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Musclin is related to insulin resistance and body composition, but not to body mass index or cardiorespiratory capacity in adults / Mauricio Estrada Castrillón
Título : Musclin is related to insulin resistance and body composition, but not to body mass index or cardiorespiratory capacity in adults Tipo de documento : documento electrónico Autores : Mauricio Estrada Castrillón, Fecha de publicación : 2021 Títulos uniformes : Endocrinology and Metabolism Idioma : Inglés (eng) Palabras clave : Hormones Musclin protein human (OSTN) Metabolic syndrome Insulin resistance Muscle skeletal Body composition Resumen : Background: We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods: A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin was measured by enzyme-linked immunosorbent assay. Insulin resistance (IR) was evaluated by the homeostatic model assessment (HOMA-IR). Body composition was determined by dual-energy X-ray absorptiometry and muscle composition by measuring carnosine in the thigh, a surrogate of fiber types, through proton magnetic resonance spectroscopy. Cardiorespiratory capacity was assessed through direct ergospirometry. Results: The control (n=29) and MS (n=61) groups were comparable in age (51.5±6.5 years old vs. 50.7±6.1 years old), sex (72.4% vs. 70.5% women), total lean mass (58.5%±7.4% vs. 57.3%±6.8%), and peak oxygen consumption (VO2peak) (31.0±5.8 mL O2./kg.min vs. 29.2±6.3 mL O2/kg.min). Individuals with MS had higher body mass index (BMI) (30.6±4.0 kg/m2 vs. 27.4±3.6 kg/m2), HOMA-IR (3.5 [95% confidence interval, CI, 2.9 to 4.6] vs. 1.7 [95% CI, 1.1 to 2.0]), and musclin (206.7 pg/mL [95% CI, 122.7 to 387.8] vs. 111.1 pg/mL [95% CI, 63.2 to 218.5]) values than controls (P Mención de responsabilidad : Yeliana L. Sánchez, Manuela Yepes-Calderón, Luis Valbuena, Andrés F. Milán, María C. Trillos-Almanza, Sergio Granados, Miguel Peña, Mauricio Estrada-Castrillón, Juan C. Aristizábal, Raúl Narvez-Sanchez, Jaime Gallo-Villegas, Juan C. Calderón Referencia : Endocrinol Metab (Seoul). 2021 Oct;36(5):1055-1068. DOI (Digital Object Identifier) : 10.3803/EnM.2021.1104 PMID : 34674511 Derechos de uso : CC BY-NC En línea : https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2021.1104 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5850 Musclin is related to insulin resistance and body composition, but not to body mass index or cardiorespiratory capacity in adults [documento electrónico] / Mauricio Estrada Castrillón, . - 2021.
Obra : Endocrinology and Metabolism
Idioma : Inglés (eng)
Palabras clave : Hormones Musclin protein human (OSTN) Metabolic syndrome Insulin resistance Muscle skeletal Body composition Resumen : Background: We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods: A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin was measured by enzyme-linked immunosorbent assay. Insulin resistance (IR) was evaluated by the homeostatic model assessment (HOMA-IR). Body composition was determined by dual-energy X-ray absorptiometry and muscle composition by measuring carnosine in the thigh, a surrogate of fiber types, through proton magnetic resonance spectroscopy. Cardiorespiratory capacity was assessed through direct ergospirometry. Results: The control (n=29) and MS (n=61) groups were comparable in age (51.5±6.5 years old vs. 50.7±6.1 years old), sex (72.4% vs. 70.5% women), total lean mass (58.5%±7.4% vs. 57.3%±6.8%), and peak oxygen consumption (VO2peak) (31.0±5.8 mL O2./kg.min vs. 29.2±6.3 mL O2/kg.min). Individuals with MS had higher body mass index (BMI) (30.6±4.0 kg/m2 vs. 27.4±3.6 kg/m2), HOMA-IR (3.5 [95% confidence interval, CI, 2.9 to 4.6] vs. 1.7 [95% CI, 1.1 to 2.0]), and musclin (206.7 pg/mL [95% CI, 122.7 to 387.8] vs. 111.1 pg/mL [95% CI, 63.2 to 218.5]) values than controls (P Mención de responsabilidad : Yeliana L. Sánchez, Manuela Yepes-Calderón, Luis Valbuena, Andrés F. Milán, María C. Trillos-Almanza, Sergio Granados, Miguel Peña, Mauricio Estrada-Castrillón, Juan C. Aristizábal, Raúl Narvez-Sanchez, Jaime Gallo-Villegas, Juan C. Calderón Referencia : Endocrinol Metab (Seoul). 2021 Oct;36(5):1055-1068. DOI (Digital Object Identifier) : 10.3803/EnM.2021.1104 PMID : 34674511 Derechos de uso : CC BY-NC En línea : https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2021.1104 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5850 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001788 AC-2021-100 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2021-100Adobe Acrobat PDF Efficacy of high-intensity, low-volume interval training compared to continuous aerobic training on insulin resistance, skeletal muscle structure and function in adults with metabolic syndrome: study protocol for a randomized controlled clinical trial (Intraining-MET) / Mauricio Estrada Castrillón
