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Management of antiepileptic drugs following epilepsy surgery: a meta-analysis / Lady Diana Ladino Malagón  

Público ISBD Título : Management of antiepileptic drugs following epilepsy surgery: a meta-analysis Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2014 Títulos uniformes : Epilepsy Research Idioma : Inglés (eng) Palabras clave : Epilepsy surgery  discontinuation  drug-resistant  AEDs  seizure recurrence  withdrawal Resumen : Objective: No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. Methods: We searched MEDLINE and Embase using Medical Subject Headings and keywords related to AEDs discontinuation after ES. Two reviewers independently applied the following inclusion criteria: original published research that directly compared seizure outcomes in patients having or not AEDs discontinuation after ES. Two investigators independently extracted data, resolving disagreements through discussion. A random and fixed-effect model was used to derive a pooled odds ratio (OR) for either seizure recurrence in both groups. Results: Of 257 abstracts initially identified by the search, 57 were reviewed as full text. Sixteen articles fulfilled eligibility criteria and described outcomes in 1456 patients with AEDs discontinuation and 685 patients with no discontinuation. The odds of having seizure recurrence after AEDs discontinuation was 0.39 times lower in patients with attempted discontinuation after surgery (OR 0.39, CI 95% 0.300—0.507, p Mención de responsabilidad : Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno Referencia : Epilepsy Res. 2014;108(4):765-74. DOI (Digital Object Identifier) : 10.1016/j.eplepsyres.2014.01.024 PMID : 24613746 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0920121114000394 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3792 Management of antiepileptic drugs following epilepsy surgery: a meta-analysis [documento electrónico] / Lady Diana Ladino Malagón,  . - 2014. Obra : Epilepsy Research Idioma : Inglés (eng) Palabras clave : Epilepsy surgery  discontinuation  drug-resistant  AEDs  seizure recurrence  withdrawal Resumen : Objective: No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. Methods: We searched MEDLINE and Embase using Medical Subject Headings and keywords related to AEDs discontinuation after ES. Two reviewers independently applied the following inclusion criteria: original published research that directly compared seizure outcomes in patients having or not AEDs discontinuation after ES. Two investigators independently extracted data, resolving disagreements through discussion. A random and fixed-effect model was used to derive a pooled odds ratio (OR) for either seizure recurrence in both groups. Results: Of 257 abstracts initially identified by the search, 57 were reviewed as full text. Sixteen articles fulfilled eligibility criteria and described outcomes in 1456 patients with AEDs discontinuation and 685 patients with no discontinuation. The odds of having seizure recurrence after AEDs discontinuation was 0.39 times lower in patients with attempted discontinuation after surgery (OR 0.39, CI 95% 0.300—0.507, p Mención de responsabilidad : Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno Referencia : Epilepsy Res. 2014;108(4):765-74. DOI (Digital Object Identifier) : 10.1016/j.eplepsyres.2014.01.024 PMID : 24613746 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0920121114000394 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3792

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD000367	AC-2014-033	Archivo digital	Producción Científica	Artículos científicos	Disponible