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Time of Cold Ischemia and Delayed Graft Function in a Cohort of Renal Transplant Patients in a Reference Center / John Fredy Nieto Ríos ; Catalina Ocampo Kohn ; Carolina Lucía Ochoa García ; Arbey Aristizabal Álzate ; Gustavo Adolfo Zuluaga Valencia
Título : Time of Cold Ischemia and Delayed Graft Function in a Cohort of Renal Transplant Patients in a Reference Center Tipo de documento : documento electrónico Autores : John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Carolina Lucía Ochoa García, ; Arbey Aristizabal Álzate, ; Gustavo Adolfo Zuluaga Valencia, Fecha de publicación : 2019 Títulos uniformes : Indian Journal of Nephrology Idioma : Inglés (eng) Palabras clave : Acute rejection cold ischemia time delayed graft function graft loss immunosuppression kidney transplantation Resumen : There are many factors involved in the delayed graft function of a renal graft, with prolonged cold ischemia time being one of the most relevant. The aim of this study is to evaluate the relationship between the time of cold ischemia and the delayed graft function, and acute rejection and graft loss at 1 year of follow-up. A retrospective cohort of 347 renal transplant patients were evaluated during the years 2009-2013. The incidence of delayed graft function was 18.4% (n = 65). The cold ischemia time was an independent risk factor for delayed graft function (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.04-1.16). By grouping the time of cold ischemia by intervals, the risk of delayed graft function was greater in the 12-18 hours group (OR 2.06, 95% CI 1.02-4.15) and in the >18 hours group (OR 3.38, 95% CI 1.57-7.27). The risk of acute rejection did not increase with longer cold ischemia (p = 0.69), and cold ischemia time was not a risk factor for renal graft loss at 1-year follow-up (hazard ratio 0.97, 95% CI 0.88-1.06). In conclusion the time of cold ischemia (>12 hours) in renal transplant recipients of optimal deceased donors increases the risk of delayed graft function; however, this does not negatively impact the results in acute rejection or graft loss in the first year of the transplant. Mención de responsabilidad : J F Nieto-Ríos, C L Ochoa-García, A Serna-Campuzano, B Benavides-Hermosa, L L Calderón-Puentes, A Aristizabal-Alzate, C Ocampo-Kohn, G Zuluaga-Valencia, L M Serna-Higuita Referencia : Indian J Nephrol. 2019 Jan-Feb;29(1):8-14. DOI (Digital Object Identifier) : 10.4103/ijn.IJN_162_18 PMID : 30814787 Derechos de uso : CC BY-NC-SA En línea : http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2019;volume=29;iss [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4259 Time of Cold Ischemia and Delayed Graft Function in a Cohort of Renal Transplant Patients in a Reference Center [documento electrónico] / John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Carolina Lucía Ochoa García, ; Arbey Aristizabal Álzate, ; Gustavo Adolfo Zuluaga Valencia, . - 2019.
Obra : Indian Journal of Nephrology
Idioma : Inglés (eng)
Palabras clave : Acute rejection cold ischemia time delayed graft function graft loss immunosuppression kidney transplantation Resumen : There are many factors involved in the delayed graft function of a renal graft, with prolonged cold ischemia time being one of the most relevant. The aim of this study is to evaluate the relationship between the time of cold ischemia and the delayed graft function, and acute rejection and graft loss at 1 year of follow-up. A retrospective cohort of 347 renal transplant patients were evaluated during the years 2009-2013. The incidence of delayed graft function was 18.4% (n = 65). The cold ischemia time was an independent risk factor for delayed graft function (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.04-1.16). By grouping the time of cold ischemia by intervals, the risk of delayed graft function was greater in the 12-18 hours group (OR 2.06, 95% CI 1.02-4.15) and in the >18 hours group (OR 3.38, 95% CI 1.57-7.27). The risk of acute rejection did not increase with longer cold ischemia (p = 0.69), and cold ischemia time was not a risk factor for renal graft loss at 1-year follow-up (hazard ratio 0.97, 95% CI 0.88-1.06). In conclusion the time of cold ischemia (>12 hours) in renal transplant recipients of optimal deceased donors increases the risk of delayed graft function; however, this does not negatively impact the results in acute rejection or graft loss in the first year of the transplant. Mención de responsabilidad : J F Nieto-Ríos, C L Ochoa-García, A Serna-Campuzano, B Benavides-Hermosa, L L Calderón-Puentes, A Aristizabal-Alzate, C Ocampo-Kohn, G Zuluaga-Valencia, L M Serna-Higuita Referencia : Indian J Nephrol. 2019 Jan-Feb;29(1):8-14. DOI (Digital Object Identifier) : 10.4103/ijn.IJN_162_18 PMID : 30814787 Derechos de uso : CC BY-NC-SA En línea : http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2019;volume=29;iss [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4259 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001238 AC-2019-027 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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