Título : Efficacy of high-intensity, low-volume interval training compared to continuous aerobic training on insulin resistance, skeletal muscle structure and function in adults with metabolic syndrome: study protocol for a randomized controlled clinical trial (Intraining-MET) Tipo de documento : documento electrónico Autores : Mauricio Estrada Castrillón, Fecha de publicación : 2018 Títulos uniformes : Trials Idioma : Inglés (eng) Palabras clave : Aerobic exercise exercise training glucose metabolism disorders hyperinsulinemia. insulin resistance interval training metabolic syndrome myokines risk factors skeletal muscle Resumen : Background: Evidence of the efficacy of high-intensity, low-volume interval training (HIIT-low volume) in treating insulin resistance (IR) in patients with metabolic disorders is contradictory. In addition, it is unknown whether this effect is mediated through muscle endocrine function, which in turn depends on muscle mass and fiber type composition. Our aims were to assess the efficacy of HIIT-low volume compared to continuous aerobic exercise (CAE) in treating IR in adults with metabolic syndrome (MS) and to establish whether musclin, apelin, muscle mass and muscle composition are mediators of the effect. Methods: This is a controlled, randomized, clinical trial using the minimization method, with blinding of those who will evaluate the outcomes and two parallel groups for the purpose of showing superiority. Sixty patients with MS and IR with ages between 40 and 60 years will be included. A clinical evaluation will be carried out, along with laboratory tests to evaluate IR (homeostatic model assessment (HOMA)), muscle endocrine function (serum levels of musclin and apelin), thigh muscle mass (by dual energy x-ray absorptiometry (DXA) and thigh muscle composition (by carnosine measurement with proton magnetic resonance spectroscopy (1H–MRS)), before and after 12 weeks of a treadmill exercise program three times a week. Participants assigned to the intervention (n = 30) will receive HIIT-low volume in 22-min sessions that will include six intervals at a load of 90% of maximum oxygen consumption (VO2 max) for 1 min followed by 2 min at 50% of VO2 max. The control group (n = 30) will receive CAE at an intensity of 60% of VO2 max for 36 min. A theoretical model based on structural equations will be proposed to estimate the total, direct and indirect effects of training on IR and the proportion explained by the mediators. Discussion: Compared with CAE, HIIT-low volume can be effective and efficient at improving physical capacity and decreasing cardiovascular risk factors, such as IR, in patients with metabolic disorders. Studies that evaluate mediating variables of the effect of HIIT-low volume on IR, such as endocrine function and skeletal muscle structure, are necessary to understand the role of skeletal muscle in the pathophysiology of MS and their regulation by exercise. Trial registration: NCT03087721. High-intensity Interval, Low Volume Training in Metabolic Syndrome (Intraining-MET). Registered on 22 March 2017, retrospectively registered. Mención de responsabilidad : Jaime Gallo-Villegas, Juan Carlos Aristizabal, Mauricio Estrada, Luis H Valbuena, Raul Narvaez-Sanchez, Jorge Osorio, Daniel C Aguirre-Acevedo, Juan C Calderón Referencia : Trials. 2018 Feb 27;19(1):144. DOI (Digital Object Identifier) : 10.1186/s13063-018-2541-7 PMID : 29482601 Derechos de uso : CC BY En línea : https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2541-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4187 Efficacy of high-intensity, low-volume interval training compared to continuous aerobic training on insulin resistance, skeletal muscle structure and function in adults with metabolic syndrome: study protocol for a randomized controlled clinical trial (Intraining-MET) [documento electrónico] / Mauricio Estrada Castrillón, . - 2018.
