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Enlace permanente de la investigaciónChanges in the incidence of acute bacterial meningitis caused by Streptococcus pneumoniae and the implications of serotype replacement in children in Colombia after mass vaccination with PCV10 / Mónica Rosa Trujillo Honeysberg
Título : Changes in the incidence of acute bacterial meningitis caused by Streptococcus pneumoniae and the implications of serotype replacement in children in Colombia after mass vaccination with PCV10 Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pneumococcal meningitis pediatrics infections vaccines microbiology serotype Resumen : Introduction: Acute bacterial meningitis (ABM) is a public health problem. The disease has reemerged after the introduction of pneumococcal conjugate vaccines (PCVs) due to an increase in serotypes that are not covered. The objective was to determine the changes in the disease incidence before and after the introduction of the 10-valent vaccine (PCV10) in Colombia. Methods: This multicenter study was conducted in 17 hospitals in Colombia. Data were collected from January 2008 to December 2019 in 10 hospitals in Bogotá and from January 2017 to December 2019 in seven hospitals in Cali, Medellín and Cartagena. The data were grouped into three periods: 2008–2011, 2012–2015, and 2016-2019. Results: Of the 706 cases of invasive pneumococcal disease, 81 (11.4%) corresponded to meningitis. The relative incidence in Bogotá in the first period was 0.6 per 100,000 patients ≤ 5 years, decreased to 0.4 per 100,000 patients ≤ 5 years in the second period and increased in the third period to 0.7 per 100,000 patients ≤ 5 years. Serotypes covered by PCV10 decreased from 75 to 9.1%, with Spn19A (31.8%) and Spn34 (13.6%) emerging in the third period. Increased resistance to penicillin (13 to 37%) and to ceftriaxone (5.9 to 16%) was due to the emergence of multidrug-resistant Spn19A. The total mortality rate was 23.5% and increased from 12 to 33%. Conclusions: ABM due to pneumococcus has high morbidity and mortality rates. Reemergence of the disease has been observed due to the inclusion of polymerase chain reaction (PCR) for diagnosis and replacement of circulating serotypes after the introduction of PCV10, with an increase in Spn19A, which causes death and exhibits antimicrobial resistance. Continued surveillance is needed. Mención de responsabilidad : Juan David Farfán-Albarracín, Germán Camacho-Moreno, Aura Lucia Leal, Jaime Patiño, Wilfrido Coronell, Iván Felipe Gutiérrez, Sandra Beltrán, Martha I Álvarez-Olmos, Cristina Mariño, Rocio Barrero, Juan Pablo Rojas, Fabio Espinosa, Catalina Arango-Ferreira, Maria Alejandra Suarez, Monica Trujillo, Eduardo López-Medina, Pio López, Hernando Pinzón, Nicolás Ramos, Vivian Marcela Moreno, Anita Montañez Referencia : Front Pediatr. 2022 Sep 23;10:1006887. DOI (Digital Object Identifier) : 10.3389/fped.2022.1006887 PMID : 36210950 En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.1006887/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6088 Changes in the incidence of acute bacterial meningitis caused by Streptococcus pneumoniae and the implications of serotype replacement in children in Colombia after mass vaccination with PCV10 [documento electrónico] / Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pneumococcal meningitis pediatrics infections vaccines microbiology serotype Resumen : Introduction: Acute bacterial meningitis (ABM) is a public health problem. The disease has reemerged after the introduction of pneumococcal conjugate vaccines (PCVs) due to an increase in serotypes that are not covered. The objective was to determine the changes in the disease incidence before and after the introduction of the 10-valent vaccine (PCV10) in Colombia. Methods: This multicenter study was conducted in 17 hospitals in Colombia. Data were collected from January 2008 to December 2019 in 10 hospitals in Bogotá and from January 2017 to December 2019 in seven hospitals in Cali, Medellín and Cartagena. The data were grouped into three periods: 2008–2011, 2012–2015, and 2016-2019. Results: Of the 706 cases of invasive pneumococcal disease, 81 (11.4%) corresponded to meningitis. The relative incidence in Bogotá in the first period was 0.6 per 100,000 patients ≤ 5 years, decreased to 0.4 per 100,000 patients ≤ 5 years in the second period and increased in the third period to 0.7 per 100,000 patients ≤ 5 years. Serotypes covered by PCV10 decreased from 75 to 9.1%, with Spn19A (31.8%) and Spn34 (13.6%) emerging in the third period. Increased resistance to penicillin (13 to 37%) and to ceftriaxone (5.9 to 16%) was due to the emergence of multidrug-resistant Spn19A. The total mortality rate was 23.5% and increased from 12 to 33%. Conclusions: ABM due to pneumococcus has high