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Enlace permanente de la investigaciónClinicopathological relationship in Colombian patients with lupus nephritis / Luis Fernando Pinto Peñaranda
Título : Clinicopathological relationship in Colombian patients with lupus nephritis Otros títulos : Relación clínicopatológica en pacientes colombianos con nefritis lúpica Tipo de documento : documento electrónico Autores : Luis Fernando Pinto Peñaranda, Fecha de publicación : 2017 Títulos uniformes : Revista Colombiana de Reumatología Idioma : Inglés (eng) Palabras clave : Lupus nephritis Systemic lupus erythematosus Biopsy Proteinuria Creatinine Hispanic Americans Resumen : Background: There are several clinical and laboratory features for lupus nephritis diagnosis; however, renal biopsy remains as the gold standard. Different series have tried to establish the relationship between these findings, with conflicting results. Objective: To describe the correlation between clinical and laboratory variables with histological biopsy-proven lupus nephritis. Methods: An analytical cross-sectional study was conducted, between January, 2004 and December, 2012. Qualitative variables were described using absolute and relative frequencies, while quantitative variables were assessed by medians with interquartile range. The relationship with clinical findings was explored using chi-square maximum likelihood test, adjusted standardized residuals, hierarchical Kruskal–Wallis test, homogeneity of variance in data, post hoc Dunn's test, Spearman's correlation coefficient, and Mann–Whitney test. Results: 132 patients were included. Proliferative lupus nephritis was the most frequent (74%). The most common clinical condition was nephritic syndrome (46%); proteinuria was observed in 80%. No relationship was found between clinical syndromes and histological types; only statistically significant differences were observed between proliferative and non-proliferative forms regarding hematuria (72.1 vs. 46.7%; p = 0.012), C3 hypocomplementemia (70.9 vs. 43.3%; p = 0.007), 24-h proteinuria (2560 vs 741 mg; p = 0.001), and serum creatinine (1 vs. 0.77 mg/dL; p = 0.006). We found positive correlations between activity index and serum creatinine values, 24-h proteinuria, C3 hypocomplementemia, along with positive anti-DNA antibodies. Conclusion: There is a clinicopathological relationship within proliferative types and certain laboratory features (hematuria, elevated 24-h protein excretion, serum creatinine level, and C3 hypocomplementemia) in a mestizo population with lupus nephritis; nonetheless, no association was found with any other variables. Mención de responsabilidad : Carlos Jaime Velásquez-Franco, Yerlin Andrés Colina Vargas, Sara Correa Pérez, Felipe Osorio Ospina, Mariana Tamayo Correa, Juliana Madrid Vargas, Aura Ligia Zapata-Castellanos, Libia María Rodríguez Padilla, Luis Fernando Pinto Peñaranda y Miguel Antonio Mesa Navas DOI (Digital Object Identifier) : 10.1016/j.rcreu.2017.10.001 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0121812317301068 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4678 Clinicopathological relationship in Colombian patients with lupus nephritis = Relación clínicopatológica en pacientes colombianos con nefritis lúpica [documento electrónico] / Luis Fernando Pinto Peñaranda, . - 2017.
