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Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease / Sergio Álvarez Vallejo ; Martín Ochoa Escudero    

Público ISBD Título : Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Brain Communications Idioma : Inglés (eng) Palabras clave : Presenilin-1  thalamus  MRI  PET imaging  preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5783 Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero,  . - 2021. Obra : Brain Communications Idioma : Inglés (eng) Palabras clave : Presenilin-1  thalamus  MRI  PET imaging  preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5783

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Contrast-enhanced T2-FLAIR MR imaging in patients with uveitis / Martín Ochoa Escudero  

Público ISBD Título : Contrast-enhanced T2-FLAIR MR imaging in patients with uveitis Tipo de documento : documento electrónico Autores : Martín Ochoa Escudero, Fecha de publicación : 2017 Títulos uniformes : International Ophthalmology Idioma : Inglés (eng) Palabras clave : Uveitis  FLAIR  MRI  gadolinium Resumen : To report MRI findings which reflect a pathological inflammatory condition of the uveal tract. This study includes single-center retrospective case series of five patients with clinical diagnosis of uveitis. There were 1 male (20 %) and 4 female patients (80 %). The average age was 29.6 years (range 25–38 years). Patients and 50 age-range-matched control subjects were scanned using a 1.5 T scanner. Ten additional control subjects scanned at 3 T were evaluated to have reference images at that high field. All patients (n = 5, 100 %) presented uveal tract enhancement on post-contrast T2-FLAIR fat-suppressed images and only 2 (40 %) had enhancement on T1-weighted images. The enhancement was anterior in 2 (40 %), pan-uveal in 2 (40 %), and posterior in 1 patient (20 %). Two patients (40 %) had unilateral increased vitreous signal on T2-FLAIR. One patient (20 %) had bilateral retrobulbar fat enhancement in both post-contrast T2-FLAIR and T1-weighted images. Post-contrast T2-FLAIR images can reveal abnormal enhancement of the uveal tract and retrobulbar fat as well as increased vitreous signal in patients with uveitis. In our small series, the sensitivity of post-contrast T2-FLAIR was higher than the conventional post-contrast T1-weighted images. Nonetheless, when bilateral uveal tract enhancement is present, there should be discretion before calling uveitis because the finding has been reported in different eye conditions as well as in a small percentage of healthy subjects at 1.5 T. In addition, it should be noted that post-contrast T2-FLAIR enhancement of the uveal tract is a normal finding at 3 T imaging. Mención de responsabilidad : Diego A Herrera, Sergio Franco, Sebastián Bustamante, Sergio A Vargas, Martin Ochoa-Escudero, Arthur B Dublin, Miguel Cuevas Referencia : Int Ophthalmol. 2017 Jun;37(3):507-512. DOI (Digital Object Identifier) : 10.1007/s10792-016-0289-1 PMID : 27405314 En línea : https://link.springer.com/article/10.1007%2Fs10792-016-0289-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4089 Contrast-enhanced T2-FLAIR MR imaging in patients with uveitis [documento electrónico] / Martín Ochoa Escudero,  . - 2017. Obra : International Ophthalmology Idioma : Inglés (eng) Palabras clave : Uveitis  FLAIR  MRI  gadolinium Resumen : To report MRI findings which reflect a pathological inflammatory condition of the uveal tract. This study includes single-center retrospective case series of five patients with clinical diagnosis of uveitis. There were 1 male (20 %) and 4 female patients (80 %). The average age was 29.6 years (range 25–38 years). Patients and 50 age-range-matched control subjects were scanned using a 1.5 T scanner. Ten additional control subjects scanned at 3 T were evaluated to have reference images at that high field. All patients (n = 5, 100 %) presented uveal tract enhancement on post-contrast T2-FLAIR fat-suppressed images and only 2 (40 %) had enhancement on T1-weighted images. The enhancement was anterior in 2 (40 %), pan-uveal in 2 (40 %), and posterior in 1 patient (20 %). Two patients (40 %) had unilateral increased vitreous signal on T2-FLAIR. One patient (20 %) had bilateral retrobulbar fat enhancement in both post-contrast T2-FLAIR and T1-weighted images. Post-contrast T2-FLAIR images can reveal abnormal enhancement of the uveal tract and retrobulbar fat as well as increased vitreous signal in patients with uveitis. In our small series, the sensitivity of post-contrast T2-FLAIR was higher than the conventional post-contrast T1-weighted images. Nonetheless, when bilateral uveal tract enhancement is present, there should be discretion before calling uveitis because the finding has been reported in different eye conditions as well as in a small percentage of healthy subjects at 1.5 T. In addition, it should be noted that post-contrast T2-FLAIR enhancement of the uveal tract is a normal finding at 3 T imaging. Mención de responsabilidad : Diego A Herrera, Sergio Franco, Sebastián Bustamante, Sergio A Vargas, Martin Ochoa-Escudero, Arthur B Dublin, Miguel Cuevas Referencia : Int Ophthalmol. 2017 Jun;37(3):507-512. DOI (Digital Object Identifier) : 10.1007/s10792-016-0289-1 PMID : 27405314 En línea : https://link.springer.com/article/10.1007%2Fs10792-016-0289-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4089

