| Título : |
Fatal disseminated infection by Trichosporon asahii under voriconazole therapy in a patient with acute myeloid leukemia: a review of breakthrough infections by Trichosporon spp |
| Tipo de documento : |
documento electrónico |
| Autores : |
Isabel Cristina Ramírez Sánchez, |
| Fecha de publicación : |
2020 |
| Títulos uniformes : |
Mycopathologia
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
Antifungal Breakthrough Fungemia Trichosporon asahii Trichosporonosis Yeast |
| Resumen : |
Introduction: Cases of invasive Trichosporon infections have increasingly emerged; it is now the second leading cause of yeast bloodstream infections after Candida spp., particularly in the immunosuppressed population, where it often causes breakthrough fungemia with high mortality. Methods: We present a case report of a breakthrough Trichosporon asahii infection in a patient with acute myeloid leukemia and review all of the cases of breakthrough Trichosporon spp. infections published in the literature to date. Results: We extracted 68 cases of breakthrough Trichosporon spp. infections, wherein 95.5% patients had hematological malignancy, 61.8% of them occurred in the presence of echinocandins, 22% of triazoles, 13.2% of amphotericin and 3% of other combinations of antifungals. The most prevalent manifestation was fungemia (94%); 82.8% of these were associated with the presence of a central venous catheter. The overall mortality was 68.7%; the patients who survived recovered from the neutropenic event. Conclusions: Invasive trichosporonosis is an acute fatal condition that occurs in immunosuppressed patients, usually under antifungal selective pressure. Typically, neutropenia and its underlying diseases are associated with adverse outcomes. |
| Mención de responsabilidad : |
I Ramírez, D Moncada |
| Referencia : |
Mycopathologia. 2020 Apr;185(2):377-388. |
| DOI (Digital Object Identifier) : |
10.1007/s11046-019-00416-w |
| PMID : |
31853871 |
| En línea : |
http://link.springer.com/10.1007/s11046-019-00416-w |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5078 |
Fatal disseminated infection by Trichosporon asahii under voriconazole therapy in a patient with acute myeloid leukemia: a review of breakthrough infections by Trichosporon spp [documento electrónico] / Isabel Cristina Ramírez Sánchez, . - 2020. Obra : MycopathologiaIdioma : Inglés ( eng) | Palabras clave : |
Antifungal Breakthrough Fungemia Trichosporon asahii Trichosporonosis Yeast |
| Resumen : |
Introduction: Cases of invasive Trichosporon infections have increasingly emerged; it is now the second leading cause of yeast bloodstream infections after Candida spp., particularly in the immunosuppressed population, where it often causes breakthrough fungemia with high mortality. Methods: We present a case report of a breakthrough Trichosporon asahii infection in a patient with acute myeloid leukemia and review all of the cases of breakthrough Trichosporon spp. infections published in the literature to date. Results: We extracted 68 cases of breakthrough Trichosporon spp. infections, wherein 95.5% patients had hematological malignancy, 61.8% of them occurred in the presence of echinocandins, 22% of triazoles, 13.2% of amphotericin and 3% of other combinations of antifungals. The most prevalent manifestation was fungemia (94%); 82.8% of these were associated with the presence of a central venous catheter. The overall mortality was 68.7%; the patients who survived recovered from the neutropenic event. Conclusions: Invasive trichosporonosis is an acute fatal condition that occurs in immunosuppressed patients, usually under antifungal selective pressure. Typically, neutropenia and its underlying diseases are associated with adverse outcomes. |
| Mención de responsabilidad : |
I Ramírez, D Moncada |
| Referencia : |
Mycopathologia. 2020 Apr;185(2):377-388. |
| DOI (Digital Object Identifier) : |
10.1007/s11046-019-00416-w |
| PMID : |
31853871 |
| En línea : |
http://link.springer.com/10.1007/s11046-019-00416-w |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5078 |
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