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Enlace permanente de la investigaciónAn observational cross-sectional study of the possible relationship between high levels of cytokines (TNF and IL10) and healthcare-associated and other infections in patients with polytrauma / Beatriz Helena Aristizábal Bernal ; Edwin Alexander Vásquez Salazar ; Olga Lucía Rincón Caballero ; Gladys Stella Mejía Pineda ; Alfredo Constain Franco ; Paula María Jaramillo Gómez ; Nelson Darío Giraldo Ramírez ; Carlos Oliver Valderrama Molina
Título : An observational cross-sectional study of the possible relationship between high levels of cytokines (TNF and IL10) and healthcare-associated and other infections in patients with polytrauma Tipo de documento : documento electrónico Autores : Beatriz Helena Aristizábal Bernal, Autor asociado al HPTU ; Edwin Alexander Vásquez Salazar, Autor asociado al HPTU ; Olga Lucía Rincón Caballero, Autor asociado al HPTU ; Gladys Stella Mejía Pineda, Autor asociado al HPTU ; Alfredo Constain Franco, Autor asociado al HPTU ; Paula María Jaramillo Gómez, Autor asociado al HPTU ; Nelson Darío Giraldo Ramírez, Autor asociado al HPTU ; Carlos Oliver Valderrama Molina, Autor asociado al HPTU Fecha de publicación : 2019 Títulos uniformes : MOJ Orthopedics & Rheumatology Idioma : Inglés (eng) Palabras clave : blunt trauma proinflammatory and anti-inflammatory cytokines infections Resumen : Background: The recognition of the relationship between cytokines and outcomes in trauma patients is important. It is possible that early detection of those patients who develop an imbalance in this dual immune response, which would be responsible for subsequent organ dysfunction and susceptibility to infections, allow differential management to reduce the occurrence of such complications. Methods: An observational cross-sectional study to describe the kinetics of cytokines/chemokines (IL-1B, IL-6, TNF-a, IL-12p70, IL-10, and IL-8) and to explore the possible relationship with the development of infectious complications during the first admission to the hospital in patients with multiple trauma admitted to the emergency room. Serum samples were used to measured cytokines/chemokines. Times of collection were: 0-6 hour’s postrauma, 24 hours and 72 hours postrauma. Results: 20 consecutive patients were included, 60% were male, the median age was 26.5 years , 90% had a traffic accident, 40% had a severe traumatic brain injury defined as Glasgow less than or equal to 8. The median ISS was 22(17,2–35,2). There was an incidence of shock defined as lactate greater than or equal to 4 of 40%. The admission to ICU was 80%. Of the 16 who entered the ICU, 94% required mechanical ventilation. There was only one hospital death. Cytokines shown to be significantly different between trauma patient’s groups; a greater severity of the trauma in the group that presented infection (ISS 27 vs 17, p=0.011). IL10 on admission and ISS are significantly associated with increased prevalence of infection in this sample of patients with multiple trauma. Conclusion: Peripheral cytokines could present a method for tracking the course of severe blunt trauma and for better understanding this process. Our results imply that measuring cytokine expression patterns after severe blunt trauma is meaningful to explore and potentially useful in developing innovative approaches for treating acute and subacute trauma. Mención de responsabilidad : Aristizabal-Bernal Beatriz Helena, Vasquez Edwin, Rincon-Caballero Olga Lucia, Mejía-Pineda Gladys S, Constain-Franco Alfredo, Jaramillo-Gomez Paula M, Giraldo Nelson, Valderrama-Molina Carlos Oliver DOI (Digital Object Identifier) : 10.15406/mojor.2019.11.00497 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/MOJOR/an-observational-cross-sectional-study-of-the-p [...] Enlace permanente : ./index.php?lvl=notice_display&id=5021 An observational cross-sectional study of the possible relationship between high levels of cytokines (TNF and IL10) and healthcare-associated and other infections in patients with polytrauma [documento electrónico] / Beatriz Helena Aristizábal Bernal, Autor asociado al HPTU ; Edwin Alexander Vásquez Salazar, Autor asociado al HPTU ; Olga Lucía Rincón Caballero, Autor asociado al HPTU ; Gladys Stella Mejía Pineda, Autor asociado al HPTU ; Alfredo Constain Franco, Autor asociado al HPTU ; Paula María Jaramillo Gómez, Autor asociado al HPTU ; Nelson Darío Giraldo Ramírez, Autor asociado al HPTU ; Carlos Oliver Valderrama Molina, Autor asociado al HPTU . - 2019.
