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Título : Forced normalization: A systematic review Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2019 Títulos uniformes : Epilepsia Idioma : Inglés (eng) Palabras clave : Alternative psychosis antiepileptic drugs dissociation epilepsy surgery limbic system vagus nerve stimulation Resumen : Objective: Forced normalization (FN) is an intriguing phenomenon characterized by the emergence of psychiatric disturbances following the establishment of seizure control or reduction in the epileptic activity in a patient with previous uncontrolled epilepsy. We aim to describe the clinical characteristics of the condition. Methods: We conducted a systematic review on MEDLINE, EMBASE, Cochrane, and Scielo from January 1953 to January 2018. Clinical, electrographic, and imaging data were gathered. We considered all outcomes in children and adults. We performed no meta‐analyses due to the limited available data. Results: Of 2606 abstracts identified, 36 fulfilled the FN diagnostic criteria; 193 FN episodes were evaluated and 77 of them were analyzed extensively. Sixty percent of cases were female. Mean age ± standard deviation (SD) was 28.3 ± 14.2 years. The majority of patients had focal (80%) symptomatic (44%) epilepsy. Most patients reported a high ictal frequency (58%) and were on polytherapy (51%). Patients presented psychosis (86.4%), mood disorders (25.8%), and dissociation (4.5%) as the main manifestations. In the psychosis group, persecutory (52.6%) and reference (47.3%) delusions were frequent. FN was provoked by an antiepileptic drug (AED) (48.5%) mainly levetiracetam, epilepsy surgery (31.8%), or vagus nerve stimulation (13.6%). Treatment was homogeneous including anticonvulsant withdrawal (47%) or taper (25%); antipsychotics were initiated in the majority of cases (73%). Psychiatric symptoms were partially controlled in 35%, with complete resolution of symptoms in the remaining 65% of cases. The majority of patients (87%) with AED trigger and withdrawal presented complete resolution of symptoms in comparison to 28.5% of patients triggered by surgery. Significance: Forced normalization is an entity whose pathophysiology remains uncertain. Antipsychotic drug use does not predict complete resolution of psychiatric symptoms in comparison with AED withdrawal. Although there is a positive response to treatment in patients with FN triggered by drugs, the prognosis is obscure in patients with surgery triggered FN. Mención de responsabilidad : Yamile Calle-López, Lady Diana Ladino, Vanessa Benjumea-Cuartas, Diana Marcela Castrillón-Velilla, José Francisco Téllez-Zenteno, Peter Wolf Referencia : Epilepsia. 2019 Aug;60(8):1610-1618. DOI (Digital Object Identifier) : 10.1111/epi.16276 PMID : 31260102 En línea : https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.16276 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4242 Forced normalization: A systematic review [documento electrónico] / Lady Diana Ladino Malagón, . - 2019.
Obra : Epilepsia
Idioma : Inglés (eng)
Palabras clave : Alternative psychosis antiepileptic drugs dissociation epilepsy surgery limbic system vagus nerve stimulation Resumen : Objective: Forced normalization (FN) is an intriguing phenomenon characterized by the emergence of psychiatric disturbances following the establishment of seizure control or reduction in the epileptic activity in a patient with previous uncontrolled epilepsy. We aim to describe the clinical characteristics of the condition. Methods: We conducted a systematic review on MEDLINE, EMBASE, Cochrane, and Scielo from January 1953 to January 2018. Clinical, electrographic, and imaging data were gathered. We considered all outcomes in children and adults. We performed no meta‐analyses due to the limited available data. Results: Of 2606 abstracts identified, 36 fulfilled the FN diagnostic criteria; 193 FN episodes were evaluated and 77 of them were analyzed extensively. Sixty percent of cases were female. Mean age ± standard deviation (SD) was 28.3 ± 14.2 years. The majority of patients had focal (80%) symptomatic (44%) epilepsy. Most patients reported a high ictal frequency (58%) and were on polytherapy (51%). Patients presented psychosis (86.4%), mood disorders (25.8%), and dissociation (4.5%) as the main manifestations. In the psychosis group, persecutory (52.6%) and reference (47.3%) delusions were frequent. FN was provoked by an antiepileptic drug (AED) (48.5%) mainly levetiracetam, epilepsy surgery (31.8%), or vagus nerve stimulation (13.6%). Treatment was homogeneous including anticonvulsant withdrawal (47%) or taper (25%); antipsychotics were initiated in the majority of cases (73%). Psychiatric symptoms were partially controlled in 35%, with complete resolution of symptoms in the remaining 65% of cases. The majority of patients (87%) with AED trigger and withdrawal presented complete resolution of symptoms in comparison to 28.5% of patients triggered by surgery. Significance: Forced normalization is an entity whose pathophysiology remains uncertain. Antipsychotic drug use does not predict complete resolution of psychiatric symptoms in comparison with AED withdrawal. Although there is a positive response to treatment in patients with FN triggered by drugs, the prognosis is obscure in patients with surgery triggered FN. Mención de responsabilidad : Yamile Calle-López, Lady Diana Ladino, Vanessa Benjumea-Cuartas, Diana Marcela Castrillón-Velilla, José Francisco Téllez-Zenteno, Peter Wolf Referencia : Epilepsia. 2019 Aug;60(8):1610-1618. DOI (Digital Object Identifier) : 10.1111/epi.16276 PMID : 31260102 En línea : https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.16276 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4242 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001222 AC-2019-011 Archivo digital Producción Científica Artículos científicos Disponible
