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Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study / Martín Ochoa Escudero ; Sergio Álvarez Vallejo    

Público ISBD Título : Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study Tipo de documento : documento electrónico Autores : Martín Ochoa Escudero, ; Sergio Álvarez Vallejo, Fecha de publicación : 2021 Títulos uniformes : Alzheimer's Research & Therapy Idioma : Inglés (eng) Palabras clave : Alzheimer’s  Amyloid  Autosomal-Dominant  Imaging  Longitudinal  Tau Resumen : Background: Neuroimaging studies of autosomal dominant Alzheimer's disease (ADAD) enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation in the decades prior to clinical symptom onset. Longitudinal rates of regional tau accumulation measured with positron emission tomography (PET) and their relationship with other biomarker and cognitive changes remain to be fully characterized in ADAD. Methods: Fourteen ADAD mutation carriers (Presenilin-1 E280A) and 15 age-matched non-carriers from the Colombian kindred underwent 2-3 sessions of Aβ (11C-Pittsburgh compound B) and tau (18F-flortaucipir) PET, structural magnetic resonance imaging, and neuropsychological evaluation over a 2-4-year follow-up period. Annualized rates of change for imaging and cognitive variables were compared between carriers and non-carriers, and relationships among baseline measurements and rates of change were assessed within carriers. Results: Longitudinal measurements were consistent with a sequence of ADAD-related changes beginning with Aβ accumulation (16 years prior to expected symptom onset, EYO), followed by entorhinal cortex (EC) tau (9 EYO), neocortical tau (6 EYO), hippocampal atrophy (6 EYO), and cognitive decline (4 EYO). Rates of tau accumulation among carriers were most rapid in parietal neocortex (~ 9%/year). EC tau PET signal at baseline was a significant predictor of subsequent neocortical tau accumulation and cognitive decline within carriers. Conclusions: Our results are consistent with the sequence of biological changes in ADAD implied by cross-sectional studies and highlight the importance of EC tau as an early biomarker and a potential link between Aβ burden and neocortical tau accumulation in ADAD. Mención de responsabilidad : Justin S. Sanchez, Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E. Martinez, Joshua T. Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I. L. Jacobs, Aaron P. Schultz, Jennifer R. Gatchel, J. Alex Becker, Samantha R. Katz, Danielle V. Mayblyum, Julie C. Price, Eric M. Reiman, Keith A. Johnson and Yakeel T. Quiroz Referencia : Alzheimers Res Ther. 2021 Jan 15;13(1):27. DOI (Digital Object Identifier) : 10.1186/s13195-020-00765-5 PMID : 33451357 Derechos de uso : CC BY En línea : https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00765-5 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5784 Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study [documento electrónico] / Martín Ochoa Escudero, ; Sergio Álvarez Vallejo,  . - 2021. Obra : Alzheimer's Research & Therapy Idioma : Inglés (eng) Palabras clave : Alzheimer’s  Amyloid  Autosomal-Dominant  Imaging  Longitudinal  Tau Resumen : Background: Neuroimaging studies of autosomal dominant Alzheimer's disease (ADAD) enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation in the decades prior to clinical symptom onset. Longitudinal rates of regional tau accumulation measured with positron emission tomography (PET) and their relationship with other biomarker and cognitive changes remain to be fully characterized in ADAD. Methods: Fourteen ADAD mutation carriers (Presenilin-1 E280A) and 15 age-matched non-carriers from the Colombian kindred underwent 2-3 sessions of Aβ (11C-Pittsburgh compound B) and tau (18F-flortaucipir) PET, structural magnetic resonance imaging, and neuropsychological evaluation over a 2-4-year follow-up period. Annualized rates of change for imaging and cognitive variables were compared between carriers and non-carriers, and relationships among baseline measurements and rates of change were assessed within carriers. Results: Longitudinal measurements were consistent with a sequence of ADAD-related changes beginning with Aβ accumulation (16 years prior to expected symptom onset, EYO), followed by entorhinal cortex (EC) tau (9 EYO), neocortical tau (6 EYO), hippocampal atrophy (6 EYO), and cognitive decline (4 EYO). Rates of tau accumulation among carriers were most rapid in parietal neocortex (~ 9%/year). EC tau PET signal at baseline was a significant predictor of subsequent neocortical tau accumulation and cognitive decline within carriers. Conclusions: Our results are consistent with the sequence of biological changes in ADAD implied by cross-sectional studies and highlight the importance of EC tau as an early biomarker and a potential link between Aβ burden and neocortical tau accumulation in ADAD. Mención de responsabilidad : Justin S. Sanchez, Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E. Martinez, Joshua T. Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I. L. Jacobs, Aaron P. Schultz, Jennifer R. Gatchel, J. Alex Becker, Samantha R. Katz, Danielle V. Mayblyum, Julie C. Price, Eric M. Reiman, Keith A. Johnson and Yakeel T. Quiroz Referencia : Alzheimers Res Ther. 2021 Jan 15;13(1):27. DOI (Digital Object Identifier) : 10.1186/s13195-020-00765-5 PMID : 33451357 Derechos de uso : CC BY En línea : https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00765-5 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5784

