1 búsqueda de la palabra clave 'MRSA'

A comparison of methicillin-resistant and methicillin-susceptible Staphylococcus aureus reveals no clinical and epidemiological but molecular differences / Andrea Victoria Restrepo Gouzy ; Carlos Guillermo Garcés Samudio  

Público ISBD Título : A comparison of methicillin-resistant and methicillin-susceptible Staphylococcus aureus reveals no clinical and epidemiological but molecular differences Tipo de documento : documento electrónico Autores : Andrea Victoria Restrepo Gouzy, ; Carlos Guillermo Garcés Samudio, Fecha de publicación : 2013 Títulos uniformes : International Journal of Medical Microbiology Idioma : Inglés (eng) Palabras clave : MSSA  MRSA  CA-MRSA  HA-MRSA  Molecular typing  Clinical characteristics Resumen : Most studies on Staphylococcus aureus have focused on the molecular epidemiology of methicillin-resistant S. aureus (MRSA) infections. In contrast, little information is available regarding the molecular epidemiology of currently circulating methicillin-susceptible S. aureus (MSSA) isolates in hospital settings, an epoch when the epidemiology of S. aureus has undergone significant changes. We conducted a cross-sectional study to compare the clinical, epidemiological, and genetic characteristics of MSSA and MRSA isolates at 3 tertiary-care hospitals in Medellín, Colombia, from February 2008 to June 2010. The infections were classified according to the Centers for Disease Control and Prevention (CDC) definitions. Genotypic analysis included spa typing, multilocus sequence typing (MLST) and staphylococcal cassette chromosome ( mec ) (SCC mec ) typing. A total of 810 patients was enrolled. One hundred infections (12.3%) were classified as community-associated (31 CA-MSSA, 69 CA-MRSA), 379 (46.8%) as healthcare-associated community-onset (136 HACO-MSSA, 243 HACO-MRSA), and 331 (40.9%) as healthcare-associated hospital-onset (104 HAHO-MSSA, 227 HAHO-MRSA). Genotype analyses showed a higher diversity and a more varied spa type repertoire in MSSA than in MRSA strains. Most of the clinical-epidemiological characteristics and risk factors evaluated did not allow for discriminating MRSA- from MSSA-infected patients. The lack of equivalence among the genetic backgrounds of the major MSSA and MRSA clones would suggest that the MRSA clones are imported instead of arising from successful MSSA clones. This study emphasizes the importance of local surveillance to create public awareness on the changing S. aureus epidemiology. Mención de responsabilidad : J Natalia Jiménez, Ana M Ocampo, Johanna M Vanegas, Erika A Rodriguez, José R Mediavilla, Liang Chen, Carlos E Muskus, Lázaro A Vélez, Carlos Rojas, Andrea V Restrepo, Carlos Garcés, Barry N Kreiswirth, Margarita M Correa Referencia : Int J Med Microbiol. 2013 Mar;303(2):76-83. DOI (Digital Object Identifier) : 10.1016/j.ijmm.2012.12.003 PMID : 23369303 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1438422112000951 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4530 A comparison of methicillin-resistant and methicillin-susceptible Staphylococcus aureus reveals no clinical and epidemiological but molecular differences [documento electrónico] / Andrea Victoria Restrepo Gouzy, ; Carlos Guillermo Garcés Samudio,  . - 2013. Obra : International Journal of Medical Microbiology Idioma : Inglés (eng) Palabras clave : MSSA  MRSA  CA-MRSA  HA-MRSA  Molecular typing  Clinical characteristics Resumen : Most studies on Staphylococcus aureus have focused on the molecular epidemiology of methicillin-resistant S. aureus (MRSA) infections. In contrast, little information is available regarding the molecular epidemiology of currently circulating methicillin-susceptible S. aureus (MSSA) isolates in hospital settings, an epoch when the epidemiology of S. aureus has undergone significant changes. We conducted a cross-sectional study to compare the clinical, epidemiological, and genetic characteristics of MSSA and MRSA isolates at 3 tertiary-care hospitals in Medellín, Colombia, from February 2008 to June 2010. The infections were classified according to the Centers for Disease Control and Prevention (CDC) definitions. Genotypic analysis included spa typing, multilocus sequence typing (MLST) and staphylococcal cassette chromosome ( mec ) (SCC mec ) typing. A total of 810 patients was enrolled. One hundred infections (12.3%) were classified as community-associated (31 CA-MSSA, 69 CA-MRSA), 379 (46.8%) as healthcare-associated community-onset (136 HACO-MSSA, 243 HACO-MRSA), and 331 (40.9%) as healthcare-associated hospital-onset (104 HAHO-MSSA, 227 HAHO-MRSA). Genotype analyses showed a higher diversity and a more varied spa type repertoire in MSSA than in MRSA strains. Most of the clinical-epidemiological characteristics and risk factors evaluated did not allow for discriminating MRSA- from MSSA-infected patients. The lack of equivalence among the genetic backgrounds of the major MSSA and MRSA clones would suggest that the MRSA clones are imported instead of arising from successful MSSA clones. This study emphasizes the importance of local surveillance to create public awareness on the changing S. aureus epidemiology. Mención de responsabilidad : J Natalia Jiménez, Ana M Ocampo, Johanna M Vanegas, Erika A Rodriguez, José R Mediavilla, Liang Chen, Carlos E Muskus, Lázaro A Vélez, Carlos Rojas, Andrea V Restrepo, Carlos Garcés, Barry N Kreiswirth, Margarita M Correa Referencia : Int J Med Microbiol. 2013 Mar;303(2):76-83. DOI (Digital Object Identifier) : 10.1016/j.ijmm.2012.12.003 PMID : 23369303 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1438422112000951 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4530

Reserva

Reservar este documento

Ejemplares(1)

Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD001029	AC-2013-117	Archivo digital	Producción Científica	Artículos científicos	Disponible