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Enlace permanente de la investigaciónEarly stimulated thyroglobulin after thyroidectomy for thyroid cancer predicts pre-radioiodine therapy thyroglobulin values / Julio Andrés Valencia Ferro
Título : Early stimulated thyroglobulin after thyroidectomy for thyroid cancer predicts pre-radioiodine therapy thyroglobulin values Tipo de documento : documento electrónico Autores : Julio Andrés Valencia Ferro, Fecha de publicación : 2022 Títulos uniformes : Minerva Endocrinology Idioma : Inglés (eng) Palabras clave : Thyroid neoplasms Thyroglobulin Thyroidectomy Resumen : Introduction: Follow-up of patients who undergo a total thyroidectomy is performed with thyroglobulin (Tg), and anti-thyroglobulin antibodies (AbTg). The objective of RAI adjuvant therapy is to negativize Tg to undetectable levels to ease the follow-up. The objective of this study was to evaluate the correlation of serum Tg values measured 2 weeks after surgery with the Tg value prior to RAI adjuvant therapy in order to define its utility as a reliable predictor of pre-therapy Tg and as a potential predictor to avoid RAI adjuvant therapy. Methods: Retrospective analysis of a cohort recruited prospectively. Adult patients with thyroid carcinoma who underwent total thyroidectomy and classified as intermediate or high risk by ATA guidelines. All patients were left without levothyroxine support after surgery and for at least two weeks. We measured biochemical markers two-four weeks after thyroidectomy and before and after RAI. Results: We included 75 patients. Thirty-three (44.0%) patients were classified as ATA high risk. In the post-RAI scan, only 1 (1.3%) showed distant metastases. The comparison between early post-operative and pre-therapy Tg values showed that Tg decreased or remained stable at postoperative levels in 75 patients (100%). Conclusions: Postoperative Tg measurements are a reliable marker of pretherapy Tg levels in patients with intermediate- and high-risk thyroid carcinoma who are candidates for RAI adjuvant therapy. These results need correlation with outcomes and response to therapy in high-risk patients. Mención de responsabilidad : Julio Valencia, Jorge Jiménez, Alvaro Sanabria Referencia : Minerva Endocrinol (Torino). 2022 Jul 13. DOI (Digital Object Identifier) : 10.23736/S2724-6507.22.03813-1 PMID : 35822431 En línea : https://www.minervamedica.it/en/journals/minerva-endocrinology/article.php?cod=R [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6059 Early stimulated thyroglobulin after thyroidectomy for thyroid cancer predicts pre-radioiodine therapy thyroglobulin values [documento electrónico] / Julio Andrés Valencia Ferro, . - 2022.
Obra : Minerva Endocrinology
Idioma : Inglés (eng)
Palabras clave : Thyroid neoplasms Thyroglobulin Thyroidectomy Resumen : Introduction: Follow-up of patients who undergo a total thyroidectomy is performed with thyroglobulin (Tg), and anti-thyroglobulin antibodies (AbTg). The objective of RAI adjuvant therapy is to negativize Tg to undetectable levels to ease the follow-up. The objective of this study was to evaluate the correlation of serum Tg values measured 2 weeks after surgery with the Tg value prior to RAI adjuvant therapy in order to define its utility as a reliable predictor of pre-therapy Tg and as a potential predictor to avoid RAI adjuvant therapy. Methods: Retrospective analysis of a cohort recruited prospectively. Adult patients with thyroid carcinoma who underwent total thyroidectomy and classified as intermediate or high risk by ATA guidelines. All patients were left without levothyroxine support after surgery and for at least two weeks. We measured biochemical markers two-four weeks after thyroidectomy and before and after RAI. Results: We included 75 patients. Thirty-three (44.0%) patients were classified as ATA high risk. In the post-RAI scan, only 1 (1.3%) showed distant metastases. The comparison between early post-operative and pre-therapy Tg values showed that Tg decreased or remained stable at postoperative levels in 75 patients (100%). Conclusions: Postoperative Tg measurements are a reliable marker of pretherapy Tg levels in patients with intermediate- and high-risk thyroid carcinoma who are candidates for RAI adjuvant therapy. These results need correlation with outcomes and response to therapy in high-risk patients. Mención de responsabilidad : Julio Valencia, Jorge Jiménez, Alvaro Sanabria Referencia : Minerva Endocrinol (Torino). 2022 Jul 13. DOI (Digital Object Identifier) : 10.23736/S2724-6507.22.03813-1 PMID : 35822431 En línea : https://www.minervamedica.it/en/journals/minerva-endocrinology/article.php?cod=R [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6059 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001903 AC-2022-067 Archivo digital Producción Científica Artículos científicos Disponible
