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Enlace permanente de la investigaciónBK virus nephropathy in a heart transplant recipient / John Fredy Nieto Ríos ; Arbey Aristizabal Álzate ; Gustavo Adolfo Zuluaga Valencia
Título : BK virus nephropathy in a heart transplant recipient Tipo de documento : documento electrónico Autores : John Fredy Nieto Ríos, ; Arbey Aristizabal Álzate, ; Gustavo Adolfo Zuluaga Valencia, Fecha de publicación : 2020 Títulos uniformes : Brazilian Journal of Nephrology Idioma : Inglés (eng) Palabras clave : Polyomavirus BK virus BK Virus Nephropathy Organ Transplantation Heart transplantation Immunosuppression Resumen : BK virus nephropathy in kidney transplantation is widely recognized as an important cause of graft dysfunction and loss. In the case of transplants of organs other than kidney, BK virus nephropathy in native kidneys has been recognized as a cause of chronic kidney disease, which is related with immunosuppression; however, the diagnosis is usually late because the renal dysfunction is attributed to other causes, such as toxicity by anticalcineurinic drugs, interstitial nephritis due to medications, hemodynamic changes, diabetes, hypertension, etc. We report a case of BK virus nephropathy in a patient who underwent heart transplantation due to peripartum cardiomyopathy. The kidney biopsy reported active chronic tubulointerstitial nephritis associated with late stage polyomavirus nephritis and the blood viral load for BK virus was positive (logarithm 4.5). The immunosuppressive treatment was reduced, and after two years of follow-up, the patient had stable renal function with a serum creatinine of 2.5 mg/dL (GFR of 23.4 mL/min/1.73m2). We recommend that the BK virus be considered as a cause of renal dysfunction in heart transplant recipients, with the aim of detecting its replication in time to reduce immunosuppressive therapy before irreversible compromise of renal function may manifest. Mención de responsabilidad : John Fredy Nieto-Ríos, Diego Armando Benavides-Henao, Arbey Aristizabal-Alzate, Carol Morales-Contreras, Diana Carolina Chacón-Jaimes, Gustavo Zuluaga-Valencia, Lina María Serna-Higuita Referencia : J Bras Nefrol. Jul-Sep 2021;43(3):434-439. DOI (Digital Object Identifier) : 10.1590/2175-8239-jbn-2020-0049 PMID : 33527977 Derechos de uso : CC BY En línea : https://bjnephrology.org/en/article/bk-virus-nephropathy-in-a-heart-transplant-r [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5735 BK virus nephropathy in a heart transplant recipient [documento electrónico] / John Fredy Nieto Ríos, ; Arbey Aristizabal Álzate, ; Gustavo Adolfo Zuluaga Valencia, . - 2020.
Obra : Brazilian Journal of Nephrology
Idioma : Inglés (eng)
Palabras clave : Polyomavirus BK virus BK Virus Nephropathy Organ Transplantation Heart transplantation Immunosuppression Resumen : BK virus nephropathy in kidney transplantation is widely recognized as an important cause of graft dysfunction and loss. In the case of transplants of organs other than kidney, BK virus nephropathy in native kidneys has been recognized as a cause of chronic kidney disease, which is related with immunosuppression; however, the diagnosis is usually late because the renal dysfunction is attributed to other causes, such as toxicity by anticalcineurinic drugs, interstitial nephritis due to medications, hemodynamic changes, diabetes, hypertension, etc. We report a case of BK virus nephropathy in a patient who underwent heart transplantation due to peripartum cardiomyopathy. The kidney biopsy reported active chronic tubulointerstitial nephritis associated with late stage polyomavirus nephritis and the blood viral load for BK virus was positive (logarithm 4.5). The immunosuppressive treatment was reduced, and after two years of follow-up, the patient had stable renal function with a serum creatinine of 2.5 mg/dL (GFR of 23.4 mL/min/1.73m2). We recommend that the BK