Obra : Revista Colombiana de Reumatología
Idioma : Inglés (eng)
Palabras clave : Lupus nephritis Systemic lupus erythematosus Biopsy Proteinuria Creatinine Hispanic Americans Resumen : Background: There are several clinical and laboratory features for lupus nephritis diagnosis; however, renal biopsy remains as the gold standard. Different series have tried to establish the relationship between these findings, with conflicting results. Objective: To describe the correlation between clinical and laboratory variables with histological biopsy-proven lupus nephritis. Methods: An analytical cross-sectional study was conducted, between January, 2004 and December, 2012. Qualitative variables were described using absolute and relative frequencies, while quantitative variables were assessed by medians with interquartile range. The relationship with clinical findings was explored using chi-square maximum likelihood test, adjusted standardized residuals, hierarchical Kruskal–Wallis test, homogeneity of variance in data, post hoc Dunn's test, Spearman's correlation coefficient, and Mann–Whitney test. Results: 132 patients were included. Proliferative lupus nephritis was the most frequent (74%). The most common clinical condition was nephritic syndrome (46%); proteinuria was observed in 80%. No relationship was found between clinical syndromes and histological types; only statistically significant differences were observed between proliferative and non-proliferative forms regarding hematuria (72.1 vs. 46.7%; p = 0.012), C3 hypocomplementemia (70.9 vs. 43.3%; p = 0.007), 24-h proteinuria (2560 vs 741 mg; p = 0.001), and serum creatinine (1 vs. 0.77 mg/dL; p = 0.006). We found positive correlations between activity index and serum creatinine values, 24-h proteinuria, C3 hypocomplementemia, along with positive anti-DNA antibodies. Conclusion: There is a clinicopathological relationship within proliferative types and certain laboratory features (hematuria, elevated 24-h protein excretion, serum creatinine level, and C3 hypocomplementemia) in a mestizo population with lupus nephritis; nonetheless, no association was found with any other variables. Mención de responsabilidad : Carlos Jaime Velásquez-Franco, Yerlin Andrés Colina Vargas, Sara Correa Pérez, Felipe Osorio Ospina, Mariana Tamayo Correa, Juliana Madrid Vargas, Aura Ligia Zapata-Castellanos, Libia María Rodríguez Padilla, Luis Fernando Pinto Peñaranda y Miguel Antonio Mesa Navas DOI (Digital Object Identifier) : 10.1016/j.rcreu.2017.10.001 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0121812317301068 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4678 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001158 AC-2017-112 Archivo digital Producción Científica Artículos científicos Disponible
Título : Systematic review of the literature on reproducibility of the interpretation of renal biopsy in lupus nephritis Tipo de documento : documento electrónico Autores : Mauricio Restrepo Escobar, ; Paula Andrea Granda Carvajal, ; Fabián Alberto Jaimes Barragán, Fecha de publicación : 2017 Títulos uniformes : Lupus Idioma : Inglés (eng) Palabras clave : Biopsy nephritis reliability renal lupus reproducibility of results systematic review Resumen : Objective: Before using a test, it should be determined whether the results are reliable. The reliability of the interpretation of renal biopsy in patients with lupus nephritis has not been clearly elucidated. Our objective was to estimate inter and intraobserver reliability of the histological classification, as well as activity and chronicity indices in renal biopsy of patients with lupus nephritis. Methods: We conducted a systematic search of the literature, which included articles in any language, using PubMed, Embase, Cochrane and Lilacs databases. Search terms included were: reproducibility, reliability, agreement, systemic lupus erythematosus and lupus nephritis. Comparative studies with any design were included, regardless of the year or the language of publication. Two investigators, independently, screened the literature published in accordance with pre-established inclusion and exclusion criteria. Results: We found 13 relevant studies. Inter-observer reproducibility of most measurements was moderate or low, despite the fact that, in most cases, the readings were made by expert nephropathologists. There was great diversity among designs, participants, including samples and outcomes evaluated in different studies. Although there are too many reports on the clinical use, studies evaluating the reliability of classifications on renal biopsy in lupus nephritis are rare. The quality of the methodological design and reporting was fair. Conclusion: The interpretation of renal biopsy in lupus nephritis is poorly reproducible, causing serious doubts about its validity and its clinical application. As it can lead to serious diagnosis, treatment and prognosis errors, it is necessary to intensify research in this field. Mención de responsabilidad : M Restrepo-Escobar, P A Granda-Carvajal, F Jaimes Referencia : Lupus. 2017 Dec;26(14):1502-1512. DOI (Digital Object Identifier) : 10.1177/0961203317706556 PMID : 28441914 En línea : https://journals.sagepub.com/doi/abs/10.1177/0961203317706556 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4048 Systematic review of the literature on reproducibility of the interpretation of renal biopsy in lupus nephritis [documento electrónico] / Mauricio Restrepo Escobar, ; Paula Andrea Granda Carvajal, ; Fabián Alberto Jaimes Barragán, . - 2017.
