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Acute intrathoracic tuberculosis in children and adolescents with community-acquired pneumonia in an area with an intermediate disease burden / Andrea Victoria Restrepo Gouzy ; Mónica Rosa Trujillo Honeysberg    

Público ISBD Título : Acute intrathoracic tuberculosis in children and adolescents with community-acquired pneumonia in an area with an intermediate disease burden Tipo de documento : documento electrónico Autores : Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Pediatric Reports Idioma : Inglés (eng) Palabras clave : cohort study  children  adolescents  community-acquired pneumonia  intrathoracic tuberculosis  acute tuberculosis Resumen : Tuberculosis (TB) in the pediatric population is a major challenge. Our objective was to describe the clinical and microbiological characteristics, radiological patterns, and treatment outcomes of children and adolescents (from 1 month to 17 years) with community-acquired pneumonia (CAP) caused by TB. We performed a prospective cohort study of a pediatric population between 1 month and 17 years of age and hospitalized in Medellín, Colombia, with the diagnosis of radiologically confirmed CAP that had ≤ 15 days of symptoms. The mycobacterial culture of induced sputum was used for the bacteriological confirmation; the history of TB contact, a tuberculin skin test, and clinical improvement with treatment were used to identify microbiologically negative TB cases. Among 499 children with CAP, TB was diagnosed in 12 (2.4%), of which 10 had less than 8 days of a cough, 10 had alveolar opacities, 9 were younger than 5 years old, and 2 had close contact with a TB patient. Among the TB cases, 50% (6) had microbiological confirmation, 8 had viral and/or bacterial confirmation, one patient had multidrug-resistant TB, and 10/12 had non-severe pneumonia. In countries with an intermediate TB burden, Mycobacterium tuberculosis should be included in the etiological differential diagnosis (as a cause or coinfection) of both pneumonia and severe CAP in the pediatric population. Mención de responsabilidad : Claudia Roya-Pabón, Andrea Restrepo, Olga Morales, Catalina Arango, María Angélica Maya, Marcela Bermúdez, Lucelly López, Carlos Garcés,Mónica Trujillo, Luisa Fernanda Carmona, Margarita Rosa Giraldo, Lázaro A. Vélez and Zulma Vanessa Rueda Referencia : Pediatr Rep. 2022 Feb 5;14(1):71-80. DOI (Digital Object Identifier) : 10.3390/pediatric14010011 PMID : 35225880 Derechos de uso : CC BY En línea : https://www.mdpi.com/2036-7503/14/1/11 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6007 Acute intrathoracic tuberculosis in children and adolescents with community-acquired pneumonia in an area with an intermediate disease burden [documento electrónico] / Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg,  . - 2022. Obra : Pediatric Reports Idioma : Inglés (eng) Palabras clave : cohort study  children  adolescents  community-acquired pneumonia  intrathoracic tuberculosis  acute tuberculosis Resumen : Tuberculosis (TB) in the pediatric population is a major challenge. Our objective was to describe the clinical and microbiological characteristics, radiological patterns, and treatment outcomes of children and adolescents (from 1 month to 17 years) with community-acquired pneumonia (CAP) caused by TB. We performed a prospective cohort study of a pediatric population between 1 month and 17 years of age and hospitalized in Medellín, Colombia, with the diagnosis of radiologically confirmed CAP that had ≤ 15 days of symptoms. The mycobacterial culture of induced sputum was used for the bacteriological confirmation; the history of TB contact, a tuberculin skin test, and clinical improvement with treatment were used to identify microbiologically negative TB cases. Among 499 children with CAP, TB was diagnosed in 12 (2.4%), of which 10 had less than 8 days of a cough, 10 had alveolar opacities, 9 were younger than 5 years old, and 2 had close contact with a TB patient. Among the TB cases, 50% (6) had microbiological confirmation, 8 had viral and/or bacterial confirmation, one patient had multidrug-resistant TB, and 10/12 had non-severe pneumonia. In countries with an intermediate TB burden, Mycobacterium tuberculosis should be included in the etiological differential diagnosis (as a cause or coinfection) of both pneumonia and severe CAP in the pediatric population. Mención de responsabilidad : Claudia Roya-Pabón, Andrea Restrepo, Olga Morales, Catalina Arango, María Angélica Maya, Marcela Bermúdez, Lucelly López, Carlos Garcés,Mónica Trujillo, Luisa Fernanda Carmona, Margarita Rosa Giraldo, Lázaro A. Vélez and Zulma Vanessa Rueda Referencia : Pediatr Rep. 2022 Feb 5;14(1):71-80. DOI (Digital Object Identifier) : 10.3390/pediatric14010011 PMID : 35225880 Derechos de uso : CC BY En línea : https://www.mdpi.com/2036-7503/14/1/11 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6007