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Congenital and Acquired Conditions of the Mesial Temporal Lobe : A Pictorial Essay / Martín Ochoa Escudero  

Público ISBD Título : Congenital and Acquired Conditions of the Mesial Temporal Lobe : A Pictorial Essay Tipo de documento : documento electrónico Autores : Martín Ochoa Escudero, Fecha de publicación : 2015 Títulos uniformes : Canadian Association of Radiologists Journal Idioma : Inglés (eng) Palabras clave : Hippocampus  malrotation  gyral pattern  focal cortical dysplasia  hippocampal sclerosis  MRI Resumen : Purpose: Our goal is to pictorially review a wide spectrum of congenital and acquired conditions affecting the medial aspect of the temporal lobe. Conclusion: After completing this article, the reader will have knowledge of the imaging appearance of diverse developmental, malformative, and acquired lesions of the mesial temporal lobe, which will be useful when evaluating pathology in this location. Mención de responsabilidad : Martin Ochoa-Escudero, Diego A Herrera, Sergio A Vargas, Arthur B Dublin Referencia : Can Assoc Radiol J. 2015 Aug;66(3):238-51. DOI (Digital Object Identifier) : 10.1016/j.carj.2014.12.006 PMID : 25978865 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0846-5371(14)00126-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3886 Congenital and Acquired Conditions of the Mesial Temporal Lobe : A Pictorial Essay [documento electrónico] / Martín Ochoa Escudero,  . - 2015. Obra : Canadian Association of Radiologists Journal Idioma : Inglés (eng) Palabras clave : Hippocampus  malrotation  gyral pattern  focal cortical dysplasia  hippocampal sclerosis  MRI Resumen : Purpose: Our goal is to pictorially review a wide spectrum of congenital and acquired conditions affecting the medial aspect of the temporal lobe. Conclusion: After completing this article, the reader will have knowledge of the imaging appearance of diverse developmental, malformative, and acquired lesions of the mesial temporal lobe, which will be useful when evaluating pathology in this location. Mención de responsabilidad : Martin Ochoa-Escudero, Diego A Herrera, Sergio A Vargas, Arthur B Dublin Referencia : Can Assoc Radiol J. 2015 Aug;66(3):238-51. DOI (Digital Object Identifier) : 10.1016/j.carj.2014.12.006 PMID : 25978865 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0846-5371(14)00126-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3886

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High origin of the anterior band of the inferior glenohumeral ligament: MR arthrography with anatomic and histologic correlation in cadavers / Francisco Alejandro Ramírez Ruiz  

