3 búsqueda de la palabra clave 'hypothalamus'

Clinical biology of the pituitary adenoma / Luis Vicente Syro Moreno    

Público ISBD Título : Clinical biology of the pituitary adenoma Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2022 Títulos uniformes : Endocrine Reviews Idioma : Inglés (eng) Palabras clave : pituitary adenoma  acromegaly  prolactinoma  Cushing’s disease  aggressive pituitary tumor  hypothalamus Resumen : All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of diverse behaviors and impact on health. To understand the clinical biology of these common yet often innocuous neoplasms, we review pituitary physiology, and adenoma epidemiology, pathophysiology, behavior, and clinical consequences. The anterior pituitary develops in response to a range of complex brain signals integrating with intrinsic ectodermal cell transcriptional events that together determine gland growth, cell type differentiation, and hormonal production, in turn maintaining optimal endocrine health. Pituitary adenomas occur in ten percent of the population; however, the overwhelming majority remain harmless during life. Triggered by somatic or germline mutations, disease-causing adenomas manifest pathogenic mechanisms that disrupt intra-pituitary signaling to promote benign cell proliferation associated with chromosomal instability. Cellular senescence acts as a mechanistic buffer protecting against malignant transformation, an extremely rare event. It is estimated that fewer than one thousandth of all pituitary adenomas cause clinically significant disease. Adenomas variably and adversely affect morbidity and mortality depending on cell type, hormone secretory activity, and growth behavior. For most clinically apparent adenomas, multimodal therapy controlling hormone secretion and adenoma growth lead to improved quality of life and normalized mortality. The clinical biology of pituitary adenomas and particularly their benign nature stands in marked contrast to other tumors of the endocrine system such as thyroid and neuroendocrine tumors. Mención de responsabilidad : Shlomo Melmed, Ursula B Kaiser, M Beatriz Lopes, Jerome Bertherat, Luis V Syro, Gerald Raverot, Martin Reincke, Gudmundur Johannsson, Albert Beckers, Maria Fleseriu, Andrea Giustina, John A H Wass, Ken K Y Ho Referencia : Endocr Rev. 2022 Apr 8;bnac010. DOI (Digital Object Identifier) : 10.1210/endrev/bnac010 PMID : 35395078 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/edrv/advance-article/doi/10.1210/endrev/bnac010/6565598 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6028 Clinical biology of the pituitary adenoma [documento electrónico] / Luis Vicente Syro Moreno,  . - 2022. Obra : Endocrine Reviews Idioma : Inglés (eng) Palabras clave : pituitary adenoma  acromegaly  prolactinoma  Cushing’s disease  aggressive pituitary tumor  hypothalamus Resumen : All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of diverse behaviors and impact on health. To understand the clinical biology of these common yet often innocuous neoplasms, we review pituitary physiology, and adenoma epidemiology, pathophysiology, behavior, and clinical consequences. The anterior pituitary develops in response to a range of complex brain signals integrating with intrinsic ectodermal cell transcriptional events that together determine gland growth, cell type differentiation, and hormonal production, in turn maintaining optimal endocrine health. Pituitary adenomas occur in ten percent of the population; however, the overwhelming majority remain harmless during life. Triggered by somatic or germline mutations, disease-causing adenomas manifest pathogenic mechanisms that disrupt intra-pituitary signaling to promote benign cell proliferation associated with chromosomal instability. Cellular senescence acts as a mechanistic buffer protecting against malignant transformation, an extremely rare event. It is estimated that fewer than one thousandth of all pituitary adenomas cause clinically significant disease. Adenomas variably and adversely affect morbidity and mortality depending on cell type, hormone secretory activity, and growth behavior. For most clinically apparent adenomas, multimodal therapy controlling hormone secretion and adenoma growth lead to improved quality of life and normalized mortality. The clinical biology of pituitary adenomas and particularly their benign nature stands in marked contrast to other tumors of the endocrine system such as thyroid and neuroendocrine tumors. Mención de responsabilidad : Shlomo Melmed, Ursula B Kaiser, M Beatriz Lopes, Jerome Bertherat, Luis V Syro, Gerald Raverot, Martin Reincke, Gudmundur Johannsson, Albert Beckers, Maria Fleseriu, Andrea Giustina, John A H Wass, Ken K Y Ho Referencia : Endocr Rev. 2022 Apr 8;bnac010. DOI (Digital Object Identifier) : 10.1210/endrev/bnac010 PMID : 35395078 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/edrv/advance-article/doi/10.1210/endrev/bnac010/6565598 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6028

