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Clinicopathologic features of familial pituitary adenomas / Luis Vicente Syro Moreno  

Público ISBD Título : Clinicopathologic features of familial pituitary adenomas Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2016 Títulos uniformes : Diagnostic Histopathology Idioma : Inglés (eng) Palabras clave : AIP  Carney complex  classification  diagnosis  DICER1  familial isolated  familial syndromes  genetics  McCune–Albright syndrome  multiple endocrine neoplasia type 1  pathology  pituitary adenoma  pituitary blastoma  X-linked acrogigantism syndrome Resumen : Pituitary adenomas are common neoplasms. Initially considered as sporadic tumours, some of them are associated with familial syndromes such as familial isolated pituitary adenoma, multiple endocrine neoplasia type 1 and type 4, X-linked acrogigantism syndrome, Carney complex, pheochromocytoma/paraganglioma–pituitary adenoma, pituitary blastoma and McCune–Albright syndrome. They represent a group of diseases with different genetic background and variable phenotype. Here, we summarize the clinicopathological features of pituitary adenomas associated with these familial syndromes. Mención de responsabilidad : Luis V. Syro, Fabio Rotondo, Kalman Kovacs, Márta Korbonits Referencia : Diag Histop. 2016;22(3):85-91. DOI (Digital Object Identifier) : 10.1016/j.mpdhp.2016.02.004 En línea : http://www.diagnostichistopathology.co.uk/article/S1756-2317(16)00022-0/fulltext Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3958 Clinicopathologic features of familial pituitary adenomas [documento electrónico] / Luis Vicente Syro Moreno,  . - 2016. Obra : Diagnostic Histopathology Idioma : Inglés (eng) Palabras clave : AIP  Carney complex  classification  diagnosis  DICER1  familial isolated  familial syndromes  genetics  McCune–Albright syndrome  multiple endocrine neoplasia type 1  pathology  pituitary adenoma  pituitary blastoma  X-linked acrogigantism syndrome Resumen : Pituitary adenomas are common neoplasms. Initially considered as sporadic tumours, some of them are associated with familial syndromes such as familial isolated pituitary adenoma, multiple endocrine neoplasia type 1 and type 4, X-linked acrogigantism syndrome, Carney complex, pheochromocytoma/paraganglioma–pituitary adenoma, pituitary blastoma and McCune–Albright syndrome. They represent a group of diseases with different genetic background and variable phenotype. Here, we summarize the clinicopathological features of pituitary adenomas associated with these familial syndromes. Mención de responsabilidad : Luis V. Syro, Fabio Rotondo, Kalman Kovacs, Márta Korbonits Referencia : Diag Histop. 2016;22(3):85-91. DOI (Digital Object Identifier) : 10.1016/j.mpdhp.2016.02.004 En línea : http://www.diagnostichistopathology.co.uk/article/S1756-2317(16)00022-0/fulltext Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3958

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Progress in the Diagnosis and Classification of Pituitary Adenomas / Luis Vicente Syro Moreno  

