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Título : Clear cell change in mucocele: an unusual histological variant Tipo de documento : documento electrónico Autores : Gabriel Jaime Varela Aguirre, Fecha de publicación : 2021 Títulos uniformes : Archives of Head and Neck Surgery Idioma : Inglés (eng) Palabras clave : Mucocele Otorhinolaryngologic Neoplasms Immunohistochemistry Resumen : Oral mucocele (OM) with clear cell change is a rare histological variant that can generate diagnostic difficulties and must be differentiated from benign, malignant and metastatic neoplasms that have this histological pattern. We present the case of a 27-year-old woman with OM with clear cell change in which the complete medical history, histopathological evaluation and immunohistochemical studies led to a correct diagnosis. Mención de responsabilidad : Camilo Andrés Pérez Montiel, Gabriel Jaime Varela Aguirre Referencia : 10.4322/ahns.2021.0015 Derechos de uso : CC BY En línea : https://archivesheadnecksurgery.com/article/doi/10.4322/ahns.2021.0015 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Clear cell change in mucocele: an unusual histological variant [documento electrónico] / Gabriel Jaime Varela Aguirre, . - 2021.
Obra : Archives of Head and Neck Surgery
Idioma : Inglés (eng)
Palabras clave : Mucocele Otorhinolaryngologic Neoplasms Immunohistochemistry Resumen : Oral mucocele (OM) with clear cell change is a rare histological variant that can generate diagnostic difficulties and must be differentiated from benign, malignant and metastatic neoplasms that have this histological pattern. We present the case of a 27-year-old woman with OM with clear cell change in which the complete medical history, histopathological evaluation and immunohistochemical studies led to a correct diagnosis. Mención de responsabilidad : Camilo Andrés Pérez Montiel, Gabriel Jaime Varela Aguirre Referencia : 10.4322/ahns.2021.0015 Derechos de uso : CC BY En línea : https://archivesheadnecksurgery.com/article/doi/10.4322/ahns.2021.0015 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001832 AC-2021-141 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2021-141Adobe Acrobat PDFMetastatic papillary carcinoma to the neck, thinking beyond the thyroid gland / Carlos Simón Duque Fisher
Título : Metastatic papillary carcinoma to the neck, thinking beyond the thyroid gland Otros títulos : Carcinoma papilar metastásico a cuello, pensar más allá de la glándula tiroides Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, Fecha de publicación : 2020 Títulos uniformes : Revista Mexicana de Patología Clínica Idioma : Inglés (eng) Palabras clave : Lung cancer thyroid cancer neck dissection immunohistochemistry Resumen : Introduction: A description of a male patient with prior treatment for a right lung adenocarcinoma and a close follow-up for a right thyroid lobe 7 mm papillary cancer, who developed massive right neck metastasis. Objective: To describe the diagnostic dilemma to confirm or rule out the origin of the multiple neck metastasis to avoid unnecessary treatments. Methods: The biopsies from the lung, thyroid and neck tissues were reviewed and examined with immunohistochemistry. Results: The neck metastasis originated from an adenocarcinoma of the lung with papillary features. Conclusions: Unnecessary radioactive iodine treatments were avoided, thanks to the tumor markers. Mención de responsabilidad : Duque CS, Moreno A, Serna OC, Agudelo M DOI (Digital Object Identifier) : 10.35366/96680 En línea : https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=96680 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Metastatic papillary carcinoma to the neck, thinking beyond the thyroid gland = Carcinoma papilar metastásico a cuello, pensar más allá de la glándula tiroides [documento electrónico] / Carlos Simón Duque Fisher, . - 2020.
