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Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease / Sergio Álvarez Vallejo ; Martín Ochoa Escudero
Título : Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Autosomal dominant Alzheimer’s disease CADASIL cardiovascular risk factors cerebral small vessel disease cognition magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5872 Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, . - 2021.
Obra : Journal of Alzheimer's Disease
Idioma : Inglés (eng)
Palabras clave : Autosomal dominant Alzheimer’s disease CADASIL cardiovascular risk factors cerebral small vessel disease cognition magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5872 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001810 AC-2021-122 Archivo digital Producción Científica Artículos científicos Disponible One year follow-up of the cardio-metabolic profile evolution in renal transplant patients treated with alemtuzumab, cyclosporine, and steroids in a reference hospital in Colombia / John Fredy Nieto Ríos ; Catalina Ocampo Kohn ; Lina Maria Serna Higuita ; Arbey Aristizabal Álzate ; Harry Abadía Guzmán
Título : One year follow-up of the cardio-metabolic profile evolution in renal transplant patients treated with alemtuzumab, cyclosporine, and steroids in a reference hospital in Colombia Otros títulos : Seguimiento por un año de la evolución del perfil cardiometabólico en pacientes trasplantados renales tratados con alemtuzumab, ciclosporina y esteroides en un hospital de referencia en Colombia Tipo de documento : documento electrónico Autores : John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Lina Maria Serna Higuita, ; Arbey Aristizabal Álzate, ; Harry Abadía Guzmán, Fecha de publicación : 2015 Títulos uniformes : Iatreia Idioma : Inglés (eng) Palabras clave : Cardiovascular disease cardiovascular risk factors Renal Transplantation Resumen : Introduction: Cardiovascular events occur 50 times more often in kidney transplant patients than in the general population and are the leading cause of death. The aim of the study was to evaluate the behavior of cardio-metabolic profile and determine the incidence of major cardiovascular events in the first year after transplantation. Methods: This prospective study evaluated the behavior of cardio-metabolic profile in adult patients that were transplanted during 2011. Results: The median age was 44.3 ± 12.05 years, 68.7 % were men and 95.5 %, hypertensive. Alemtuzumab-cyclosporine and steroids were used in 89.6 %, delaying the introduction of the antimetabolite. In the first year after transplantation there were three cases of diabetes mellitus, three major cardiovascular events, and 12 cases of acute rejection. Albumin, hemoglobin, weight, body mass index (BMI), calcium and HbA1C increased (p Mención de responsabilidad : John Fredy Nieto-Ríos, Narly Viviana Gómez-Rueda, Lina María Serna-Higuita, Catalina Ocampo-Kohn, Arbey Aristizábal-Alzate,Harry Abadía-Guzmán, Carlos Enrique Yepes-Delgado, Gustavo Zuluaga-Valencia Referencia : Iatreia. 2015;28(4):378-87. DOI (Digital Object Identifier) : 10.17533/udea.iatreia.v28n4a04 Derechos de uso : CC BY-NC-SA En línea : https://revistas.udea.edu.co/index.php/iatreia/article/view/19976 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3914 One year follow-up of the cardio-metabolic profile evolution in renal transplant patients treated with alemtuzumab, cyclosporine, and steroids in a reference hospital in Colombia = Seguimiento por un año de la evolución del perfil cardiometabólico en pacientes trasplantados renales tratados con alemtuzumab, ciclosporina y esteroides en un hospital de referencia en Colombia [documento electrónico] / John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Lina Maria Serna Higuita, ; Arbey Aristizabal Álzate, ; Harry Abadía Guzmán, . - 2015.
Obra : Iatreia
Idioma : Inglés (eng)
Palabras clave : Cardiovascular disease cardiovascular risk factors Renal Transplantation Resumen : Introduction: Cardiovascular events occur 50 times more often in kidney transplant patients than in the general population and are the leading cause of death. The aim of the study was to evaluate the behavior of cardio-metabolic profile and determine the incidence of major cardiovascular events in the first year after transplantation. Methods: This prospective study evaluated the behavior of cardio-metabolic profile in adult patients that were transplanted during 2011. Results: The median age was 44.3 ± 12.05 years, 68.7 % were men and 95.5 %, hypertensive. Alemtuzumab-cyclosporine and steroids were used in 89.6 %, delaying the introduction of the antimetabolite. In the first year after transplantation there were three cases of diabetes mellitus, three major cardiovascular events, and 12 cases of acute rejection. Albumin, hemoglobin, weight, body mass index (BMI), calcium and HbA1C increased (p Mención de responsabilidad : John Fredy Nieto-Ríos, Narly Viviana Gómez-Rueda, Lina María Serna-Higuita, Catalina Ocampo-Kohn, Arbey Aristizábal-Alzate,Harry Abadía-Guzmán, Carlos Enrique Yepes-Delgado, Gustavo Zuluaga-Valencia Referencia : Iatreia. 2015;28(4):378-87. DOI (Digital Object Identifier) : 10.17533/udea.iatreia.v28n4a04 Derechos de uso : CC BY-NC-SA En línea : https://revistas.udea.edu.co/index.php/iatreia/article/view/19976 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3914 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000495 AC-2015-048 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2015-048.pdfAdobe Acrobat PDF