Público ISBD Título : Progress in the Diagnosis and Classification of Pituitary Adenomas Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2015 Títulos uniformes : Frontiers in Endocrinology Idioma : Inglés (eng) Palabras clave : Diagnosis  genetics  pathology  acromegaly  multiple endocrine neoplasia type 1  pituitary adenoma  familial isolated  carney complex Resumen : Pituitary adenomas are common neoplasms. Their classification is based upon size, invasion of adjacent structures, sporadic or familial cases, biochemical activity, clinical manifestations, morphological characteristics, response to treatment and recurrence. Although they are considered benign tumors, some of them are difficult to treat due to their tendency to recur despite standardized treatment. Functional tumors present other challenges for normalizing their biochemical activity. Novel approaches for early diagnosis, as well as different perspectives on classification, may help to identify subgroups of patients with similar characteristics, creating opportunities to match each patient with the best personalized treatment option. In this paper, we present the progress in the diagnosis and classification of different subgroups of patients with pituitary tumors that may be managed with specific considerations according to their tumor subtype. Mención de responsabilidad : Luis V Syro, Fabio Rotondo, Alex Ramirez, Antonio Di Ieva, Murat Aydin Sav, Lina M Restrepo, Carlos A Serna, Kalman Kovacs Referencia : Front Endocrinol (Lausanne). 2015 Jun 12;6:97. DOI (Digital Object Identifier) : 10.3389/fendo.2015.00097 PMID : 26124750 En línea : https://www.frontiersin.org/articles/10.3389/fendo.2015.00097/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3893 Progress in the Diagnosis and Classification of Pituitary Adenomas [documento electrónico] / Luis Vicente Syro Moreno,  . - 2015. Obra : Frontiers in Endocrinology Idioma : Inglés (eng) Palabras clave : Diagnosis  genetics  pathology  acromegaly  multiple endocrine neoplasia type 1  pituitary adenoma  familial isolated  carney complex Resumen : Pituitary adenomas are common neoplasms. Their classification is based upon size, invasion of adjacent structures, sporadic or familial cases, biochemical activity, clinical manifestations, morphological characteristics, response to treatment and recurrence. Although they are considered benign tumors, some of them are difficult to treat due to their tendency to recur despite standardized treatment. Functional tumors present other challenges for normalizing their biochemical activity. Novel approaches for early diagnosis, as well as different perspectives on classification, may help to identify subgroups of patients with similar characteristics, creating opportunities to match each patient with the best personalized treatment option. In this paper, we present the progress in the diagnosis and classification of different subgroups of patients with pituitary tumors that may be managed with specific considerations according to their tumor subtype. Mención de responsabilidad : Luis V Syro, Fabio Rotondo, Alex Ramirez, Antonio Di Ieva, Murat Aydin Sav, Lina M Restrepo, Carlos A Serna, Kalman Kovacs Referencia : Front Endocrinol (Lausanne). 2015 Jun 12;6:97. DOI (Digital Object Identifier) : 10.3389/fendo.2015.00097 PMID : 26124750 En línea : https://www.frontiersin.org/articles/10.3389/fendo.2015.00097/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3893

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Improving differential diagnosis of pituitary adenomas / Carlos Esteban Builes Montaño ; Luis Vicente Syro Moreno  

Público ISBD Título : Improving differential diagnosis of pituitary adenomas Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, ; Luis Vicente Syro Moreno, Fecha de publicación : 2014 Títulos uniformes : Expert Review of Endocrinology and Metabolism Idioma : Inglés (eng) Palabras clave : Classification  diagnosis  familial syndrome  genetics  pathology  pituitary adenoma Resumen : Pituitary adenomas are common tumors arising in adenohypophysial cells or their precursors. For improving control of the disease an early diagnosis is important. Initially considered sporadic tumors, some of them are associated with familial syndromes and their recognition and classification is also required. Morphologically, pituitary adenomas represent a heterogeneous group of tumors with several subtypes and different clinical behavior thus a precise pathological diagnosis is crucial. The simple diagnosis of pituitary adenoma is not satisfactory and the correct classification of histological subtypes may predict aggressiveness in the majority of cases. Although considered not malignant, some of them are clinically aggressive and their recognition remains a challenge. In this paper we present the recent advances in the event of improving early recognition and differential diagnosis of pituitary tumors. Mención de responsabilidad : Luis V Syro, Carlos E Builes, Antonio Di Ieva, Aydin Sav, Fabio Rotondo, Kalman Kovacs Referencia : Expert Rev Endocrinol Metab. 2014 Jul;9(4):377-386. DOI (Digital Object Identifier) : 10.1586/17446651.2014.922412 PMID : 30763997 En línea : https://www.tandfonline.com/doi/abs/10.1586/17446651.2014.922412?journalCode=ier [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3801 Improving differential diagnosis of pituitary adenomas [documento electrónico] / Carlos Esteban Builes Montaño, ; Luis Vicente Syro Moreno,  . - 2014. Obra : Expert Review of Endocrinology and Metabolism Idioma : Inglés (eng) Palabras clave : Classification  diagnosis  familial syndrome  genetics  pathology  pituitary adenoma Resumen : Pituitary adenomas are common tumors arising in adenohypophysial cells or their precursors. For improving control of the disease an early diagnosis is important. Initially considered sporadic tumors, some of them are associated with familial syndromes and their recognition and classification is also required. Morphologically, pituitary adenomas represent a heterogeneous group of tumors with several subtypes and different clinical behavior thus a precise pathological diagnosis is crucial. The simple diagnosis of pituitary adenoma is not satisfactory and the correct classification of histological subtypes may predict aggressiveness in the majority of cases. Although considered not malignant, some of them are clinically aggressive and their recognition remains a challenge. In this paper we present the recent advances in the event of improving early recognition and differential diagnosis of pituitary tumors. Mención de responsabilidad : Luis V Syro, Carlos E Builes, Antonio Di Ieva, Aydin Sav, Fabio Rotondo, Kalman Kovacs Referencia : Expert Rev Endocrinol Metab. 2014 Jul;9(4):377-386. DOI (Digital Object Identifier) : 10.1586/17446651.2014.922412 PMID : 30763997 En línea : https://www.tandfonline.com/doi/abs/10.1586/17446651.2014.922412?journalCode=ier [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3801