Obra : Lupus
Idioma : Inglés (eng)
Palabras clave : Biopsy nephritis reliability renal lupus reproducibility of results systematic review Resumen : Objective: Before using a test, it should be determined whether the results are reliable. The reliability of the interpretation of renal biopsy in patients with lupus nephritis has not been clearly elucidated. Our objective was to estimate inter and intraobserver reliability of the histological classification, as well as activity and chronicity indices in renal biopsy of patients with lupus nephritis. Methods: We conducted a systematic search of the literature, which included articles in any language, using PubMed, Embase, Cochrane and Lilacs databases. Search terms included were: reproducibility, reliability, agreement, systemic lupus erythematosus and lupus nephritis. Comparative studies with any design were included, regardless of the year or the language of publication. Two investigators, independently, screened the literature published in accordance with pre-established inclusion and exclusion criteria. Results: We found 13 relevant studies. Inter-observer reproducibility of most measurements was moderate or low, despite the fact that, in most cases, the readings were made by expert nephropathologists. There was great diversity among designs, participants, including samples and outcomes evaluated in different studies. Although there are too many reports on the clinical use, studies evaluating the reliability of classifications on renal biopsy in lupus nephritis are rare. The quality of the methodological design and reporting was fair. Conclusion: The interpretation of renal biopsy in lupus nephritis is poorly reproducible, causing serious doubts about its validity and its clinical application. As it can lead to serious diagnosis, treatment and prognosis errors, it is necessary to intensify research in this field. Mención de responsabilidad : M Restrepo-Escobar, P A Granda-Carvajal, F Jaimes Referencia : Lupus. 2017 Dec;26(14):1502-1512. DOI (Digital Object Identifier) : 10.1177/0961203317706556 PMID : 28441914 En línea : https://journals.sagepub.com/doi/abs/10.1177/0961203317706556 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4048 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000648 AC-2017-037 Archivo digital Producción Científica Artículos científicos Disponible
Título : Factors associated with recurrence and survival in liver transplant patients with HCC - a single center retrospective study Tipo de documento : documento electrónico Autores : Sergio Iván Hoyos Duque, ; Carlos Ernesto Guzmán Luna, ; Álvaro Mena Hurtado, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Juan Camilo Pérez Cadavid, Fecha de publicación : 2015 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Cancer liver transplant cirrhosis biopsy Resumen : Introduction: Hepatocellular carcinoma is the most common primary tumor of the liver and is diagnosed in more than a half million people worldwide each year. This study aims to assess factors associated with the recurrence and survival of patients with hepatocellular carcinoma and liver transplantation in a cohort of patients from Medellín, Colombia. Material and methods. This was a descriptive retrospective study of a consecutive series of liver transplant patients from the Pablo Tobon Uribe Hospital of Medellín from January 2004 to May 2013. Demographic, clinical, imaging, and pathology variables were analyzed. Results: Three hundred thirty liver transplants were performed during the study period, 54 cases (16.4%) had one or more hepatocellular carcinomas in the explant, and 79.6% of these patients were men. Cirrhotic patients had different etiologies, but most of them were due to alcohol abuse (22.2%), followed by hepatitis B virus infection (20.4 %), and hepatitis C virus infection (18.5%). In the pathology specimen, 51.9% had only one focus of hepatocellular carcinoma, 22.2% had two foci and 12.9% had three tumors. Recurrence of hepatocellular carcinoma occurred in 7.4% patients with an average time of 81 months. During follow-up, 25.9% of the patients died in an average time of 67.9 months (CI95 59.1-80.1 months). Conclusion: Recurrence and survival of patients with liver transplantation for hepatocellular carcinoma in this study had a similar behavior as that reported in the world literature. The factors associated with these outcomes were vascular invasion, poor tumor differentiation and satellitosis. Mención de responsabilidad : Sergio Hoyos, Jorge Escobar, Doris Cardona, Carlos Guzmán, Álvaro Mena, Germán Osorio, Camilo Pérez, Juan C Restrepo, Gonzalo Correa Referencia : Ann Hepatol. 2015 Jan-Feb;14(1):58-63. PMID : 25536642 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268119308014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3871 Factors associated with recurrence and survival in liver transplant patients with HCC - a single center retrospective study [documento electrónico] / Sergio Iván Hoyos Duque, ; Carlos Ernesto Guzmán Luna, ; Álvaro Mena Hurtado, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Juan Camilo Pérez Cadavid, . - 2015.