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Enlace permanente de la investigaciónHaploidentical stem cell transplant with post-transplant cyclophosphamide in pediatric hemophagocytic lymphohistiocytosis / Luz Natalia Builes Restrepo ; Andrés Felipe Escobar González
Título : Haploidentical stem cell transplant with post-transplant cyclophosphamide in pediatric hemophagocytic lymphohistiocytosis Tipo de documento : documento electrónico Autores : Luz Natalia Builes Restrepo, ; Andrés Felipe Escobar González, Fecha de publicación : 2021 Títulos uniformes : Journal of Clinical Immunology Idioma : Inglés (eng) Palabras clave : Hemophagocytic lymphohistiocytosis hematopoietic stem cell transplantation child cyclophosphamide haploidentical Resumen : Purpose: Primary hemophagocytic lymphohistiocytosis is a severe and uncommon disease affecting pediatric patients. Genetic abnormalities have been related to altered apoptosis and exaggerated inflammatory reactions. Chemoimmunotherapy and stem cell transplantation are treatment options, but transplant is the only curative treatment. Here we aim to describe the treatment with hematopoietic stem cell transplantation with a novel strategy and the outcomes. Methods: An observational, descriptive, case series study was performed in pediatric patients of two high complexity medical centers in Colombia. Data was collected retrospectively between 2015 and 2020. Results: We describe five pediatric cases with a diagnosis of primary hemophagocytic lymphohistiocytosis. All were treated with replete-cell haploidentical hematopoietic stem transplantation, reduced-intensity conditioning, and post-transplant cyclophosphamide, in two high-complexity centers in Colombia. All patients are alive, and one is receiving management for chronic graft-versus-host disease. Conclusion: To the best of our knowledge, there are few reports in the literature with this strategy, promising a possible alternative when there are no other donor options. Mención de responsabilidad : Diego Medina-Valencia, Daniela Cleves, Estefania Beltran, Natalia Builes, Alexis A. Franco, Andrés Felipe Escobar-González & Manuela Olaya Referencia : J Clin Immunol. 2021 Aug;41(6):1172-1177. DOI (Digital Object Identifier) : 10.1007/s10875-021-01009-3 PMID : 33687579 En línea : https://link.springer.com/article/10.1007%2Fs10875-021-01009-3 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5762 Haploidentical stem cell transplant with post-transplant cyclophosphamide in pediatric hemophagocytic lymphohistiocytosis [documento electrónico] / Luz Natalia Builes Restrepo, ; Andrés Felipe Escobar González, . - 2021.
Obra : Journal of Clinical Immunology
Idioma : Inglés (eng)
Palabras clave : Hemophagocytic lymphohistiocytosis hematopoietic stem cell transplantation child cyclophosphamide haploidentical Resumen : Purpose: Primary hemophagocytic lymphohistiocytosis is a severe and uncommon disease affecting pediatric patients. Genetic abnormalities have been related to altered apoptosis and exaggerated inflammatory reactions. Chemoimmunotherapy and stem cell transplantation are treatment options, but transplant is the only curative treatment. Here we aim to describe the treatment with hematopoietic stem cell transplantation with a novel strategy and the outcomes. Methods: An observational, descriptive, case series study was performed in pediatric patients of two high complexity medical centers in Colombia. Data was collected retrospectively between 2015 and 2020. Results: We describe five pediatric cases with a diagnosis of primary hemophagocytic lymphohistiocytosis. All were treated with replete-cell haploidentical hematopoietic stem transplantation, reduced-intensity conditioning, and post-transplant cyclophosphamide, in two high-complexity centers in Colombia. All patients are alive, and one is receiving management for chronic graft-versus-host disease. Conclusion: To the best of our knowledge, there are few reports in the literature with this strategy, promising a possible alternative when there are no other donor options. Mención de responsabilidad : Diego Medina-Valencia, Daniela Cleves, Estefania Beltran, Natalia Builes, Alexis A. Franco, Andrés Felipe Escobar-González & Manuela Olaya Referencia : J Clin Immunol. 