Obra : Trials
Idioma : Inglés (eng)
Palabras clave : Aerobic exercise exercise training glucose metabolism disorders hyperinsulinemia. insulin resistance interval training metabolic syndrome myokines risk factors skeletal muscle Resumen : Background: Evidence of the efficacy of high-intensity, low-volume interval training (HIIT-low volume) in treating insulin resistance (IR) in patients with metabolic disorders is contradictory. In addition, it is unknown whether this effect is mediated through muscle endocrine function, which in turn depends on muscle mass and fiber type composition. Our aims were to assess the efficacy of HIIT-low volume compared to continuous aerobic exercise (CAE) in treating IR in adults with metabolic syndrome (MS) and to establish whether musclin, apelin, muscle mass and muscle composition are mediators of the effect. Methods: This is a controlled, randomized, clinical trial using the minimization method, with blinding of those who will evaluate the outcomes and two parallel groups for the purpose of showing superiority. Sixty patients with MS and IR with ages between 40 and 60 years will be included. A clinical evaluation will be carried out, along with laboratory tests to evaluate IR (homeostatic model assessment (HOMA)), muscle endocrine function (serum levels of musclin and apelin), thigh muscle mass (by dual energy x-ray absorptiometry (DXA) and thigh muscle composition (by carnosine measurement with proton magnetic resonance spectroscopy (1H–MRS)), before and after 12 weeks of a treadmill exercise program three times a week. Participants assigned to the intervention (n = 30) will receive HIIT-low volume in 22-min sessions that will include six intervals at a load of 90% of maximum oxygen consumption (VO2 max) for 1 min followed by 2 min at 50% of VO2 max. The control group (n = 30) will receive CAE at an intensity of 60% of VO2 max for 36 min. A theoretical model based on structural equations will be proposed to estimate the total, direct and indirect effects of training on IR and the proportion explained by the mediators. Discussion: Compared with CAE, HIIT-low volume can be effective and efficient at improving physical capacity and decreasing cardiovascular risk factors, such as IR, in patients with metabolic disorders. Studies that evaluate mediating variables of the effect of HIIT-low volume on IR, such as endocrine function and skeletal muscle structure, are necessary to understand the role of skeletal muscle in the pathophysiology of MS and their regulation by exercise. Trial registration: NCT03087721. High-intensity Interval, Low Volume Training in Metabolic Syndrome (Intraining-MET). Registered on 22 March 2017, retrospectively registered. Mención de responsabilidad : Jaime Gallo-Villegas, Juan Carlos Aristizabal, Mauricio Estrada, Luis H Valbuena, Raul Narvaez-Sanchez, Jorge Osorio, Daniel C Aguirre-Acevedo, Juan C Calderón Referencia : Trials. 2018 Feb 27;19(1):144. DOI (Digital Object Identifier) : 10.1186/s13063-018-2541-7 PMID : 29482601 Derechos de uso : CC BY En línea : https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2541-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4187 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000801 AC-2018-088 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2018-088.pdfAdobe Acrobat PDF