4 búsqueda de la palabra clave 'histology'

Acute respiratory distress syndrome in patients with and without diffuse alveolar damage: an autopsy study / Diego Alejandro Muñoz Rincón  

Público ISBD Título : Acute respiratory distress syndrome in patients with and without diffuse alveolar damage: an autopsy study Tipo de documento : documento electrónico Autores : Diego Alejandro Muñoz Rincón, Fecha de publicación : 2015 Títulos uniformes : Intensive Care Medicine Idioma : Inglés (eng) Palabras clave : Adult respiratory distress syndrome  diffuse alveolar damage  subphenotype  histology  autopsy  hyaline membranes Resumen : Objective: To demonstrate that among patients with acute respiratory distress syndrome (ARDS), the presence of diffuse alveolar damage (DAD) at histological examination, as compared to its absence, defines a specific subphenotype. Methods: We studied 149 patients who died in our ICU with the clinical diagnosis of ARDS according to the Berlin Definition (BD) and who had autopsy examination. We compared the change over time of different clinical variables in patients with (n = 49) and without (n = 100) DAD. A predictive model for the presence of DAD was developed and validated in an independent cohort of 57 patients with ARDS and postmortem examination (21 of them with DAD). Results: Patients with DAD, as compared to patients without DAD, had a lower PaO2/FiO2 ratio and dynamic respiratory system compliance, and a higher SOFA score and INR, and were more likely to die of hypoxemia and less likely to die of shock. In multivariate analysis, variables associated with DAD [odds ratio, 95 % confidence interval (CI)] were PaO2/FiO2 ratio [0.988 (0.981–0.995)], dynamic respiratory system compliance [0.937 (0.892–0.984)] and age [0.972 (0.946–0.999)]. Areas under the ROC curve (95 % CI) for the classification of DAD using the regression model or the BD were, respectively, 0.74 (0.65–0.82) and 0.64 (0.55–0.72) (p = 0.03). In the validation cohort, the areas under the ROC curve for the diagnosis of DAD were 0.73 (0.56–0.90) and 0.67 (0.54–0.81) for the regression model and the BD, respectively. Conclusions: The presence of DAD appears to define a specific subphenotype in patients with ARDS. Targeting patients with DAD within the population of patients with the clinical diagnosis of ARDS might be appropriate to find effective therapies for this condition. Mención de responsabilidad : José A Lorente, Pablo Cardinal-Fernández, Diego Muñoz, Fernando Frutos-Vivar, Arnaud W Thille, Carlos Jaramillo, Aida Ballén-Barragán, José M Rodríguez, Oscar Peñuelas, Guillermo Ortiz, José Blanco, Bruno Valle Pinheiro, Nicolás Nin, María del Carmen Marin, Andrés Esteban, Taylor B Thompson Referencia : Intensive Care Med. 2015 Nov;41(11):1921-30. DOI (Digital Object Identifier) : 10.1007/s00134-015-4046-0 PMID : 26385863 En línea : https://link.springer.com/article/10.1007%2Fs00134-015-4046-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3937 Acute respiratory distress syndrome in patients with and without diffuse alveolar damage: an autopsy study [documento electrónico] / Diego Alejandro Muñoz Rincón,  . - 2015. Obra : Intensive Care Medicine Idioma : Inglés (eng) Palabras clave : Adult respiratory distress syndrome  diffuse alveolar damage  subphenotype  histology  autopsy  hyaline membranes Resumen : Objective: To demonstrate that among patients with acute respiratory distress syndrome (ARDS), the presence of diffuse alveolar damage (DAD) at histological examination, as compared to its absence, defines a specific subphenotype. Methods: We studied 149 patients who died in our ICU with the clinical diagnosis of ARDS according to the Berlin Definition (BD) and who had autopsy examination. We compared the change over time of different clinical variables in patients with (n = 49) and without (n = 100) DAD. A predictive model for the presence of DAD was developed and validated in an independent cohort of 57 patients with ARDS and postmortem examination (21 of them with DAD). Results: Patients with DAD, as compared to patients without DAD, had a lower PaO2/FiO2 ratio and dynamic respiratory system compliance, and a higher SOFA score and INR, and were more likely to die of hypoxemia and less likely to die of shock. In multivariate analysis, variables associated with DAD [odds ratio, 95 % confidence interval (CI)] were PaO2/FiO2 ratio [0.988 (0.981–0.995)], dynamic respiratory system compliance [0.937 (0.892–0.984)] and age [0.972 (0.946–0.999)]. Areas under the ROC curve (95 % CI) for the classification of DAD using the regression model or the BD were, respectively, 0.74 (0.65–0.82) and 0.64 (0.55–0.72) (p = 0.03). In the validation cohort, the areas under the ROC curve for the diagnosis of DAD were 0.73 (0.56–0.90) and 0.67 (0.54–0.81) for the regression model and the BD, respectively. Conclusions: The presence of DAD appears to define a specific subphenotype in patients with ARDS. Targeting patients with DAD within the population of patients with the clinical diagnosis of ARDS might be appropriate to find effective therapies for this condition. Mención de responsabilidad : José A Lorente, Pablo Cardinal-Fernández, Diego Muñoz, Fernando Frutos-Vivar, Arnaud W Thille, Carlos Jaramillo, Aida Ballén-Barragán, José M Rodríguez, Oscar Peñuelas, Guillermo Ortiz, José Blanco, Bruno Valle Pinheiro, Nicolás Nin, María del Carmen Marin, Andrés Esteban, Taylor B Thompson Referencia : Intensive Care Med. 2015 Nov;41(11):1921-30. DOI (Digital Object Identifier) : 10.1007/s00134-015-4046-0 PMID : 26385863 En línea : https://link.springer.com/article/10.1007%2Fs00134-015-4046-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3937