2021 Aug;41(6):1172-1177. DOI (Digital Object Identifier) : 10.1007/s10875-021-01009-3 PMID : 33687579 En línea : https://link.springer.com/article/10.1007%2Fs10875-021-01009-3 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5762 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001687 AC-2021-013 Archivo digital Producción Científica Artículos científicos Disponible 
Título : Malignant peripheral nerve sheath tumor in a child Tipo de documento : documento electrónico Autores : Lina Marcela Cadavid Álvarez, ; Gabriel Jaime Varela Aguirre, Fecha de publicación : 2021 Títulos uniformes : Radiology Case Reports Idioma : Inglés (eng) Palabras clave : Child Malignant peripheral nerve sheath tumor Nerve sheath neoplasms Neurofibroma Peripheral nerve Schwannoma Resumen : Among the diverse causes of posterior mediastinal masses, malignant peripheral nerve sheath tumors is a very rare neurogenic tumor. Imaging features tend to be variable. A 20-month-old toddler presented with a 3-month history of persistent diffuse thoracic and abdominal pain. A chest magnetic resonance imaging was taken and shown a posterior mediastinal lesion. Histopathology and immunohistochemical analysis confirmed the diagnosis of a malignant peripheral nerve sheath tumor with myxoid areas. Malignant peripheral nerve sheath tumors are an uncommon entity in the children with a poor prognosis. Magnetic resonance imaging is the preferred technique in children to limit the use of ionizing radiation and because has a higher contrast resolution; however, all suspicious tumors should be biopsied to make an appropriate diagnosis. Treatment is radical surgery with excision of the entire mass; however, there is a high incidence of local recurrence. Mención de responsabilidad : Brian Daniel Noreña-Rengifo MD, Lina Marcela Cadavid-Alvarez RR, Patricia Eugenia Gil-Serrano RR y Gabriel Jaime Varela-Aguirre PR Referencia : Radiol Case Rep. 2020 Nov 12;16(1):145-151. DOI (Digital Object Identifier) : 10.1016/j.radcr.2020.10.028 PMID : 33224401 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1930-0433(20)30547-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5750 Malignant peripheral nerve sheath tumor in a child [documento electrónico] / Lina Marcela Cadavid Álvarez, ; Gabriel Jaime Varela Aguirre, . - 2021.
Obra : Radiology Case Reports
Idioma : Inglés (eng)
Palabras clave : Child Malignant peripheral nerve sheath tumor Nerve sheath neoplasms Neurofibroma Peripheral nerve Schwannoma Resumen : Among the diverse causes of posterior mediastinal masses, malignant peripheral nerve sheath tumors is a very rare neurogenic tumor. Imaging features tend to be variable. A 20-month-old toddler presented with a 3-month history of persistent diffuse thoracic and abdominal pain. A chest magnetic resonance imaging was taken and shown a posterior mediastinal lesion. Histopathology and immunohistochemical analysis confirmed the diagnosis of a malignant peripheral nerve sheath tumor with myxoid areas. Malignant peripheral nerve sheath tumors are an uncommon entity in the children with a poor prognosis. Magnetic resonance imaging is the preferred technique in children to limit the use of ionizing radiation and because has a higher contrast