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Clinical Characteristics of Carbapenem-resistant Klebsiella pneumoniae Infections in Ill and Colonized Children in Colombia / Mónica Rosa Trujillo Honeysberg
Título : Clinical Characteristics of Carbapenem-resistant Klebsiella pneumoniae Infections in Ill and Colonized Children in Colombia Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2016 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Palabras clave : Klebsiella pneumoniae beta-lactamases children carbapenem resistance Medellin Colombia Resumen : Background: Multidrug-resistant Gram-negative infections represent a growing problem and a serious global threat. Data in children are scarce. Klebsiella pneumoniae carbapenemases (KPC) are the most common mechanism of resistance this organism has developed. We report the clinical characteristics and outcomes from a cohort of children infected or colonized with carbapenem-resistant K. pneumoniae (CRKp) at a tertiary care center in Medellín, Colombia. Methods: We performed a retrospective chart review of all pediatric cases from whom CRKp isolates were obtained from 2008 to 2013. Clinical characteristics and outcomes were recorded. Results: A total of 34 infected children (median age, 22.8 months) with 43 episodes and 55 colonized patients (median age, 33 months) were identified. All patients had at least 1 risk factor previously related with multidrug-resistant Gram-negative infections (premorbid conditions, previous exposure to antibiotics, prolonged length of stay and use of indwelling devices). Urinary tract infections, abdominal infections and bacteremia were the most common clinical presentations. Overall mortality was 38%, and it was lower when a meropenem-containing regimen was used. Colistin was the most used antibiotic either alone or in combination and was associated with 8.8% of nephrotoxicity. Conclusion: CRKp infections have high mortality in children and usually occur in children with comorbidities, prolonged hospital stay and prior antibiotic exposure. Combined therapy with meropenem-containing regimens seems to be the best option in severely ill children. Mención de responsabilidad : Alejandro Díaz, Diana Cristina Ortiz, Mónica Trujillo, Carlos Garcés, Fabian Jaimes, Andrea Victoria Restrepo Referencia : Pediatr Infect Dis J. 2016 Mar;35(3):237-41. DOI (Digital Object Identifier) : 10.1097/INF.0000000000000987 PMID : 26569194 En línea : https://journals.lww.com/pidj/Abstract/2016/03000/Clinical_Characteristics_of_Ca [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3994 Clinical Characteristics of Carbapenem-resistant Klebsiella pneumoniae Infections in Ill and Colonized Children in Colombia [documento electrónico] / Mónica Rosa Trujillo Honeysberg, . - 2016.
Obra : Pediatric Infectious Disease Journal
Idioma : Inglés (eng)
Palabras clave : Klebsiella pneumoniae beta-lactamases children carbapenem resistance Medellin Colombia Resumen : Background: Multidrug-resistant Gram-negative infections represent a growing problem and a serious global threat. Data in children are scarce. Klebsiella pneumoniae carbapenemases (KPC) are the most common mechanism of resistance this organism has developed. We report the clinical characteristics and outcomes from a cohort of children infected or colonized with carbapenem-resistant K. pneumoniae (CRKp) at a tertiary care center in Medellín, Colombia. Methods: We performed a retrospective chart review of all pediatric cases from whom CRKp isolates were obtained from 2008 to 2013. Clinical characteristics and outcomes were recorded. Results: A total of 34 infected children (median age, 22.8 months) with 43 episodes and 55 colonized patients (median age, 33 months) were identified. All patients had at least 1 risk factor previously related with multidrug-resistant Gram-negative infections (premorbid conditions, previous exposure to antibiotics, prolonged length of stay and use of indwelling devices). Urinary tract infections, abdominal infections and bacteremia were the most common clinical presentations. Overall mortality was 38%, and it was lower when a meropenem-containing regimen was used. Colistin was the most used antibiotic either alone or in combination and was associated with 8.8% of nephrotoxicity. Conclusion: CRKp infections have high mortality in children and usually occur in children with comorbidities, prolonged hospital stay and prior antibiotic exposure. Combined therapy with meropenem-containing regimens seems to be the best option in severely ill children. Mención de responsabilidad : Alejandro Díaz, Diana Cristina Ortiz, Mónica Trujillo, Carlos Garcés, Fabian Jaimes, Andrea Victoria Restrepo Referencia : Pediatr Infect Dis J. 2016 Mar;35(3):237-41. DOI (Digital Object Identifier) : 10.1097/INF.0000000000000987 PMID : 26569194 En línea : https://journals.lww.com/pidj/Abstract/2016/03000/Clinical_Characteristics_of_Ca [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3994 Reserva
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