Obra : Revista Mexicana de Patología Clínica
Idioma : Inglés (eng)
Palabras clave : Lung cancer thyroid cancer neck dissection immunohistochemistry Resumen : Introduction: A description of a male patient with prior treatment for a right lung adenocarcinoma and a close follow-up for a right thyroid lobe 7 mm papillary cancer, who developed massive right neck metastasis. Objective: To describe the diagnostic dilemma to confirm or rule out the origin of the multiple neck metastasis to avoid unnecessary treatments. Methods: The biopsies from the lung, thyroid and neck tissues were reviewed and examined with immunohistochemistry. Results: The neck metastasis originated from an adenocarcinoma of the lung with papillary features. Conclusions: Unnecessary radioactive iodine treatments were avoided, thanks to the tumor markers. Mención de responsabilidad : Duque CS, Moreno A, Serna OC, Agudelo M DOI (Digital Object Identifier) : 10.35366/96680 En línea : https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=96680 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001740 AC-2020-157 Archivo digital Producción Científica Artículos científicos Disponible
Título : Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2017 Títulos uniformes : Pituitary Idioma : Inglés (eng) Palabras clave : Acromegaly classification diagnosis immunohistochemistry pathology pituitary neoplasms Resumen : Introduction: Histologic, immunohistochemical and electron microscopic studies have provided conclusive evidence that a marked diversity exists between tumors which secrete growth hormone (GH) in excess. GH cell hyperplasia can also be associated with acromegaly in patients with extrapituitary GH—releasing hormone secreting tumors or in familial pituitary tumor syndromes. Materials and methods: A literature search was performed for information regarding pathology, GH-producing tumors and acromegaly. Results: This review summarizes the current knowledge on the morphology of GH-producing and silent GH adenomas, as well as GH hyperplasia of the pituitary. Conclusion: The importance of morphologic classification and identification of different subgroups of patients with GH-producing adenomas and their impact on clinical management is discussed. Mención de responsabilidad : Luis V Syro, Fabio Rotondo, Carlos A Serna, Leon D Ortiz, Kalman Kovacs Referencia : Pituitary. 2017 Feb;20(1):84-92. DOI (Digital Object Identifier) : 10.1007/s11102-016-0748-8 PMID : 27586499 En línea : https://link.springer.com/article/10.1007%2Fs11102-016-0748-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary [documento electrónico] / Luis Vicente Syro Moreno, . - 2017.
Obra : Pituitary
Idioma : Inglés (eng)
Palabras clave : Acromegaly classification diagnosis immunohistochemistry pathology pituitary neoplasms Resumen : Introduction: Histologic, immunohistochemical and electron microscopic studies have provided conclusive evidence that a marked diversity exists between tumors which secrete growth hormone (GH) in excess. GH cell hyperplasia can also be associated with acromegaly in patients with extrapituitary GH—releasing hormone secreting tumors or in familial pituitary tumor syndromes. Materials and methods: A literature search was performed for information regarding pathology, GH-producing tumors and acromegaly. Results: This review summarizes the current knowledge on the morphology of GH-producing and silent GH adenomas, as well as GH hyperplasia of the pituitary. Conclusion: The importance of morphologic classification and identification of different subgroups of patients with GH-producing adenomas and their impact on clinical management is discussed. Mención de responsabilidad : Luis V Syro, Fabio Rotondo, Carlos A Serna, Leon D Ortiz, Kalman Kovacs Referencia : Pituitary. 2017 Feb;20(1):84-92. DOI (Digital Object Identifier) : 10.1007/s11102-016-0748-8 PMID : 27586499 En línea : https://link.springer.com/article/10.1007%2Fs11102-016-0748-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000697 AC-2017-086 Archivo digital Producción Científica Artículos científicos Disponible
