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Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country / Mónica Rosa Trujillo Honeysberg  

Público ISBD Título : Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Palabras clave : Encephalitis  risk factors  PICU  etiology  children Resumen : Objective: To describe a cohort of pediatric patients with encephalitis and their risk factors for admission to the pediatric intensive care unit (PICU). Study Design: Children ( Mención de responsabilidad : Guerrero, María P. MD; Romero, Andrés F. MD; Luengas, Miguel MD; Dávalos, Diana M. MD, MPH, DrPH; Mesa-Monsalve, Juan Gonzalo MD; Vivas-Trochez, Rosalba MD; Camacho-Moreno, German MD; Trujillo-Valencia, Mónica MD; Giraldo, Juan P. Calle MD; Mejía, Luis F. MD; Rojas-Hernández, Juan P. MD, MSc; Vinasco, Nathaly MD; Racines, Andrea Ruiz MD; Meléndez, Alejandro MD; Beltrán, Claudia P. MD; López, Pio MD; Chaucanez, Yamile MD; Patiño, Jaime MD; Rodríguez, Wilfrido Coronell MD, PhD; Salgado, Doris MD; Martínez, Marly MD; Restrepo, Andrea MD; Márquez, Kelly MD; Galvis, Diego MD; Benavidez, Iván MD; Rojas, Christian A. MD; Cantor, Erika MSC; López Medina, Eduardo MD, MSc Referencia : Pediatr Infect Dis J. 2022 Oct 1;41(10):806-812. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003637 PMID : 35830514 En línea : https://journals.lww.com/pidj/Abstract/2022/10000/Etiology_and_Risk_Factors_for_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6086 Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country [documento electrónico] / Mónica Rosa Trujillo Honeysberg,  . - 2022. Obra : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Palabras clave : Encephalitis  risk factors  PICU  etiology  children Resumen : Objective: To describe a cohort of pediatric patients with encephalitis and their risk factors for admission to the pediatric intensive care unit (PICU). Study Design: Children ( Mención de responsabilidad : Guerrero, María P. MD; Romero, Andrés F. MD; Luengas, Miguel MD; Dávalos, Diana M. MD, MPH, DrPH; Mesa-Monsalve, Juan Gonzalo MD; Vivas-Trochez, Rosalba MD; Camacho-Moreno, German MD; Trujillo-Valencia, Mónica MD; Giraldo, Juan P. Calle MD; Mejía, Luis F. MD; Rojas-Hernández, Juan P. MD, MSc; Vinasco, Nathaly MD; Racines, Andrea Ruiz MD; Meléndez, Alejandro MD; Beltrán, Claudia P. MD; López, Pio MD; Chaucanez, Yamile MD; Patiño, Jaime MD; Rodríguez, Wilfrido Coronell MD, PhD; Salgado, Doris MD; Martínez, Marly MD; Restrepo, Andrea MD; Márquez, Kelly MD; Galvis, Diego MD; Benavidez, Iván MD; Rojas, Christian A. MD; Cantor, Erika MSC; López Medina, Eduardo MD, MSc Referencia : Pediatr Infect Dis J. 2022 Oct 1;41(10):806-812. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003637 PMID : 35830514 En línea : https://journals.lww.com/pidj/Abstract/2022/10000/Etiology_and_Risk_Factors_for_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6086

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Etiology and the challenge of diagnostic testing of community-acquired pneumonia in children and adolescents / Andrea Victoria Restrepo Gouzy ; Mónica Rosa Trujillo Honeysberg    