resolution; however, all suspicious tumors should be biopsied to make an appropriate diagnosis. Treatment is radical surgery with excision of the entire mass; however, there is a high incidence of local recurrence. Mención de responsabilidad : Brian Daniel Noreña-Rengifo MD, Lina Marcela Cadavid-Alvarez RR, Patricia Eugenia Gil-Serrano RR y Gabriel Jaime Varela-Aguirre PR Referencia : Radiol Case Rep. 2020 Nov 12;16(1):145-151. DOI (Digital Object Identifier) : 10.1016/j.radcr.2020.10.028 PMID : 33224401 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1930-0433(20)30547-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5750 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001645 AC-2021-001 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2021-001Adobe Acrobat PDF
Título : Hematopoietic stem cell transplantation in children with inborn errors of immunity: a multi-center experience in Colombia Tipo de documento : documento electrónico Autores : Luz Natalia Builes Restrepo, Fecha de publicación : 2020 Títulos uniformes : Journal of Clinical Immunology Idioma : Inglés (eng) Palabras clave : Hematopoietic stem cell transplantation child haploidentical transplantations pediatrics primary immunodeficiency diseases transplant recipients Resumen : Purpose: To characterize the pediatric population with inborn errors of immunity (IEI) that was treated with hematopoietic stem cell transplantation (HSCT) in three reference centers in Colombia. What have been the characteristics and outcomes of hematopoietic stem cell transplantation in pediatric patients with inborn errors of immunity in three reference care centers in Colombia between 2007 and 2018. Methods: We conducted an observational, retrospective cohort study in children with a diagnosis of IEI who underwent HSCT between 2007 and 2018. Results: Forty-seven patients were identified, and 5 were re-transplanted. Sixty-eight percent were male. The median age at diagnosis was 0.6 years, and for HSCT was 1.4 years. The most common diseases were chronic granulomatous disease (38%) followed by severe combined immune deficiencies (19%) and hemophagocytic lymphohistiocytosis (15%). Cord blood donors were the most used source of HSCT (44%). T cell-replete grafts from haploidentical donors using post-transplantation cyclophosphamide represent 37% of the cohort. All patients received conditioning, 62% with a non-myeloablative regimen. Calcineurin inhibitors were the main graft-versus-host disease prophylaxis (63.8%). Acute graft-versus-host disease developed in 35% of the total patients. The most frequent post-transplant infections were viral and fungal infections. The 1-year overall survival rates for the patients who received HSCT from identical, haploidentical, and cord sources were 80%, 72%, and 63%, respectively. The 5-year overall survival was 63%. Conclusions: HSCT is a curative treatment option for some IEI and can be performed with any donor type. Early and timely treatment in referral centers can improve survival. Mención de responsabilidad : Manuela Olaya, Alexis Franco, Mauricio Chaparro, Marcela Estupiñan, David Aristizabal, Natalia Builes-Restrepo, José L Franco, Andrés F Zea-Vera, Mayra Estacio, Eliana Manzi, Estefania Beltran, Paola Perez, Jaime Patiño, Harry Pachajoa & Diego Medina-Valencia Referencia : J Clin Immunol. 2020 Nov;40(8):1116-1123. DOI (Digital Object Identifier) : 10.1007/s10875-020-00856-w PMID : 32880086 En línea : https://link.springer.com/article/10.1007/s10875-020-00856-w Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5135 Hematopoietic stem cell transplantation in children with inborn errors of immunity: a multi-center experience in Colombia [documento electrónico] / Luz Natalia Builes Restrepo, . - 2020.