morbidity and mortality rates. Reemergence of the disease has been observed due to the inclusion of polymerase chain reaction (PCR) for diagnosis and replacement of circulating serotypes after the introduction of PCV10, with an increase in Spn19A, which causes death and exhibits antimicrobial resistance. Continued surveillance is needed. Mención de responsabilidad : Juan David Farfán-Albarracín, Germán Camacho-Moreno, Aura Lucia Leal, Jaime Patiño, Wilfrido Coronell, Iván Felipe Gutiérrez, Sandra Beltrán, Martha I Álvarez-Olmos, Cristina Mariño, Rocio Barrero, Juan Pablo Rojas, Fabio Espinosa, Catalina Arango-Ferreira, Maria Alejandra Suarez, Monica Trujillo, Eduardo López-Medina, Pio López, Hernando Pinzón, Nicolás Ramos, Vivian Marcela Moreno, Anita Montañez Referencia : Front Pediatr. 2022 Sep 23;10:1006887. DOI (Digital Object Identifier) : 10.3389/fped.2022.1006887 PMID : 36210950 En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.1006887/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6088 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001935 AC-2022-096 Archivo digital Producción Científica Artículos científicos Disponible 
Título : An observational cross-sectional study of the possible relationship between high levels of cytokines (TNF and IL10) and healthcare-associated and other infections in patients with polytrauma Tipo de documento : documento electrónico Autores : Beatriz Helena Aristizábal Bernal, ; Edwin Alexander Vásquez Salazar, ; Olga Lucía Rincón Caballero, ; Gladys Stella Mejía Pineda, ; Alfredo Constain Franco, ; Paula María Jaramillo Gómez, ; Nelson Darío Giraldo Ramírez, ; Carlos Oliver Valderrama Molina, Fecha de publicación : 2019 Títulos uniformes : MOJ Orthopedics & Rheumatology Idioma : Inglés (eng) Palabras clave : blunt trauma proinflammatory and anti-inflammatory cytokines infections Resumen : Background: The recognition of the relationship between cytokines and outcomes in trauma patients is important. It is possible that early detection of those patients who develop an imbalance in this dual immune response, which would be responsible for subsequent organ dysfunction and susceptibility to infections, allow differential management to reduce the occurrence of such complications. Methods: An observational cross-sectional study to describe the kinetics of cytokines/chemokines (IL-1B, IL-6, TNF-a, IL-12p70, IL-10, and IL-8) and to explore the possible relationship with the development of infectious complications during the first admission to the hospital in patients with multiple trauma admitted to the emergency room. Serum samples were used to measured cytokines/chemokines. Times of collection were: 0-6 hour’s postrauma, 24 hours and 72 hours postrauma. Results: 20 consecutive patients were included, 60% were male, the median age was 26.5 years , 90% had a traffic accident, 40% had a severe traumatic brain injury defined as Glasgow less than or equal to 8. The median ISS was 22(17,2–35,2). There was an incidence of shock defined as lactate greater than or equal to 4 of 40%. The admission to ICU was 80%. Of the 16 who entered the ICU, 94% required mechanical ventilation. There was only one hospital death. Cytokines shown to be significantly different between trauma patient’s groups; a greater severity of the trauma in the group that presented infection (ISS 27 vs 17, p=0.011). IL10 on admission and ISS are significantly associated with increased prevalence of infection in this sample of patients with multiple trauma. Conclusion: Peripheral cytokines could present a method for tracking the course of severe blunt trauma and for better understanding this process. Our results imply that measuring cytokine expression patterns after severe blunt trauma is meaningful to explore and potentially useful in developing innovative approaches for treating acute and subacute trauma. Mención de responsabilidad : Aristizabal-Bernal Beatriz Helena, Vasquez Edwin, Rincon-Caballero Olga Lucia, Mejía-Pineda Gladys S, Constain-Franco Alfredo, Jaramillo-Gomez Paula M, Giraldo Nelson, Valderrama-Molina Carlos Oliver DOI (Digital Object Identifier) : 10.15406/mojor.2019.11.00497 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/MOJOR/an-observational-cross-sectional-study-of-the-p [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5021 An observational cross-sectional study of the possible relationship between high levels of cytokines (TNF and IL10) and healthcare-associated and other infections in patients with polytrauma [documento electrónico] / Beatriz Helena Aristizábal Bernal, ; Edwin Alexander Vásquez Salazar, ; Olga Lucía Rincón Caballero, ; Gladys Stella Mejía Pineda, ; Alfredo Constain Franco, ; Paula María Jaramillo Gómez, ; Nelson Darío Giraldo Ramírez, ; Carlos Oliver Valderrama Molina, . - 2019.