Público ISBD Título : Etiology and the challenge of diagnostic testing of community-acquired pneumonia in children and adolescents Tipo de documento : documento electrónico Autores : Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : BMC Pediatrics Idioma : Inglés (eng) Palabras clave : Pneumonia  Diagnosis  Etiology  Multiplex PCR  Serology  Induced sputum  Nasopharyngeal swab  Urine antigen  Children Resumen : Background: Pneumonia is the leading cause of mortality in pediatric population. The etiology of pneumonia in this population is variable and changes according to age and disease severity and where the study is conducted. Our aim was to determine the etiology of community-acquired pneumonia (CAP) in children aged 1 month to 17 years admitted to 13 Colombian hospitals. Methods: Prospective cohort study. Hospitalized children with radiologically confirmed CAP and ≤ 15 days of symptoms were included and followed together with a control group. Induced sputum (IS) was submitted for stains and cultures for pyogenic bacteria and Mycobacterium tuberculosis, and multiplex PCR (mPCR) for bacteria and viruses; urinary antigens for pneumococcus and Legionella pneumophila; nasopharyngeal swabs for viruses, and paired serology for atypical bacteria and viruses. Additional cultures were taken at the discretion of primary care pediatricians. Results: Among 525 children with CAP, 71.6% had non-severe pneumonia; 24.8% severe and 3.6% very severe pneumonia, and no fatal cases. At least one microorganism was identified in 84% of children and 61% were of mixed etiology; 72% had at least one respiratory virus, 28% pyogenic bacteria and 21% atypical bacteria. Respiratory syncytial virus, Parainfluenza, Rhinovirus, Influenza, Mycoplasma pneumoniae, Adenovirus and Streptococcus pneumoniae were the most common etiologies of CAP. Respiratory syncytial virus was more frequent in children under 2 years and in severe pneumonia. Tuberculosis was diagnosed in 2.3% of children. IS was the most useful specimen to identify the etiology (33.6%), and blood cultures were positive in 3.6%. The concordance between all available diagnostic tests was low. A high percentage of healthy children were colonized by S. pneumoniae and Haemophilus influenzae, or were infected by Parainfluenza, Rhinovirus, Influenza and Adenovirus. Conclusions: Respiratory viruses are the most frequent etiology of CAP in children and adolescents, in particular in those under 5 years. This study shows the challenges in making an etiologic diagnosis of CAP in pediatric population because of the poor concordance between tests and the high percentage of multiple microorganisms in healthy children. IS is useful for CAP diagnosis in pediatric population. Mención de responsabilidad : Zulma Vanessa Rueda, Yudy Aguilar, María Angélica Maya, Lucelly López, Andrea Restrepo, Carlos Garcés, Olga Morales, Claudia Roya-Pabón, Mónica Trujillo, Catalina Arango, Ángela Rocio Copete, Cristian Vera, Margarita Rosa Giraldo, Mariana Herrera & Lázaro A. Vélez Referencia : BMC Pediatr. 2022 Mar 31;22(1):169. DOI (Digital Object Identifier) : 10.1186/s12887-022-03235-z PMID : 35361166 Derechos de uso : CC BY En línea : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03235-z Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6029 Etiology and the challenge of diagnostic testing of community-acquired pneumonia in children and adolescents [documento electrónico] / Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg,  . - 2022. Obra : BMC Pediatrics Idioma : Inglés (eng) Palabras clave : Pneumonia  Diagnosis  Etiology  Multiplex PCR  Serology  Induced sputum  Nasopharyngeal swab  Urine antigen  Children Resumen : Background: Pneumonia is the leading cause of mortality in pediatric population. The etiology of pneumonia in this population is variable and changes according to age and disease severity and where the study is conducted. Our aim was to determine the etiology of community-acquired pneumonia (CAP) in children aged 1 month to 17 years admitted to 13 Colombian hospitals. Methods: Prospective cohort study. Hospitalized children with radiologically confirmed CAP and ≤ 15 days of symptoms were included and followed together with a control group. Induced sputum (IS) was submitted for stains and cultures for pyogenic bacteria and Mycobacterium tuberculosis, and multiplex PCR (mPCR) for bacteria and viruses; urinary antigens for pneumococcus and Legionella pneumophila; nasopharyngeal swabs for viruses, and paired serology for atypical bacteria and viruses. Additional cultures were taken at the discretion of primary care pediatricians. Results: Among 525 children with CAP, 71.6% had non-severe pneumonia; 24.8% severe and 3.6% very severe pneumonia, and no fatal cases. At least one microorganism was identified in 84% of children and 61% were of mixed etiology; 72% had at least one respiratory virus, 28% pyogenic bacteria and 21% atypical bacteria. Respiratory syncytial virus, Parainfluenza, Rhinovirus, Influenza, Mycoplasma pneumoniae, Adenovirus and Streptococcus pneumoniae were the most common etiologies of CAP. Respiratory syncytial virus was more frequent in children under 2 years and in severe pneumonia. Tuberculosis was diagnosed in 2.3% of children. IS was the most useful specimen to identify the etiology (33.6%), and blood cultures were positive in 3.6%. The concordance between all available diagnostic tests was low. A high percentage of healthy children were colonized by S. pneumoniae and Haemophilus influenzae, or were infected by Parainfluenza, Rhinovirus, Influenza and Adenovirus. Conclusions: Respiratory viruses are the most frequent etiology of CAP in children and adolescents, in particular in those under 5 years. This study shows the challenges in making an etiologic diagnosis of CAP in pediatric population because of the poor concordance between tests and the high percentage of multiple microorganisms in healthy children. IS is useful for CAP diagnosis in pediatric population. Mención de responsabilidad : Zulma Vanessa Rueda, Yudy Aguilar, María Angélica Maya, Lucelly López, Andrea Restrepo, Carlos Garcés, Olga Morales, Claudia Roya-Pabón, Mónica Trujillo, Catalina Arango, Ángela Rocio Copete, Cristian Vera, Margarita Rosa Giraldo, Mariana Herrera & Lázaro A. Vélez Referencia : BMC Pediatr. 2022 Mar 31;22(1):169. DOI (Digital Object Identifier) : 10.1186/s12887-022-03235-z PMID : 35361166 Derechos de uso : CC BY En línea : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03235-z Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6029