Obra : Journal of Clinical Immunology
Idioma : Inglés (eng)
Palabras clave : Hematopoietic stem cell transplantation child haploidentical transplantations pediatrics primary immunodeficiency diseases transplant recipients Resumen : Purpose: To characterize the pediatric population with inborn errors of immunity (IEI) that was treated with hematopoietic stem cell transplantation (HSCT) in three reference centers in Colombia. What have been the characteristics and outcomes of hematopoietic stem cell transplantation in pediatric patients with inborn errors of immunity in three reference care centers in Colombia between 2007 and 2018. Methods: We conducted an observational, retrospective cohort study in children with a diagnosis of IEI who underwent HSCT between 2007 and 2018. Results: Forty-seven patients were identified, and 5 were re-transplanted. Sixty-eight percent were male. The median age at diagnosis was 0.6 years, and for HSCT was 1.4 years. The most common diseases were chronic granulomatous disease (38%) followed by severe combined immune deficiencies (19%) and hemophagocytic lymphohistiocytosis (15%). Cord blood donors were the most used source of HSCT (44%). T cell-replete grafts from haploidentical donors using post-transplantation cyclophosphamide represent 37% of the cohort. All patients received conditioning, 62% with a non-myeloablative regimen. Calcineurin inhibitors were the main graft-versus-host disease prophylaxis (63.8%). Acute graft-versus-host disease developed in 35% of the total patients. The most frequent post-transplant infections were viral and fungal infections. The 1-year overall survival rates for the patients who received HSCT from identical, haploidentical, and cord sources were 80%, 72%, and 63%, respectively. The 5-year overall survival was 63%. Conclusions: HSCT is a curative treatment option for some IEI and can be performed with any donor type. Early and timely treatment in referral centers can improve survival. Mención de responsabilidad : Manuela Olaya, Alexis Franco, Mauricio Chaparro, Marcela Estupiñan, David Aristizabal, Natalia Builes-Restrepo, José L Franco, Andrés F Zea-Vera, Mayra Estacio, Eliana Manzi, Estefania Beltran, Paola Perez, Jaime Patiño, Harry Pachajoa & Diego Medina-Valencia Referencia : J Clin Immunol. 2020 Nov;40(8):1116-1123. DOI (Digital Object Identifier) : 10.1007/s10875-020-00856-w PMID : 32880086 En línea : https://link.springer.com/article/10.1007/s10875-020-00856-w Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5135 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001395 AC-2020-072 Archivo digital Producción Científica Artículos científicos Disponible
Título : Evaluación del riesgo quirúrgico en pacientes con cirrosis hepática Otros títulos : Surgical risk assessment in patients with liver cirrosis Tipo de documento : documento electrónico Autores : Óscar Mauricio Santos Sánchez, Fecha de publicación : 2018 Títulos uniformes : Revista Colombiana de Gastroenterología Idioma : Español (spa) Palabras clave : Riesgo quirúrgico cirrosis cirugía resultados child MELD Resumen : Los pacientes cirróticos pueden requerir procedimientos quirúrgicos y están relacionados con mayor morbimortalidad que la población general. Los resultados adversos están asociados con múltiples factores, pero los más importantes son la severidad de la enfermedad hepática, la urgencia del procedimiento y el tipo de cirugía. El puntaje Child-Turcott-Pugh (CTP) y el puntaje MELD pueden ser usados para determinar la severidad de la enfermedad hepática y estratificar el riesgo. Se considera que la cirugía electiva se tolera bien en pacientes con CTP A, es permisible con una buena preparación preoperatoria en pacientes con CTP B o MELD 15 con albúmina Mención de responsabilidad : Oscar Mauricio Santos-Sánchez Referencia : Rev. colomb. gastroenterol ; 33(4): 431-436, oct.-dic. 2018. DOI (Digital Object Identifier) : 10.22516/25007440.313 Derechos de uso : CC BY-NC-ND En línea : https://revistagastrocol.com/index.php/rcg/article/view/313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4697 Evaluación del riesgo quirúrgico en pacientes con cirrosis hepática = Surgical risk assessment in patients with liver cirrosis [documento electrónico] / Óscar Mauricio Santos Sánchez, . - 2018.
