicine (Baltimore)
Idioma : Inglés (eng)
Palabras clave : Colombians Crohn’s disease Epidemiology Hispanics Latinos Ulcerative colitis Resumen : The incidence of inflammatory bowel disease (IBD) is on the rise in Latin America. The aims of this study were to examine epidemiologic trends of IBD in Colombia by demographics, region, urbanicity, and to describe the IBD phenotype in a large well-characterized Colombian cohort. We used a national database of 33 million adults encompassing 97.6% of the Colombian population in order to obtain epidemiologic trends of IBD using International Classification of Diseases 10codes for adults with ulcerative colitis (UC) and Crohn disease (CD). We calculated the incidence and prevalence of UC and CD from 2010–2017 and examined epidemiologic trends by urbanicity, demographics, and region. We then examined the IBD phenotype (using Montreal Classification), prevalence of IBD-related surgeries, and types of IBD-medications prescribed to adult patients attending a regional IBD clinic in Medellin, Colombia between 2001 and 2017. The incidence of UC increased from 5.59/100,000 in 2010 to 6.3/100,000 in 2017 (relative risk [RR] 1.12, confidence interval (CI) (1.09–1.18), P Mención de responsabilidad : Juliao-Baños, Fabian MD; Kock, Joshua MD, MSc; Arrubla, Mateo MD; Calixto, Omar MD; Camargo, Joselyn MD; Cruz, Lina MD; Hurtado, Juan MD; Clavijo, Absalon MD; Donado, Jorge MD, MSc; Schwartz, Seth PhD; Abreu, Maria T. MD; Damas, Oriana M. MD Referencia : Medicine (Baltimore). 2021 Feb 19;100(7):e24729. DOI (Digital Object Identifier) : 10.1097/MD.0000000000024729 PMID : 33607817 Derechos de uso : CC BY-NC En línea : https://journals.lww.com/md-journal/Fulltext/2021/02190/Trends_in_the_epidemiolo [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5760 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001680 AC-2021-011 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2021-011Adobe Acrobat PDF
Título : Clinical features of Hispanic thyroid cancer cases and the role of known genetic variants on disease risk Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Jorge Hernando Donado Gómez, Fecha de publicación : 2016 Títulos uniformes : Medicine (Baltimore) Idioma : Inglés (eng) Palabras clave : Association Hispanics risk variants thyroid cancer Resumen : Thyroid cancer (TC) is the second most common cancer among Hispanic women. Recent genome-wide association (GWA) and candidate studies identified 6 single nucleotide polymorphisms (SNPs; rs966423, rs2439302, rs965513, rs6983267, rs944289, and rs116909374), associated with increased TC risk in Europeans but their effects on disease risk have not been comprehensively tested in Hispanics. In this study, we aimed to describe the main clinicopathological manifestations and to evaluate the effects of known SNPs on TC risk and on clinicopathological manifestations in a Hispanic population. We analyzed 281 nonmedullary TC cases and 1146 cancer-free controls recruited in a multicenter population-based study in Colombia. SNPs were genotyped by Kompetitive allele specific polymerase chain reaction (KASP) technique. Association between genetic variants and TC risk was assessed by computing odds ratios (OR) and confidence intervals (CIs). Consistent with published data in U.S. Hispanics, our cases had a high prevalence of large tumors (>2 cm, 43%) and a high female/male ratio (5:1). We detected significant associations between TC risk and rs965513A (OR = 1.41), rs944289T (OR = 1.26), rs116909374A (OR = 1.96), rs2439302G (OR = 1.19), and rs6983267G (OR = 1.18). Cases carried more risk alleles than controls (5.16 vs. 4.78, P = 4.8 × 10−6). Individuals with ≥6 risk alleles had >6-fold increased TC risk (OR = 6.33, P = 4.0 × 10−6) compared to individuals with ≤2 risk alleles. rs944289T and rs116909374A were strongly associated with follicular histology (ORs = 1.61 and 3.33, respectively); rs2439302G with large tumors (OR = 1.50); and rs965513A with regional disease (OR = 1.92). To our knowledge, this is the first study of known TC risk variants in South American Hispanics and suggests that they increase TC susceptibility in this population and can identify patients at higher risk of severe disease. Back to Top | Article Outline Mención de responsabilidad : Ana P Estrada-Florez, Mabel E Bohórquez, Ruta Sahasrabudhe, Rodrigo Prieto, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Medicine (Baltimore). 2016 Aug;95(32):e4148. DOI (Digital Object Identifier) : 10.1097/MD.0000000000004148. PMID : 27512836 En línea : https://journals.lww.com/md-journal/fulltext/2016/08090/Clinical_features_of_His [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3954 Clinical features of Hispanic thyroid cancer cases and the role of known genetic variants on disease risk [documento electrónico] / Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Jorge Hernando Donado Gómez, . - 2016.