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DD001870	AC-2022-035	Archivo digital	Producción Científica	Artículos científicos	Disponible

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Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents / Andrea Victoria Restrepo Gouzy ; Mónica Rosa Trujillo Honeysberg    

Público ISBD Título : Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents Tipo de documento : documento electrónico Autores : Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : International Journal of Infectious Diseases Idioma : Inglés (eng) Palabras clave : Induced sputum  adolescents  children  diagnosis  etiology  pneumonia Resumen : Objectives: This study aimed to evaluate the utility of induced sputum (IS) for the diagnosis of community-acquired pneumonia (CAP) in pediatric population. Methods: This cross-sectional study included pediatric population aged between 1 month and 17 years who were hospitalized with a diagnosis of CAP in 13 hospitals in Colombia, in whom an IS sample was obtained. Gram staining, aerobic bacterial and mycobacterial culture tests, and polymerase chain reaction (PCR) for 6 atypical bacteria and 15 respiratory viruses were performed. We evaluated the quality of IS samples. Results: IS samples were collected in 516 of 525 children included in this study. The median age was 32 months, 38.6% were younger than 2 years, and 40.9% were between 2 and 5 years. Two patients had transient hypoxemia during the procedure. The quality of the IS obtained was good in 48.4% and intermediate in 24.5%. Identification of a respiratory pathogen was achieved with an IS sample (with Gram staining, culture test, and PCR) in 372 of 516 children with CAP. Conclusion: Our study shows that IS is an adequate sample for the diagnosis of CAP in pediatric population that required hospitalization. The procedure was safe, well tolerated, and with better diagnostic yields compared with the rest of the samples obtained. Mención de responsabilidad : Zulma Vanessa Rueda, Marcela Bermúdez, Andrea Restrepo, Carlos Garcés, Olga Morales, Claudia Roya-Pabón, Luisa Fernanda Carmona, Catalina Arango, Jose Luis Albarracín, Lucelly López, Yudy Aguilar, María Angélica Maya, Mónica Trujillo, Ángela Rocio Copete, Cristian Vera, Mariana Herrera, Margarita Rosa Giraldo, Gloria Isabel Niño-Cruz, Lázaro A Vélez Referencia : Int J Infect Dis. 2022 Jan 19;116:348-354. DOI (Digital Object Identifier) : 10.1016/j.ijid.2022.01.026 PMID : 35063681 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(22)00025-X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6010 Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents [documento electrónico] / Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg,  . - 2022. Obra : International Journal of Infectious Diseases Idioma : Inglés (eng) Palabras clave : Induced sputum  adolescents  children  diagnosis  etiology  pneumonia Resumen : Objectives: This study aimed to evaluate the utility of induced sputum (IS) for the diagnosis of community-acquired pneumonia (CAP) in pediatric population. Methods: This cross-sectional study included pediatric population aged between 1 month and 17 years who were hospitalized with a diagnosis of CAP in 13 hospitals in Colombia, in whom an IS sample was obtained. Gram staining, aerobic bacterial and mycobacterial culture tests, and polymerase chain reaction (PCR) for 6 atypical bacteria and 15 respiratory viruses were performed. We evaluated the quality of IS samples. Results: IS samples were collected in 516 of 525 children included in this study. The median age was 32 months, 38.6% were younger than 2 years, and 40.9% were between 2 and 5 years. Two patients had transient hypoxemia during the procedure. The quality of the IS obtained was good in 48.4% and intermediate in 24.5%. Identification of a respiratory pathogen was achieved with an IS sample (with Gram staining, culture test, and PCR) in 372 of 516 children with CAP. Conclusion: Our study shows that IS is an adequate sample for the diagnosis of CAP in pediatric population that required hospitalization. The procedure was safe, well tolerated, and with better diagnostic yields compared with the rest of the samples obtained. Mención de responsabilidad : Zulma Vanessa Rueda, Marcela Bermúdez, Andrea Restrepo, Carlos Garcés, Olga Morales, Claudia Roya-Pabón, Luisa Fernanda Carmona, Catalina Arango, Jose Luis Albarracín, Lucelly López, Yudy Aguilar, María Angélica Maya, Mónica Trujillo, Ángela Rocio Copete, Cristian Vera, Mariana Herrera, Margarita Rosa Giraldo, Gloria Isabel Niño-Cruz, Lázaro A Vélez Referencia : Int J Infect Dis. 2022 Jan 19;116:348-354. DOI (Digital Object Identifier) : 10.1016/j.ijid.2022.01.026 PMID : 35063681 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(22)00025-X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6010

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DD001845	AC-2022-016	Archivo digital	Producción Científica	Artículos científicos	Disponible

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AC-2022-016 Adobe Acrobat PDF