Obra : Revista Colombiana de Gastroenterología
Idioma : Español (spa)
Palabras clave : Riesgo quirúrgico cirrosis cirugía resultados child MELD Resumen : Los pacientes cirróticos pueden requerir procedimientos quirúrgicos y están relacionados con mayor morbimortalidad que la población general. Los resultados adversos están asociados con múltiples factores, pero los más importantes son la severidad de la enfermedad hepática, la urgencia del procedimiento y el tipo de cirugía. El puntaje Child-Turcott-Pugh (CTP) y el puntaje MELD pueden ser usados para determinar la severidad de la enfermedad hepática y estratificar el riesgo. Se considera que la cirugía electiva se tolera bien en pacientes con CTP A, es permisible con una buena preparación preoperatoria en pacientes con CTP B o MELD 15 con albúmina Mención de responsabilidad : Oscar Mauricio Santos-Sánchez Referencia : Rev. colomb. gastroenterol ; 33(4): 431-436, oct.-dic. 2018. DOI (Digital Object Identifier) : 10.22516/25007440.313 Derechos de uso : CC BY-NC-ND En línea : https://revistagastrocol.com/index.php/rcg/article/view/313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4697 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001171 AC-2018-111 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2018-111.pdfAdobe Acrobat PDF
Título : Lupus erythematosus tumidus in childhood treated with antimalarials Otros títulos : Lupus eritematoso tumidus en la infancia tratado con antimalárico Tipo de documento : documento electrónico Autores : Ana María Toro Cadavid, ; Delsy Yurledy del Río Cobaleda, ; Ana Cristina Ruiz Suárez, Fecha de publicación : 2018 Títulos uniformes : CES Medicina Idioma : Español (spa) Palabras clave : Cutaneous lupus erythematosus Skin abnormalities Photosensitivity disorders Child Antimalarial drugs Resumen : Lupus erythematosus tumidus is a rare dermatosis. It is considered a subtype of chronic cutaneous lupus erythematosus of uncertain pathogenesis, favorable prognosis and rare association with systemic lupus erythematosus. Clinically, it manifests as urticarial-like plaques in photo exposed areas, mainly affecting adults, being extremely rare in pediatric age. Herein, we present two cases of six and nine-year-old male patients with clinical and histological cha-racteristics typical of lupus erythematosus tumidus and poor response to first-line treatment (topical, intralesional steroids and topical calcineurin inhibitors); therefore, it was decided to start systemic therapy with antimalarials, obtaining a very good response. Mención de responsabilidad : Lina Maria Aguirre Hernández, Ana María Toro, Delsy Yurledy Del Río, Ana Cristina Ruiz DOI (Digital Object Identifier) : 10.21615/cesmedicina.32.2.7 Derechos de uso : CC BY-NC-ND En línea : http://revistas.ces.edu.co/index.php/medicina/article/view/4132 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4738 Lupus erythematosus tumidus in childhood treated with antimalarials = Lupus eritematoso tumidus en la infancia tratado con antimalárico [documento electrónico] / Ana María Toro Cadavid, ; Delsy Yurledy del Río Cobaleda, ; Ana Cristina Ruiz Suárez, . - 2018.
Obra : CES Medicina
Idioma : Español (spa)
Palabras clave : Cutaneous lupus erythematosus Skin abnormalities Photosensitivity disorders Child Antimalarial drugs Resumen : Lupus erythematosus tumidus is a rare dermatosis. It is considered a subtype of chronic cutaneous lupus erythematosus of uncertain pathogenesis, favorable prognosis and rare association with systemic lupus erythematosus. Clinically, it manifests as urticarial-like plaques in photo exposed areas, mainly affecting adults, being extremely rare in pediatric age. Herein, we present two cases of six and nine-year-old male patients with clinical and histological cha-racteristics typical of lupus erythematosus tumidus and poor response to first-line treatment (topical, intralesional steroids and topical calcineurin inhibitors); therefore, it was decided to start systemic therapy with antimalarials, obtaining a very good response. Mención de responsabilidad : Lina Maria Aguirre Hernández, Ana María Toro, Delsy Yurledy Del Río, Ana Cristina Ruiz DOI (Digital Object Identifier) : 10.21615/cesmedicina.32.2.7 Derechos de uso : CC BY-NC-ND En línea : http://revistas.ces.edu.co/index.php/medicina/article/view/4132 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4738 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001371 AC-2018-156 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2018-156.pdfAdobe Acrobat PDF