Título : Chyle fistula in advanced and metastatic thyroid cancer Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, Fecha de publicación : 2017 Títulos uniformes : Gland Surgery Idioma : Inglés (eng) Palabras clave : Thyroid thyroidectomy morbidity chyle fistula (CF) management Resumen : Background: Chyle fistula (CF) is a rare but challenging condition for the surgeon and the patient’s health. Methods: A retrospective review of single surgeon’s case load in a 12-year period is presented, reviewing the case of those patients presenting with a CF. Results: Three patients were found during this study period from more than 1,050 surgeries performed due to thyroid cancer. Patients underwent extensive lymph node dissection for advanced, metastatic and infiltrative disease. In all patients, a long hospital stay and surgical re-interventions were required. Conclusions: A description of the management of CF is presented along with a review of current Literature. Mención de responsabilidad : Carlos S Duque, Juan Guillermo Sánchez, Gianlorenzo Dionigi Referencia : Gland Surg. 2017 Oct;6(5):437-442. DOI (Digital Object Identifier) : 10.21037/gs.2017.07.13 PMID : 29142832 En línea : http://gs.amegroups.com/article/view/16331/17412 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4074 Chyle fistula in advanced and metastatic thyroid cancer [documento electrónico] / Carlos Simón Duque Fisher, . - 2017.
Obra : Gland Surgery
Idioma : Inglés (eng)
Palabras clave : Thyroid thyroidectomy morbidity chyle fistula (CF) management Resumen : Background: Chyle fistula (CF) is a rare but challenging condition for the surgeon and the patient’s health. Methods: A retrospective review of single surgeon’s case load in a 12-year period is presented, reviewing the case of those patients presenting with a CF. Results: Three patients were found during this study period from more than 1,050 surgeries performed due to thyroid cancer. Patients underwent extensive lymph node dissection for advanced, metastatic and infiltrative disease. In all patients, a long hospital stay and surgical re-interventions were required. Conclusions: A description of the management of CF is presented along with a review of current Literature. Mención de responsabilidad : Carlos S Duque, Juan Guillermo Sánchez, Gianlorenzo Dionigi Referencia : Gland Surg. 2017 Oct;6(5):437-442. DOI (Digital Object Identifier) : 10.21037/gs.2017.07.13 PMID : 29142832 En línea : http://gs.amegroups.com/article/view/16331/17412 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4074 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000682 AC-2017-071 Archivo digital Producción Científica Artículos científicos Disponible
Título : Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy Tipo de documento : documento electrónico Autores : Álvaro Enrique Sanabria Quiroga, Fecha de publicación : 2015 Títulos uniformes : Biomédica Idioma : Inglés (eng) Palabras clave : Thyroid gland thyroidectomy cost-benefit analysis meta-analysis Resumen : Introduction: Thyroidectomy is a common surgery. Routine searching of the recurrent laryngeal nerve is the most important strategy to avoid palsy. Neuromonitoring has been recommended to decrease recurrent laryngeal nerve palsy. Objective: To assess if neuromonitoring of recurrent laryngeal nerve during thyroidectomy is cost-effective in a developing country. Materials and methods: We designed a decision analysis to assess the cost-effectiveness of recurrent laryngeal nerve neuromonitoring. For probabilities, we used data from a meta-analysis. Utility was measured using preference values. We considered direct costs. We conducted a deterministic and a probabilistic analysis. Results: We did not find differences in utility between arms. The frequency of recurrent laryngeal nerve injury was 1% in the neuromonitor group and 1.6% for the standard group. Thyroidectomy without monitoring was the less expensive alternative. The incremental cost-effectiveness ratio was COP$ 9,112,065. Conclusion: Routine neuromonitoring in total thyroidectomy with low risk of recurrent laryngeal nerve injury is neither cost-useful nor cost-effective in the Colombian health system. Mención de responsabilidad : Álvaro Sanabria, Adonis Ramírez Referencia : Biomedica. 2015 Jul-Sep;35(3):363-71. DOI (Digital Object Identifier) : 10.7705/biomedica.v35i3.2371 PMID : 26849698 En línea : https://www.revistabiomedica.org/index.php/biomedica/article/view/2371 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3929 Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy [documento electrónico] / Álvaro Enrique Sanabria Quiroga, . - 2015.