Título : The Montreal procedure: The legacy of the great Wilder Penfield Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2018 Títulos uniformes : Epilepsy & Behavior Idioma : Inglés (eng) Palabras clave : Direct cortical stimulation electrocorticography epilepsy surgery history homunculus montreal neurological institute Resumen : Wilder Penfield pioneered the early practice of brain surgery. In binding together the disciplines of neurosurgery, neurology, neuropathology, psychology, and related basic sciences, Penfield transformed our understanding of the field of neuroscience. He brought to the operating room the meticulous techniques of Sherrington, combined with methods of stimulation described by Foerster, which he complemented with expert knowledge of the neurocytology of nervous tissue. While developing surgical treatments for epilepsy, Penfield began to map the brain. He established the "Montreal procedure" for the surgical treatment of epilepsy. His scientific contributions on neurostimulation were transformative in their time and continue to resonate today. This article reviews the life of Wilder Penfield and summarizes key scientific contributions. Specifically, we detail the Montreal procedure. We additionally present a painting by Canadian artist Iris Hauser, which purports to display the hidden treasures of the human mind. Mención de responsabilidad : Lady Diana Ladino, Syed Rizvi, José Francisco Téllez-Zenteno Referencia : Epilepsy Behav. 2018 Jun;83:151-161. DOI (Digital Object Identifier) : 10.1016/j.yebeh.2018.04.001 PMID : 29705626 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1525-5050(18)30167-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4126 The Montreal procedure: The legacy of the great Wilder Penfield [documento electrónico] / Lady Diana Ladino Malagón, . - 2018.
Obra : Epilepsy & Behavior
Idioma : Inglés (eng)
Palabras clave : Direct cortical stimulation electrocorticography epilepsy surgery history homunculus montreal neurological institute Resumen : Wilder Penfield pioneered the early practice of brain surgery. In binding together the disciplines of neurosurgery, neurology, neuropathology, psychology, and related basic sciences, Penfield transformed our understanding of the field of neuroscience. He brought to the operating room the meticulous techniques of Sherrington, combined with methods of stimulation described by Foerster, which he complemented with expert knowledge of the neurocytology of nervous tissue. While developing surgical treatments for epilepsy, Penfield began to map the brain. He established the "Montreal procedure" for the surgical treatment of epilepsy. His scientific contributions on neurostimulation were transformative in their time and continue to resonate today. This article reviews the life of Wilder Penfield and summarizes key scientific contributions. Specifically, we detail the Montreal procedure. We additionally present a painting by Canadian artist Iris Hauser, which purports to display the hidden treasures of the human mind. Mención de responsabilidad : Lady Diana Ladino, Syed Rizvi, José Francisco Téllez-Zenteno Referencia : Epilepsy Behav. 2018 Jun;83:151-161. DOI (Digital Object Identifier) : 10.1016/j.yebeh.2018.04.001 PMID : 29705626 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1525-5050(18)30167-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4126 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000737 AC-2018-024 Archivo digital Producción Científica Artículos científicos Disponible Intracranial investigation of a patient with nodular heterotopia and hippocampal sclerosis: dealing with a dual pathology / Lady Diana Ladino Malagón
Título : Intracranial investigation of a patient with nodular heterotopia and hippocampal sclerosis: dealing with a dual pathology Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2017 Títulos uniformes : Epileptic Disorders Idioma : Inglés (eng) Palabras clave : Dual pathology epilepsy surgery periventricular nodular heterotopia posterior-quadrant epilepsy temporal lobectomy Resumen : The pre-operative assessment and surgical management of patients with dual pathology is challenging. We describe a patient with drug-resistant focal epilepsy with hippocampal sclerosis and extensive periventricular nodular heterotopia in the same hemisphere. The semiology, scalp EEG, and imaging were divergent, but the presence of focal interictal and ictal epileptic discharges of the putative ictal onset zone resulted in successful localization of the epileptogenic zone. A less aggressive resection was performed based on intracranial EEG recording. The patient has been seizure-free for three years since resection. Electroclinical hypotheses and challenges in defining the epileptogenic network are discussed. Mención de responsabilidad : Lady Diana Ladino, Chelsea Dash, Adam Wu, Jose Francisco Tellez-Zenteno Referencia : Epileptic Disord. 2017 Jun 1;19(2):195-201. DOI (Digital Object Identifier) : 10.1684/epd.2017.0912 PMID : 28625947 En línea : https://www.jle.com/fr/revues/epd/e-docs/intracranial_investigation_of_a_patient [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4027 Intracranial investigation of a patient with nodular heterotopia and hippocampal sclerosis: dealing with a dual pathology [documento electrónico] / Lady Diana Ladino Malagón, . - 2017.