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Documentos electrónicos

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Arginine vasopressin (AVP): a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system / Luis Vicente Syro Moreno  

Público ISBD Título : Arginine vasopressin (AVP): a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2016 Títulos uniformes : Pituitary Idioma : Inglés (eng) Palabras clave : Arginine vasopressin  corticotroph cells  hypothalamus  pituitary  receptors Resumen : Introduction: This publication reviews the function of arginine vasopressin and focuses on the morphologic and functional correlation between the hormone and its effect on stress, the hypophysial–adrenocortical axis, neuroimmune responses, renal function and corticotroph pituitary tumors. Materials and methods: A literature review was performed using various search engines for information regarding the morphology and the multifunctional role of arginine vasopressin. Results: Although a large number of studies were published discussing these interactions, there are several important areas that are still obscure. Conclusion: The questions of how does arginine vasopressin affect the morphology and function of these various areas, and how does the secretion of ACTH and adreno-cortical hormones influence the morphology of arginine vasopressin-producing cells and their hormone secretion requires further investigation. Mención de responsabilidad : Fabio Rotondo, Henriett Butz, Luis V Syro, George M Yousef, Antonio Di Ieva, Lina M Restrepo, Andres Quintanar-Stephano, Istvan Berczi, Kalman Kovacs Referencia : Pituitary. 2016 Aug;19(4):345-55. DOI (Digital Object Identifier) : 10.1007/s11102-015-0703-0 PMID : 26762848 En línea : https://link.springer.com/article/10.1007%2Fs11102-015-0703-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3948 Arginine vasopressin (AVP): a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system [documento electrónico] / Luis Vicente Syro Moreno,  . - 2016. Obra : Pituitary Idioma : Inglés (eng) Palabras clave : Arginine vasopressin  corticotroph cells  hypothalamus  pituitary  receptors Resumen : Introduction: This publication reviews the function of arginine vasopressin and focuses on the morphologic and functional correlation between the hormone and its effect on stress, the hypophysial–adrenocortical axis, neuroimmune responses, renal function and corticotroph pituitary tumors. Materials and methods: A literature review was performed using various search engines for information regarding the morphology and the multifunctional role of arginine vasopressin. Results: Although a large number of studies were published discussing these interactions, there are several important areas that are still obscure. Conclusion: The questions of how does arginine vasopressin affect the morphology and function of these various areas, and how does the secretion of ACTH and adreno-cortical hormones influence the morphology of arginine vasopressin-producing cells and their hormone secretion requires further investigation. Mención de responsabilidad : Fabio Rotondo, Henriett Butz, Luis V Syro, George M Yousef, Antonio Di Ieva, Lina M Restrepo, Andres Quintanar-Stephano, Istvan Berczi, Kalman Kovacs Referencia : Pituitary. 2016 Aug;19(4):345-55. DOI (Digital Object Identifier) : 10.1007/s11102-015-0703-0 PMID : 26762848 En línea : https://link.springer.com/article/10.1007%2Fs11102-015-0703-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3948

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Pituitary immunoexpression of ghrelin in anorexia nervosa / Luis Vicente Syro Moreno  

