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Título : Melanoma of the sellar region mimicking pituitary adenoma Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2013 Títulos uniformes : Neuropathology Idioma : Inglés (eng) Palabras clave : Histology melanoma neoplasm pathology pituitary Resumen : We report here the case of an 82‐year‐old woman who presented with visual disturbance. MRI demonstrated a sellar mass. The diagnosis of pituitary adenoma was made. She underwent transnasal surgery. Histologic, immunohistochemical and ultrastructural studies indicated that the tumor was a melanoma. Despite an exhaustive search for a primary lesion elsewhere, none was found. The sellar tumor was considered a primary lesion, although extrasellar primary tumor imaging cannot be excluded with 100% certainty. Reported examples of melanoma affecting the sellar region are few. They exhibit morphologic features identical to those of melanomas arising elsewhere. Although very rare, primary melanomas enter into the differential diagnosis of sellar lesions. Mención de responsabilidad : Michael Sidiropoulos, Luis V Syro, Fabio Rotondo, Bernd W Scheithauer, Luis Carlos Penagos, Humberto Uribe, Maria Del Pilar Ramirez, Eva Horvath, Miklos Goth, Kalman Kovacs Referencia : Neuropathology. 2013 Apr;33(2):175-8. DOI (Digital Object Identifier) : 10.1111/j.1440-1789.2012.01331.x PMID : 22624497 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1789.2012.01331.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3663 Melanoma of the sellar region mimicking pituitary adenoma [documento electrónico] / Luis Vicente Syro Moreno, . - 2013.
Obra : Neuropathology
Idioma : Inglés (eng)
Palabras clave : Histology melanoma neoplasm pathology pituitary Resumen : We report here the case of an 82‐year‐old woman who presented with visual disturbance. MRI demonstrated a sellar mass. The diagnosis of pituitary adenoma was made. She underwent transnasal surgery. Histologic, immunohistochemical and ultrastructural studies indicated that the tumor was a melanoma. Despite an exhaustive search for a primary lesion elsewhere, none was found. The sellar tumor was considered a primary lesion, although extrasellar primary tumor imaging cannot be excluded with 100% certainty. Reported examples of melanoma affecting the sellar region are few. They exhibit morphologic features identical to those of melanomas arising elsewhere. Although very rare, primary melanomas enter into the differential diagnosis of sellar lesions. Mención de responsabilidad : Michael Sidiropoulos, Luis V Syro, Fabio Rotondo, Bernd W Scheithauer, Luis Carlos Penagos, Humberto Uribe, Maria Del Pilar Ramirez, Eva Horvath, Miklos Goth, Kalman Kovacs Referencia : Neuropathology. 2013 Apr;33(2):175-8. DOI (Digital Object Identifier) : 10.1111/j.1440-1789.2012.01331.x PMID : 22624497 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1789.2012.01331.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3663 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000236 AC-2013-004 Archivo digital Producción Científica Artículos científicos Disponible Effect of temozolomide in a patient with recurring oncocytic gonadotrophic pituitary adenoma / Luis Vicente Syro Moreno
Título : Effect of temozolomide in a patient with recurring oncocytic gonadotrophic pituitary adenoma Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2009 Títulos uniformes : Hormones Idioma : Inglés (eng) Palabras clave : MGMT Neoplasm Pathology Pituitary Temozolomide Resumen : The patient was a 70-year-old man with a recurrent pituitary tumor. Three surgeries were performed but the tumor recurred. Based on histologic, immunohistochemical and ultrastructural studies, the diagnosis of oncocytic gonadotrophic pituitary adenoma was made. The tumor was a macroadenoma partly immunopositive for LH. Immunohistochemistry for O6 Methylguanine-DNA Methyl-Transferase (MGMT) showed an admixture of immunopositive and immunonegative cells. After recurrence following operations, the patient was treated with Temozolomide, an imidazotetrazine derivative, DNA-alkylating drug. Following Temozolomide administration the MRI demonstrated significant tumor necrosis. A few months later, the patient died of massive pulmonary embolism. No autopsy was performed. The present case indicates that benign, typically slow-growing pituitary adenomas of oncocytic gonadotrophic type may respond to Temozolomide even when the tumor consists of an admixture of MGMT immunopositive and immunonegative cells. Mención de responsabilidad : Luis V Syro, Bernd W Scheithauer, Leon D Ortiz, Camilo E Fadul, Eva Horvath, Fabio Rotondo, Kalman Kovacs Referencia : Hormones (Athens). 2009 Oct-Dec;8(4):303-6. DOI (Digital Object Identifier) : 10.14310/horm.2002.1247 PMID : 20045804 En línea : https://link.springer.com/article/10.14310/horm.2002.1247 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4443 Effect of temozolomide in a patient with recurring oncocytic gonadotrophic pituitary adenoma [documento electrónico] / Luis Vicente Syro Moreno, . - 2009.
Obra : Hormones
Idioma : Inglés (eng)
Palabras clave : MGMT Neoplasm Pathology Pituitary Temozolomide Resumen : The patient was a 70-year-old man with a recurrent pituitary tumor. Three surgeries were performed but the tumor recurred. Based on histologic, immunohistochemical and ultrastructural studies, the diagnosis of oncocytic gonadotrophic pituitary adenoma was made. The tumor was a macroadenoma partly immunopositive for LH. Immunohistochemistry for O6 Methylguanine-DNA Methyl-Transferase (MGMT) showed an admixture of immunopositive and immunonegative cells. After recurrence following operations, the patient was treated with Temozolomide, an imidazotetrazine derivative, DNA-alkylating drug. Following Temozolomide administration the MRI demonstrated significant tumor necrosis. A few months later, the patient died of massive pulmonary embolism. No autopsy was performed. The present case indicates that benign, typically slow-growing pituitary adenomas of oncocytic gonadotrophic type may respond to Temozolomide even when the tumor consists of an admixture of MGMT immunopositive and immunonegative cells. Mención de responsabilidad : Luis V Syro, Bernd W Scheithauer, Leon D Ortiz, Camilo E Fadul, Eva Horvath, Fabio Rotondo, Kalman Kovacs Referencia : Hormones (Athens). 2009 Oct-Dec;8(4):303-6. DOI (Digital Object Identifier) : 10.14310/horm.2002.1247 PMID : 20045804 En línea : https://link.springer.com/article/10.14310/horm.2002.1247 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4443 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000943 AC-2009-031 Archivo digital Producción Científica Artículos científicos Disponible