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD001841	AC-2022-013	Archivo digital	Producción Científica	Artículos científicos	Disponible

Documentos electrónicos

AC-2022-013 Adobe Acrobat PDF

Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents / Andrea Victoria Restrepo Gouzy ; Mónica Rosa Trujillo Honeysberg    

Público ISBD Título : Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents Tipo de documento : documento electrónico Autores : Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : International Journal of Infectious Diseases Idioma : Inglés (eng) Palabras clave : Induced sputum  adolescents  children  diagnosis  etiology  pneumonia Resumen : Objectives: This study aimed to evaluate the utility of induced sputum (IS) for the diagnosis of community-acquired pneumonia (CAP) in pediatric population. Methods: This cross-sectional study included pediatric population aged between 1 month and 17 years who were hospitalized with a diagnosis of CAP in 13 hospitals in Colombia, in whom an IS sample was obtained. Gram staining, aerobic bacterial and mycobacterial culture tests, and polymerase chain reaction (PCR) for 6 atypical bacteria and 15 respiratory viruses were performed. We evaluated the quality of IS samples. Results: IS samples were collected in 516 of 525 children included in this study. The median age was 32 months, 38.6% were younger than 2 years, and 40.9% were between 2 and 5 years. Two patients had transient hypoxemia during the procedure. The quality of the IS obtained was good in 48.4% and intermediate in 24.5%. Identification of a respiratory pathogen was achieved with an IS sample (with Gram staining, culture test, and PCR) in 372 of 516 children with CAP. Conclusion: Our study shows that IS is an adequate sample for the diagnosis of CAP in pediatric population that required hospitalization. The procedure was safe, well tolerated, and with better diagnostic yields compared with the rest of the samples obtained. Mención de responsabilidad : Zulma Vanessa Rueda, Marcela Bermúdez, Andrea Restrepo, Carlos Garcés, Olga Morales, Claudia Roya-Pabón, Luisa Fernanda Carmona, Catalina Arango, Jose Luis Albarracín, Lucelly López, Yudy Aguilar, María Angélica Maya, Mónica Trujillo, Ángela Rocio Copete, Cristian Vera, Mariana Herrera, Margarita Rosa Giraldo, Gloria Isabel Niño-Cruz, Lázaro A Vélez Referencia : Int J Infect Dis. 2022 Jan 19;116:348-354. DOI (Digital Object Identifier) : 10.1016/j.ijid.2022.01.026 PMID : 35063681 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(22)00025-X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6010 Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents [documento electrónico] / Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg,  . - 2022. Obra : International Journal of Infectious Diseases Idioma : Inglés (eng) Palabras clave : Induced sputum  adolescents  children  diagnosis  etiology  pneumonia Resumen : Objectives: This study aimed to evaluate the utility of induced sputum (IS) for the diagnosis of community-acquired pneumonia (CAP) in pediatric population. Methods: This cross-sectional study included pediatric population aged between 1 month and 17 years who were hospitalized with a diagnosis of CAP in 13 hospitals in Colombia, in whom an IS sample was obtained. Gram staining, aerobic bacterial and mycobacterial culture tests, and polymerase chain reaction (PCR) for 6 atypical bacteria and 15 respiratory viruses were performed. We evaluated the quality of IS samples. Results: IS samples were collected in 516 of 525 children included in this study. The median age was 32 months, 38.6% were younger than 2 years, and 40.9% were between 2 and 5 years. Two patients had transient hypoxemia during the procedure. The quality of the IS obtained was good in 48.4% and intermediate in 24.5%. Identification of a respiratory pathogen was achieved with an IS sample (with Gram staining, culture test, and PCR) in 372 of 516 children with CAP. Conclusion: Our study shows that IS is an adequate sample for the diagnosis of CAP in pediatric population that required hospitalization. The procedure was safe, well tolerated, and with better diagnostic yields compared with the rest of the samples obtained. Mención de responsabilidad : Zulma Vanessa Rueda, Marcela Bermúdez, Andrea Restrepo, Carlos Garcés, Olga Morales, Claudia Roya-Pabón, Luisa Fernanda Carmona, Catalina Arango, Jose Luis Albarracín, Lucelly López, Yudy Aguilar, María Angélica Maya, Mónica Trujillo, Ángela Rocio Copete, Cristian Vera, Mariana Herrera, Margarita Rosa Giraldo, Gloria Isabel Niño-Cruz, Lázaro A Vélez Referencia : Int J Infect Dis. 2022 Jan 19;116:348-354. DOI (Digital Object Identifier) : 10.1016/j.ijid.2022.01.026 PMID : 35063681 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(22)00025-X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6010

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD001845	AC-2022-016	Archivo digital	Producción Científica	Artículos científicos	Disponible

Documentos electrónicos

AC-2022-016 Adobe Acrobat PDF