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Enlace permanente de la investigaciónEtiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country / Mónica Rosa Trujillo Honeysberg
Título : Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Palabras clave : Encephalitis risk factors PICU etiology children Resumen : Objective: To describe a cohort of pediatric patients with encephalitis and their risk factors for admission to the pediatric intensive care unit (PICU). Study Design: Children ( Mención de responsabilidad : Guerrero, María P. MD; Romero, Andrés F. MD; Luengas, Miguel MD; Dávalos, Diana M. MD, MPH, DrPH; Mesa-Monsalve, Juan Gonzalo MD; Vivas-Trochez, Rosalba MD; Camacho-Moreno, German MD; Trujillo-Valencia, Mónica MD; Giraldo, Juan P. Calle MD; Mejía, Luis F. MD; Rojas-Hernández, Juan P. MD, MSc; Vinasco, Nathaly MD; Racines, Andrea Ruiz MD; Meléndez, Alejandro MD; Beltrán, Claudia P. MD; López, Pio MD; Chaucanez, Yamile MD; Patiño, Jaime MD; Rodríguez, Wilfrido Coronell MD, PhD; Salgado, Doris MD; Martínez, Marly MD; Restrepo, Andrea MD; Márquez, Kelly MD; Galvis, Diego MD; Benavidez, Iván MD; Rojas, Christian A. MD; Cantor, Erika MSC; López Medina, Eduardo MD, MSc Referencia : Pediatr Infect Dis J. 2022 Oct 1;41(10):806-812. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003637 PMID : 35830514 En línea : https://journals.lww.com/pidj/Abstract/2022/10000/Etiology_and_Risk_Factors_for_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6086 Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country [documento electrónico] / Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Pediatric Infectious Disease Journal
Idioma : Inglés (eng)
Palabras clave : Encephalitis risk factors PICU etiology children Resumen : Objective: To describe a cohort of pediatric patients with encephalitis and their risk factors for admission to the pediatric intensive care unit (PICU). Study Design: Children ( Mención de responsabilidad : Guerrero, María P. MD; Romero, Andrés F. MD; Luengas, Miguel MD; Dávalos, Diana M. MD, MPH, DrPH; Mesa-Monsalve, Juan Gonzalo MD; Vivas-Trochez, Rosalba MD; Camacho-Moreno, German MD; Trujillo-Valencia, Mónica MD; Giraldo, Juan P. Calle MD; Mejía, Luis F. MD; Rojas-Hernández, Juan P. MD, MSc; Vinasco, Nathaly MD; Racines, Andrea Ruiz MD; Meléndez, Alejandro MD; Beltrán, Claudia P. MD; López, Pio MD; Chaucanez, Yamile MD; Patiño, Jaime MD; Rodríguez, Wilfrido Coronell MD, PhD; Salgado, Doris MD; Martínez, Marly MD; Restrepo, Andrea MD; Márquez, Kelly MD; Galvis, Diego MD; Benavidez, Iván MD; Rojas, Christian A. MD; Cantor, Erika MSC; López Medina, Eduardo MD, MSc Referencia : Pediatr Infect Dis J. 2022 Oct 1;41(10):806-812. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003637 PMID : 35830514 En línea : https://journals.lww.com/pidj/Abstract/2022/10000/Etiology_and_Risk_Factors_for_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6086 Reserva
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Título : Efficacy of high-intensity, low-volume interval training compared to continuous aerobic training on insulin resistance, skeletal muscle structure and function in adults with metabolic syndrome: study protocol for a randomized controlled clinical trial (Intraining-MET) Tipo de documento : documento electrónico Autores : Mauricio Estrada Castrillón, Fecha de publicación : 2018 Títulos uniformes : Trials Idioma : Inglés (eng) Palabras clave : Aerobic exercise exercise training glucose metabolism disorders hyperinsulinemia. insulin resistance interval training metabolic syndrome myokines risk factors skeletal muscle Resumen : Background: Evidence of the efficacy of high-intensity, low-volume interval training (HIIT-low volume) in treating insulin resistance (IR) in patients with metabolic disorders is contradictory. In addition, it is unknown whether this effect is mediated through muscle endocrine function, which in turn depends on muscle mass and fiber type composition. Our aims were to assess the efficacy of HIIT-low volume compared to continuous aerobic exercise (CAE) in treating IR in adults with metabolic syndrome (MS) and to establish whether musclin, apelin, muscle mass and muscle composition are mediators of the effect. Methods: This is a controlled, randomized, clinical trial using the minimization method, with blinding of those