2 búsqueda de la palabra clave 'Porphyria'

Comparative effectiveness of human hematin and heme arginate in themanagement of porphyria attacks: an observational study across three hospitals inColombia / Andrés Felipe Valencia Quintero ; Natalia Andrea Rojas Henao ; Enyd Estefanía Rave Builes ; Nieto López, Emmanuel Salvador  

Público ISBD Título : Comparative effectiveness of human hematin and heme arginate in themanagement of porphyria attacks: an observational study across three hospitals inColombia Tipo de documento : documento electrónico Autores : Andrés Felipe Valencia Quintero, Autor ; Natalia Andrea Rojas Henao, Autor ; Enyd Estefanía Rave Builes, Autor ; Nieto López, Emmanuel Salvador, Autor Fecha de publicación : 2025 Títulos uniformes : Hospital Practice Idioma : Inglés (eng) Palabras clave : Porphyria  hematin  heme arginate  treatment outcome  Drug effects Resumen : Background: Porphyria is an orphan disease classified as a genetic disorder caused by a partial or high-grade deficiency of enzymes involved in the synthesis of heme, an essential component of hemoglobin.This deficiency results in the accumulation of porphyrins (ALAS1 and PBG), intermediates in the hememetabolic pathway. This accumulation triggers porphyria attacks. In Colombia the Heme Arginate andHuman Hematin are the therapeutics alternatives for the management of porphyria AttacksObjective: To evaluate the comparative effectiveness of heme arginate versus human hemin fortreating porphyria attacks in hospitalized patients across three institutions in Medellin, Colombia.Methods: An observational and analytical study was conducted to compare the outcomes of treatmentwith human hematin versus heme arginate in clinical episodes of patients diagnosed with porphyriabetween 2015–2021.Results: In episodes treated with heme arginate (ArgH), 75% achieved pain control or reduction, 41.6%showed a reduction in opioid dosage, and 88.8% achieved resolution of the Porphyria attack. Forepisodes treated with human hematin (HH), 85.3% achieved pain control or reduction, 53.6% showeda reduction in opioid dosage, and 90.2% achieved resolution of the attack. When evaluating theeffectiveness of both treatments, no statistically significant differences were observed across thethree predefined effectiveness outcomes of the study.Conclusions: This study provides a comparative evaluation of heme arginate (ArgH) and humanhematin (HH) in the management of Porphyria attacks, demonstrating that both treatments are similarlyeffective in achieving pain control, reducing opioid use, and resolving clinical attacks. Mención de responsabilidad : Natalia A Rojas Henao, Andres Felipe Valencia, Emmanuel Salvador Nieto López DOI (Digital Object Identifier) : 10.1080/21548331.2025.2520743 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/21548331.2025.2520743#abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Comparative effectiveness of human hematin and heme arginate in themanagement of porphyria attacks: an observational study across three hospitals inColombia [documento electrónico] / Andrés Felipe Valencia Quintero, Autor ; Natalia Andrea Rojas Henao, Autor ; Enyd Estefanía Rave Builes, Autor ; Nieto López, Emmanuel Salvador, Autor . - 2025. Obra : Hospital Practice Idioma : Inglés (eng) Palabras clave : Porphyria  hematin  heme arginate  treatment outcome  Drug effects Resumen : Background: Porphyria is an orphan disease classified as a genetic disorder caused by a partial or high-grade deficiency of enzymes involved in the synthesis of heme, an essential component of hemoglobin.This deficiency results in the accumulation of porphyrins (ALAS1 and PBG), intermediates in the hememetabolic pathway. This accumulation triggers porphyria attacks. In Colombia the Heme Arginate andHuman Hematin are the therapeutics alternatives for the management of porphyria AttacksObjective: To evaluate the comparative effectiveness of heme arginate versus human hemin fortreating porphyria attacks in hospitalized patients across three institutions in Medellin, Colombia.Methods: An observational and analytical study was conducted to compare the outcomes of treatmentwith human hematin versus heme arginate in clinical episodes of patients diagnosed with porphyriabetween 2015–2021.Results: In episodes treated with heme arginate (ArgH), 75% achieved pain control or reduction, 41.6%showed a reduction in opioid dosage, and 88.8% achieved resolution of the Porphyria attack. Forepisodes treated with human hematin (HH), 85.3% achieved pain control or reduction, 53.6% showeda reduction in opioid dosage, and 90.2% achieved resolution of the attack. When evaluating theeffectiveness of both treatments, no statistically significant differences were observed across thethree predefined effectiveness outcomes of the study.Conclusions: This study provides a comparative evaluation of heme arginate (ArgH) and humanhematin (HH) in the management of Porphyria attacks, demonstrating that both treatments are similarlyeffective in achieving pain control, reducing opioid use, and resolving clinical attacks. Mención de responsabilidad : Natalia A Rojas Henao, Andres Felipe Valencia, Emmanuel Salvador Nieto López DOI (Digital Object Identifier) : 10.1080/21548331.2025.2520743 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/21548331.2025.2520743#abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD002385	AC-2025-068	Archivo digital	Producción Científica	Artículos científicos	Disponible

