| Título : |
The 8q24 rs6983267G variant is associated with increased thyroid cancer risk |
| Tipo de documento : |
documento electrónico |
| Autores : |
Alejandro Vélez Hoyos, ; Carlos Simón Duque Fisher, ; Alejandro Rios, |
| Fecha de publicación : |
2015 |
| Títulos uniformes : |
Endocrine Related Cancer
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
Thyroid cancer rs6983267G 8q24 genetic susceptibility |
| Resumen : |
The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11–1.27, P=4.03×10−7), Japan (OR=1.20, 95% CI: 1.03–1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99–1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10−7, OR=1.13, 95% CI: 1.08–1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%. |
| Mención de responsabilidad : |
Ruta Sahasrabudhe, Ana Estrada, Paul Lott, Lynn Martin, Guadalupe Polanco Echeverry, Alejandro Velez, Gila Neta, Meiko Takahasi, Vladimir Saenko, Norisato Mitsutake, JTCMS Consortium; Emma Jaeguer, Carlos Simon Duque, Alejandro Rios, Mabel Bohorquez, Rodrigo Prieto, Angel Criollo, Magdalena Echeverry, Ian Tomlinson, CORGI Consortium; TCUKIN Consortiums; Luis G Carvajal Carmona |
| Referencia : |
Endocr Relat Cancer. 2015 Oct;22(5):841-9. |
| DOI (Digital Object Identifier) : |
10.1530/ERC-15-0081 |
| PMID : |
26290501 |
| En línea : |
https://erc.bioscientifica.com/view/journals/erc/22/5/841.xml |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3938 |
The 8q24 rs6983267G variant is associated with increased thyroid cancer risk [documento electrónico] / Alejandro Vélez Hoyos, ; Carlos Simón Duque Fisher, ; Alejandro Rios, . - 2015. Obra : Endocrine Related CancerIdioma : Inglés ( eng) | Palabras clave : |
Thyroid cancer rs6983267G 8q24 genetic susceptibility |
| Resumen : |
The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11–1.27, P=4.03×10−7), Japan (OR=1.20, 95% CI: 1.03–1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99–1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10−7, OR=1.13, 95% CI: 1.08–1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%. |
| Mención de responsabilidad : |
Ruta Sahasrabudhe, Ana Estrada, Paul Lott, Lynn Martin, Guadalupe Polanco Echeverry, Alejandro Velez, Gila Neta, Meiko Takahasi, Vladimir Saenko, Norisato Mitsutake, JTCMS Consortium; Emma Jaeguer, Carlos Simon Duque, Alejandro Rios, Mabel Bohorquez, Rodrigo Prieto, Angel Criollo, Magdalena Echeverry, Ian Tomlinson, CORGI Consortium; TCUKIN Consortiums; Luis G Carvajal Carmona |
| Referencia : |
Endocr Relat Cancer. 2015 Oct;22(5):841-9. |
| DOI (Digital Object Identifier) : |
10.1530/ERC-15-0081 |
| PMID : |
26290501 |
| En línea : |
https://erc.bioscientifica.com/view/journals/erc/22/5/841.xml |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3938 |
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