virus be considered as a cause of renal dysfunction in heart transplant recipients, with the aim of detecting its replication in time to reduce immunosuppressive therapy before irreversible compromise of renal function may manifest. Mención de responsabilidad : John Fredy Nieto-Ríos, Diego Armando Benavides-Henao, Arbey Aristizabal-Alzate, Carol Morales-Contreras, Diana Carolina Chacón-Jaimes, Gustavo Zuluaga-Valencia, Lina María Serna-Higuita Referencia : J Bras Nefrol. Jul-Sep 2021;43(3):434-439. DOI (Digital Object Identifier) : 10.1590/2175-8239-jbn-2020-0049 PMID : 33527977 Derechos de uso : CC BY En línea : https://bjnephrology.org/en/article/bk-virus-nephropathy-in-a-heart-transplant-r [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5735 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001674 AC-2020-145 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2020-145Adobe Acrobat PDF
Título : Development and Internal Validation of a Prediction Model to Estimate the Probability of Needing Aggressive Immunosuppressive Therapy With Cytostatics in de Novo Lupus Nephritis Patients Otros títulos : Desarrollo y validación interna de un modelo de predicción para estimar la probabilidad de requerir inmunosupresión intensiva con citostáticos en pacientes con nefritis lúpica de novo Tipo de documento : documento electrónico Autores : Mauricio Restrepo Escobar, ; Paula Andrea Granda Carvajal, ; Fabián Alberto Jaimes Barragán, Fecha de publicación : 2019 Títulos uniformes : Reumatología Clínica Idioma : Inglés (eng) Palabras clave : Systemic lupus erythematosus lupus nephritis immunosuppression multivariate analysis decision support techniques logistic models Resumen : Objective: To develop a multivariable clinical prediction model for the requirement of aggressive immunosuppression with cytostatics, based on simple clinical record data and lab tests. The model is defined in accordance with the result of the kidney biopsies. Methods: Retrospective study conducted with data from patients 16 years and older, with SLE and nephritis with less than 6 months of evolution. An initial bivariate analysis was conducted to select the variables to be included in a multiple logistic regression model. Goodness of fit was evaluated using a Hosmer–Lemeshow test (H–L) and the discrimination capacity of the model by means of the area under the ROC (AUC) curve. Results: Data from 242 patients was gathered; of these, 18.2% (n = 44) did not need an addition of cytostatics according to the findings of their kidney biopsies. The variables included in the final model were 24-h proteinuria, diastolic blood pressure, creatinine, C3 complement and the interaction of hematuria with leukocyturia in urinary sediment. The model showed excellent discrimination (AUC = 0.929; 95% CI = 0.894–0.963) and adequate calibration (H–L, P = .959). Conclusion: In recent-onset LN patients, the decision to use or not to use intensive immunosuppressive therapy could be performed based on our prediction model as an alternative to kidney biopsies. Mención de responsabilidad : Mauricio Restrepo-Escobar, Paula Andrea Granda-Carvajal, Fabián Jaimes Referencia : Reumatol Clin. 2019 Jan - Feb;15(1):27-33. DOI (Digital Object Identifier) : 10.1016/j.reuma.2017.05.010 PMID : 28732643 En línea : https://www.reumatologiaclinica.org/en-linkresolver-development-internal-validat [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4052 Development and Internal Validation of a Prediction Model to Estimate the Probability of Needing Aggressive Immunosuppressive Therapy With Cytostatics in de Novo Lupus Nephritis Patients = Desarrollo y validación interna de un modelo de predicción para estimar la probabilidad de requerir inmunosupresión intensiva con citostáticos en pacientes con nefritis lúpica de novo [documento electrónico] / Mauricio Restrepo Escobar, ; Paula Andrea Granda Carvajal, ; Fabián Alberto Jaimes Barragán, . - 2019.