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Melanoma of the sellar region mimicking pituitary adenoma / Luis Vicente Syro Moreno  

Público ISBD Título : Melanoma of the sellar region mimicking pituitary adenoma Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2013 Títulos uniformes : Neuropathology Idioma : Inglés (eng) Palabras clave : Histology  melanoma  neoplasm  pathology  pituitary Resumen : We report here the case of an 82‐year‐old woman who presented with visual disturbance. MRI demonstrated a sellar mass. The diagnosis of pituitary adenoma was made. She underwent transnasal surgery. Histologic, immunohistochemical and ultrastructural studies indicated that the tumor was a melanoma. Despite an exhaustive search for a primary lesion elsewhere, none was found. The sellar tumor was considered a primary lesion, although extrasellar primary tumor imaging cannot be excluded with 100% certainty. Reported examples of melanoma affecting the sellar region are few. They exhibit morphologic features identical to those of melanomas arising elsewhere. Although very rare, primary melanomas enter into the differential diagnosis of sellar lesions. Mención de responsabilidad : Michael Sidiropoulos, Luis V Syro, Fabio Rotondo, Bernd W Scheithauer, Luis Carlos Penagos, Humberto Uribe, Maria Del Pilar Ramirez, Eva Horvath, Miklos Goth, Kalman Kovacs Referencia : Neuropathology. 2013 Apr;33(2):175-8. DOI (Digital Object Identifier) : 10.1111/j.1440-1789.2012.01331.x PMID : 22624497 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1789.2012.01331.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3663 Melanoma of the sellar region mimicking pituitary adenoma [documento electrónico] / Luis Vicente Syro Moreno,  . - 2013. Obra : Neuropathology Idioma : Inglés (eng) Palabras clave : Histology  melanoma  neoplasm  pathology  pituitary Resumen : We report here the case of an 82‐year‐old woman who presented with visual disturbance. MRI demonstrated a sellar mass. The diagnosis of pituitary adenoma was made. She underwent transnasal surgery. Histologic, immunohistochemical and ultrastructural studies indicated that the tumor was a melanoma. Despite an exhaustive search for a primary lesion elsewhere, none was found. The sellar tumor was considered a primary lesion, although extrasellar primary tumor imaging cannot be excluded with 100% certainty. Reported examples of melanoma affecting the sellar region are few. They exhibit morphologic features identical to those of melanomas arising elsewhere. Although very rare, primary melanomas enter into the differential diagnosis of sellar lesions. Mención de responsabilidad : Michael Sidiropoulos, Luis V Syro, Fabio Rotondo, Bernd W Scheithauer, Luis Carlos Penagos, Humberto Uribe, Maria Del Pilar Ramirez, Eva Horvath, Miklos Goth, Kalman Kovacs Referencia : Neuropathology. 2013 Apr;33(2):175-8. DOI (Digital Object Identifier) : 10.1111/j.1440-1789.2012.01331.x PMID : 22624497 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1789.2012.01331.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3663

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Silent somatotroph adenoma: a morphologic, immunohistochemical and electron microscopic study: a case report / Carlos Esteban Builes Montaño ; Luis Vicente Syro Moreno    

