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Gender differences in disease activity and clinical features in newly diagnosed systemic lupus erythematosus patients / Carolina Muñoz Grajales
Título : Gender differences in disease activity and clinical features in newly diagnosed systemic lupus erythematosus patients Tipo de documento : documento electrónico Autores : Carolina Muñoz Grajales, Fecha de publicación : 2016 Títulos uniformes : Lupus Idioma : Inglés (eng) Palabras clave : Systemic lupus erythematosus gender male SLEDAI (Systemic Lupus |Erythematosus Disease Activity Index) Resumen : Objective: The objective of this paper is to compare disease activity and clinical features at diagnosis in male and female patients with systemic lupus erythematosus (SLE). Methods: This was a cross-sectional study in which every male patient (n 1⁄4 40) was matched with three female patients of the same age (5 years) and racial/ethnic group; disease activity as per the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and disease manifestations at the time of diagnosis were compared. Results: Alopecia and anti-Ro antibodies were more frequent in female patients. No statistically significant difference in any other disease characteristics was found. However, male gender was associated with a risk of severe disease activity at the time of diagnosis (as determined by SLEDAI 12 score) independent of age, racial/ethnic group, anti-Ro positivity or time to criteria accrual (OR: 3.11 95% CI, 1.09–8.92; p 1⁄4 0.035). Conclusion: In newly diagnosed SLE patients, male gender is associated with higher disease activity despite the fact that male and female patients seem to experience similaroverall disease manifestations. Mención de responsabilidad : C Muñoz-Grajales, L A González, G S Alarcón, J Acosta-Reyes Referencia : Lupus. 2016 Oct;25(11):1217-23. DOI (Digital Object Identifier) : 10.1177/0961203316635286 PMID : 26921269 En línea : https://journals.sagepub.com/doi/abs/10.1177/0961203316635286 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3987 Gender differences in disease activity and clinical features in newly diagnosed systemic lupus erythematosus patients [documento electrónico] / Carolina Muñoz Grajales, . - 2016.
Obra : Lupus
Idioma : Inglés (eng)
Palabras clave : Systemic lupus erythematosus gender male SLEDAI (Systemic Lupus |Erythematosus Disease Activity Index) Resumen : Objective: The objective of this paper is to compare disease activity and clinical features at diagnosis in male and female patients with systemic lupus erythematosus (SLE). Methods: This was a cross-sectional study in which every male patient (n 1⁄4 40) was matched with three female patients of the same age (5 years) and racial/ethnic group; disease activity as per the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and disease manifestations at the time of diagnosis were compared. Results: Alopecia and anti-Ro antibodies were more frequent in female patients. No statistically significant difference in any other disease characteristics was found. However, male gender was associated with a risk of severe disease activity at the time of diagnosis (as determined by SLEDAI 12 score) independent of age, racial/ethnic group, anti-Ro positivity or time to criteria accrual (OR: 3.11 95% CI, 1.09–8.92; p 1⁄4 0.035). Conclusion: In newly diagnosed SLE patients, male gender is associated with higher disease activity despite the fact that male and female patients seem to experience similaroverall disease manifestations. Mención de responsabilidad : C Muñoz-Grajales, L A González, G S Alarcón, J Acosta-Reyes Referencia : Lupus. 2016 Oct;25(11):1217-23. DOI (Digital Object Identifier) : 10.1177/0961203316635286 PMID : 26921269 En línea : https://journals.sagepub.com/doi/abs/10.1177/0961203316635286 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3987 Reserva
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