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Subjective cognitive and communicative complaints and health-related quality of life in Parkinson's disease with and without mild cognitive impairment / Leonardo Fabio Moreno Gómez  

Público ISBD Título : Subjective cognitive and communicative complaints and health-related quality of life in Parkinson's disease with and without mild cognitive impairment Otros títulos : Quejas subjetivas cognitivas y comunicativas y calidad de vida relacionada con la salud en la enfermedad de Parkinson con y sin deterioro cognitivo leve Tipo de documento : documento electrónico Autores : Leonardo Fabio Moreno Gómez, Fecha de publicación : 2021 Títulos uniformes : Revista Colombiana de Psiquiatría Idioma : Inglés (eng) Palabras clave : Parkinson’s disease  Health-related quality of life  Quality of life  Cognitive decline  Mild cognitive impairment Resumen : Introduction: Mild Cognitive Impairment (MCI) is common in Parkinson's Disease (PD). Few studies have compared the Health-Related Quality of Life (HRQoL) in patients with and without MCI due to PD (PD-MCI), and its correlation to patients’ subjective cognitive and communicative difficulties has not been explored. Objective: We aimed to compare HRQoL in PD-MCI and PD without MCI (PD-nMCI), and explore its possible relationship to subjective cognitive and communicative complaints. Methods: We included 29 PD-nMCI and 11 PD-MCI patients. The HRQoL was assessed with the Parkinson's Disease Questionnaire-39 (PDQ-39): its Cognition dimension was used as a measure of subjective cognitive complaints, its Communication dimension for subjective communicative complaints, and the summary index (PDQ-39 SI) as an indicator of HRQoL. Non-parametric partial correlations between the Cognition and Communication dimensions, and the adjusted PDQ-39 SI were conducted. Results: PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients. In the PD-MCI group, both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores. Conclusions: HRQoL seems to be affected in PD-MCI, and it might be influenced by greater subjective cognitive and communicative complaints. Including patient-reported outcome measures of HRQoL, and providing cognitive and speech rehabilitation, as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Yamile Bocanegra, Omar Buriticá, David Antonio Pineda Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Daniel Camilo Aguirre-Acevedo, Melissa Sierra Castrillon, Daniel Vasquez, Juan Esteban Velez-Hernandez, Miguel Germán Borda, Elkin García-Cifuentes, David Fernando Aguillón, Lucía Madrigal-Zapata, Dag Aarsland y Francisco Lopera Referencia : Rev Colomb Psiquiatr (Engl Ed). 2021 Sep 3;S0034-7450(21)00134-7. DOI (Digital Object Identifier) : 10.1016/j.rcp.2021.07.005 PMID : 34489098 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0034745021001347 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5869 Subjective cognitive and communicative complaints and health-related quality of life in Parkinson's disease with and without mild cognitive impairment = Quejas subjetivas cognitivas y comunicativas y calidad de vida relacionada con la salud en la enfermedad de Parkinson con y sin deterioro cognitivo leve [documento electrónico] / Leonardo Fabio Moreno Gómez,  . - 2021. Obra : Revista Colombiana de Psiquiatría Idioma : Inglés (eng) Palabras clave : Parkinson’s disease  Health-related quality of life  Quality of life  Cognitive decline  Mild cognitive impairment Resumen : Introduction: Mild Cognitive Impairment (MCI) is common in Parkinson's Disease (PD). Few studies have compared the Health-Related Quality of Life (HRQoL) in patients with and without MCI due to PD (PD-MCI), and its correlation to patients’ subjective cognitive and communicative difficulties has not been explored. Objective: We aimed to compare HRQoL in PD-MCI and PD without MCI (PD-nMCI), and explore its possible relationship to subjective cognitive and communicative complaints. Methods: We included 29 PD-nMCI and 11 PD-MCI patients. The HRQoL was assessed with the Parkinson's Disease Questionnaire-39 (PDQ-39): its Cognition dimension was used as a measure of subjective cognitive complaints, its Communication dimension for subjective communicative complaints, and the summary index (PDQ-39 SI) as an indicator of HRQoL. Non-parametric partial correlations between the Cognition and Communication dimensions, and the adjusted PDQ-39 SI were conducted. Results: PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients. In the PD-MCI group, both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores. Conclusions: HRQoL seems to be affected in PD-MCI, and it might be influenced by greater subjective cognitive and communicative complaints. Including patient-reported outcome measures of HRQoL, and providing cognitive and speech rehabilitation, as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Yamile Bocanegra, Omar Buriticá, David Antonio Pineda Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Daniel Camilo Aguirre-Acevedo, Melissa Sierra Castrillon, Daniel Vasquez, Juan Esteban Velez-Hernandez, Miguel Germán Borda, Elkin García-Cifuentes, David Fernando Aguillón, Lucía Madrigal-Zapata, Dag Aarsland y Francisco Lopera Referencia : Rev Colomb Psiquiatr (Engl Ed). 2021 Sep 3;S0034-7450(21)00134-7. DOI (Digital Object Identifier) : 10.1016/j.rcp.2021.07.005 PMID : 34489098 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0034745021001347 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5869