Obra : Biomédica
Idioma : Inglés (eng)
Palabras clave : Thyroid gland thyroidectomy cost-benefit analysis meta-analysis Resumen : Introduction: Thyroidectomy is a common surgery. Routine searching of the recurrent laryngeal nerve is the most important strategy to avoid palsy. Neuromonitoring has been recommended to decrease recurrent laryngeal nerve palsy. Objective: To assess if neuromonitoring of recurrent laryngeal nerve during thyroidectomy is cost-effective in a developing country. Materials and methods: We designed a decision analysis to assess the cost-effectiveness of recurrent laryngeal nerve neuromonitoring. For probabilities, we used data from a meta-analysis. Utility was measured using preference values. We considered direct costs. We conducted a deterministic and a probabilistic analysis. Results: We did not find differences in utility between arms. The frequency of recurrent laryngeal nerve injury was 1% in the neuromonitor group and 1.6% for the standard group. Thyroidectomy without monitoring was the less expensive alternative. The incremental cost-effectiveness ratio was COP$ 9,112,065. Conclusion: Routine neuromonitoring in total thyroidectomy with low risk of recurrent laryngeal nerve injury is neither cost-useful nor cost-effective in the Colombian health system. Mención de responsabilidad : Álvaro Sanabria, Adonis Ramírez Referencia : Biomedica. 2015 Jul-Sep;35(3):363-71. DOI (Digital Object Identifier) : 10.7705/biomedica.v35i3.2371 PMID : 26849698 En línea : https://www.revistabiomedica.org/index.php/biomedica/article/view/2371 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3929 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000513 AC-2015-066 Archivo digital Producción Científica Artículos científicos Disponible
Título : Total thyroidectomy versus hemithyroidectomy for patients with follicular neoplasm. A cost-utility analysis Tipo de documento : documento electrónico Autores : Álvaro Enrique Sanabria Quiroga, Fecha de publicación : 2014 Títulos uniformes : International Journal of Surgery Idioma : Inglés (eng) Palabras clave : Thyroidectomy thyroid cancer goiter cost-benefit Resumen : Introduction:Thyroid nodules are a common condition. Overall, 20% of the nodules assessed with FNAB correspond to the follicular pattern. A partial thyroidectomy is the minimal procedure that should be performed to determine the nature of these nodules. Some authors have suggested performing a total thyroidectomy based on the elimination of reoperation and ultrasound follow-up. The aim of this study was to evaluate the most cost-useful surgical strategy in a patient with an undetermined nodule, assessing complications, reoperation, recurrence and costs. Material and methods: A cost-utility study was designed to compare hemithyroidectomy and total thyroidectomy. The outcomes were complications (definitive RLN palsy, permanent hypoparathyroidism, reoperation for cancer, and recurrence of the disease), direct costs and utility. We used the payer perspective at 5 years. A deterministic and probabilistic sensitivity analysis was completed. Results: In a deterministic analysis, the cost, utility and cost-utility ratio was COP $12.981.801, 44.5 and COP $291.310 for total thyroidectomy and COP $14.309.889, 42.0 and $340.044 for partial thyroidectomy, respectively. The incremental cost-utility ratio was −$535.302 favoring total thyroidectomy. Partial thyroidectomy was more cost-effective when the risks of RLN injury and definitive hypoparathyroidism were greater than 8% and 9% in total thyroidectomy, respectively. In total, 46.8% of the simulations for partial thyroidectomy were located in the quadrant of more costly and less effective. Conclusion: Under a common range of complications, and considering the patient's preference and costs, total thyroidectomy should be selected as the most cost-effective treatment for patients with thyroid nodules and follicular patterns. Mención de responsabilidad : C Corso, X Gomez, A Sanabria, V Vega, L C Dominguez, C Osorio Referencia : Int J Surg. 2014;12(8):837-42. DOI (Digital Object Identifier) : 10.1016/j.ijsu.2014.07.005 PMID : 25017947 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1743-9191(14)00202-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3822 Total thyroidectomy versus hemithyroidectomy for patients with follicular neoplasm. A cost-utility analysis [documento electrónico] / Álvaro Enrique Sanabria Quiroga, . - 2014.
