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Título : Biomarkers of pituitary carcinomas Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2016 Títulos uniformes : Expert Review of Endocrinology and Metabolism Idioma : Inglés (eng) Palabras clave : Angiogenesis Galectin-3 HIF-1 H-ras Ki-67 microRNA P27/KIP1 P53 pituitary carcinoma telomerase Resumen : Pituitary carcinoma is a rare tumor originating from adenohypophyseal cells. Currently, diverse pathogenetic mechanisms, i.e. de novo versus malignant transformation from pituitary adenoma, remain obscure and require further investigation. During the last two decades, scientific research added new horizons not only in regards to general tumor concepts but also in next generation biomarker armamentarium that sheds light on alternate pathways in carcinogenesis. Areas covered: In this review, the impact of apoptotic and proliferative markers, angiogenesis, telomerase activity, H-ras, HIF-1, HER-2/neu, Rb gene, and microRNAs in pathogenetic mechanisms of pituitary carcinomas were revised. Expert commentary: It is becoming increasingly important for the need of standardization of new biomarkers but also for better comprehension of the diverse pathways in tumorigenesis. This can only be accomplished by tapping into the continuously expanding spectrum of new biomarkers. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V Syro, Antonio Di Ieva, Michael D Cusimano, Kalman Kovacs Referencia : Expert Rev Endocrinol Metab. 2016 May;11(3):253-261. DOI (Digital Object Identifier) : 10.1080/17446651.2016.1179110 PMID : 30058931 En línea : https://www.tandfonline.com/doi/abs/10.1080/17446651.2016.1179110 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4611 Biomarkers of pituitary carcinomas [documento electrónico] / Luis Vicente Syro Moreno, . - 2016.
Obra : Expert Review of Endocrinology and Metabolism
Idioma : Inglés (eng)
Palabras clave : Angiogenesis Galectin-3 HIF-1 H-ras Ki-67 microRNA P27/KIP1 P53 pituitary carcinoma telomerase Resumen : Pituitary carcinoma is a rare tumor originating from adenohypophyseal cells. Currently, diverse pathogenetic mechanisms, i.e. de novo versus malignant transformation from pituitary adenoma, remain obscure and require further investigation. During the last two decades, scientific research added new horizons not only in regards to general tumor concepts but also in next generation biomarker armamentarium that sheds light on alternate pathways in carcinogenesis. Areas covered: In this review, the impact of apoptotic and proliferative markers, angiogenesis, telomerase activity, H-ras, HIF-1, HER-2/neu, Rb gene, and microRNAs in pathogenetic mechanisms of pituitary carcinomas were revised. Expert commentary: It is becoming increasingly important for the need of standardization of new biomarkers but also for better comprehension of the diverse pathways in tumorigenesis. This can only be accomplished by tapping into the continuously expanding spectrum of new biomarkers. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V Syro, Antonio Di Ieva, Michael D Cusimano, Kalman Kovacs Referencia : Expert Rev Endocrinol Metab. 2016 May;11(3):253-261. DOI (Digital Object Identifier) : 10.1080/17446651.2016.1179110 PMID : 30058931 En línea : https://www.tandfonline.com/doi/abs/10.1080/17446651.2016.1179110 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4611 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001109 AC-2016-090 Archivo digital Producción Científica Artículos científicos Disponible
Título : Biomarkers of pituitary neoplasms Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2012 Títulos uniformes : Anticancer Research Idioma : Inglés (eng) Palabras clave : Angiogenesis apoptosis p53 p27 cox-2 folliculostellate cells galectin-3 hif-1alpha inflammation and tumor matrix metalloproteinases (MMPS) microarray microenvironment microvessel density (MVD) pituitary stem cells proliferative marker (ki-67) pituitary tumor-transforming gene (PTTG) topoisomerase-2-alpha tumor heterogeneity VEGF review Resumen : In a wide spectrum of tumors, cell proliferation, vascularity, apoptosis, cell adhesion, and cell-cycle progression may indicate tumor progression. In this review article, the literature regarding apoptotic markers and p53, as well as cyclooxygenase-2, galectin-3, and pituitary tumor transforming factor, proliferative markers, angiogenesis, including vascular endothelial growth factor and its receptor, pituitary tumor-transforming gene, microarrays, stem cells, and microenvironment and tumor heterogeneity are presented. Only a particular group of selected biomarkers show promise in differentiating pituitary tumors which will behave in an aggressive manner. Therefore, the most common and promising biomarkers and terms were analyzed, proposing the need for uniform design and application of methods and standardized criteria for the interpretation of results. The new spectrum of biomarkers may shed light upon the pathogenetic mechanisms and also may serve as standardized diagnostic tool for daily pathologic practice. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V. Syro, Bernd W. Scheithauer, and Kalman Kovacs Referencia : Anticancer Res. 2012; 32:(11)4639-54. En línea : http://ar.iiarjournals.org/content/32/11/4639.abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3635 Biomarkers of pituitary neoplasms [documento electrónico] / Luis Vicente Syro Moreno, . - 2012.
Obra : Anticancer Research
Idioma : Inglés (eng)
Palabras clave : Angiogenesis apoptosis p53 p27 cox-2 folliculostellate cells galectin-3 hif-1alpha inflammation and tumor matrix metalloproteinases (MMPS) microarray microenvironment microvessel density (MVD) pituitary stem cells proliferative marker (ki-67) pituitary tumor-transforming gene (PTTG) topoisomerase-2-alpha tumor heterogeneity VEGF review Resumen : In a wide spectrum of tumors, cell proliferation, vascularity, apoptosis, cell adhesion, and cell-cycle progression may indicate tumor progression. In this review article, the literature regarding apoptotic markers and p53, as well as cyclooxygenase-2, galectin-3, and pituitary tumor transforming factor, proliferative markers, angiogenesis, including vascular endothelial growth factor and its receptor, pituitary tumor-transforming gene, microarrays, stem cells, and microenvironment and tumor heterogeneity are presented. Only a particular group of selected biomarkers show promise in differentiating pituitary tumors which will behave in an aggressive manner. Therefore, the most common and promising biomarkers and terms were analyzed, proposing the need for uniform design and application of methods and standardized criteria for the interpretation of results. The new spectrum of biomarkers may shed light upon the pathogenetic mechanisms and also may serve as standardized diagnostic tool for daily pathologic practice. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V. Syro, Bernd W. Scheithauer, and Kalman Kovacs Referencia : Anticancer Res. 2012; 32:(11)4639-54. En línea : http://ar.iiarjournals.org/content/32/11/4639.abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3635 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000206 AC-2012-046 Archivo digital Producción Científica Artículos científicos Disponible