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Microvessel density and VEGF expression in pituitaries of pregnant women / Jorge Hernando Donado Gómez ; Luis Vicente Syro Moreno
Título : Microvessel density and VEGF expression in pituitaries of pregnant women Tipo de documento : documento electrónico Autores : Jorge Hernando Donado Gómez, ; Luis Vicente Syro Moreno, Fecha de publicación : 2013 Títulos uniformes : Hormones Idioma : Inglés (eng) Palabras clave : Angiogenesis Immunohistochemistry Pituitary Pregnancy Vascular endothelial growth factor Resumen : Objective: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprol-actinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of non pregnant women who had no endocrine diseases. Design: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abor- tion or during post-partum were immunostained for CD-34 and VEGF using the streptavidin-biotin-peroxidase complex method. Results: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. Conclusion: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression. Mención de responsabilidad : Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W Scheithauer, Luis V Syro, Jorge H Donado, James E Tarara, Kalman Kovacs Referencia : Hormones. 2013;12(2):292-7. DOI (Digital Object Identifier) : 10.14310/horm.2002.1413 PMID : 23933698 En línea : https://link.springer.com/article/10.14310/horm.2002.1413 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3699 Microvessel density and VEGF expression in pituitaries of pregnant women [documento electrónico] / Jorge Hernando Donado Gómez, ; Luis Vicente Syro Moreno, . - 2013.
Obra : Hormones
Idioma : Inglés (eng)
Palabras clave : Angiogenesis Immunohistochemistry Pituitary Pregnancy Vascular endothelial growth factor Resumen : Objective: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprol-actinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of non pregnant women who had no endocrine diseases. Design: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abor- tion or during post-partum were immunostained for CD-34 and VEGF using the streptavidin-biotin-peroxidase complex method. Results: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. Conclusion: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression. Mención de responsabilidad : Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W Scheithauer, Luis V Syro, Jorge H Donado, James E Tarara, Kalman Kovacs Referencia : Hormones. 2013;12(2):292-7. DOI (Digital Object Identifier) : 10.14310/horm.2002.1413 PMID : 23933698 En línea : https://link.springer.com/article/10.14310/horm.2002.1413 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3699 Reserva
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