Obra : International Journal of Surgery
Idioma : Inglés (eng)
Palabras clave : Thyroidectomy thyroid cancer goiter cost-benefit Resumen : Introduction:Thyroid nodules are a common condition. Overall, 20% of the nodules assessed with FNAB correspond to the follicular pattern. A partial thyroidectomy is the minimal procedure that should be performed to determine the nature of these nodules. Some authors have suggested performing a total thyroidectomy based on the elimination of reoperation and ultrasound follow-up. The aim of this study was to evaluate the most cost-useful surgical strategy in a patient with an undetermined nodule, assessing complications, reoperation, recurrence and costs. Material and methods: A cost-utility study was designed to compare hemithyroidectomy and total thyroidectomy. The outcomes were complications (definitive RLN palsy, permanent hypoparathyroidism, reoperation for cancer, and recurrence of the disease), direct costs and utility. We used the payer perspective at 5 years. A deterministic and probabilistic sensitivity analysis was completed. Results: In a deterministic analysis, the cost, utility and cost-utility ratio was COP $12.981.801, 44.5 and COP $291.310 for total thyroidectomy and COP $14.309.889, 42.0 and $340.044 for partial thyroidectomy, respectively. The incremental cost-utility ratio was −$535.302 favoring total thyroidectomy. Partial thyroidectomy was more cost-effective when the risks of RLN injury and definitive hypoparathyroidism were greater than 8% and 9% in total thyroidectomy, respectively. In total, 46.8% of the simulations for partial thyroidectomy were located in the quadrant of more costly and less effective. Conclusion: Under a common range of complications, and considering the patient's preference and costs, total thyroidectomy should be selected as the most cost-effective treatment for patients with thyroid nodules and follicular patterns. Mención de responsabilidad : C Corso, X Gomez, A Sanabria, V Vega, L C Dominguez, C Osorio Referencia : Int J Surg. 2014;12(8):837-42. DOI (Digital Object Identifier) : 10.1016/j.ijsu.2014.07.005 PMID : 25017947 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1743-9191(14)00202-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3822 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000397 AC-2014-063 Archivo digital Producción Científica Artículos científicos Disponible
Título : Neuromonitoring in thyroidectomy: a meta-analysis of effectiveness from randomized controlled trials Tipo de documento : documento electrónico Autores : Álvaro Enrique Sanabria Quiroga, Fecha de publicación : 2013 Títulos uniformes : European Archives of Oto-rhino-laryngology Idioma : Inglés (eng) Palabras clave : Thyroidectomy laryngeal nerve injuries neuromonitoring meta-analysis systematic review Resumen : Neuromonitoring in thyroid surgery has been employed to make nerve identification easier and decrease the rates of laryngeal nerve injuries. Several individual randomized controlled trials (RCTs) have been published, which did not identify statistical differences in the rates of recurrent laryngeal nerve (RLN) or external branch of the superior laryngeal nerve (EBSLN) injuries. The objective of this report is to perform meta-analysis of the combined results of individual studies to measure the frequency of RLN and EBSLN injuries in patients who underwent thyroidectomy with routine neuromonitoring in comparison with common practice of search and identification. RCTs comparing routine neuromonitoring versus no use in patients who underwent elective partial or total thyroidectomy were evaluated. Outcomes measured were temporary and definitive palsy of the RLN and EBSLN. A systematic review and meta-analysis was done using random effects model. GRADE was used to classify quality of evidence. Six studies with 1,602 patients and 3,064 nerves at risk were identified. Methodological quality