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Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment / Omar Fredy Buriticá Henao ; Leonardo Fabio Moreno Gómez  

Público ISBD Título : Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment Tipo de documento : documento electrónico Autores : Omar Fredy Buriticá Henao, ; Leonardo Fabio Moreno Gómez, Fecha de publicación : 2017 Títulos uniformes : Brain & Language Idioma : Inglés (eng) Palabras clave : Parkinson’s disease  Mild cognitive impairment  Picture naming  Action verbs  Manipulable nouns  Motor semantics Resumen : Parkinson's disease (PD) patients show marked impairments in processing action verbs, and to a lesser extent, concrete (specially, manipulable) nouns. However, it is still unclear to what extent deficits in each of these categories are influenced by more general cognitive dysfunctions, and whether they are modulated by the words' implied motility. To examine these issues, we evaluated 49 non-demented PD patients and 49 healthy volunteers in an oral production task. The patients were divided into two groups depending on the presence or absence of mild cognitive impairment (PD-MCI and PD-nMCI, respectively). Participants named pictures of actions varying in motion content (low and high) and of objects varying in manipulability (low and high). The PD-MCI group showed deficits across all four categories. However, PD-nMCI patients exhibited a selective difficulty for high-motion action verbs. This finding corroborates and refines previous results suggesting that disturbances of action-related lexico-semantic information in PD constitute a sui generis alteration manifested early in the course of the disease's physiopathology. Moreover, it suggests that the grounding of action verbs on motor circuits could depend on fine-grained intracategorical semantic distinctions. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, Francisco Lopera, David Pineda, Ana Baena, Paula Ospina, Diana Alzate, Omar Buriticá, Leonardo Moreno, Agustín Ibáñez, Fernando Cuetos Referencia : Brain Lang. 2017 May;168:37-46. DOI (Digital Object Identifier) : 10.1016/j.bandl.2017.01.005 PMID : 28131052 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0093934X16301262 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4038 Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment [documento electrónico] / Omar Fredy Buriticá Henao, ; Leonardo Fabio Moreno Gómez,  . - 2017. Obra : Brain & Language Idioma : Inglés (eng) Palabras clave : Parkinson’s disease  Mild cognitive impairment  Picture naming  Action verbs  Manipulable nouns  Motor semantics Resumen : Parkinson's disease (PD) patients show marked impairments in processing action verbs, and to a lesser extent, concrete (specially, manipulable) nouns. However, it is still unclear to what extent deficits in each of these categories are influenced by more general cognitive dysfunctions, and whether they are modulated by the words' implied motility. To examine these issues, we evaluated 49 non-demented PD patients and 49 healthy volunteers in an oral production task. The patients were divided into two groups depending on the presence or absence of mild cognitive impairment (PD-MCI and PD-nMCI, respectively). Participants named pictures of actions varying in motion content (low and high) and of objects varying in manipulability (low and high). The PD-MCI group showed deficits across all four categories. However, PD-nMCI patients exhibited a selective difficulty for high-motion action verbs. This finding corroborates and refines previous results suggesting that disturbances of action-related lexico-semantic information in PD constitute a sui generis alteration manifested early in the course of the disease's physiopathology. Moreover, it suggests that the grounding of action verbs on motor circuits could depend on fine-grained intracategorical semantic distinctions. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, Francisco Lopera, David Pineda, Ana Baena, Paula Ospina, Diana Alzate, Omar Buriticá, Leonardo Moreno, Agustín Ibáñez, Fernando Cuetos Referencia : Brain Lang. 2017 May;168:37-46. DOI (Digital Object Identifier) : 10.1016/j.bandl.2017.01.005 PMID : 28131052 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0093934X16301262 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4038