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Palabras clave : Cancer liver transplant cirrhosis biopsy Resumen : Introduction: Hepatocellular carcinoma is the most common primary tumor of the liver and is diagnosed in more than a half million people worldwide each year. This study aims to assess factors associated with the recurrence and survival of patients with hepatocellular carcinoma and liver transplantation in a cohort of patients from Medellín, Colombia. Material and methods. This was a descriptive retrospective study of a consecutive series of liver transplant patients from the Pablo Tobon Uribe Hospital of Medellín from January 2004 to May 2013. Demographic, clinical, imaging, and pathology variables were analyzed. Results: Three hundred thirty liver transplants were performed during the study period, 54 cases (16.4%) had one or more hepatocellular carcinomas in the explant, and 79.6% of these patients were men. Cirrhotic patients had different etiologies, but most of them were due to alcohol abuse (22.2%), followed by hepatitis B virus infection (20.4 %), and hepatitis C virus infection (18.5%). In the pathology specimen, 51.9% had only one focus of hepatocellular carcinoma, 22.2% had two foci and 12.9% had three tumors. Recurrence of hepatocellular carcinoma occurred in 7.4% patients with an average time of 81 months. During follow-up, 25.9% of the patients died in an average time of 67.9 months (CI95 59.1-80.1 months). Conclusion: Recurrence and survival of patients with liver transplantation for hepatocellular carcinoma in this study had a similar behavior as that reported in the world literature. The factors associated with these outcomes were vascular invasion, poor tumor differentiation and satellitosis. Mención de responsabilidad : Sergio Hoyos, Jorge Escobar, Doris Cardona, Carlos Guzmán, Álvaro Mena, Germán Osorio, Camilo Pérez, Juan C Restrepo, Gonzalo Correa Referencia : Ann Hepatol. 2015 Jan-Feb;14(1):58-63. PMID : 25536642 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268119308014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3871 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000451 AC-2015-004 Archivo digital Producción Científica Artículos científicos Disponible 
Título : The Bethesda system for reporting thyroid cytopathology in Colombia : Correlation with histopathological diagnoses in oncology and non-oncology institutions Tipo de documento : documento electrónico Autores : Álvaro Enrique Sanabria Quiroga, Fecha de publicación : 2015 Títulos uniformes : Journal of Cytology Idioma : Inglés (eng) Palabras clave : Bethesda system biopsy fine needle multicenter study pathology terminology thyroid cytopathology thyroid gland thyroid neoplasms Resumen : Aim: To determine the correlation between the results of thyroid fine-needle aspirations interpreted using the Bethesda system and final histopathological reports for patients at an oncology hospital (OH) and non-oncology hospitals (NOHs).Materials and Methods: A retrospective, cross-sectional, descriptive study was performed to compare the cytology and histopathology results for patients with thyroid nodules in three Colombian hospitals. The final correlation of diagnoses between the two methods is reported. In Colombia, the health system provides the existence of general care hospitals and hospitals specializing in care of patients with cancer.Results: A total of 196 reports were reviewed, of which 53% were from OH and 47% were from NOHs. A greater proportion of category V (37.5%) was diagnosed at the OH, whereas NOHs diagnosed a greater proportion of category II (42.3%). The global correlation between diagnoses made using cytology and histopathology was 93.3% for categories V and VI (based on the final malignant diagnosis) and 86.9% for benign category II. Significant differences between institution types were observed when category IV and V and malignant histopathology were compared (56.3% OH vs. 23.5% NOH; P = 0.05 for category IV, 97.4% OH vs. 82.3% NOH; P = 0.03 for category V), while no significant difference between institution types was observed when category II and final benign diagnosis were compared (P = 0.6).Conclusions: The Bethesda system for thyroid cytology correlates adequately with final histopathological diagnosis in Colombia. Significant differences were identified in the diagnostic correlation for malignant lesions between the OH and NOHs in categories IV and V caused by selection bias of the population. Mención de responsabilidad : Mario Alexander Melo-Uribe, Álvaro Sanabria, Alfredo Romero-Rojas, Gabriel Pérez, Elga Johanna Vargas, María Claudia Abaúnza, Víctor Gutiérrez Referencia : J Cytol. 2015 Jan-Mar;32(1):12-6. DOI (Digital Object Identifier) : 10.4103/0970-9371.155224. PMID : 25948937 Derechos de uso : CC BY-NC-SA En línea : http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=1;spa [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3900 The Bethesda system for reporting thyroid cytopathology in Colombia : Correlation with histopathological diagnoses in oncology and non-oncology institutions [documento electrónico] / Álvaro Enrique Sanabria Quiroga, . - 2015.