Obra : Epileptic Disorders
Idioma : Inglés (eng)
Palabras clave : Dual pathology epilepsy surgery periventricular nodular heterotopia posterior-quadrant epilepsy temporal lobectomy Resumen : The pre-operative assessment and surgical management of patients with dual pathology is challenging. We describe a patient with drug-resistant focal epilepsy with hippocampal sclerosis and extensive periventricular nodular heterotopia in the same hemisphere. The semiology, scalp EEG, and imaging were divergent, but the presence of focal interictal and ictal epileptic discharges of the putative ictal onset zone resulted in successful localization of the epileptogenic zone. A less aggressive resection was performed based on intracranial EEG recording. The patient has been seizure-free for three years since resection. Electroclinical hypotheses and challenges in defining the epileptogenic network are discussed. Mención de responsabilidad : Lady Diana Ladino, Chelsea Dash, Adam Wu, Jose Francisco Tellez-Zenteno Referencia : Epileptic Disord. 2017 Jun 1;19(2):195-201. DOI (Digital Object Identifier) : 10.1684/epd.2017.0912 PMID : 28625947 En línea : https://www.jle.com/fr/revues/epd/e-docs/intracranial_investigation_of_a_patient [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4027 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000622 AC-2017-011 Archivo digital Producción Científica Artículos científicos Disponible
Título : Clinical Benefit of 3 Tesla Magnetic Resonance Imaging Rescanning in Patients With Focal Epilepsy and Negative 1.5 Tesla Magnetic Resonance Imaging Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2016 Títulos uniformes : Revista de Investigación Clínica Idioma : Inglés (eng) Palabras clave : Epilepsy surgery lesional epilepsy magnetic resonance imaging partial epilepsy refractory epilepsy 3 Tesla Resumen : Background: Magnetic resonance imaging is an essential tool in the pre-surgical evaluation of patients with drug-resistant epilepsy. Objective: Our aim was to assess the value of re-imaging patients with focal drug-resistant epilepsy. Methods: Thirty patients with negative or non-conclusive 1.5 Tesla magnetic resonance imaging were rescanned with 1.5T and 3T. All of them had previous 1.5 scans with no seizure protocol in a non-specialized center. Two neuroradiologists who were blinded to prior imaging results randomly reviewed the magnetic resonance images. Kappa score was used to assess the reliability. Results: Mean age of patients was 30 (SD ± 11) years. The intra-observer agreement for the first radiologist was 0.74 for 1.5T and 0.71 for 3T. In the second radiologist it was 0.82 and 0.66, respectively. Three lesions (10%) were identified by general radiologists in non-specialized centers using a 1.5T standard protocol. In our center a consensus between two neuroradiologists using epilepsy protocol identified seven lesions (23%) using 1.5T and 10 (33%) using 3T (p Mención de responsabilidad : Lady D Ladino, Pedro Balaguera, Simon Rascovsky, Jorge Delgado, Juan Llano, Lizbeth Hernández-Ronquillo, Bety Gómez-Arias, José F Téllez-Zenteno Referencia : Rev Invest Clin. 2016 May-Jun;68(3):112-8. PMID : 27408997 En línea : http://clinicalandtranslationalinvestigation.com/abstract.php?id=86 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3945 Clinical Benefit of 3 Tesla Magnetic Resonance Imaging Rescanning in Patients With Focal Epilepsy and Negative 1.5 Tesla Magnetic Resonance Imaging [documento electrónico] / Lady Diana Ladino Malagón, . - 2016.