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Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene / Fabián Alberto Jaimes Barragán  

Público ISBD Título : Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2016 Títulos uniformes : International Psychogeriatrics Idioma : Inglés (eng) Palabras clave : Alzheimer’s disease  CERAD  mild cognitive impairment  validity  sensitivity Resumen : Background:This study aimed to determine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery total score diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and dementia in familial Alzheimer's disease (FAD) with E280A mutation on presenilin-1 gene (PSEN1). Methods: A cross-sectional study was conducted in a cohort of PSEN1 E280A carriers and non-carriers assessed between January 1995 and February 2013. During the first neuropsychological assessment, 76 were having dementia, 46 had MCI, and 1,576 were asymptomatic. CERAD cut-off points were established for MCI and dementia using a Receiver Operating Characteristics (ROC) analysis, and were further analyzed according to education level in two groups: low education level (eight years or less), and high education level (over eight years). Results: The area under curve–ROC CERAD total score for dementia was 0.994 (95% CI = 0.989–0.999), and that for MCI was 0.862 (95% CI = 0.816–0.908). The dementia diagnosis cut-off point for the low education group was 54, (98.4% sensitivity, 92.6% specificity), and that for the high education group was 67 (100% sensitivity, 94.1% specificity). The MCI diagnosis cut-off point for the low education group was 66 (91.2% sensitivity, 56.4% specificity), and that for the high education group was 72 (91.7% sensitivity, 76.3% specificity). Conclusions: The CERAD total score is a useful screening tool for dementia and MCI in a population at risk of FAD. Mención de responsabilidad : Daniel Camilo Aguirre-Acevedo, Fabian Jaimes-Barragán, Eliana Henao, Victoria Tirado, Claudia Muñoz, Eric M Reiman, Pierre N Tariot, Jessica B Langbaum, Francisco Lopera Referencia : Int Psychogeriatr. 2016 Mar;28(3):503-10. DOI (Digital Object Identifier) : 10.1017/S1041610215001660 PMID : 26478578 En línea : https://www.cambridge.org/core/journals/international-psychogeriatrics/aticle/di [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3996 Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene [documento electrónico] / Fabián Alberto Jaimes Barragán,  . - 2016. Obra : International Psychogeriatrics Idioma : Inglés (eng) Palabras clave : Alzheimer’s disease  CERAD  mild cognitive impairment  validity  sensitivity Resumen : Background:This study aimed to determine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery total score diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and dementia in familial Alzheimer's disease (FAD) with E280A mutation on presenilin-1 gene (PSEN1). Methods: A cross-sectional study was conducted in a cohort of PSEN1 E280A carriers and non-carriers assessed between January 1995 and February 2013. During the first neuropsychological assessment, 76 were having dementia, 46 had MCI, and 1,576 were asymptomatic. CERAD cut-off points were established for MCI and dementia using a Receiver Operating Characteristics (ROC) analysis, and were further analyzed according to education level in two groups: low education level (eight years or less), and high education level (over eight years). Results: The area under curve–ROC CERAD total score for dementia was 0.994 (95% CI = 0.989–0.999), and that for MCI was 0.862 (95% CI = 0.816–0.908). The dementia diagnosis cut-off point for the low education group was 54, (98.4% sensitivity, 92.6% specificity), and that for the high education group was 67 (100% sensitivity, 94.1% specificity). The MCI diagnosis cut-off point for the low education group was 66 (91.2% sensitivity, 56.4% specificity), and that for the high education group was 72 (91.7% sensitivity, 76.3% specificity). Conclusions: The CERAD total score is a useful screening tool for dementia and MCI in a population at risk of FAD. Mención de responsabilidad : Daniel Camilo Aguirre-Acevedo, Fabian Jaimes-Barragán, Eliana Henao, Victoria Tirado, Claudia Muñoz, Eric M Reiman, Pierre N Tariot, Jessica B Langbaum, Francisco Lopera Referencia : Int Psychogeriatr. 2016 Mar;28(3):503-10. DOI (Digital Object Identifier) : 10.1017/S1041610215001660 PMID : 26478578 En línea : https://www.cambridge.org/core/journals/international-psychogeriatrics/aticle/di [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3996

