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Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis / Adriana Giraldo Villa    

Público ISBD Título : Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis Tipo de documento : documento electrónico Autores : Adriana Giraldo Villa, Fecha de publicación : 2020 Títulos uniformes : Gut Microbes Idioma : Inglés (eng) Palabras clave : Intestinal microbiota  antibiotics  critically ill patient  intensive care unit  sepsis Resumen : Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients. Mención de responsabilidad : Gloria M Agudelo-Ochoa, Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Alfonso Benítez-Paéz Referencia : Gut Microbes. 2020 Nov 9;12(1):1707610. DOI (Digital Object Identifier) : 10.1080/19490976.2019.1707610 PMID : 31924126 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1707610 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5072 Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis [documento electrónico] / Adriana Giraldo Villa,  . - 2020. Obra : Gut Microbes Idioma : Inglés (eng) Palabras clave : Intestinal microbiota  antibiotics  critically ill patient  intensive care unit  sepsis Resumen : Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients. Mención de responsabilidad : Gloria M Agudelo-Ochoa, Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Alfonso Benítez-Paéz Referencia : Gut Microbes. 2020 Nov 9;12(1):1707610. DOI (Digital Object Identifier) : 10.1080/19490976.2019.1707610 PMID : 31924126 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1707610 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5072

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Stool short-chain fatty acids in critically ill patients with sepsis / Adriana Giraldo Villa  

Público ISBD Título : Stool short-chain fatty acids in critically ill patients with sepsis Tipo de documento : documento electrónico Autores : Adriana Giraldo Villa, Fecha de publicación : 2020 Títulos uniformes : Journal of the American College of Nutrition Idioma : Inglés (eng) Palabras clave : Short-chain fatty acids  critically ill patient  sepsis  acetic  propionic  butyric  intensive care unit Resumen : Objective: To determine the concentration of stool short-chain fatty acids (SCFAs) in critically ill patients with sepsis and to compare the results between the critically ill patient and the control group. Methods: This descriptive, multicenter, observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients with sepsis who were admitted to the intensive care unit (ICU) and met the inclusion criteria were enrolled, and a control, paired by age and sex, was recruited for each patient. A spontaneous stool sample was collected from each participant and a gas chromatograph coupled to a mass spectrometer (Agilent 7890/MSD 5975 C) was used to measure the concentrations SCFAs. Results: The final sample included 44 patients and 45 controls. There were no differences in the age and sex distributions between the groups (p > 0.05). According to body mass index (BMI), undernutrition was more prevalent among critically ill patients, and BMI in control subjects was most frequently classified as overweight (p = 0.024). Propionic acid, acetic acid, butyric acid, and isobutyric acid concentrations were significantly lower in the critically ill patient group than in the control group (p = 0.000). No association with outcome variables (complications, ICU stay, and discharge condition) was found in the patients, and patients diagnosed with infection on ICU admission showed significant decreases in butyric and isobutyric acid concentrations with respect to other diagnostic criteria (p  Mención de responsabilidad : Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Carlos J Barrera-Causil, Gloria M Agudelo-Ochoa Referencia : J Am Coll Nutr. Nov-Dec 2020;39(8):706-712. DOI (Digital Object Identifier) : 10.1080/07315724.2020.1727379 PMID : 32163012 En línea : https://www.tandfonline.com/doi/full/10.1080/07315724.2020.1727379 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5084 Stool short-chain fatty acids in critically ill patients with sepsis [documento electrónico] / Adriana Giraldo Villa,  . - 2020. Obra : Journal of the American College of Nutrition Idioma : Inglés (eng) Palabras clave : Short-chain fatty acids  critically ill patient  sepsis  acetic  propionic  butyric  intensive care unit Resumen : Objective: To determine the concentration of stool short-chain fatty acids (SCFAs) in critically ill patients with sepsis and to compare the results between the critically ill patient and the control group. Methods: This descriptive, multicenter, observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients with sepsis who were admitted to the intensive care unit (ICU) and met the inclusion criteria were enrolled, and a control, paired by age and sex, was recruited for each patient. A spontaneous stool sample was collected from each participant and a gas chromatograph coupled to a mass spectrometer (Agilent 7890/MSD 5975 C) was used to measure the concentrations SCFAs. Results: The final sample included 44 patients and 45 controls. There were no differences in the age and sex distributions between the groups (p > 0.05). According to body mass index (BMI), undernutrition was more prevalent among critically ill patients, and BMI in control subjects was most frequently classified as overweight (p = 0.024). Propionic acid, acetic acid, butyric acid, and isobutyric acid concentrations were significantly lower in the critically ill patient group than in the control group (p = 0.000). No association with outcome variables (complications, ICU stay, and discharge condition) was found in the patients, and patients diagnosed with infection on ICU admission showed significant decreases in butyric and isobutyric acid concentrations with respect to other diagnostic criteria (p  Mención de responsabilidad : Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Carlos J Barrera-Causil, Gloria M Agudelo-Ochoa Referencia : J Am Coll Nutr. Nov-Dec 2020;39(8):706-712. DOI (Digital Object Identifier) : 10.1080/07315724.2020.1727379 PMID : 32163012 En línea : https://www.tandfonline.com/doi/full/10.1080/07315724.2020.1727379 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5084

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DD001314	AC-2020-018	Archivo digital	Producción Científica	Artículos científicos	Disponible