Título : Human kallikrein 10 expression in surgically removed human pituitary corticotroph adenomas: an immunohistochemical study Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2015 Títulos uniformes : Applied Immunohistochemistry and Molecular Morphology Idioma : Inglés (eng) Palabras clave : Human kallkrein 10 immunohistochemistry neoplasms pituitary adenoma prognostic marker Resumen : Human kallikrein 10 (hk10), a secreted serine protease, was reported to function as a tumor suppressor. hK10 immunoexpression has been demonstrated in lactrotrophs and corticotrophs of the nontumorous human adenohypophysis. In the present study, for the first time we report hK10 immunoexpression in various surgically removed corticotroph adenoma subtypes. Specimens were fixed in formalin and embedded in paraffin. Immunostaining was performed using the streptavidin-biotin peroxidase complex method with an hK10-specific rabbit polyclonal antibody. Results showed that the endocrinologically active adrenocorticotropic hormone (ACTH)-producing pituitary tumors and the silent subtypes were immunopositve for hK10. Intensity of staining varied between the different subtypes. Intensity was lowest in the silent subtypes (silent corticotroph subtypes 1 and 2) compared with nontumorous human adenohypophysial corticotrophs, whereas the endocrinologically active subtypes (ACTH-secreting adenomas, corticotroph carcinomas, Crooke cell adenomas, Crooke cell carcinomas), showed the highest hK10 immunoexpression. Immunopositivity in the nuclei of the ACTH-secreting adenomas and carcinomas, as well as dual cytoplasmic and nuclear localization of hK10 in some of the secreting tumor types was an intriguing finding. Immunoexpression of hK10 in the ACTH-secreting tumors as well as in the Crooke cell tumors was significantly increased when compared with the nonfunctioning tumors and in the corticotrophs of nontumorous pituitaries. Mención de responsabilidad : Ashley Di Meo, Fabio Rotondo, Kalman Kovacs, Michael D Cusimano, Luis V Syro, Antonio Di Ieva, Eleftheros P Diamandis, George M Yousef Referencia : Appl Immunohistochem Mol Morphol. 2015 Jul;23(6):433-7. DOI (Digital Object Identifier) : 10.1097/PAI.0000000000000108 PMID : 25517869 En línea : https://journals.lww.com/appliedimmunohist/Abstract/2015/07000/Human_Kallikrein_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Human kallikrein 10 expression in surgically removed human pituitary corticotroph adenomas: an immunohistochemical study [documento electrónico] / Luis Vicente Syro Moreno, . - 2015.
Obra : Applied Immunohistochemistry and Molecular Morphology
Idioma : Inglés (eng)
Palabras clave : Human kallkrein 10 immunohistochemistry neoplasms pituitary adenoma prognostic marker Resumen : Human kallikrein 10 (hk10), a secreted serine protease, was reported to function as a tumor suppressor. hK10 immunoexpression has been demonstrated in lactrotrophs and corticotrophs of the nontumorous human adenohypophysis. In the present study, for the first time we report hK10 immunoexpression in various surgically removed corticotroph adenoma subtypes. Specimens were fixed in formalin and embedded in paraffin. Immunostaining was performed using the streptavidin-biotin peroxidase complex method with an hK10-specific rabbit polyclonal antibody. Results showed that the endocrinologically active adrenocorticotropic hormone (ACTH)-producing pituitary tumors and the silent subtypes were immunopositve for hK10. Intensity of staining varied between the different subtypes. Intensity was lowest in the silent subtypes (silent corticotroph subtypes 1 and 2) compared with nontumorous human adenohypophysial corticotrophs, whereas the endocrinologically active subtypes (ACTH-secreting adenomas, corticotroph carcinomas, Crooke cell adenomas, Crooke cell carcinomas), showed the highest hK10 immunoexpression. Immunopositivity in the nuclei of the ACTH-secreting adenomas and carcinomas, as well as dual cytoplasmic and nuclear localization of hK10 in some of the secreting tumor types was an intriguing finding. Immunoexpression of hK10 in the ACTH-secreting tumors as well as in the Crooke cell tumors was significantly increased when compared with the nonfunctioning tumors and in the corticotrophs of nontumorous pituitaries. Mención de responsabilidad : Ashley Di Meo, Fabio Rotondo, Kalman Kovacs, Michael D Cusimano, Luis V Syro, Antonio Di Ieva, Eleftheros P Diamandis, George M Yousef Referencia : Appl Immunohistochem Mol Morphol. 2015 Jul;23(6):433-7. DOI (Digital Object Identifier) : 10.1097/PAI.0000000000000108 PMID : 25517869 En línea : https://journals.lww.com/appliedimmunohist/Abstract/2015/07000/Human_Kallikrein_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000455 AC-2015-008 Archivo digital Producción Científica Artículos científicos Disponible