Acute intermittent porphyria: general aspects with focus on pain / Jhon Lidemberto Cárdenas Cárdenas  

Público ISBD Título : Acute intermittent porphyria: general aspects with focus on pain Tipo de documento : documento electrónico Autores : Jhon Lidemberto Cárdenas Cárdenas, Fecha de publicación : 2018 Títulos uniformes : Current Medical Research and Opinion Idioma : Inglés (eng) Palabras clave : Porphyria  acute intermittent  acute pain  analgesia  narcotics  pain management  polyneuropathy Resumen : Despite medical advances, the diagnosis and management of acute intermittent porphyria continues to be challenging. Acute pain is one of the most important clinical manifestations in acute intermittent porphyria, but management and pain assessment have been poorly studied in these patients. The lack of information and evidence based recommendations regarding these topics in the medical literature is certainly surprising. Furthermore, pain management is discussed based on extrapolating concepts adopted for other pain syndromes. An important arsenal of medications, including reportedly safe opioid and non-opioid analgesics, is available for use in this type of patient. In addition to conducting an extensive review of the current literature, the present article aims to show the general aspects of a disease that generates a challenge for the clinician, emphasizing what is related to pain as a cardinal symptom and to create awareness about the need for studies supporting the development of guidelines, based on evidence obtained from analgesic management in patients presenting with this disorder. A systematic assessment directed at understanding the physiopathological processes underlying acute pain combined with a stepwise approach to pain management with safe opioid and non-opioid drugs constitutes the fundamental basis for a successful pain management program in patients with acute intermittent porphyria. Mención de responsabilidad : John Lidemberto Cardenas, Carlos Guerrero Referencia : Curr Med Res Opin. 2018 Jul;34(7):1309-1315. DOI (Digital Object Identifier) : 10.1080/03007995.2018.1435521 PMID : 29383964 En línea : https://www.tandfonline.com/doi/full/10.1080/03007995.2018.1435521 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Acute intermittent porphyria: general aspects with focus on pain [documento electrónico] / Jhon Lidemberto Cárdenas Cárdenas,  . - 2018. Obra : Current Medical Research and Opinion Idioma : Inglés (eng) Palabras clave : Porphyria  acute intermittent  acute pain  analgesia  narcotics  pain management  polyneuropathy Resumen : Despite medical advances, the diagnosis and management of acute intermittent porphyria continues to be challenging. Acute pain is one of the most important clinical manifestations in acute intermittent porphyria, but management and pain assessment have been poorly studied in these patients. The lack of information and evidence based recommendations regarding these topics in the medical literature is certainly surprising. Furthermore, pain management is discussed based on extrapolating concepts adopted for other pain syndromes. An important arsenal of medications, including reportedly safe opioid and non-opioid analgesics, is available for use in this type of patient. In addition to conducting an extensive review of the current literature, the present article aims to show the general aspects of a disease that generates a challenge for the clinician, emphasizing what is related to pain as a cardinal symptom and to create awareness about the need for studies supporting the development of guidelines, based on evidence obtained from analgesic management in patients presenting with this disorder. A systematic assessment directed at understanding the physiopathological processes underlying acute pain combined with a stepwise approach to pain management with safe opioid and non-opioid drugs constitutes the fundamental basis for a successful pain management program in patients with acute intermittent porphyria. Mención de responsabilidad : John Lidemberto Cardenas, Carlos Guerrero Referencia : Curr Med Res Opin. 2018 Jul;34(7):1309-1315. DOI (Digital Object Identifier) : 10.1080/03007995.2018.1435521 PMID : 29383964 En línea : https://www.tandfonline.com/doi/full/10.1080/03007995.2018.1435521 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD000750	AC-2018-037	Archivo digital	Producción Científica	Artículos científicos	Disponible