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Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene / Fabián Alberto Jaimes Barragán
Título : Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2016 Títulos uniformes : International Psychogeriatrics Idioma : Inglés (eng) Palabras clave : Alzheimer’s disease CERAD mild cognitive impairment validity sensitivity Resumen : Background:This study aimed to determine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery total score diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and dementia in familial Alzheimer's disease (FAD) with E280A mutation on presenilin-1 gene (PSEN1). Methods: A cross-sectional study was conducted in a cohort of PSEN1 E280A carriers and non-carriers assessed between January 1995 and February 2013. During the first neuropsychological assessment, 76 were having dementia, 46 had MCI, and 1,576 were asymptomatic. CERAD cut-off points were established for MCI and dementia using a Receiver Operating Characteristics (ROC) analysis, and were further analyzed according to education level in two groups: low education level (eight years or less), and high education level (over eight years). Results: The area under curve–ROC CERAD total score for dementia was 0.994 (95% CI = 0.989–0.999), and that for MCI was 0.862 (95% CI = 0.816–0.908). The dementia diagnosis cut-off point for the low education group was 54, (98.4% sensitivity, 92.6% specificity), and that for the high education group was 67 (100% sensitivity, 94.1% specificity). The MCI diagnosis cut-off point for the low education group was 66 (91.2% sensitivity, 56.4% specificity), and that for the high education group was 72 (91.7% sensitivity, 76.3% specificity). Conclusions: The CERAD total score is a useful screening tool for dementia and MCI in a population at risk of FAD. Mención de responsabilidad : Daniel Camilo Aguirre-Acevedo, Fabian Jaimes-Barragán, Eliana Henao, Victoria Tirado, Claudia Muñoz, Eric M Reiman, Pierre N Tariot, Jessica B Langbaum, Francisco Lopera Referencia : Int Psychogeriatr. 2016 Mar;28(3):503-10. DOI (Digital Object Identifier) : 10.1017/S1041610215001660 PMID : 26478578 En línea : https://www.cambridge.org/core/journals/international-psychogeriatrics/aticle/di [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3996 Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene [documento electrónico] / Fabián Alberto Jaimes Barragán, . - 2016.
Obra : International Psychogeriatrics
Idioma : Inglés (eng)
Palabras clave : Alzheimer’s disease CERAD mild cognitive impairment validity sensitivity Resumen : Background:This study aimed to determine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery total score diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and dementia in familial Alzheimer's disease (FAD) with E280A mutation on presenilin-1 gene (PSEN1). Methods: A cross-sectional study was conducted in a cohort of PSEN1 E280A carriers and non-carriers assessed between January 1995 and February 2013. During the first neuropsychological assessment, 76 were having dementia, 46 had MCI, and 1,576 were asymptomatic. CERAD cut-off points were established for MCI and dementia using a Receiver Operating Characteristics (ROC) analysis, and were further analyzed according to education level in two groups: low education level (eight years or less), and high education level (over eight years). Results: The area under curve–ROC CERAD total score for dementia was 0.994 (95% CI = 0.989–0.999), and that for MCI was 0.862 (95% CI = 0.816–0.908). The dementia diagnosis cut-off point for the low education group was 54, (98.4% sensitivity, 92.6% specificity), and that for the high education group was 67 (100% sensitivity, 94.1% specificity). The MCI diagnosis cut-off point for the low education group was 66 (91.2% sensitivity, 56.4% specificity), and that for the high education group was 72 (91.7% sensitivity, 76.3% specificity). Conclusions: The CERAD total score is a useful screening tool for dementia and MCI in a population at risk of FAD. Mención de responsabilidad : Daniel Camilo Aguirre-Acevedo, Fabian Jaimes-Barragán, Eliana Henao, Victoria Tirado, Claudia Muñoz, Eric M Reiman, Pierre N Tariot, Jessica B Langbaum, Francisco Lopera Referencia : Int Psychogeriatr. 2016 Mar;28(3):503-10. DOI (Digital Object Identifier) : 10.1017/S1041610215001660 PMID : 26478578 En línea : https://www.cambridge.org/core/journals/international-psychogeriatrics/aticle/di [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3996 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000589 AC-2016-064 Archivo digital Producción Científica Artículos científicos Disponible Validation of Thwaites Index for diagnosing tuberculous meningitis in a Colombian population / Andrés Franco Chica