who will evaluate the outcomes and two parallel groups for the purpose of showing superiority. Sixty patients with MS and IR with ages between 40 and 60 years will be included. A clinical evaluation will be carried out, along with laboratory tests to evaluate IR (homeostatic model assessment (HOMA)), muscle endocrine function (serum levels of musclin and apelin), thigh muscle mass (by dual energy x-ray absorptiometry (DXA) and thigh muscle composition (by carnosine measurement with proton magnetic resonance spectroscopy (1H–MRS)), before and after 12 weeks of a treadmill exercise program three times a week. Participants assigned to the intervention (n = 30) will receive HIIT-low volume in 22-min sessions that will include six intervals at a load of 90% of maximum oxygen consumption (VO2 max) for 1 min followed by 2 min at 50% of VO2 max. The control group (n = 30) will receive CAE at an intensity of 60% of VO2 max for 36 min. A theoretical model based on structural equations will be proposed to estimate the total, direct and indirect effects of training on IR and the proportion explained by the mediators. Discussion: Compared with CAE, HIIT-low volume can be effective and efficient at improving physical capacity and decreasing cardiovascular risk factors, such as IR, in patients with metabolic disorders. Studies that evaluate mediating variables of the effect of HIIT-low volume on IR, such as endocrine function and skeletal muscle structure, are necessary to understand the role of skeletal muscle in the pathophysiology of MS and their regulation by exercise. Trial registration: NCT03087721. High-intensity Interval, Low Volume Training in Metabolic Syndrome (Intraining-MET). Registered on 22 March 2017, retrospectively registered. Mención de responsabilidad : Jaime Gallo-Villegas, Juan Carlos Aristizabal, Mauricio Estrada, Luis H Valbuena, Raul Narvaez-Sanchez, Jorge Osorio, Daniel C Aguirre-Acevedo, Juan C Calderón Referencia : Trials. 2018 Feb 27;19(1):144. DOI (Digital Object Identifier) : 10.1186/s13063-018-2541-7 PMID : 29482601 Derechos de uso : CC BY En línea : https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2541-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4187 Efficacy of high-intensity, low-volume interval training compared to continuous aerobic training on insulin resistance, skeletal muscle structure and function in adults with metabolic syndrome: study protocol for a randomized controlled clinical trial (Intraining-MET) [documento electrónico] / Mauricio Estrada Castrillón, . - 2018.
Obra : Trials
Idioma : Inglés (eng)
Palabras clave : Aerobic exercise exercise training glucose metabolism disorders hyperinsulinemia. insulin resistance interval training metabolic syndrome myokines risk factors skeletal muscle Resumen : Background: Evidence of the efficacy of high-intensity, low-volume interval training (HIIT-low volume) in treating insulin resistance (IR) in patients with metabolic disorders is contradictory. In addition, it is unknown whether this effect is mediated through muscle endocrine function, which in turn depends on muscle mass and fiber type composition. Our aims were to assess the efficacy of HIIT-low volume compared to continuous aerobic exercise (CAE) in treating IR in adults with metabolic syndrome (MS) and to establish whether musclin, apelin, muscle mass and muscle composition are mediators of the effect. Methods: This is a controlled, randomized, clinical trial using the minimization method, with blinding of those who will evaluate the outcomes and two parallel groups for the purpose of showing superiority. Sixty patients with MS and IR with ages between 40 and 60 years will be included. A clinical evaluation will be carried out, along with laboratory tests to evaluate IR (homeostatic model assessment (HOMA)), muscle endocrine function (serum levels of musclin and apelin), thigh muscle mass (by dual energy x-ray absorptiometry (DXA) and thigh muscle composition (by carnosine measurement with proton magnetic resonance spectroscopy (1H–MRS)), before and after 12 weeks of a treadmill exercise program three times a week. Participants assigned to the intervention (n = 30) will receive HIIT-low volume in 22-min sessions that will include six intervals at a load of 90% of maximum oxygen consumption (VO2 max) for 1 min followed by 2 min at 