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Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease / Sergio Álvarez Vallejo ; Martín Ochoa Escudero    

Público ISBD Título : Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Brain Communications Idioma : Inglés (eng) Palabras clave : Presenilin-1  thalamus  MRI  PET imaging  preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5783 Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero,  . - 2021. Obra : Brain Communications Idioma : Inglés (eng) Palabras clave : Presenilin-1  thalamus  MRI  PET imaging  preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5783

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