Obra : Journal of Cytology
Idioma : Inglés (eng)
Palabras clave : Bethesda system biopsy fine needle multicenter study pathology terminology thyroid cytopathology thyroid gland thyroid neoplasms Resumen : Aim: To determine the correlation between the results of thyroid fine-needle aspirations interpreted using the Bethesda system and final histopathological reports for patients at an oncology hospital (OH) and non-oncology hospitals (NOHs).Materials and Methods: A retrospective, cross-sectional, descriptive study was performed to compare the cytology and histopathology results for patients with thyroid nodules in three Colombian hospitals. The final correlation of diagnoses between the two methods is reported. In Colombia, the health system provides the existence of general care hospitals and hospitals specializing in care of patients with cancer.Results: A total of 196 reports were reviewed, of which 53% were from OH and 47% were from NOHs. A greater proportion of category V (37.5%) was diagnosed at the OH, whereas NOHs diagnosed a greater proportion of category II (42.3%). The global correlation between diagnoses made using cytology and histopathology was 93.3% for categories V and VI (based on the final malignant diagnosis) and 86.9% for benign category II. Significant differences between institution types were observed when category IV and V and malignant histopathology were compared (56.3% OH vs. 23.5% NOH; P = 0.05 for category IV, 97.4% OH vs. 82.3% NOH; P = 0.03 for category V), while no significant difference between institution types was observed when category II and final benign diagnosis were compared (P = 0.6).Conclusions: The Bethesda system for thyroid cytology correlates adequately with final histopathological diagnosis in Colombia. Significant differences were identified in the diagnostic correlation for malignant lesions between the OH and NOHs in categories IV and V caused by selection bias of the population. Mención de responsabilidad : Mario Alexander Melo-Uribe, Álvaro Sanabria, Alfredo Romero-Rojas, Gabriel Pérez, Elga Johanna Vargas, María Claudia Abaúnza, Víctor Gutiérrez Referencia : J Cytol. 2015 Jan-Mar;32(1):12-6. DOI (Digital Object Identifier) : 10.4103/0970-9371.155224. PMID : 25948937 Derechos de uso : CC BY-NC-SA En línea : http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=1;spa [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3900 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000480 AC-2015-033 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2015-033.pdfAdobe Acrobat PDF
Título : Biopsia aspiración con aguja fina (BACAF) en el diagnóstico de endometriosis Otros títulos : Fine-Needle Aspiration Biopsy (FNAB) for the diagnosis of endometriosis Tipo de documento : documento electrónico Autores : Alejandro Vélez Hoyos, Fecha de publicación : 2009 Títulos uniformes : Medicina U.P.B. Idioma : Español (spa) Palabras clave : Endometriosis biopsy fine-needle biopsia con aguja fina Resumen : La Biopsia por Aspiración con Aguja Fina (BACAF) es el método de elección en el diagnóstico de nódulos tiroideos, mamarios, ganglios linfáticos y glándulas salivares. En piel y tejidos blandos ha sido utilizada con poca frecuencia. Presentamos dos casos de endometriosis extrapélvica, localizada en tejidos blandos y pared abdominal. Se trata de dos mujeres con nódulos dolorosos en la pared abdominal y sobre cicatriz de cirugía ginecológica. El diagnóstico se confirmó en una de las pacientes con biopsia excisional, otra recibió tratamiento médico. Mención de responsabilidad : Ángela María Pérez Herrera, Edgar Armando Zapata Jaramillo, Luis Felipe Roldán Zapata,Alejandro Vélez Hoyos Referencia : Med. U.P.B ; 28(2): 142-146, jul.-dic. 2009. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/2139 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4856 Biopsia aspiración con aguja fina (BACAF) en el diagnóstico de endometriosis = Fine-Needle Aspiration Biopsy (FNAB) for the diagnosis of endometriosis [documento electrónico] / Alejandro Vélez Hoyos, . - 2009.
Obra : Medicina U.P.B.
Idioma : Español (spa)
Palabras clave : Endometriosis biopsy fine-needle biopsia con aguja fina Resumen : La Biopsia por Aspiración con Aguja Fina (BACAF) es el método de elección en el diagnóstico de nódulos tiroideos, mamarios, ganglios linfáticos y glándulas salivares. En piel y tejidos blandos ha sido utilizada con poca frecuencia. Presentamos dos casos de endometriosis extrapélvica, localizada en tejidos blandos y pared abdominal. Se trata de dos mujeres con nódulos dolorosos en la pared abdominal y sobre cicatriz de cirugía ginecológica. El diagnóstico se confirmó en una de las pacientes con biopsia excisional, otra recibió tratamiento médico. Mención de responsabilidad : Ángela María Pérez Herrera, Edgar Armando Zapata Jaramillo, Luis Felipe Roldán Zapata,Alejandro Vélez Hoyos Referencia : Med. U.P.B ; 28(2): 142-146, jul.-dic. 2009. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/2139 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4856 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001483 AC-2009-047 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2009-047.pdfAdobe Acrobat PDF