Título : Human kallikrein 10 in surgically removed human pituitary adenomas Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2015 Títulos uniformes : Hormones Idioma : Inglés (eng) Palabras clave : Human kallikrein 10 immunohistochemistry pathology pituitary adenoma prognostic marker Resumen : Objective: Human kallikrein-like peptidase 10 (KLK10), a serine protease, plays an important role in the regulation of cell proliferation and tumor growth. In this work, we investigated KLK10 immunoexpression in various types of surgically removed human pituitary tumors. Design: Specimens were fixed in formalin and embedded in paraffin. Immunostaining was performed by the streptavidin-biotin-peroxidase complex protocol using the LSAB+ Kit and a KLK10-specific rabbit polyclonal antibody. Results: Results showed that both treated and untreated prolactin-producing pituitary adenomas and carcinomas as well as TSH-producing pituitary adenomas and carcinomas were conclusively immunopositive for KLK10. Immunostaining was mainly localized in the cytoplasm and was clearly visible in many adenoma cells. In various other tumor types (oncocytoma, gonadotroph, somatotroph adenomas, and carcinomas), cytoplasmic immunopositivity was mild to moderate and seen only in a few unevenly distributed adenoma cells. Immunopositivity in the nuclei of various tumor types, as well as dual cytoplasmic and nuclear localization of KLK10 in some of the tumor types, was an intriguing finding. Immunoexpression in GH-producing adenomas exposed to octreotide, a long-acting somatostatin analog, was significantly increased when compared to unexposed GH-producing tumors. Conclusion: More studies are needed to ascertain the role of KLK10 in pituitary tumor development, prognosis, and progression. The question of whether genetic abnormalities and the microenvironment can affect KLK10 immunoexpression should also be investigated. Mención de responsabilidad : Fabio Rotondo, Antonio Di Ieva, Kalman Kovacs, Michael D Cusimano, Luis V Syro, Eleftherios P Diamandis, George M Yousef Referencia : Hormones (Athens). 2015 Apr-Jun;14(2):272-9. DOI (Digital Object Identifier) : 10.14310/horm.2002.1558. PMID : 25553760 En línea : http://www.hormones.gr/8536/article/human-kallikrein-10-in-surgically-removed%E2 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Human kallikrein 10 in surgically removed human pituitary adenomas [documento electrónico] / Luis Vicente Syro Moreno, . - 2015.
Obra : Hormones
Idioma : Inglés (eng)
Palabras clave : Human kallikrein 10 immunohistochemistry pathology pituitary adenoma prognostic marker Resumen : Objective: Human kallikrein-like peptidase 10 (KLK10), a serine protease, plays an important role in the regulation of cell proliferation and tumor growth. In this work, we investigated KLK10 immunoexpression in various types of surgically removed human pituitary tumors. Design: Specimens were fixed in formalin and embedded in paraffin. Immunostaining was performed by the streptavidin-biotin-peroxidase complex protocol using the LSAB+ Kit and a KLK10-specific rabbit polyclonal antibody. Results: Results showed that both treated and untreated prolactin-producing pituitary adenomas and carcinomas as well as TSH-producing pituitary adenomas and carcinomas were conclusively immunopositive for KLK10. Immunostaining was mainly localized in the cytoplasm and was clearly visible in many adenoma cells. In various other tumor types (oncocytoma, gonadotroph, somatotroph adenomas, and carcinomas), cytoplasmic immunopositivity was mild to moderate and seen only in a few unevenly distributed adenoma cells. Immunopositivity in the nuclei of various tumor types, as well as dual cytoplasmic and nuclear localization of KLK10 in some of the tumor types, was an intriguing finding. Immunoexpression in GH-producing adenomas exposed to octreotide, a long-acting somatostatin analog, was significantly increased when compared to unexposed GH-producing tumors. Conclusion: More studies are needed to ascertain the role of KLK10 in pituitary tumor development, prognosis, and progression. The question of whether genetic abnormalities and the microenvironment can affect KLK10 immunoexpression should also be investigated. Mención de responsabilidad : Fabio Rotondo, Antonio Di Ieva, Kalman Kovacs, Michael D Cusimano, Luis V Syro, Eleftherios P Diamandis, George M Yousef Referencia : Hormones (Athens). 2015 Apr-Jun;14(2):272-9. DOI (Digital Object Identifier) : 10.14310/horm.2002.1558. PMID : 25553760 En línea : http://www.hormones.gr/8536/article/human-kallikrein-10-in-surgically-removed%E2 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000454 AC-2015-007 Archivo digital Producción Científica Artículos científicos Disponible
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