50% of VO2 max. The control group (n = 30) will receive CAE at an intensity of 60% of VO2 max for 36 min. A theoretical model based on structural equations will be proposed to estimate the total, direct and indirect effects of training on IR and the proportion explained by the mediators. Discussion: Compared with CAE, HIIT-low volume can be effective and efficient at improving physical capacity and decreasing cardiovascular risk factors, such as IR, in patients with metabolic disorders. Studies that evaluate mediating variables of the effect of HIIT-low volume on IR, such as endocrine function and skeletal muscle structure, are necessary to understand the role of skeletal muscle in the pathophysiology of MS and their regulation by exercise. Trial registration: NCT03087721. High-intensity Interval, Low Volume Training in Metabolic Syndrome (Intraining-MET). Registered on 22 March 2017, retrospectively registered. Mención de responsabilidad : Jaime Gallo-Villegas, Juan Carlos Aristizabal, Mauricio Estrada, Luis H Valbuena, Raul Narvaez-Sanchez, Jorge Osorio, Daniel C Aguirre-Acevedo, Juan C Calderón Referencia : Trials. 2018 Feb 27;19(1):144. DOI (Digital Object Identifier) : 10.1186/s13063-018-2541-7 PMID : 29482601 Derechos de uso : CC BY En línea : https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2541-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4187 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000801 AC-2018-088 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2018-088.pdfAdobe Acrobat PDF
Título : Colombian multicentric study on epidemiology of diabetic ketoacidosis in children with type 1 diabetes mellitus Tipo de documento : documento electrónico Autores : Carolina Jaramillo Arango, ; Mauricio Fernández Laverde, Fecha de publicación : 2017 Títulos uniformes : Endocrinology and Metabolism International Journal Idioma : Inglés (eng) Palabras clave : Type 1 diabetes mellitus Diabetic ketoacidosis Risk factors Pediatric intensive care units Epidemiology Multicenter studies Resumen : Background: Type 1 diabetes is a growing disease worldwide, where ketoacidosis is a serious cause commonly resulting in hospitalization. Little is known regarding the epidemiology of the development of ketoacidosis in Colombian children with a known diagnosis of diabetes. Objective: To describe the epidemiological profile of children with type 1 diabetes and ketoacidosis diagnosis. Settings: Using the online survey, http://www.e-encuesta.com/answer.do?testid=cRctXSlVSLk, seven pediatric intensive care units of the four main cities throughout the country reported epidemiological data of the patients that were admitted with episodes of ketoacidosis other than diabetes debut, between May of 2014 and May of 2016. Measurement and main results: Fifty-two events of diabetic ketoacidosis in 47 patients between ages 3 and 17 were included. The patients had mean glycosylated hemoglobin of 12% (SD: 2.9) and the median insulin dose used was 0.91 (IQR 0.74 – 1.2 UI/kg). One hundred percent of patients belonged to middle and low socioeconomic classes, 98.1% of patients were insured by the health care system, and 27.4% of patients did not have the necessary supplies for glucose control. Conclusion: The glycosylated hemoglobin levels can evidence that diabetic ketoacidosis patients were generally not well controlled prior to admission. The most common precipitating factors of diabetic ketoacidosis were the low adherence to treatment and infections. Patients must be informed about the importance of adherence to treatment and how to adjust insulin on sick days; the health care system must ensure patients have the supplies necessary for optimal diabetes control. Mención de responsabilidad : Carolina Jaramillo Arango, Yúrika P López-Alarcón, Juan C Jaramillo Bustamante, Mauricio Fernández-Laverde, Rosalba Pardo Carrero, Alejandro Marín-Agudelo Referencia : Endocrinol Metab Int J. 2017;5(2):205-9 DOI (Digital Object Identifier) : 10.15406/emij.2017.05.00118 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/EMIJ/EMIJ-05-00118.php Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4057 Colombian multicentric study on epidemiology of diabetic ketoacidosis in children with type 1 diabetes mellitus [documento electrónico] / Carolina Jaramillo Arango, ; Mauricio Fernández Laverde, . - 2017.