Obra : Reumatología Clínica
Idioma : Inglés (eng)
Palabras clave : Systemic lupus erythematosus lupus nephritis immunosuppression multivariate analysis decision support techniques logistic models Resumen : Objective: To develop a multivariable clinical prediction model for the requirement of aggressive immunosuppression with cytostatics, based on simple clinical record data and lab tests. The model is defined in accordance with the result of the kidney biopsies. Methods: Retrospective study conducted with data from patients 16 years and older, with SLE and nephritis with less than 6 months of evolution. An initial bivariate analysis was conducted to select the variables to be included in a multiple logistic regression model. Goodness of fit was evaluated using a Hosmer–Lemeshow test (H–L) and the discrimination capacity of the model by means of the area under the ROC (AUC) curve. Results: Data from 242 patients was gathered; of these, 18.2% (n = 44) did not need an addition of cytostatics according to the findings of their kidney biopsies. The variables included in the final model were 24-h proteinuria, diastolic blood pressure, creatinine, C3 complement and the interaction of hematuria with leukocyturia in urinary sediment. The model showed excellent discrimination (AUC = 0.929; 95% CI = 0.894–0.963) and adequate calibration (H–L, P = .959). Conclusion: In recent-onset LN patients, the decision to use or not to use intensive immunosuppressive therapy could be performed based on our prediction model as an alternative to kidney biopsies. Mención de responsabilidad : Mauricio Restrepo-Escobar, Paula Andrea Granda-Carvajal, Fabián Jaimes Referencia : Reumatol Clin. 2019 Jan - Feb;15(1):27-33. DOI (Digital Object Identifier) : 10.1016/j.reuma.2017.05.010 PMID : 28732643 En línea : https://www.reumatologiaclinica.org/en-linkresolver-development-internal-validat [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4052 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000652 AC-2017-041 Archivo digital Producción Científica Artículos científicos Disponible
Título : Time of Cold Ischemia and Delayed Graft Function in a Cohort of Renal Transplant Patients in a Reference Center Tipo de documento : documento electrónico Autores : John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Carolina Lucía Ochoa García, ; Arbey Aristizabal Álzate, ; Gustavo Adolfo Zuluaga Valencia, Fecha de publicación : 2019 Títulos uniformes : Indian Journal of Nephrology Idioma : Inglés (eng) Palabras clave : Acute rejection cold ischemia time delayed graft function graft loss immunosuppression kidney transplantation Resumen : There are many factors involved in the delayed graft function of a renal graft, with prolonged cold ischemia time being one of the most relevant. The aim of this study is to evaluate the relationship between the time of cold ischemia and the delayed graft function, and acute rejection and graft loss at 1 year of follow-up. A retrospective cohort of 347 renal transplant patients were evaluated during the years 2009-2013. The incidence of delayed graft function was 18.4% (n = 65). The cold ischemia time was an independent risk factor for delayed graft function (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.04-1.16). By grouping the time of cold ischemia by intervals, the risk of delayed graft function was greater in the 12-18 hours group (OR 2.06, 95% CI 1.02-4.15) and in the >18 hours group (OR 3.38, 95% CI 1.57-7.27). The risk of acute rejection did not increase with longer cold ischemia (p = 0.69), and cold ischemia time was not a risk factor for renal graft loss at 1-year follow-up (hazard ratio 0.97, 95% CI 0.88-1.06). In conclusion the time of cold ischemia (>12 hours) in renal transplant recipients of optimal deceased donors increases the risk of delayed graft function; however, this does not negatively impact the results in acute rejection or graft loss in the first year of the transplant. Mención de responsabilidad : J F Nieto-Ríos, C L Ochoa-García, A Serna-Campuzano, B Benavides-Hermosa, L L Calderón-Puentes, A Aristizabal-Alzate, C Ocampo-Kohn, G Zuluaga-Valencia, L M Serna-Higuita Referencia : Indian J Nephrol. 2019 Jan-Feb;29(1):8-14. DOI (Digital Object Identifier) : 10.4103/ijn.IJN_162_18 PMID : 30814787 Derechos de uso : CC BY-NC-SA En línea : http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2019;volume=29;iss [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4259 Time of Cold Ischemia and Delayed Graft Function in a Cohort of Renal Transplant Patients in a Reference Center [documento electrónico] / John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Carolina Lucía Ochoa García, ; Arbey Aristizabal Álzate, ; Gustavo Adolfo Zuluaga Valencia, . - 2019.