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Pituitary tumors in patients with MEN1 syndrome / Luis Vicente Syro Moreno  

Público ISBD Título : Pituitary tumors in patients with MEN1 syndrome Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2012 Títulos uniformes : Clinics (Sao Paulo) Idioma : Inglés (eng) Palabras clave : Pituitary neoplasms  multiple endocrine neoplasia type 1  review  genetics Resumen : We briefly review the characteristics of pituitary tumors associated with multiple endocrine neoplasia type 1. Multiple endocrine neoplasia type 1 is an autosomal-dominant disorder most commonly characterized by tumors of the pituitary, parathyroid, endocrine-gastrointestinal tract, and pancreas. A MEDLINE search for all available publications regarding multiple endocrine neoplasia type 1 and pituitary adenomas was undertaken. The prevalence of pituitary tumors in multiple endocrine neoplasia type 1 may vary from 10% to 60% depending on the studied series, and such tumors may occur as the first clinical manifestation of multiple endocrine neoplasia type 1 in 25% of sporadic and 10% of familial cases. Patients were younger and the time between initial and subsequent multiple endocrine neoplasia type 1 endocrine lesions was significantly longer when pituitary disease was the initial manifestation of multiple endocrine neoplasia type 1. Tumors were larger and more invasive and clinical manifestations related to the size of the pituitary adenoma were significantly more frequent in patients with multiple endocrine neoplasia type 1 than in subjects with non-multiple endocrine neoplasia type 1. Normalization of pituitary hypersecretion was much less frequent in patients with multiple endocrine neoplasia type 1 than in subjects with non-multiple endocrine neoplasia type 1. Pituitary tumors in patients with multiple endocrine neoplasia type 1 syndrome tend to be larger, invasive and more symptomatic, and they tend to occur in younger patients when they are the initial presentation of multiple endocrine neoplasia type 1. Mención de responsabilidad : Luis V Syro, Bernd W Scheithauer, Kalman Kovacs, Rodrigo A Toledo, Francisco J Londoño, Leon D Ortiz, Fabio Rotondo, Eva Horvath, Humberto Uribe Referencia : Clinics (Sao Paulo). 2012;67 Suppl 1:43-8. DOI (Digital Object Identifier) : 10.6061/clinics/2012(Sup01)09 PMID : 22584705 En línea : https://www.revistas.usp.br/clinics/article/view/19720 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3610 Pituitary tumors in patients with MEN1 syndrome [documento electrónico] / Luis Vicente Syro Moreno,  . - 2012. Obra : Clinics (Sao Paulo) Idioma : Inglés (eng) Palabras clave : Pituitary neoplasms  multiple endocrine neoplasia type 1  review  genetics Resumen : We briefly review the characteristics of pituitary tumors associated with multiple endocrine neoplasia type 1. Multiple endocrine neoplasia type 1 is an autosomal-dominant disorder most commonly characterized by tumors of the pituitary, parathyroid, endocrine-gastrointestinal tract, and pancreas. A MEDLINE search for all available publications regarding multiple endocrine neoplasia type 1 and pituitary adenomas was undertaken. The prevalence of pituitary tumors in multiple endocrine neoplasia type 1 may vary from 10% to 60% depending on the studied series, and such tumors may occur as the first clinical manifestation of multiple endocrine neoplasia type 1 in 25% of sporadic and 10% of familial cases. Patients were younger and the time between initial and subsequent multiple endocrine neoplasia type 1 endocrine lesions was significantly longer when pituitary disease was the initial manifestation of multiple endocrine neoplasia type 1. Tumors were larger and more invasive and clinical manifestations related to the size of the pituitary adenoma were significantly more frequent in patients with multiple endocrine neoplasia type 1 than in subjects with non-multiple endocrine neoplasia type 1. Normalization of pituitary hypersecretion was much less frequent in patients with multiple endocrine neoplasia type 1 than in subjects with non-multiple endocrine neoplasia type 1. Pituitary tumors in patients with multiple endocrine neoplasia type 1 syndrome tend to be larger, invasive and more symptomatic, and they tend to occur in younger patients when they are the initial presentation of multiple endocrine neoplasia type 1. Mención de responsabilidad : Luis V Syro, Bernd W Scheithauer, Kalman Kovacs, Rodrigo A Toledo, Francisco J Londoño, Leon D Ortiz, Fabio Rotondo, Eva Horvath, Humberto Uribe Referencia : Clinics (Sao Paulo). 2012;67 Suppl 1:43-8. DOI (Digital Object Identifier) : 10.6061/clinics/2012(Sup01)09 PMID : 22584705 En línea : https://www.revistas.usp.br/clinics/article/view/19720 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3610