Público ISBD Título : Pituitary immunoexpression of ghrelin in anorexia nervosa Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2012 Títulos uniformes : Pituitary Idioma : Inglés (eng) Palabras clave : Anorexia nervosa  Ghrelin  Hypothalamus  Immunohistochemistry  Pituitary Resumen : Ghrelin, an orexigenic hormone, is known to occur in the normal anterior pituitary where its physiologic role is uncertain but may include promotion of appetite. We sought to investigate anticipated differences in adenohypophysial and neurohypophysial ghrelin immunoexpression between normal subjects and patients with anorexia nervosa who had succumbed to complications of the disease. We hypothesized that the glands of anorexia nervosa patients would show relative diminished action in ghrelin content. The study included 12 autopsy-derived pituitaries of anorexia nervosa and 10 control glands. The streptavidin-biotin-peroxidase complex method and double immunohistochemical staining method were used to determine which cell types expressed both ghrelin and adenohypophysial hormones. Nontumorous control pituitaries were also obtained at autopsy. In anorexia nervosa and control adenohypophyses, ghrelin was mainly localized in somatotrophs and to a lesser extent in corticotrophs and gonadotrophs. Ghrelin accumulated within nerve fibers and Herring bodies in the neurohypophysis and pituitary stalk. In the controls, ghrelin expression was apparent in only a few cases. It was mild and only along few nerve fibers. In the adenohypophyses of anorexia nervosa patients, ghrelin was not depleted. It appears that in these patients, ghrelin is transported in excess from the hypothalamic neurohypophysial tract to the neurohypophysis. Mención de responsabilidad : Fabio Rotondo, Bernd W Scheithauer, Luis V Syro, Angelo Rotondo, Kalman Kovacs Referencia : Pituitary. 2012 Dec;15(4):533-8. DOI (Digital Object Identifier) : 10.1007/s11102-011-0364-6 PMID : 22081273 En línea : http://link.springer.com/10.1007/s11102-011-0364-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4495 Pituitary immunoexpression of ghrelin in anorexia nervosa [documento electrónico] / Luis Vicente Syro Moreno,  . - 2012. Obra : Pituitary Idioma : Inglés (eng) Palabras clave : Anorexia nervosa  Ghrelin  Hypothalamus  Immunohistochemistry  Pituitary Resumen : Ghrelin, an orexigenic hormone, is known to occur in the normal anterior pituitary where its physiologic role is uncertain but may include promotion of appetite. We sought to investigate anticipated differences in adenohypophysial and neurohypophysial ghrelin immunoexpression between normal subjects and patients with anorexia nervosa who had succumbed to complications of the disease. We hypothesized that the glands of anorexia nervosa patients would show relative diminished action in ghrelin content. The study included 12 autopsy-derived pituitaries of anorexia nervosa and 10 control glands. The streptavidin-biotin-peroxidase complex method and double immunohistochemical staining method were used to determine which cell types expressed both ghrelin and adenohypophysial hormones. Nontumorous control pituitaries were also obtained at autopsy. In anorexia nervosa and control adenohypophyses, ghrelin was mainly localized in somatotrophs and to a lesser extent in corticotrophs and gonadotrophs. Ghrelin accumulated within nerve fibers and Herring bodies in the neurohypophysis and pituitary stalk. In the controls, ghrelin expression was apparent in only a few cases. It was mild and only along few nerve fibers. In the adenohypophyses of anorexia nervosa patients, ghrelin was not depleted. It appears that in these patients, ghrelin is transported in excess from the hypothalamic neurohypophysial tract to the neurohypophysis. Mención de responsabilidad : Fabio Rotondo, Bernd W Scheithauer, Luis V Syro, Angelo Rotondo, Kalman Kovacs Referencia : Pituitary. 2012 Dec;15(4):533-8. DOI (Digital Object Identifier) : 10.1007/s11102-011-0364-6 PMID : 22081273 En línea : http://link.springer.com/10.1007/s11102-011-0364-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4495

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