Público ISBD Título : High origin of the anterior band of the inferior glenohumeral ligament: MR arthrography with anatomic and histologic correlation in cadavers Tipo de documento : documento electrónico Autores : Francisco Alejandro Ramírez Ruiz, Fecha de publicación : 2012 Títulos uniformes : Skeletal Radiology Idioma : Inglés (eng) Palabras clave : Shoulder  Inferior glenohumeral ligament  Labrum  MRI  Arthrography Resumen : Introduction: The anterior band of the inferior glenohumeral ligament has been described to arise from the anteroinferior labrum, but we have observed that in some persons its origin is from the anterior or anterosuperior labrum, creating diagnostic difficulties. Materials and methods: Ten fresh unembalmed cadaveric shoulders underwent magnetic resonance arthrography (MRA) using a posterior approach with a 1.5 T GE magnet, with the following sequences: T1-weighted fast spin-echo in axial, coronal and sagittal planes, and T1 fat-suppressed spin-echo in the axial plane (TR/TE 600/20, section thickness 2.5 mm, 0.5 mm interslice space, number of signals acquired, two, field of view 12 × 12 cm, and matrix 512 × 256 pixels). Following imaging, the shoulders were frozen and later sectioned using a band saw into 3-mm sections corresponding to the axial imaging plane. Histological analysis was also performed to determine the origin of the anterior band. Results: Four of the ten shoulders had an origin of the anterior band above or at the 3 o’clock position: one at the 1 o’clock position, two at the 2 o’clock position, and one at the 3 o’clock position. In another shoulder, the anterior band of the inferior glenohumeral ligament originated from the middle glenohumeral ligament, and in five other shoulders, the anterior band originated from the anteroinferior labrum as has been described in the literature. Conclusions: This finding is of clinical significance as a high origin of the anterior band of the inferior glenohumeral ligament leads to MR arthrographic finding that can simulate those of labral tears or detachments. Mención de responsabilidad : Francisco Alejandro Ramirez Ruiz, Beatriz Cristina Baranski Kaniak, Parviz Haghighi, Debra Trudell, Donald L Resnick Referencia : Skeletal Radiol. 2012 May;41(5):525-30. DOI (Digital Object Identifier) : 10.1007/s00256-011-1201-8 PMID : 21603871 En línea : http://link.springer.com/10.1007/s00256-011-1201-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4506 High origin of the anterior band of the inferior glenohumeral ligament: MR arthrography with anatomic and histologic correlation in cadavers [documento electrónico] / Francisco Alejandro Ramírez Ruiz,  . - 2012. Obra : Skeletal Radiology Idioma : Inglés (eng) Palabras clave : Shoulder  Inferior glenohumeral ligament  Labrum  MRI  Arthrography Resumen : Introduction: The anterior band of the inferior glenohumeral ligament has been described to arise from the anteroinferior labrum, but we have observed that in some persons its origin is from the anterior or anterosuperior labrum, creating diagnostic difficulties. Materials and methods: Ten fresh unembalmed cadaveric shoulders underwent magnetic resonance arthrography (MRA) using a posterior approach with a 1.5 T GE magnet, with the following sequences: T1-weighted fast spin-echo in axial, coronal and sagittal planes, and T1 fat-suppressed spin-echo in the axial plane (TR/TE 600/20, section thickness 2.5 mm, 0.5 mm interslice space, number of signals acquired, two, field of view 12 × 12 cm, and matrix 512 × 256 pixels). Following imaging, the shoulders were frozen and later sectioned using a band saw into 3-mm sections corresponding to the axial imaging plane. Histological analysis was also performed to determine the origin of the anterior band. Results: Four of the ten shoulders had an origin of the anterior band above or at the 3 o’clock position: one at the 1 o’clock position, two at the 2 o’clock position, and one at the 3 o’clock position. In another shoulder, the anterior band of the inferior glenohumeral ligament originated from the middle glenohumeral ligament, and in five other shoulders, the anterior band originated from the anteroinferior labrum as has been described in the literature. Conclusions: This finding is of clinical significance as a high origin of the anterior band of the inferior glenohumeral ligament leads to MR arthrographic finding that can simulate those of labral tears or detachments. Mención de responsabilidad : Francisco Alejandro Ramirez Ruiz, Beatriz Cristina Baranski Kaniak, Parviz Haghighi, Debra Trudell, Donald L Resnick Referencia : Skeletal Radiol. 2012 May;41(5):525-30. DOI (Digital Object Identifier) : 10.1007/s00256-011-1201-8 PMID : 21603871 En línea : http://link.springer.com/10.1007/s00256-011-1201-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4506

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