Obra : Indian Journal of Nephrology
Idioma : Inglés (eng)
Palabras clave : Acute rejection cold ischemia time delayed graft function graft loss immunosuppression kidney transplantation Resumen : There are many factors involved in the delayed graft function of a renal graft, with prolonged cold ischemia time being one of the most relevant. The aim of this study is to evaluate the relationship between the time of cold ischemia and the delayed graft function, and acute rejection and graft loss at 1 year of follow-up. A retrospective cohort of 347 renal transplant patients were evaluated during the years 2009-2013. The incidence of delayed graft function was 18.4% (n = 65). The cold ischemia time was an independent risk factor for delayed graft function (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.04-1.16). By grouping the time of cold ischemia by intervals, the risk of delayed graft function was greater in the 12-18 hours group (OR 2.06, 95% CI 1.02-4.15) and in the >18 hours group (OR 3.38, 95% CI 1.57-7.27). The risk of acute rejection did not increase with longer cold ischemia (p = 0.69), and cold ischemia time was not a risk factor for renal graft loss at 1-year follow-up (hazard ratio 0.97, 95% CI 0.88-1.06). In conclusion the time of cold ischemia (>12 hours) in renal transplant recipients of optimal deceased donors increases the risk of delayed graft function; however, this does not negatively impact the results in acute rejection or graft loss in the first year of the transplant. Mención de responsabilidad : J F Nieto-Ríos, C L Ochoa-García, A Serna-Campuzano, B Benavides-Hermosa, L L Calderón-Puentes, A Aristizabal-Alzate, C Ocampo-Kohn, G Zuluaga-Valencia, L M Serna-Higuita Referencia : Indian J Nephrol. 2019 Jan-Feb;29(1):8-14. DOI (Digital Object Identifier) : 10.4103/ijn.IJN_162_18 PMID : 30814787 Derechos de uso : CC BY-NC-SA En línea : http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2019;volume=29;iss [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4259 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001238 AC-2019-027 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2019-027.pdfAdobe Acrobat PDF
Título : Differential characteristics in drug-induced autoimmune hepatitis Tipo de documento : documento electrónico Autores : Juan Ignacio Marín Zuluaga, ; Octavio Germán Muñoz Maya, ; Óscar Mauricio Santos Sánchez, ; Jorge Hernando Donado Gómez, ; Juan Carlos Restrepo Gutiérrez, Fecha de publicación : 2018 Títulos uniformes : JGH Open Idioma : Inglés (eng) Palabras clave : Autoimmune hepatitis autoimmunity drug‐induced liver injury immunosuppression prognosis Resumen : Background and Aim: Drug‐induced autoimmune hepatitis (DIAIH) is an adverse effect associated with several drugs that usually occurs acutely, with variable latency, and it may potentially be mortal. There are a few reports and studies about DIAIH. Methods: This was an analytical study of a retrospective cohort of patients, discriminated according to idiopathic or drug‐induced etiology, followed up for a 7‐year period until 31 December 2016. Results: A total of 190 patients were selected for the analysis, 12 (6.3%) with DIAIH. The two main drugs related to DIAIH were nitrofurantoin, n = 8 (67%), and NSAID, n = 2 (17%), constituting 84% of the cases. There were no significant differences in seropositivity between AIH with DIAIH in antinuclear antibodies (ANA) and anti‐smooth muscle antibodies (ASMA) antibodies, with 82.6% versus 82.6% and 34% versus 16%, respectively. The fibrosis stages were similar, except for the F4 stage, in a greater proportion in AIH. None of the patients with DIAIH had cirrhosis or developed it during follow‐up, but it was present in 42.1% of the AIH cases at diagnosis (P = 0.003). Biochemical remission with management was higher in DIAIH but not significant (91.7% vs 80.9%, P = 0.35). The definitive interruption of immunosuppression was successfully performed in 25% of those with DIAIH without relapses but was only possible in 2.8% in AIH (P Mención de responsabilidad : Omar Yesid Martínez-Casas, Gabriel Sebastián Díaz-Ramírez, Juan Ignacio Marín-Zuluaga, Octavio Muñoz-Maya, Oscar Santos, Jorge Hernando Donado-Gómez, Juan Carlos Restrepo-Gutiérrez Referencia : JGH Open. 2018 May 24;2(3):97-104. DOI (Digital Object Identifier) : 10.1002/jgh3.12054 PMID : 30483571 Derechos de uso : CC BY-NC En línea : https://onlinelibrary.wiley.com/doi/full/10.1002/jgh3.12054 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4143 Differential characteristics in drug-induced autoimmune hepatitis [documento electrónico] / Juan Ignacio Marín Zuluaga, ; Octavio Germán Muñoz Maya, ; Óscar Mauricio Santos Sánchez, ; Jorge Hernando Donado Gómez, ; Juan Carlos Restrepo Gutiérrez, . - 2018.