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Physicians' awareness of gadolinium retention and MRI timing practices in the longitudinal management of pituitary tumors: a "Pituitary Society" survey / Luis Vicente Syro Moreno  

Público ISBD Título : Physicians' awareness of gadolinium retention and MRI timing practices in the longitudinal management of pituitary tumors: a "Pituitary Society" survey Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2019 Títulos uniformes : Pituitary Idioma : Inglés (eng) Palabras clave : Adenoma  Contrast  Gadolinium  Imaging  Neuroendocrinologists  Neurosurgeons  Pituitar  Safety  Survey  Tumor Resumen : Purpose: In view of mounting attention related to possible brain retention of gadolinium-based contrast agents (GBCAs) in patients with normal renal function, our purpose was to detail results from a survey of pituitary experts to assess: 1) the timing interval and frequency of pituitary magnetic resonance imaging (MRI) following surgical and/or medical and/or radiation therapy of pituitary tumors, 2) awareness of the types of GBCAs used and their possible safety issues. Methods: The Pituitary Society Education Committee composed a survey with 12 multiple choice questions, 8 of which specifically addressed the time interval and frequency of MRI in the longitudinal management of pituitary tumors. The survey was distributed at two meetings; the International Pituitary Neurosurgeons Society conference in San Diego, CA, on February 18th, 2018, and the Pituitary Society Membership and Career Development Forum, Chicago, IL on March 18th, 2018. Results: There is consensus among pituitary endocrinologists and neurosurgeons that long-term repeated imaging is recommended in most pituitary tumors, although the precise strategy of timing varied depending on the specialist group and the specific clinical context of the adenoma. The data also suggest that International Pituitary Neurosurgeons Society neurosurgeons, as well as Pituitary Society neuroendocrinologists, are sometimes unaware of which contrast agents are used by their institution, and many are also unaware that evidence of long-term brain retention has been reported with the use of GBCAsin patients with normal function. Conclusions: International pituitary endocrinologists and pituitary neurosurgeons experts suggest ongoing MRIs for the management of pituitary tumors; strategies vary based on clinical context, but also on individual experience and practice. Mención de responsabilidad : Lisa B Nachtigall, Niki Karavitaki, Katja Kiseljak-Vassiliades, Luma Ghalib, Hidenori Fukuoka, Luis V Syro, Daniel Kelly, Maria Fleseriu Referencia : Pituitary. 2019 Feb;22(1):37-45. DOI (Digital Object Identifier) : 10.1007/s11102-018-0924-0 PMID : 30456434 En línea : https://link.springer.com/article/10.1007%2Fs11102-018-0924-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4128 Physicians' awareness of gadolinium retention and MRI timing practices in the longitudinal management of pituitary tumors: a "Pituitary Society" survey [documento electrónico] / Luis Vicente Syro Moreno,  . - 2019. Obra : Pituitary Idioma : Inglés (eng) Palabras clave : Adenoma  Contrast  Gadolinium  Imaging  Neuroendocrinologists  Neurosurgeons  Pituitar  Safety  Survey  Tumor Resumen : Purpose: In view of mounting attention related to possible brain retention of gadolinium-based contrast agents (GBCAs) in patients with normal renal function, our purpose was to detail results from a survey of pituitary experts to assess: 1) the timing interval and frequency of pituitary magnetic resonance imaging (MRI) following surgical and/or medical and/or radiation therapy of pituitary tumors, 2) awareness of the types of GBCAs used and their possible safety issues. Methods: The Pituitary Society Education Committee composed a survey with 12 multiple choice questions, 8 of which specifically addressed the time interval and frequency of MRI in the longitudinal management of pituitary tumors. The survey was distributed at two meetings; the International Pituitary Neurosurgeons Society conference in San Diego, CA, on February 18th, 2018, and the Pituitary Society Membership and Career Development Forum, Chicago, IL on March 18th, 2018. Results: There is consensus among pituitary endocrinologists and neurosurgeons that long-term repeated imaging is recommended in most pituitary tumors, although the precise strategy of timing varied depending on the specialist group and the specific clinical context of the adenoma. The data also suggest that International Pituitary Neurosurgeons Society neurosurgeons, as well as Pituitary Society neuroendocrinologists, are sometimes unaware of which contrast agents are used by their institution, and many are also unaware that evidence of long-term brain retention has been reported with the use of GBCAsin patients with normal function. Conclusions: International pituitary endocrinologists and pituitary neurosurgeons experts suggest ongoing MRIs for the management of pituitary tumors; strategies vary based on clinical context, but also on individual experience and practice. Mención de responsabilidad : Lisa B Nachtigall, Niki Karavitaki, Katja Kiseljak-Vassiliades, Luma Ghalib, Hidenori Fukuoka, Luis V Syro, Daniel Kelly, Maria Fleseriu Referencia : Pituitary. 2019 Feb;22(1):37-45. DOI (Digital Object Identifier) : 10.1007/s11102-018-0924-0 PMID : 30456434 En línea : https://link.springer.com/article/10.1007%2Fs11102-018-0924-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4128

