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Cost–effectiveness analysis of interventions for prevention of invasive aspergillosis among leukemia patients during hospital construction activities / Marcos Arango Barrientos ; Juan Felipe Combariza Vallejo  

Público ISBD Título : Cost–effectiveness analysis of interventions for prevention of invasive aspergillosis among leukemia patients during hospital construction activities Tipo de documento : documento electrónico Autores : Marcos Arango Barrientos, ; Juan Felipe Combariza Vallejo, Fecha de publicación : 2018 Títulos uniformes : European Journal of Haematology Idioma : Inglés (eng) Palabras clave : Acute lymphoid leukemia  acute myeloid leukemia  aspergillosis  high efficiency particulate absorption filters  hospital design and construction Resumen : Objectives: Invasive Aspergillosis (IA) is a serious problem among hematological patients and it is associated with high mortality. This situation can worsen at times of hospital construction, however there are several preventive measures available. This work aims to define the cost-effectiveness of some of these interventions. Patients and methods: A decision tree model was used, it was divided into four arms according to each 1 of the interventions performed. A cost-effectiveness incremental analysis comparing environmental control measures, high efficiency particulate absorption (HEPA) filter installation and prophylaxis with posaconazole was done.Probabilistic and deterministic sensitivity analyses were also carried out. Results: Among 86 patients with 175 hospitalization episodes, the incidence of IA with environmental protection measures, antifungal prophylaxis and hospitalization in rooms with HEPA filters was 14.4%, 6.3% and 0%, respectively. An Incremental Cost Effectiveness Ratio analysis was performed and it was found that HEPA filtered rooms and environmental protection measures are cost saving interventions when compared with posaconazole prophylaxis (−$2665 vs −$4073 vs $42 531 US dollars, respectively) for IA episode prevented. Conclusion: The isolation of inpatients with acute leukemia during hospital construction periods in HEPA filtered rooms could reduce the incidence of IA and might be a cost-effective prevention strategy. Mención de responsabilidad : Juan F Combariza, Luis F Toro, John J Orozco, Marcos Arango Referencia : Eur J Haematol. 2018 Feb;100(2):140-146. DOI (Digital Object Identifier) : 10.1111/ejh.12991 PMID : 29105850 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/ejh.12991 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4106 Cost–effectiveness analysis of interventions for prevention of invasive aspergillosis among leukemia patients during hospital construction activities [documento electrónico] / Marcos Arango Barrientos, ; Juan Felipe Combariza Vallejo,  . - 2018. Obra : European Journal of Haematology Idioma : Inglés (eng) Palabras clave : Acute lymphoid leukemia  acute myeloid leukemia  aspergillosis  high efficiency particulate absorption filters  hospital design and construction Resumen : Objectives: Invasive Aspergillosis (IA) is a serious problem among hematological patients and it is associated with high mortality. This situation can worsen at times of hospital construction, however there are several preventive measures available. This work aims to define the cost-effectiveness of some of these interventions. Patients and methods: A decision tree model was used, it was divided into four arms according to each 1 of the interventions performed. A cost-effectiveness incremental analysis comparing environmental control measures, high efficiency particulate absorption (HEPA) filter installation and prophylaxis with posaconazole was done.Probabilistic and deterministic sensitivity analyses were also carried out. Results: Among 86 patients with 175 hospitalization episodes, the incidence of IA with environmental protection measures, antifungal prophylaxis and hospitalization in rooms with HEPA filters was 14.4%, 6.3% and 0%, respectively. An Incremental Cost Effectiveness Ratio analysis was performed and it was found that HEPA filtered rooms and environmental protection measures are cost saving interventions when compared with posaconazole prophylaxis (−$2665 vs −$4073 vs $42 531 US dollars, respectively) for IA episode prevented. Conclusion: The isolation of inpatients with acute leukemia during hospital construction periods in HEPA filtered rooms could reduce the incidence of IA and might be a cost-effective prevention strategy. Mención de responsabilidad : Juan F Combariza, Luis F Toro, John J Orozco, Marcos Arango Referencia : Eur J Haematol. 2018 Feb;100(2):140-146. DOI (Digital Object Identifier) : 10.1111/ejh.12991 PMID : 29105850 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/ejh.12991 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4106

