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Reinforced Portland cement porous scaffolds for load-bearing bone tissue engineering applications / Carlos Augusto Sarassa Velásquez  

Público ISBD Título : Reinforced Portland cement porous scaffolds for load-bearing bone tissue engineering applications Tipo de documento : documento electrónico Autores : Carlos Augusto Sarassa Velásquez, Fecha de publicación : 2012 Títulos uniformes : Journal of Biomedical Materials Research. Part B, Applied Biomaterials Idioma : Inglés (eng) Palabras clave : bone  tissue engineering  scaffolds  cell-material interactions  composite/hard tissue Resumen : Modified Portland cement porous scaffolds with suitable characteristics for load‐bearing bone tissue engineering applications were manufactured by combining the particulate leaching and foaming methods. Non‐crosslinked polydimethylsiloxane was evaluated as a potential reinforcing material. The scaffolds presented average porosities between 70 and 80% with mean pore sizes ranging from 300 μm up to 5.0 mm. Non‐reinforced scaffolds presented compressive strengths and elastic modulus values of 2.6 and 245 MPa, respectively, whereas reinforced scaffolds exhibited 4.2 and 443 MPa, respectively, an increase of ∼62 and 80%. Portland cement scaffolds supported human osteoblast‐like cell adhesion, spreading, and propagation (t = 1–28 days). Cell metabolism and alkaline phosphatase activity were found to be enhanced at longer culture intervals (t ≥ 14 days). These results suggest the possibility of obtaining strong and biocompatible scaffolds for bone repair applications from inexpensive, yet technologically advanced materials such as Portland cement. Mención de responsabilidad : Natalia Higuita-Castro, Daniel Gallego-Perez, Alejandro Pelaez-Vargas, Felipe García Quiroz, Olga M Posada, Luis E López, Carlos A Sarassa, Piedad Agudelo-Florez, Fernando J Monteiro, Alan S Litsky, Derek J Hansford Referencia : J Biomed Mater Res B Appl Biomater. 2012 Feb;100(2):501-7. DOI (Digital Object Identifier) : 10.1002/jbm.b.31976 PMID : 22121151 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.31976 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4516 Reinforced Portland cement porous scaffolds for load-bearing bone tissue engineering applications [documento electrónico] / Carlos Augusto Sarassa Velásquez,  . - 2012. Obra : Journal of Biomedical Materials Research. Part B, Applied Biomaterials Idioma : Inglés (eng) Palabras clave : bone  tissue engineering  scaffolds  cell-material interactions  composite/hard tissue Resumen : Modified Portland cement porous scaffolds with suitable characteristics for load‐bearing bone tissue engineering applications were manufactured by combining the particulate leaching and foaming methods. Non‐crosslinked polydimethylsiloxane was evaluated as a potential reinforcing material. The scaffolds presented average porosities between 70 and 80% with mean pore sizes ranging from 300 μm up to 5.0 mm. Non‐reinforced scaffolds presented compressive strengths and elastic modulus values of 2.6 and 245 MPa, respectively, whereas reinforced scaffolds exhibited 4.2 and 443 MPa, respectively, an increase of ∼62 and 80%. Portland cement scaffolds supported human osteoblast‐like cell adhesion, spreading, and propagation (t = 1–28 days). Cell metabolism and alkaline phosphatase activity were found to be enhanced at longer culture intervals (t ≥ 14 days). These results suggest the possibility of obtaining strong and biocompatible scaffolds for bone repair applications from inexpensive, yet technologically advanced materials such as Portland cement. Mención de responsabilidad : Natalia Higuita-Castro, Daniel Gallego-Perez, Alejandro Pelaez-Vargas, Felipe García Quiroz, Olga M Posada, Luis E López, Carlos A Sarassa, Piedad Agudelo-Florez, Fernando J Monteiro, Alan S Litsky, Derek J Hansford Referencia : J Biomed Mater Res B Appl Biomater. 2012 Feb;100(2):501-7. DOI (Digital Object Identifier) : 10.1002/jbm.b.31976 PMID : 22121151 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.31976 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4516

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