Obra : Medicine (Baltimore)
Idioma : Inglés (eng)
Palabras clave : Association Hispanics risk variants thyroid cancer Resumen : Thyroid cancer (TC) is the second most common cancer among Hispanic women. Recent genome-wide association (GWA) and candidate studies identified 6 single nucleotide polymorphisms (SNPs; rs966423, rs2439302, rs965513, rs6983267, rs944289, and rs116909374), associated with increased TC risk in Europeans but their effects on disease risk have not been comprehensively tested in Hispanics. In this study, we aimed to describe the main clinicopathological manifestations and to evaluate the effects of known SNPs on TC risk and on clinicopathological manifestations in a Hispanic population. We analyzed 281 nonmedullary TC cases and 1146 cancer-free controls recruited in a multicenter population-based study in Colombia. SNPs were genotyped by Kompetitive allele specific polymerase chain reaction (KASP) technique. Association between genetic variants and TC risk was assessed by computing odds ratios (OR) and confidence intervals (CIs). Consistent with published data in U.S. Hispanics, our cases had a high prevalence of large tumors (>2 cm, 43%) and a high female/male ratio (5:1). We detected significant associations between TC risk and rs965513A (OR = 1.41), rs944289T (OR = 1.26), rs116909374A (OR = 1.96), rs2439302G (OR = 1.19), and rs6983267G (OR = 1.18). Cases carried more risk alleles than controls (5.16 vs. 4.78, P = 4.8 × 10−6). Individuals with ≥6 risk alleles had >6-fold increased TC risk (OR = 6.33, P = 4.0 × 10−6) compared to individuals with ≤2 risk alleles. rs944289T and rs116909374A were strongly associated with follicular histology (ORs = 1.61 and 3.33, respectively); rs2439302G with large tumors (OR = 1.50); and rs965513A with regional disease (OR = 1.92). To our knowledge, this is the first study of known TC risk variants in South American Hispanics and suggests that they increase TC susceptibility in this population and can identify patients at higher risk of severe disease. Back to Top | Article Outline Mención de responsabilidad : Ana P Estrada-Florez, Mabel E Bohórquez, Ruta Sahasrabudhe, Rodrigo Prieto, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Medicine (Baltimore). 2016 Aug;95(32):e4148. DOI (Digital Object Identifier) : 10.1097/MD.0000000000004148. PMID : 27512836 En línea : https://journals.lww.com/md-journal/fulltext/2016/08090/Clinical_features_of_His [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3954 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000540 AC-2016-015 Archivo digital Producción Científica Artículos científicos Disponible
Título : The HABP2 G534E polymorphism does not increase nonmedullary thyroid cancer risk in Hispanics Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, ; Jorge Hernando Donado Gómez, ; Alejandro Vélez Hoyos, Fecha de publicación : 2016 Títulos uniformes : Endocrine Connections Idioma : Inglés (eng) Palabras clave : HABP2 G534E thyroid cancer hispanics Resumen : Familial nonmedullary thyroid cancer (NMTC) has not been clearly linked to causal germline variants, despite the large role that genetic factors play in risk. Recently, HABP2 G534E (rs7080536A) has been implicated as a causal variant in NMTC. We have previously shown that the HABP2 G534E variant is not associated with TC risk in patients from the British Isles. Hispanics are the largest and the youngest minority in the United States and NMTC is now the second most common malignancy in women from this population. In order to determine if the HABP2 G534E variant played a role in NMTC risk among Hispanic populations, we analyzed 281 cases and 1105 population-matched controls from a multicenter study in Colombia, evaluating the association through logistic regression. We found that the HABP2 G534E variant was not significantly associated with NMTC risk (P=0.843) in this Hispanic group. We also stratified available clinical data by multiple available clinicopathological variables and further analyzed the effect of HABP2 on NMTC presentation. However, we failed to detect associations between HABP2 G534E and NMTC risk, regardless of disease presentation (P≥0.273 for all cases). Therefore, without any significant associations between the HABP2 G534E variant and NMTC risk, we conclude that the variant is not causal of NMTC in this Hispanic population. Mención de responsabilidad : Mabel E Bohórquez, Ana P Estrada, Jacob Stultz, Ruta Sahasrabudhe, John Williamson, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Endocr Connect. 2016 May;5(3):123-7. DOI (Digital Object Identifier) : 10.1530/EC-16-0017 PMID : 27097599 Derechos de uso : CC BY-NC En línea : https://ec.bioscientifica.com/view/journals/ec/5/3/123.xml Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3953 The HABP2 G534E polymorphism does not increase nonmedullary thyroid cancer risk in Hispanics [documento electrónico] / Carlos Simón Duque Fisher, ; Jorge Hernando Donado Gómez, ; Alejandro Vélez Hoyos, . - 2016.
Obra : Endocrine Connections
Idioma : Inglés (eng)
Palabras clave : HABP2 G534E thyroid cancer hispanics Resumen : Familial nonmedullary thyroid cancer (NMTC) has not been clearly linked to causal germline variants, despite the large role that genetic factors play in risk. Recently, HABP2 G534E (rs7080536A) has been implicated as a causal variant in NMTC. We have previously shown that the HABP2 G534E variant is not associated with TC risk in patients from the British Isles. Hispanics are the largest and the youngest minority in the United States and NMTC is now the second most common malignancy in women from this population. In order to determine if the HABP2 G534E variant played a role in NMTC risk among Hispanic populations, we analyzed 281 cases and 1105 population-matched controls from a multicenter study in Colombia, evaluating the association through logistic regression. We found that the HABP2 G534E variant was not significantly associated with NMTC risk (P=0.843) in this Hispanic group. We also stratified available clinical data by multiple available clinicopathological variables and further analyzed the effect of HABP2 on NMTC presentation. However, we failed to detect associations between HABP2 G534E and NMTC risk, regardless of disease presentation (P≥0.273 for all cases). Therefore, without any significant associations between the HABP2 G534E variant and NMTC risk, we conclude that the variant is not causal of NMTC in this Hispanic population. Mención de responsabilidad : Mabel E Bohórquez, Ana P Estrada, Jacob Stultz, Ruta Sahasrabudhe, John Williamson, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Endocr Connect. 2016 May;5(3):123-7. DOI (Digital Object Identifier) : 10.1530/EC-16-0017 PMID : 27097599 Derechos de uso : CC BY-NC En línea : https://ec.bioscientifica.com/view/journals/ec/5/3/123.xml Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3953 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000538 AC-2016-013 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2016-013.pdfAdobe Acrobat PDF