Obra : MOJ Orthopedics & Rheumatology
Idioma : Inglés (eng)
Palabras clave : blunt trauma proinflammatory and anti-inflammatory cytokines infections Resumen : Background: The recognition of the relationship between cytokines and outcomes in trauma patients is important. It is possible that early detection of those patients who develop an imbalance in this dual immune response, which would be responsible for subsequent organ dysfunction and susceptibility to infections, allow differential management to reduce the occurrence of such complications. Methods: An observational cross-sectional study to describe the kinetics of cytokines/chemokines (IL-1B, IL-6, TNF-a, IL-12p70, IL-10, and IL-8) and to explore the possible relationship with the development of infectious complications during the first admission to the hospital in patients with multiple trauma admitted to the emergency room. Serum samples were used to measured cytokines/chemokines. Times of collection were: 0-6 hour’s postrauma, 24 hours and 72 hours postrauma. Results: 20 consecutive patients were included, 60% were male, the median age was 26.5 years , 90% had a traffic accident, 40% had a severe traumatic brain injury defined as Glasgow less than or equal to 8. The median ISS was 22(17,2–35,2). There was an incidence of shock defined as lactate greater than or equal to 4 of 40%. The admission to ICU was 80%. Of the 16 who entered the ICU, 94% required mechanical ventilation. There was only one hospital death. Cytokines shown to be significantly different between trauma patient’s groups; a greater severity of the trauma in the group that presented infection (ISS 27 vs 17, p=0.011). IL10 on admission and ISS are significantly associated with increased prevalence of infection in this sample of patients with multiple trauma. Conclusion: Peripheral cytokines could present a method for tracking the course of severe blunt trauma and for better understanding this process. Our results imply that measuring cytokine expression patterns after severe blunt trauma is meaningful to explore and potentially useful in developing innovative approaches for treating acute and subacute trauma. Mención de responsabilidad : Aristizabal-Bernal Beatriz Helena, Vasquez Edwin, Rincon-Caballero Olga Lucia, Mejía-Pineda Gladys S, Constain-Franco Alfredo, Jaramillo-Gomez Paula M, Giraldo Nelson, Valderrama-Molina Carlos Oliver DOI (Digital Object Identifier) : 10.15406/mojor.2019.11.00497 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/MOJOR/an-observational-cross-sectional-study-of-the-p [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5021 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001548 AC-2019-095 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : Congenital brain infections Tipo de documento : documento electrónico Autores : Feliza Restrepo Restrepo, ; Andrés Ignacio Arbeláez Medina, Fecha de publicación : 2014 Títulos uniformes : Topics in Magnetic Resonance Imaging: TMRI Idioma : Inglés (eng) Palabras clave : Pediatric intracranial congenital infections cytomegalovirus HIV toxoplasmosis rubella herpes Resumen : Pediatric congenital intracranial infections are a group of different and important entities that constitute a small percentage of all pediatric infections. The causal factors and clinical presentations are different in children compared with adults. They require early recognition because delay diagnosis and initiation of treatment may have catastrophic consequences. Despite improvements in prenatal screening, vaccine safety, and antibiotics, infections of the central nervous system remain an important cause of neurological disabilities worldwide. This article reviews the most common congenital infections and their imaging findings. Mención de responsabilidad : Andres Arbelaez, Feliza Restrepo, Jorge Davila, Mauricio Castillo Referencia : Top Magn Reson Imaging.2014;23 (3): 165–72. DOI (Digital Object Identifier) : 10.1097/RMR.0000000000000024 PMID : 24887693 En línea : https://journals.lww.com/topicsinmri/Abstract/2014/06000/Congenital_Brain_Infect [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3777 Congenital brain infections [documento electrónico] / Feliza Restrepo Restrepo, ; Andrés Ignacio Arbeláez Medina, . - 2014.