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Hepatic transplantation in a child with giant multicystic tumor: pathological and imaging findings / María Elsy Sepúlveda Hincapie ; Nora Luz Yepes Palacio ; Sergio Iván Hoyos Duque  

Público ISBD Título : Hepatic transplantation in a child with giant multicystic tumor: pathological and imaging findings Tipo de documento : documento electrónico Autores : María Elsy Sepúlveda Hincapie, ; Nora Luz Yepes Palacio, ; Sergio Iván Hoyos Duque, Fecha de publicación : 2010 Títulos uniformes : Pediatric Transplantation Idioma : Francés (fre) Palabras clave : Hepatic  cystic  tumor  transplantation  pathological  imaging Resumen : A 30 month old male white child presented with 13 months of increasing abdominal girth. The MRI and MDCT showed a giant heterogeneous and predominantly cystic mass with thick and nodular septation, measuring approximately 18, 15, 20 cm, which occupied almost the whole liver. A histological diagnosis was not possible, which necessitated transplantation. One year after transplantation the course has been satisfactory without recurrence and with normal hepatic function and negative tumor markers Mención de responsabilidad : Germán A Castrillon, Elsy Sepúlveda, Nora L Yepez, Sergio Hoyos, Germán Osorio Referencia : Pediatr Transplantation 2010 Aug;14(5):e58-61. DOI (Digital Object Identifier) : 10.1111/j.1399-3046.2009.01166.x PMID : 19413715 En línea : https://onlinelibrary.wiley.com/doi/10.1111/j.1399-3046.2009.01166.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3545 Hepatic transplantation in a child with giant multicystic tumor: pathological and imaging findings [documento electrónico] / María Elsy Sepúlveda Hincapie, ; Nora Luz Yepes Palacio, ; Sergio Iván Hoyos Duque,  . - 2010. Obra : Pediatric Transplantation Idioma : Francés (fre) Palabras clave : Hepatic  cystic  tumor  transplantation  pathological  imaging Resumen : A 30 month old male white child presented with 13 months of increasing abdominal girth. The MRI and MDCT showed a giant heterogeneous and predominantly cystic mass with thick and nodular septation, measuring approximately 18, 15, 20 cm, which occupied almost the whole liver. A histological diagnosis was not possible, which necessitated transplantation. One year after transplantation the course has been satisfactory without recurrence and with normal hepatic function and negative tumor markers Mención de responsabilidad : Germán A Castrillon, Elsy Sepúlveda, Nora L Yepez, Sergio Hoyos, Germán Osorio Referencia : Pediatr Transplantation 2010 Aug;14(5):e58-61. DOI (Digital Object Identifier) : 10.1111/j.1399-3046.2009.01166.x PMID : 19413715 En línea : https://onlinelibrary.wiley.com/doi/10.1111/j.1399-3046.2009.01166.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3545

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