Obra : JGH Open
Idioma : Inglés (eng)
Palabras clave : Autoimmune hepatitis autoimmunity drug‐induced liver injury immunosuppression prognosis Resumen : Background and Aim: Drug‐induced autoimmune hepatitis (DIAIH) is an adverse effect associated with several drugs that usually occurs acutely, with variable latency, and it may potentially be mortal. There are a few reports and studies about DIAIH. Methods: This was an analytical study of a retrospective cohort of patients, discriminated according to idiopathic or drug‐induced etiology, followed up for a 7‐year period until 31 December 2016. Results: A total of 190 patients were selected for the analysis, 12 (6.3%) with DIAIH. The two main drugs related to DIAIH were nitrofurantoin, n = 8 (67%), and NSAID, n = 2 (17%), constituting 84% of the cases. There were no significant differences in seropositivity between AIH with DIAIH in antinuclear antibodies (ANA) and anti‐smooth muscle antibodies (ASMA) antibodies, with 82.6% versus 82.6% and 34% versus 16%, respectively. The fibrosis stages were similar, except for the F4 stage, in a greater proportion in AIH. None of the patients with DIAIH had cirrhosis or developed it during follow‐up, but it was present in 42.1% of the AIH cases at diagnosis (P = 0.003). Biochemical remission with management was higher in DIAIH but not significant (91.7% vs 80.9%, P = 0.35). The definitive interruption of immunosuppression was successfully performed in 25% of those with DIAIH without relapses but was only possible in 2.8% in AIH (P Mención de responsabilidad : Omar Yesid Martínez-Casas, Gabriel Sebastián Díaz-Ramírez, Juan Ignacio Marín-Zuluaga, Octavio Muñoz-Maya, Oscar Santos, Jorge Hernando Donado-Gómez, Juan Carlos Restrepo-Gutiérrez Referencia : JGH Open. 2018 May 24;2(3):97-104. DOI (Digital Object Identifier) : 10.1002/jgh3.12054 PMID : 30483571 Derechos de uso : CC BY-NC En línea : https://onlinelibrary.wiley.com/doi/full/10.1002/jgh3.12054 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4143 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000756 AC-2018-043 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2018-043.pdfAdobe Acrobat PDF
Título : Successful treatment of pulmonary invasive fungal infection by Penicillium non-marneffei in lymphoblastic lymphoma: case report and literature review Tipo de documento : documento electrónico Autores : Isabel Cristina Ramírez Sánchez, ; Alicia Inés Hidrón Botero, ; Ricardo Andrés Cardona Quiceno, Fecha de publicación : 2018 Títulos uniformes : Clinical Case Reports Idioma : Inglés (eng) Palabras clave : Chemotherapy immunosuppression leukemia lymphoma Penicillium non-marneffei transplant Resumen : Penicillium non‐marneffei species rarely cause disease in humans and are encountered most commonly in the clinical laboratory as culture contaminants; however, recently they have emerged as opportunistic pathogens in immunocompromised hosts; therefore, it should not be routinely disregarded without a thorough investigation, especially if normally sterile sites are involved. Mención de responsabilidad : Isabel Ramírez, Alicia Hidrón, Ricardo Cardona Referencia : Clinical Case Reports 2018;6(6):1153-7. DOI (Digital Object Identifier) : 10.1002/ccr3.1527 PMID : 29881585 Derechos de uso : CC BY En línea : https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.1527 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4158 Successful treatment of pulmonary invasive fungal infection by Penicillium non-marneffei in lymphoblastic lymphoma: case report and literature review [documento electrónico] / Isabel Cristina Ramírez Sánchez, ; Alicia Inés Hidrón Botero, ; Ricardo Andrés Cardona Quiceno, . - 2018.
Obra : Clinical Case Reports
Idioma : Inglés (eng)
Palabras clave : Chemotherapy immunosuppression leukemia lymphoma Penicillium non-marneffei transplant Resumen : Penicillium non‐marneffei species rarely cause disease in humans and are encountered most commonly in the clinical laboratory as culture contaminants; however, recently they have emerged as opportunistic pathogens in immunocompromised hosts; therefore, it should not be routinely disregarded without a thorough investigation, especially if normally sterile sites are involved. Mención de responsabilidad : Isabel Ramírez, Alicia Hidrón, Ricardo Cardona Referencia : Clinical Case Reports 2018;6(6):1153-7. DOI (Digital Object Identifier) : 10.1002/ccr3.1527 PMID : 29881585 Derechos de uso : CC BY En línea : https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.1527 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4158 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000772 AC-2018-059 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2018-059.pdfAdobe Acrobat PDF