Título : Validation of Thwaites Index for diagnosing tuberculous meningitis in a Colombian population Tipo de documento : documento electrónico Autores : Andrés Franco Chica, Fecha de publicación : 2016 Títulos uniformes : Journal of the Neurological Sciences Idioma : Inglés (eng) Palabras clave : Meningeal tuberculosis bacterial meningitis diagnosis sensitivity specificity ROC curve Resumen : Objective: To determine the diagnostic accuracy of Thwaites Index (TI) in a Colombian population to distinguish meningeal tuberculosis (MTB) from bacterial meningitis (BM) and from non-tuberculous meningitis. Exploratory analyses were conducted to assess the TI's validity for patients with human immunodeficiency virus (HIV) and children above six-years-old. Methods: The study included 527 patients, the TI was calculated and results compared with those of a reference standard established by expert neurologists. Sensitivity, specificity, area under the curve of receiver-operator characteristics (AUC-ROC) and likelihood ratios were calculated. Results: The AUC-ROC to distinguish MTB from non-tuberculous meningitis was 0.72 (95% CI: 0.67–0.77) for HIV negative adults. AUC-ROC was 0.62 (95% CI: 0.50–0.74) for HIV positive adults and 0.83 (95% CI: 0.68–0.97) for children. For distinguishing MTB from BM the AUC-ROC was 0.78 (95% CI: 0.73–0.83); furthermore, the AUC-ROC was 0.57 (95% CI: 0.31–0.83) for HIV positive adults and 0.86 (95% CI: 0.73–0.99) for children. Conclusion: The TI was sensitive but not specific when used to distinguish MTB from BM in HIV negative adults. In HIV positive adults the index had low diagnostic accuracy. Moreover, the TI showed discrimination capability for children over 6 years; however, research with larger samples is required in these. Mención de responsabilidad : Juan Sebastián Saavedra, Sebastián Urrego, María Eugenia Toro, Carlos Santiago Uribe, Jenny García, Olga Hernández, Juan Carlos Arango, Ángela Beatriz Pérez, Andrés Franco, Isabel Cristina Vélez, Helena Del Corral Referencia : J Neurol Sci. 2016 15;370:112-118. DOI (Digital Object Identifier) : 10.1016/j.jns.2016.09.007 PMID : 27772738 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(16)30562-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3973 Validation of Thwaites Index for diagnosing tuberculous meningitis in a Colombian population [documento electrónico] / Andrés Franco Chica, . - 2016.
Obra : Journal of the Neurological Sciences
Idioma : Inglés (eng)
Palabras clave : Meningeal tuberculosis bacterial meningitis diagnosis sensitivity specificity ROC curve Resumen : Objective: To determine the diagnostic accuracy of Thwaites Index (TI) in a Colombian population to distinguish meningeal tuberculosis (MTB) from bacterial meningitis (BM) and from non-tuberculous meningitis. Exploratory analyses were conducted to assess the TI's validity for patients with human immunodeficiency virus (HIV) and children above six-years-old. Methods: The study included 527 patients, the TI was calculated and results compared with those of a reference standard established by expert neurologists. Sensitivity, specificity, area under the curve of receiver-operator characteristics (AUC-ROC) and likelihood ratios were calculated. Results: The AUC-ROC to distinguish MTB from non-tuberculous meningitis was 0.72 (95% CI: 0.67–0.77) for HIV negative adults. AUC-ROC was 0.62 (95% CI: 0.50–0.74) for HIV positive adults and 0.83 (95% CI: 0.68–0.97) for children. For distinguishing MTB from BM the AUC-ROC was 0.78 (95% CI: 0.73–0.83); furthermore, the AUC-ROC was 0.57 (95% CI: 0.31–0.83) for HIV positive adults and 0.86 (95% CI: 0.73–0.99) for children. Conclusion: The TI was sensitive but not specific when used to distinguish MTB from BM in HIV negative adults. In HIV positive adults the index had low diagnostic accuracy. Moreover, the TI showed discrimination capability for children over 6 years; however, research with larger samples is required in these. Mención de responsabilidad : Juan Sebastián Saavedra, Sebastián Urrego, María Eugenia Toro, Carlos Santiago Uribe, Jenny García, Olga Hernández, Juan Carlos Arango, Ángela Beatriz Pérez, Andrés Franco, Isabel Cristina Vélez, Helena Del Corral Referencia : J Neurol Sci. 2016 15;370:112-118. DOI (Digital Object Identifier) : 10.1016/j.jns.2016.09.007 PMID : 27772738 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(16)30562-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3973 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000564 AC-2016-039 Archivo digital Producción Científica Artículos científicos Disponible A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis / Gisela de la Rosa Echavez ; Clara María Arango Toro ; Carlos Ignacio Gómez Roldán ; Fabián Alberto Jaimes Barragán