Obra : Endocrinology and Metabolism International Journal
Idioma : Inglés (eng)
Palabras clave : Type 1 diabetes mellitus Diabetic ketoacidosis Risk factors Pediatric intensive care units Epidemiology Multicenter studies Resumen : Background: Type 1 diabetes is a growing disease worldwide, where ketoacidosis is a serious cause commonly resulting in hospitalization. Little is known regarding the epidemiology of the development of ketoacidosis in Colombian children with a known diagnosis of diabetes. Objective: To describe the epidemiological profile of children with type 1 diabetes and ketoacidosis diagnosis. Settings: Using the online survey, http://www.e-encuesta.com/answer.do?testid=cRctXSlVSLk, seven pediatric intensive care units of the four main cities throughout the country reported epidemiological data of the patients that were admitted with episodes of ketoacidosis other than diabetes debut, between May of 2014 and May of 2016. Measurement and main results: Fifty-two events of diabetic ketoacidosis in 47 patients between ages 3 and 17 were included. The patients had mean glycosylated hemoglobin of 12% (SD: 2.9) and the median insulin dose used was 0.91 (IQR 0.74 – 1.2 UI/kg). One hundred percent of patients belonged to middle and low socioeconomic classes, 98.1% of patients were insured by the health care system, and 27.4% of patients did not have the necessary supplies for glucose control. Conclusion: The glycosylated hemoglobin levels can evidence that diabetic ketoacidosis patients were generally not well controlled prior to admission. The most common precipitating factors of diabetic ketoacidosis were the low adherence to treatment and infections. Patients must be informed about the importance of adherence to treatment and how to adjust insulin on sick days; the health care system must ensure patients have the supplies necessary for optimal diabetes control. Mención de responsabilidad : Carolina Jaramillo Arango, Yúrika P López-Alarcón, Juan C Jaramillo Bustamante, Mauricio Fernández-Laverde, Rosalba Pardo Carrero, Alejandro Marín-Agudelo Referencia : Endocrinol Metab Int J. 2017;5(2):205-9 DOI (Digital Object Identifier) : 10.15406/emij.2017.05.00118 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/EMIJ/EMIJ-05-00118.php Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4057 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000657 AC-2017-046 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2017-046.pdfAdobe Acrobat PDF
Título : Prediction of prolonged mechanical ventilation for intensive care unit patients: A cohort study Otros títulos : Predicción de la ventilación mecánica prolongada en pacientes de la unidad de cuidado intensivo: Estudio de cohorte Tipo de documento : documento electrónico Autores : Álvaro Enrique Sanabria Quiroga, Fecha de publicación : 2013 Títulos uniformes : Colombia Médica Idioma : Inglés (eng) Palabras clave : tracheostomy artificial respiration intensive care units ventilator weaning intratracheal intubation risk factors Resumen : Introduction: There are no established guidelines for selecting patients for early tracheostomy. The aim was to determine the factors that could predict the possibility of intubation longer than 7 days in critically ill adult patients. Methods: This is cohort study made at a general intensive care unit. Patients who required at least 48 hours of mechanical ventilation were included. Data on the clinical and physiologic features were collected for every intubated patient on the third day. Uni- and multivariate statistical analyses were conducted to determine the variables associated with extubation. Results: 163 (62%) were male, and the median age was 59±17 years. Almost one-third (36%) of patients required mechanical ventilation longer than 7 days. The variables strongly associated with prolonged mechanical ventilation were: age (HR 0.97 (95% CI 0.96-0.99); diagnosis of surgical emergency in a patient with a medical condition (HR 3.68 (95% CI 1.62-8.35), diagnosis of surgical condition-non emergency (HR 8.17 (95% CI 2.12-31.3); diagnosis of non-surgical-medical condition (HR 5.26 (95% CI 1.85-14.9); APACHE II (HR 0.91 (95% CI 0.85-0.97) and SAPS II score (HR 1.04 (95% CI 1.00-1.09) The area under ROC curve used for prediction was 0.52. 16% of patients were extubated after day 8 of intubation. Conclusions: It was not possible to predict early extubation in critically ill adult patients with invasive mechanical ventilation with common clinical scales used at the ICU. However, the probability of successfully weaning patients from mechanical ventilation without a tracheostomy is low after the eighth day of intubation. Mención de responsabilidad : Alvaro Sanabria, Ximena Gomez, Valentin Vega, Luis Carlos Dominguez, Camilo Osorio DOI (Digital Object Identifier) : 10.25100/cm.v44i3.1285 Derechos de uso : CC BY-NC-ND En línea : https://colombiamedica.univalle.edu.co/index.php/comedica/article/view/1285 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4527 Prediction of prolonged mechanical ventilation for intensive care unit patients: A cohort study = Predicción de la ventilación mecánica prolongada en pacientes de la unidad de cuidado intensivo: Estudio de cohorte [documento electrónico] / Álvaro Enrique Sanabria Quiroga, . - 2013.