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Effectiveness of environmental control measures to decrease the risk of invasive aspergillosis in acute leukaemia patients during hospital building work / Juan Felipe Combariza Vallejo  

Público ISBD Título : Effectiveness of environmental control measures to decrease the risk of invasive aspergillosis in acute leukaemia patients during hospital building work Tipo de documento : documento electrónico Autores : Juan Felipe Combariza Vallejo, Fecha de publicación : 2017 Títulos uniformes : Journal of Hospital Infection Idioma : Inglés (eng) Palabras clave : Aspergillosis  leukaemia  lymphoblastic lymphoma  myeloid  hospital construction Resumen : Background: Invasive aspergillosis (IA) is a significant problem in acute leukaemia patients. Construction work near hospital wards caring for immunocompromised patients is one of the main risk factors for developing invasive pulmonary aspergillosis (IPA). Aim: To assess the impact of environmental control measures used during hospital construction for the prevention of IA in acute leukaemia patients. Methods: A retrospective cohort study was developed to evaluate the IA incidence in acute leukaemia patients with different environmental control measures employed during hospital construction. We used European Organisation for the Research and Treatment of Cancer (EORTC) criterial diagnosis parameters for definition of IA. Findings: A total of 175 episodes of inpatient care were evaluated, 62 of which did not have any environmental control measures (when an outbreak occurred), and 113 that were subject to environmental control measures directed to preventing IA. The study showed an IA incidence of 25.8% for the group without environmental control measures vs 12.4% for those who did receive environmental control measures (P 1⁄4 0.024). The relative risk for IA was 0.595 (95% confidence interval: 0.394e0.897) for the group with environmental control measures. Conclusion: The current study suggests that the implementation of environmental control measures during a hospital construction has a positive impact for prevention of IA in patients hospitalized with acute leukaemia. Mención de responsabilidad : J F Combariza, L F Toro, J J Orozco Referencia : J Hosp Infect. 2017 Aug;96(4):336-341. DOI (Digital Object Identifier) : 10.1016/j.jhin.2017.04.022 PMID : 28545828 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0195-6701(17)30238-4 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4080 Effectiveness of environmental control measures to decrease the risk of invasive aspergillosis in acute leukaemia patients during hospital building work [documento electrónico] / Juan Felipe Combariza Vallejo,  . - 2017. Obra : Journal of Hospital Infection Idioma : Inglés (eng) Palabras clave : Aspergillosis  leukaemia  lymphoblastic lymphoma  myeloid  hospital construction Resumen : Background: Invasive aspergillosis (IA) is a significant problem in acute leukaemia patients. Construction work near hospital wards caring for immunocompromised patients is one of the main risk factors for developing invasive pulmonary aspergillosis (IPA). Aim: To assess the impact of environmental control measures used during hospital construction for the prevention of IA in acute leukaemia patients. Methods: A retrospective cohort study was developed to evaluate the IA incidence in acute leukaemia patients with different environmental control measures employed during hospital construction. We used European Organisation for the Research and Treatment of Cancer (EORTC) criterial diagnosis parameters for definition of IA. Findings: A total of 175 episodes of inpatient care were evaluated, 62 of which did not have any environmental control measures (when an outbreak occurred), and 113 that were subject to environmental control measures directed to preventing IA. The study showed an IA incidence of 25.8% for the group without environmental control measures vs 12.4% for those who did receive environmental control measures (P 1⁄4 0.024). The relative risk for IA was 0.595 (95% confidence interval: 0.394e0.897) for the group with environmental control measures. Conclusion: The current study suggests that the implementation of environmental control measures during a hospital construction has a positive impact for prevention of IA in patients hospitalized with acute leukaemia. Mención de responsabilidad : J F Combariza, L F Toro, J J Orozco Referencia : J Hosp Infect. 2017 Aug;96(4):336-341. DOI (Digital Object Identifier) : 10.1016/j.jhin.2017.04.022 PMID : 28545828 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0195-6701(17)30238-4 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4080

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