Título : A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis Tipo de documento : documento electrónico Autores : Gisela de la Rosa Echavez, ; Clara María Arango Toro, ; Carlos Ignacio Gómez Roldán, ; Fabián Alberto Jaimes Barragán, Fecha de publicación : 2013 Títulos uniformes : BMC Anesthesiology Idioma : Inglés (eng) Palabras clave : Sensitivity specificity sepsis latent class C-reactive protein procalcitonin D-dimer Resumen : Background: Given the acknowledged problems in sepsis diagnosis, we use a novel way with the application of the latent class analysis (LCA) to determine the operative characteristics of C-reactive protein (CRP), D-dimer (DD) and Procalcitonin (PCT) as diagnostic tests for sepsis in patients admitted to hospital care with a presumptive infection. Methods: Cross-sectional study to determine the diagnostic accuracy of three biological markers against the gold standard of clinical definition of sepsis provided by an expert committee, and also against the likelihood of sepsis according to LCA. Patients were recruited in the emergency room within 24 hours of hospitalization and were follow-up daily until discharge. Results: Among 765 patients, the expert committee classified 505 patients (66%) with sepsis, 112 (15%) with infection but without sepsis and 148 (19%) without infection. The best cut-offs points for CRP, DD, and PCT were 7.8 mg/dl, 1616 ng/ml and 0.3 ng/ml, respectively; but, neither sensitivity nor specificity reach 70% for any biomarker. The LCA analysis with the same three tests identified a “cluster” of 187 patients with several characteristics suggesting a more severe condition as well as better microbiological confirmation. Assuming this subset of patients as the new prevalence of sepsis, the ROC curve analysis identified new cut-off points for the tests and suggesting a better discriminatory ability for PCT with a value of 2 ng/ml. Conclusions: Under a “classical” definition of sepsis three typical biomarkers (CRP, PCT and DD) are not capable enough to differentiate septic from non-septic patients in the ER. However, a higher level of PCT discriminates a selected group of patients with severe sepsis. Mención de responsabilidad : Fabián A Jaimes, Gisela D De La Rosa, Marta L Valencia, Clara M Arango, Carlos I Gomez, Alex Garcia, Sigifredo Ospina, Susana C Osorno, Adriana I Henao Referencia : BMC Anesthesiol. 2013 Sep 19;13(1):23. DOI (Digital Object Identifier) : 10.1186/1471-2253-13-23 PMID : 24050481 Derechos de uso : CC BY En línea : https://bmcanesthesiol.biomedcentral.com/articles/10.1186/1471-2253-13-23#Abs1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3689 A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis [documento electrónico] / Gisela de la Rosa Echavez, ; Clara María Arango Toro, ; Carlos Ignacio Gómez Roldán, ; Fabián Alberto Jaimes Barragán, . - 2013.
Obra : BMC Anesthesiology
Idioma : Inglés (eng)
Palabras clave : Sensitivity specificity sepsis latent class C-reactive protein procalcitonin D-dimer Resumen : Background: Given the acknowledged problems in sepsis diagnosis, we use a novel way with the application of the latent class analysis (LCA) to determine the operative characteristics of C-reactive protein (CRP), D-dimer (DD) and Procalcitonin (PCT) as diagnostic tests for sepsis in patients admitted to hospital care with a presumptive infection. Methods: Cross-sectional study to determine the diagnostic accuracy of three biological markers against the gold standard of clinical definition of sepsis provided by an expert committee, and also against the likelihood of sepsis according to LCA. Patients were recruited in the emergency room within 24 hours of hospitalization and were follow-up daily until discharge. Results: Among 765 patients, the expert committee classified 505 patients (66%) with sepsis, 112 (15%) with infection but without sepsis and 148 (19%) without infection. The best cut-offs points for CRP, DD, and PCT were 7.8 mg/dl, 1616 ng/ml and 0.3 ng/ml, respectively; but, neither sensitivity nor specificity reach 70% for any biomarker. The LCA analysis with the same three tests identified a “cluster” of 187 patients with several characteristics suggesting a more severe condition as well as better microbiological confirmation. Assuming this subset of patients as the new prevalence of sepsis, the ROC curve analysis identified new cut-off points for the tests and suggesting a better discriminatory ability for PCT with a value of 2 ng/ml. Conclusions: Under a “classical” definition of sepsis three typical biomarkers (CRP, PCT and DD) are not capable enough to differentiate septic from non-septic patients in the ER. However, a higher level of PCT discriminates a selected group of patients with severe sepsis. Mención de responsabilidad : Fabián A Jaimes, Gisela D De La Rosa, Marta L Valencia, Clara M Arango, Carlos I Gomez, Alex Garcia, Sigifredo Ospina, Susana C Osorno, Adriana I Henao Referencia : BMC Anesthesiol. 2013 Sep 19;13(1):23. DOI (Digital Object Identifier) : 10.1186/1471-2253-13-23 PMID : 24050481 Derechos de uso : CC BY En línea : https://bmcanesthesiol.biomedcentral.com/articles/10.1186/1471-2253-13-23#Abs1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3689 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000262 AC-2013-030 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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