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Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences / Omar Fredy Buriticá Henao  

Público ISBD Título : Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences Tipo de documento : documento electrónico Autores : Omar Fredy Buriticá Henao, Fecha de publicación : 2015 Títulos uniformes : Cortex Idioma : Inglés (eng) Palabras clave : Parkinson's disease  syntax  action verbs  action semantics  object semantics  executive functions  mild cognitive impairment Resumen : Several studies have recently shown that basal ganglia (BG) deterioration leads to distinctive impairments in the domains of syntax, action verbs, and action semantics. In particular, such disruptions have been repeatedly observed in Parkinson's disease (PD) patients. However, it remains unclear whether these deficits are language-specific and whether they are equally dissociable from other reported disturbances –viz., processing of object semantics. To address these issues, we administered linguistic, semantic, and executive function (EFs) tasks to two groups of non-demented PD patients, with and without mild cognitive impairment (PD-MCI and PD-nMCI, respectively). We compared these two groups with each other and with matched samples of healthy controls. Our results showed that PD patients exhibited linguistic and semantic deficits even in the absence of MCI. However, not all domains were equally related to EFs and MCI across samples. Whereas EFs predicted disturbances of syntax and object semantics in both PD-nMCI and PD-MCI, they had no impact on action-verb and action-semantic impairments in either group. Critically, patients showed disruptions of action-verb production and action semantics in the absence of MCI and without any executive influence, suggesting a sui generis deficit present since early stages of the disease. These findings indicate that varied language domains are differentially related to the BG, contradicting popular approaches to neurolinguistics. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, David Pineda, Omar Buriticá, Andrés Villegas, Francisco Lopera, Diana Gómez, Catalina Gómez-Arias, Juan F Cardona, Natalia Trujillo, Agustín Ibáñez Referencia : Cortex. 2015 Aug;69:237-54. DOI (Digital Object Identifier) : 10.1016/j.cortex.2015.05.022 PMID : 26103601 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0010945215001811#abs0010 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3895 Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences [documento electrónico] / Omar Fredy Buriticá Henao,  . - 2015. Obra : Cortex Idioma : Inglés (eng) Palabras clave : Parkinson's disease  syntax  action verbs  action semantics  object semantics  executive functions  mild cognitive impairment Resumen : Several studies have recently shown that basal ganglia (BG) deterioration leads to distinctive impairments in the domains of syntax, action verbs, and action semantics. In particular, such disruptions have been repeatedly observed in Parkinson's disease (PD) patients. However, it remains unclear whether these deficits are language-specific and whether they are equally dissociable from other reported disturbances –viz., processing of object semantics. To address these issues, we administered linguistic, semantic, and executive function (EFs) tasks to two groups of non-demented PD patients, with and without mild cognitive impairment (PD-MCI and PD-nMCI, respectively). We compared these two groups with each other and with matched samples of healthy controls. Our results showed that PD patients exhibited linguistic and semantic deficits even in the absence of MCI. However, not all domains were equally related to EFs and MCI across samples. Whereas EFs predicted disturbances of syntax and object semantics in both PD-nMCI and PD-MCI, they had no impact on action-verb and action-semantic impairments in either group. Critically, patients showed disruptions of action-verb production and action semantics in the absence of MCI and without any executive influence, suggesting a sui generis deficit present since early stages of the disease. These findings indicate that varied language domains are differentially related to the BG, contradicting popular approaches to neurolinguistics. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, David Pineda, Omar Buriticá, Andrés Villegas, Francisco Lopera, Diana Gómez, Catalina Gómez-Arias, Juan F Cardona, Natalia Trujillo, Agustín Ibáñez Referencia : Cortex. 2015 Aug;69:237-54. DOI (Digital Object Identifier) : 10.1016/j.cortex.2015.05.022 PMID : 26103601 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0010945215001811#abs0010 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3895

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