Público ISBD Título : Silent somatotroph adenoma: a morphologic, immunohistochemical and electron microscopic study: a case report Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, ; Luis Vicente Syro Moreno, Fecha de publicación : 2012 Títulos uniformes : Journal of Medical Cases Idioma : Inglés (eng) Palabras clave : Electron microscopy  histology  immunohistochemistry  pituitary adenoma  endocrine silence Resumen : Pituitary adenoma, removed surgically from a 22 old young man with normal serum growth hormone level, and no evidence of acromegaly by histology, immunohistochemistry and electron microscopy was studied. Ultrastructurally the tumor cells were shown to correspond to sparsely granulated somatotrophs and immunohisto chemistry showed no, moderate, or little growth hormone. Clinically silent somatotroph adenomas so far are unresolved entities; although electron microscopy shows that they are consisted of sparsely granulated somatotrophs they do not secrete substantial amounts to raise growth hormone and IGF-1 blood levels. Further work is required to clarify the mechanisms accounting for the clinical and biochemical silence of these tumors. Mención de responsabilidad : Aydin Sav, Luis V Syro, Bernd W Scheithauer, Fabio Rotondo, Carlos A Builes, Eva Horvath, Kalman Kovacs Referencia : J Med Cases. 2012;3(1):43-8. DOI (Digital Object Identifier) : 10.4021/jmc416w Derechos de uso : CC BY-NC En línea : https://www.journalmc.org/index.php/JMC/article/view/416 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3612 Silent somatotroph adenoma: a morphologic, immunohistochemical and electron microscopic study: a case report [documento electrónico] / Carlos Esteban Builes Montaño, ; Luis Vicente Syro Moreno,  . - 2012. Obra : Journal of Medical Cases Idioma : Inglés (eng) Palabras clave : Electron microscopy  histology  immunohistochemistry  pituitary adenoma  endocrine silence Resumen : Pituitary adenoma, removed surgically from a 22 old young man with normal serum growth hormone level, and no evidence of acromegaly by histology, immunohistochemistry and electron microscopy was studied. Ultrastructurally the tumor cells were shown to correspond to sparsely granulated somatotrophs and immunohisto chemistry showed no, moderate, or little growth hormone. Clinically silent somatotroph adenomas so far are unresolved entities; although electron microscopy shows that they are consisted of sparsely granulated somatotrophs they do not secrete substantial amounts to raise growth hormone and IGF-1 blood levels. Further work is required to clarify the mechanisms accounting for the clinical and biochemical silence of these tumors. Mención de responsabilidad : Aydin Sav, Luis V Syro, Bernd W Scheithauer, Fabio Rotondo, Carlos A Builes, Eva Horvath, Kalman Kovacs Referencia : J Med Cases. 2012;3(1):43-8. DOI (Digital Object Identifier) : 10.4021/jmc416w Derechos de uso : CC BY-NC En línea : https://www.journalmc.org/index.php/JMC/article/view/416 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3612

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Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma / Luis Vicente Syro Moreno  

Público ISBD Título : Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2000 Títulos uniformes : Journal of Endocrinological Investigation Idioma : Inglés (eng) Palabras clave : Pituitary neoplasm  pathology  histology  immunocytochemistry  ultrastructure  acromegaly  somatotroph adenoma  gonadotroph adenoma  double adenomas  collision tumors Resumen : Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic resonance imaging demonstrated a pituitary tumor. The surgically removed sellar mass was investigated by histology, immunocytochemistry and electron microscopy. Morphologic study revealed a collision tumor; one was a somatotroph adenoma, the other a gonadotroph adenoma. Authors call attention to the difficulties in clinical, imaging and pathological diagnosis. Detailed morphologic studies are needed to establish the presence of two distinct tumors composed of two different cell types. Mención de responsabilidad : L. V. Syro, E. Horvath & Kalman Kovacs Referencia : J Endocrinol Invest. 2000 Jan;23(1):37-41. DOI (Digital Object Identifier) : 10.1007/BF03343674 PMID : 10698050 En línea : https://link.springer.com/article/10.1007/BF03343674 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4387 Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma [documento electrónico] / Luis Vicente Syro Moreno,  . - 2000. Obra : Journal of Endocrinological Investigation Idioma : Inglés (eng) Palabras clave : Pituitary neoplasm  pathology  histology  immunocytochemistry  ultrastructure  acromegaly  somatotroph adenoma  gonadotroph adenoma  double adenomas  collision tumors Resumen : Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic resonance imaging demonstrated a pituitary tumor. The surgically removed sellar mass was investigated by histology, immunocytochemistry and electron microscopy. Morphologic study revealed a collision tumor; one was a somatotroph adenoma, the other a gonadotroph adenoma. Authors call attention to the difficulties in clinical, imaging and pathological diagnosis. Detailed morphologic studies are needed to establish the presence of two distinct tumors composed of two different cell types. Mención de responsabilidad : L. V. Syro, E. Horvath & Kalman Kovacs Referencia : J Endocrinol Invest. 2000 Jan;23(1):37-41. DOI (Digital Object Identifier) : 10.1007/BF03343674 PMID : 10698050 En línea : https://link.springer.com/article/10.1007/BF03343674 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4387

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