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Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus / Alejandro Daniel Velásquez Urzola  

Público ISBD Título : Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus Tipo de documento : documento electrónico Autores : Alejandro Daniel Velásquez Urzola, Fecha de publicación : 2006 Títulos uniformes : Journal of Autoimmunity Idioma : Inglés (eng) Palabras clave : Aggregation  autoimmunity  type 1 diabetes mellitus  hypothyroidism  genetics Resumen : We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] 1⁄4 1.74e9.0, p 1⁄4 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI 1⁄4 1.64e7.73, p 1⁄4 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. Mención de responsabilidad : Juan-Manuel Anaya, John Castiblanco, Gabriel J Tobón, Jorge García, Verónica Abad, Héctor Cuervo, Alejandro Velásquez, Ivan D Angel, Patricia Vega, Alvaro Arango Referencia : J Autoimmun. 2006 May;26(3):208-14. DOI (Digital Object Identifier) : 10.1016/j.jaut.2006.01.001 PMID : 16503115 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0896841106000096 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3439 Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus [documento electrónico] / Alejandro Daniel Velásquez Urzola,  . - 2006. Obra : Journal of Autoimmunity Idioma : Inglés (eng) Palabras clave : Aggregation  autoimmunity  type 1 diabetes mellitus  hypothyroidism  genetics Resumen : We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] 1⁄4 1.74e9.0, p 1⁄4 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI 1⁄4 1.64e7.73, p 1⁄4 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. Mención de responsabilidad : Juan-Manuel Anaya, John Castiblanco, Gabriel J Tobón, Jorge García, Verónica Abad, Héctor Cuervo, Alejandro Velásquez, Ivan D Angel, Patricia Vega, Alvaro Arango Referencia : J Autoimmun. 2006 May;26(3):208-14. DOI (Digital Object Identifier) : 10.1016/j.jaut.2006.01.001 PMID : 16503115 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0896841106000096 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3439

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