Obra : Revista de Investigación Clínica
Idioma : Inglés (eng)
Palabras clave : Epilepsy surgery lesional epilepsy magnetic resonance imaging partial epilepsy refractory epilepsy 3 Tesla Resumen : Background: Magnetic resonance imaging is an essential tool in the pre-surgical evaluation of patients with drug-resistant epilepsy. Objective: Our aim was to assess the value of re-imaging patients with focal drug-resistant epilepsy. Methods: Thirty patients with negative or non-conclusive 1.5 Tesla magnetic resonance imaging were rescanned with 1.5T and 3T. All of them had previous 1.5 scans with no seizure protocol in a non-specialized center. Two neuroradiologists who were blinded to prior imaging results randomly reviewed the magnetic resonance images. Kappa score was used to assess the reliability. Results: Mean age of patients was 30 (SD ± 11) years. The intra-observer agreement for the first radiologist was 0.74 for 1.5T and 0.71 for 3T. In the second radiologist it was 0.82 and 0.66, respectively. Three lesions (10%) were identified by general radiologists in non-specialized centers using a 1.5T standard protocol. In our center a consensus between two neuroradiologists using epilepsy protocol identified seven lesions (23%) using 1.5T and 10 (33%) using 3T (p Mención de responsabilidad : Lady D Ladino, Pedro Balaguera, Simon Rascovsky, Jorge Delgado, Juan Llano, Lizbeth Hernández-Ronquillo, Bety Gómez-Arias, José F Téllez-Zenteno Referencia : Rev Invest Clin. 2016 May-Jun;68(3):112-8. PMID : 27408997 En línea : http://clinicalandtranslationalinvestigation.com/abstract.php?id=86 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3945 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000530 AC-2016-005 Archivo digital Producción Científica Artículos científicos Disponible
Título : Management of antiepileptic drugs following epilepsy surgery: a meta-analysis Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2014 Títulos uniformes : Epilepsy Research Idioma : Inglés (eng) Palabras clave : Epilepsy surgery discontinuation drug-resistant AEDs seizure recurrence withdrawal Resumen : Objective: No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. Methods: We searched MEDLINE and Embase using Medical Subject Headings and keywords related to AEDs discontinuation after ES. Two reviewers independently applied the following inclusion criteria: original published research that directly compared seizure outcomes in patients having or not AEDs discontinuation after ES. Two investigators independently extracted data, resolving disagreements through discussion. A random and fixed-effect model was used to derive a pooled odds ratio (OR) for either seizure recurrence in both groups. Results: Of 257 abstracts initially identified by the search, 57 were reviewed as full text. Sixteen articles fulfilled eligibility criteria and described outcomes in 1456 patients with AEDs discontinuation and 685 patients with no discontinuation. The odds of having seizure recurrence after AEDs discontinuation was 0.39 times lower in patients with attempted discontinuation after surgery (OR 0.39, CI 95% 0.300—0.507, p Mención de responsabilidad : Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno Referencia : Epilepsy Res. 2014;108(4):765-74. DOI (Digital Object Identifier) : 10.1016/j.eplepsyres.2014.01.024 PMID : 24613746 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0920121114000394 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3792 Management of antiepileptic drugs following epilepsy surgery: a meta-analysis [documento electrónico] / Lady Diana Ladino Malagón, . - 2014.
Obra : Epilepsy Research
Idioma : Inglés (eng)
Palabras clave : Epilepsy surgery discontinuation drug-resistant AEDs seizure recurrence withdrawal Resumen : Objective: No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. Methods: We searched MEDLINE and Embase using Medical Subject Headings and keywords related to AEDs discontinuation after ES. Two reviewers independently applied the following inclusion criteria: original published research that directly compared seizure outcomes in patients having or not AEDs discontinuation after ES. Two investigators independently extracted data, resolving disagreements through discussion. A random and fixed-effect model was used to derive a pooled odds ratio (OR) for either seizure recurrence in both groups. Results: Of 257 abstracts initially identified by the search, 57 were reviewed as full text. Sixteen articles fulfilled eligibility criteria and described outcomes in 1456 patients with AEDs discontinuation and 685 patients with no discontinuation. The odds of having seizure recurrence after AEDs discontinuation was 0.39 times lower in patients with attempted discontinuation after surgery (OR 0.39, CI 95% 0.300—0.507, p Mención de responsabilidad : Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno Referencia : Epilepsy Res. 2014;108(4):765-74. DOI (Digital Object Identifier) : 10.1016/j.eplepsyres.2014.01.024 PMID : 24613746 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0920121114000394 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3792 Reserva
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