Obra : Topics in Magnetic Resonance Imaging: TMRI
Idioma : Inglés (eng)
Palabras clave : Pediatric intracranial congenital infections cytomegalovirus HIV toxoplasmosis rubella herpes Resumen : Pediatric congenital intracranial infections are a group of different and important entities that constitute a small percentage of all pediatric infections. The causal factors and clinical presentations are different in children compared with adults. They require early recognition because delay diagnosis and initiation of treatment may have catastrophic consequences. Despite improvements in prenatal screening, vaccine safety, and antibiotics, infections of the central nervous system remain an important cause of neurological disabilities worldwide. This article reviews the most common congenital infections and their imaging findings. Mención de responsabilidad : Andres Arbelaez, Feliza Restrepo, Jorge Davila, Mauricio Castillo Referencia : Top Magn Reson Imaging.2014;23 (3): 165–72. DOI (Digital Object Identifier) : 10.1097/RMR.0000000000000024 PMID : 24887693 En línea : https://journals.lww.com/topicsinmri/Abstract/2014/06000/Congenital_Brain_Infect [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3777 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000352 AC-2014-018 Archivo digital Producción Científica Artículos científicos Disponible
Título : Spinal infections: clinical and imaging features Tipo de documento : documento electrónico Autores : Feliza Restrepo Restrepo, ; Andrés Ignacio Arbeláez Medina, Fecha de publicación : 2014 Títulos uniformes : Topics in Magnetic Resonance Imaging: TMRI Idioma : Inglés (eng) Palabras clave : Spinal spinal cord infections spondylitis discitis epidural abscess myelitis Resumen : Spinal infections represent a group of rare conditions affecting vertebral bodies, intervertebral discs, paraspinal soft tissues, epidural space, meninges, and spinal cord. The causal factors, clinical presentations, and imaging features are a challenge because the difficulty to differentiate them from other conditions, such as degenerative and inflammatory disorders and spinal neoplasm. They require early recognition because delay diagnosis, imaging, and intervention may have devastating consequences especially in children and the elderly. This article reviews the most common spinal infections, their pathophysiologic, clinical manifestation, and their imaging findings. Mención de responsabilidad : Andres Arbelaez, Feliza Restrepo, Mauricio Castillo Referencia : Top Magn Reson Imaging. 2014 Oct;23(5):303-14. DOI (Digital Object Identifier) : 10.1097/RMR.0000000000000032 PMID : 25296275 En línea : https://journals.lww.com/topicsinmri/Abstract/2014/10000/Spinal_Infections___Cli [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3779 Spinal infections: clinical and imaging features [documento electrónico] / Feliza Restrepo Restrepo, ; Andrés Ignacio Arbeláez Medina, . - 2014.
Obra : Topics in Magnetic Resonance Imaging: TMRI
Idioma : Inglés (eng)
Palabras clave : Spinal spinal cord infections spondylitis discitis epidural abscess myelitis Resumen : Spinal infections represent a group of rare conditions affecting vertebral bodies, intervertebral discs, paraspinal soft tissues, epidural space, meninges, and spinal cord. The causal factors, clinical presentations, and imaging features are a challenge because the difficulty to differentiate them from other conditions, such as degenerative and inflammatory disorders and spinal neoplasm. They require early recognition because delay diagnosis, imaging, and intervention may have devastating consequences especially in children and the elderly. This article reviews the most common spinal infections, their pathophysiologic, clinical manifestation, and their imaging findings. Mención de responsabilidad : Andres Arbelaez, Feliza Restrepo, Mauricio Castillo Referencia : Top Magn Reson Imaging. 2014 Oct;23(5):303-14. DOI (Digital Object Identifier) : 10.1097/RMR.0000000000000032 PMID : 25296275 En línea : https://journals.lww.com/topicsinmri/Abstract/2014/10000/Spinal_Infections___Cli [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3779 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000354 AC-2014-020 Archivo digital Producción Científica Artículos científicos Disponible