Obra : Colombia Médica
Idioma : Inglés (eng)
Palabras clave : tracheostomy artificial respiration intensive care units ventilator weaning intratracheal intubation risk factors Resumen : Introduction: There are no established guidelines for selecting patients for early tracheostomy. The aim was to determine the factors that could predict the possibility of intubation longer than 7 days in critically ill adult patients. Methods: This is cohort study made at a general intensive care unit. Patients who required at least 48 hours of mechanical ventilation were included. Data on the clinical and physiologic features were collected for every intubated patient on the third day. Uni- and multivariate statistical analyses were conducted to determine the variables associated with extubation. Results: 163 (62%) were male, and the median age was 59±17 years. Almost one-third (36%) of patients required mechanical ventilation longer than 7 days. The variables strongly associated with prolonged mechanical ventilation were: age (HR 0.97 (95% CI 0.96-0.99); diagnosis of surgical emergency in a patient with a medical condition (HR 3.68 (95% CI 1.62-8.35), diagnosis of surgical condition-non emergency (HR 8.17 (95% CI 2.12-31.3); diagnosis of non-surgical-medical condition (HR 5.26 (95% CI 1.85-14.9); APACHE II (HR 0.91 (95% CI 0.85-0.97) and SAPS II score (HR 1.04 (95% CI 1.00-1.09) The area under ROC curve used for prediction was 0.52. 16% of patients were extubated after day 8 of intubation. Conclusions: It was not possible to predict early extubation in critically ill adult patients with invasive mechanical ventilation with common clinical scales used at the ICU. However, the probability of successfully weaning patients from mechanical ventilation without a tracheostomy is low after the eighth day of intubation. Mención de responsabilidad : Alvaro Sanabria, Ximena Gomez, Valentin Vega, Luis Carlos Dominguez, Camilo Osorio DOI (Digital Object Identifier) : 10.25100/cm.v44i3.1285 Derechos de uso : CC BY-NC-ND En línea : https://colombiamedica.univalle.edu.co/index.php/comedica/article/view/1285 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4527 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001026 AC-2013-113 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2013-113.pdfAdobe Acrobat PDF
Título : Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia Otros títulos : Factores clínicos y epidemiológicos asociados con nefritis lúpica en pacientes del noroccidente colombiano Tipo de documento : documento electrónico Autores : Luis Fernando Pinto Peñaranda, Fecha de publicación : 2003 Títulos uniformes : Biomédica Idioma : Inglés (eng) Palabras clave : systemic lupus erythematosus lupus nephritis risk factors autoantibodies hypertension hyperlipidemia Colombia Resumen : A cross-sectional and multicenter study was undertaken to analyze the clinical and immunological characteristics at diagnosis associated with nephritis in northwestern Colombian patients with systemic lupus erythematosus (SLE). Thirty-nine patients with lupus nephritis were included and were compared to 100 SLE patients without nephritis. A multivariate analysis was performed. The patients who developed nephritis had a higher frequency of oral ulcers (41% vs. 21%, OR = 3.1, 95% CI: 1.3-7.5 p = 0.01) and malar erythema (77% vs. 45%, OR = 4.4, 95% CI: 1.8-10.8 p = 0.001). Lupus nephritis was observed in 77% of cases during the first year of the disease. The frequency of anti-DNA antibodies was higher in patients with nephritis, however, differences were not statistically significant (83% vs 64%, OR = 2.6, 95% CI: 1.03-6.41, p = 0.06). The presence of other autoantibodies (anti-Ro, anti-La, anti-RNP, anti-Sm and anticardiolipin) at diagnosis was similar in both groups. This autoantibody profile remained unchanged throughout the evolution of the disease. Patients with lupus nephritis had a higher prevalence of arterial hypertension (60% vs 10%, OR = 13.7, 95% IC: 5-37, p = 0.00001) and hyperlipidemia (30% vs 7%, OR = 8.1, 95% IC: 2.5-27, p = 0.0006) at onset. Finally, patients with lupus nephritis required more hospitalizations (> 1) over the course of disease (89% vs 60%, OR = 7.8, 95% CI: 2.1-29, p = 0.002). In conclusion, lupus nephritis appears early during the course of SLE. Malar erythema, oral ulcers, hypertension and hyperlipidemia at onset of disease are associated factors. Lupus nephritis is a major risk factor leading to repeated hospitalizations. This study may help to assist in public health policies in our population in order to improve patient outcomes while simultaneously reducing disease costs. Mención de responsabilidad : Juan Manuel Anaya, Mauricio Uribe, Adriana Pérez, Juan F. Sánchez, Luis F. Pinto, José F. Molina, María C. Londoño, Martha E. Cadavid, Gustavo Matute Referencia : Biomedica. 2003 Sep;23(3):293-300. DOI (Digital Object Identifier) : 10.7705/biomedica.v23i3.1223 PMID : 14582332 En línea : https://revistabiomedica.org/index.php/biomedica/article/view/1223 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5056 Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia = Factores clínicos y epidemiológicos asociados con nefritis lúpica en pacientes del noroccidente colombiano [documento electrónico] / Luis Fernando Pinto Peñaranda, . - 2003.
Obra : Biomédica
Idioma : Inglés (eng)
Palabras clave : systemic lupus erythematosus lupus nephritis risk factors autoantibodies hypertension hyperlipidemia Colombia Resumen : A cross-sectional and multicenter study was undertaken to analyze the clinical and immunological characteristics at diagnosis associated with nephritis in northwestern Colombian patients with systemic lupus erythematosus (SLE). Thirty-nine patients with lupus nephritis were included and were compared to 100 SLE patients without nephritis. A multivariate analysis was performed. The patients who developed nephritis had a higher frequency of oral ulcers (41% vs. 21%, OR = 3.1, 95% CI: 1.3-7.5 p = 0.01) and malar erythema (77% vs. 45%, OR = 4.4, 95% CI: 1.8-10.8 p = 0.001). Lupus nephritis was observed in 77% of cases during the first year of the disease. The frequency of anti-DNA antibodies was higher in patients with nephritis, however, differences were not statistically significant (83% vs 64%, OR = 2.6, 95% CI: 1.03-6.41, p = 0.06). The presence of other autoantibodies (anti-Ro, anti-La, anti-RNP, anti-Sm and anticardiolipin) at diagnosis was similar in both groups. This autoantibody profile remained unchanged throughout the evolution of the disease. Patients with lupus nephritis had a higher prevalence of arterial hypertension (60% vs 10%, OR = 13.7, 95% IC: 5-37, p = 0.00001) and hyperlipidemia (30% vs 7%, OR = 8.1, 95% IC: 2.5-27, p = 0.0006) at onset. Finally, patients with lupus nephritis required more hospitalizations (> 1) over the course of disease (89% vs 60%, OR = 7.8, 95% CI: 2.1-29, p = 0.002). In conclusion, lupus nephritis appears early during the course of SLE. Malar erythema, oral ulcers, hypertension and hyperlipidemia at onset of disease are associated factors. Lupus nephritis is a major risk factor leading to repeated hospitalizations. This study may help to assist in public health policies in our population in order to improve patient outcomes while simultaneously reducing disease costs. Mención de responsabilidad : Juan Manuel Anaya, Mauricio Uribe, Adriana Pérez, Juan F. Sánchez, Luis F. Pinto, José F. Molina, María C. Londoño, Martha E. Cadavid, Gustavo Matute Referencia : Biomedica. 2003 Sep;23(3):293-300. DOI (Digital Object Identifier) : 10.7705/biomedica.v23i3.1223 PMID : 14582332 En línea : https://revistabiomedica.org/index.php/biomedica/article/view/1223 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5056 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001618 AC-2003-006 Archivo digital Producción Científica Artículos científicos Disponible
