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Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas / Luis Vicente Syro Moreno
Título : Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 1999 Títulos uniformes : Ultrastructural Pathology Idioma : Inglés (eng) Palabras clave : Human Immunoelectron Microscopy Pituitary Adenoma Plurihormonality Ultrastructure Resumen : Momomorphous pituitary adenomas expressing several hormones by immunocytochemistry are common, whereas adenomas displaying multiple immunoreactivities and consisting of more than one morphologic cell types are rare. Three such unusual pituitary adenomas, surgically removed from two patients with acromegaly and one patient with hyperprolactinemia, were investigated by histology, immunocytochemistry, transmission electron microscopy, as well as immunoelectron microscopy using double immunogold labeling. Immunocytochemistry revealed variable degrees of immunoreactivities for growth hormone (GH), prolactin (PRL), thyroid-stimulating hormone (beta-TSH), and alpha-subunit of glycoprotein hormones in all three tumors. The three adenomas consisted of phenotypically diverse cell populations as documented by transmission electron microscopy. In addition to monohormonal GH cells, immunoelectron microscopy demonstrated numerous cells colocalizing GH and PRL or GH and beta-TSH, and rarely PRL and beta-TSH in tumors of acromegalics. The adenoma causing hyperprolactinemia consisted chiefly of mammosomatotrophs colocalizing PRL and GH, whereas beta-TSH labeling was scant. The three tumors in the study were selected from a cluster of five plurimorphous plurihormonal adenomas received from the same locale where they accounted for an unprecedented 21% of adenomas producing GH and/or PRL. The enhanced susceptibility to develop plurimorphous adenomas of the acidophil cell line may have a genetic basis in the stable population the patients came from. Mención de responsabilidad : J F Molina, L R Espinoza Referencia : Ultrastruct Pathol. May-Jun 1999;23(3):141-8. DOI (Digital Object Identifier) : 10.1080/019131299281635 PMID : 10445280 En línea : https://www.tandfonline.com/doi/abs/10.1080/019131299281635 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4385 Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas [documento electrónico] / Luis Vicente Syro Moreno, . - 1999.
Obra : Ultrastructural Pathology
Idioma : Inglés (eng)
Palabras clave : Human Immunoelectron Microscopy Pituitary Adenoma Plurihormonality Ultrastructure Resumen : Momomorphous pituitary adenomas expressing several hormones by immunocytochemistry are common, whereas adenomas displaying multiple immunoreactivities and consisting of more than one morphologic cell types are rare. Three such unusual pituitary adenomas, surgically removed from two patients with acromegaly and one patient with hyperprolactinemia, were investigated by histology, immunocytochemistry, transmission electron microscopy, as well as immunoelectron microscopy using double immunogold labeling. Immunocytochemistry revealed variable degrees of immunoreactivities for growth hormone (GH), prolactin (PRL), thyroid-stimulating hormone (beta-TSH), and alpha-subunit of glycoprotein hormones in all three tumors. The three adenomas consisted of phenotypically diverse cell populations as documented by transmission electron microscopy. In addition to monohormonal GH cells, immunoelectron microscopy demonstrated numerous cells colocalizing GH and PRL or GH and beta-TSH, and rarely PRL and beta-TSH in tumors of acromegalics. The adenoma causing hyperprolactinemia consisted chiefly of mammosomatotrophs colocalizing PRL and GH, whereas beta-TSH labeling was scant. The three tumors in the study were selected from a cluster of five plurimorphous plurihormonal adenomas received from the same locale where they accounted for an unprecedented 21% of adenomas producing GH and/or PRL. The enhanced susceptibility to develop plurimorphous adenomas of the acidophil cell line may have a genetic basis in the stable population the patients came from. Mención de responsabilidad : J F Molina, L R Espinoza Referencia : Ultrastruct Pathol. May-Jun 1999;23(3):141-8. DOI (Digital Object Identifier) : 10.1080/019131299281635 PMID : 10445280 En línea : https://www.tandfonline.com/doi/abs/10.1080/019131299281635 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4385 Reserva
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