assessment showed high risk of bias in most items. Funnel plot did not reveal publication bias. The risk difference for temporary RLN palsy, definitive RLN palsy, temporary EBSLN palsy, and definitive EBSLN palsy were −2 % (95 % confidence interval −5.1 to 1); 0 % (−1 to 1); −9 % (−15 to −2) and −1 % (−4 to 2), respectively. Quality was rated low or very low in most outcomes due to methodological flaws. Meta-analysis did not demonstrate a statistically significant decrease in the risk of temporary or definitive RLN injury and definitive EBSLN injury with the use of neuromonitoring. The neuromonitoring group had a statistically significant decrease in the risk of temporary EBSLN injury. Mención de responsabilidad : Alvaro Sanabria, Adonis Ramirez, Luiz P Kowalski, Carl E Silver, Ashok R Shaha, Randall P Owen, Carlos Suárez, Avi Khafif, Alessandra Rinaldo, Alfio Ferlito Referencia : Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2175-89. DOI (Digital Object Identifier) : 10.1007/s00405-013-2557-2 PMID : 23681545 En línea : https://link.springer.com/article/10.1007%2Fs00405-013-2557-2 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3714 Neuromonitoring in thyroidectomy: a meta-analysis of effectiveness from randomized controlled trials [documento electrónico] / Álvaro Enrique Sanabria Quiroga, . - 2013.
Obra : European Archives of Oto-rhino-laryngology
Idioma : Inglés (eng)
Palabras clave : Thyroidectomy laryngeal nerve injuries neuromonitoring meta-analysis systematic review Resumen : Neuromonitoring in thyroid surgery has been employed to make nerve identification easier and decrease the rates of laryngeal nerve injuries. Several individual randomized controlled trials (RCTs) have been published, which did not identify statistical differences in the rates of recurrent laryngeal nerve (RLN) or external branch of the superior laryngeal nerve (EBSLN) injuries. The objective of this report is to perform meta-analysis of the combined results of individual studies to measure the frequency of RLN and EBSLN injuries in patients who underwent thyroidectomy with routine neuromonitoring in comparison with common practice of search and identification. RCTs comparing routine neuromonitoring versus no use in patients who underwent elective partial or total thyroidectomy were evaluated. Outcomes measured were temporary and definitive palsy of the RLN and EBSLN. A systematic review and meta-analysis was done using random effects model. GRADE was used to classify quality of evidence. Six studies with 1,602 patients and 3,064 nerves at risk were identified. Methodological quality assessment showed high risk of bias in most items. Funnel plot did not reveal publication bias. The risk difference for temporary RLN palsy, definitive RLN palsy, temporary EBSLN palsy, and definitive EBSLN palsy were −2 % (95 % confidence interval −5.1 to 1); 0 % (−1 to 1); −9 % (−15 to −2) and −1 % (−4 to 2), respectively. Quality was rated low or very low in most outcomes due to methodological flaws. Meta-analysis did not demonstrate a statistically significant decrease in the risk of temporary or definitive RLN injury and definitive EBSLN injury with the use of neuromonitoring. The neuromonitoring group had a statistically significant decrease in the risk of temporary EBSLN injury. Mención de responsabilidad : Alvaro Sanabria, Adonis Ramirez, Luiz P Kowalski, Carl E Silver, Ashok R Shaha, Randall P Owen, Carlos Suárez, Avi Khafif, Alessandra Rinaldo, Alfio Ferlito Referencia : Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2175-89. DOI (Digital Object Identifier) : 10.1007/s00405-013-2557-2 PMID : 23681545 En línea : https://link.springer.com/article/10.1007%2Fs00405-013-2557-2 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3714 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000287 AC-2013-055 Archivo digital Producción Científica Artículos científicos Disponible Permalink