Obra : MOJ Orthopedics & Rheumatology
Idioma : Inglés (eng)
Palabras clave : blunt trauma proinflammatory and anti-inflammatory cytokines infections Resumen : Background: The recognition of the relationship between cytokines and outcomes in trauma patients is important. It is possible that early detection of those patients who develop an imbalance in this dual immune response, which would be responsible for subsequent organ dysfunction and susceptibility to infections, allow differential management to reduce the occurrence of such complications. Methods: An observational cross-sectional study to describe the kinetics of cytokines/chemokines (IL-1B, IL-6, TNF-a, IL-12p70, IL-10, and IL-8) and to explore the possible relationship with the development of infectious complications during the first admission to the hospital in patients with multiple trauma admitted to the emergency room. Serum samples were used to measured cytokines/chemokines. Times of collection were: 0-6 hour’s postrauma, 24 hours and 72 hours postrauma. Results: 20 consecutive patients were included, 60% were male, the median age was 26.5 years , 90% had a traffic accident, 40% had a severe traumatic brain injury defined as Glasgow less than or equal to 8. The median ISS was 22(17,2–35,2). There was an incidence of shock defined as lactate greater than or equal to 4 of 40%. The admission to ICU was 80%. Of the 16 who entered the ICU, 94% required mechanical ventilation. There was only one hospital death. Cytokines shown to be significantly different between trauma patient’s groups; a greater severity of the trauma in the group that presented infection (ISS 27 vs 17, p=0.011). IL10 on admission and ISS are significantly associated with increased prevalence of infection in this sample of patients with multiple trauma. Conclusion: Peripheral cytokines could present a method for tracking the course of severe blunt trauma and for better understanding this process. Our results imply that measuring cytokine expression patterns after severe blunt trauma is meaningful to explore and potentially useful in developing innovative approaches for treating acute and subacute trauma. Mención de responsabilidad : Aristizabal-Bernal Beatriz Helena, Vasquez Edwin, Rincon-Caballero Olga Lucia, Mejía-Pineda Gladys S, Constain-Franco Alfredo, Jaramillo-Gomez Paula M, Giraldo Nelson, Valderrama-Molina Carlos Oliver DOI (Digital Object Identifier) : 10.15406/mojor.2019.11.00497 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/MOJOR/an-observational-cross-sectional-study-of-the-p [...] Enlace permanente : ./index.php?lvl=notice_display&id=5021 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001548 AC-2019-095 Archivo digital Publicaciones HPTU Artículos científicos Disponible Documentos electrónicos
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Título : Congenital brain infections Tipo de documento : documento electrónico Autores : Feliza Restrepo Restrepo, Autor asociado al HPTU ; Andrés Ignacio Arbeláez Medina, Autor asociado al HPTU Fecha de publicación : 2014 Títulos uniformes : Topics in Magnetic Resonance Imaging: TMRI Idioma : Inglés (eng) Palabras clave : Pediatric intracranial congenital infections cytomegalovirus HIV toxoplasmosis rubella herpes Resumen : Pediatric congenital intracranial infections are a group of different and important entities that constitute a small percentage of all pediatric infections. The causal factors and clinical presentations are different in children compared with adults. They require early recognition because delay diagnosis and initiation of treatment may have catastrophic consequences. Despite improvements in prenatal screening, vaccine safety, and antibiotics, infections of the central nervous system remain an important cause of neurological disabilities worldwide. This article reviews the most common congenital infections and their imaging findings. Mención de responsabilidad : Andres Arbelaez, Feliza Restrepo, Jorge Davila, Mauricio Castillo Referencia : Top Magn Reson Imaging.2014;23 (3): 165–72. DOI (Digital Object Identifier) : 10.1097/RMR.0000000000000024 PMID : 24887693 En línea : https://journals.lww.com/topicsinmri/Abstract/2014/06000/Congenital_Brain_Infect [...] Enlace permanente : ./index.php?lvl=notice_display&id=3777 Congenital brain infections [documento electrónico] / Feliza Restrepo Restrepo, Autor asociado al HPTU ; Andrés Ignacio Arbeláez Medina, Autor asociado al HPTU . - 2014.
Obra : Topics in Magnetic Resonance Imaging: TMRI
Idioma : Inglés (eng)
Palabras clave : Pediatric intracranial congenital infections cytomegalovirus HIV toxoplasmosis rubella herpes Resumen : Pediatric congenital intracranial infections are a group of different and important entities that constitute a small percentage of all pediatric infections. The causal factors and clinical presentations are different in children compared with adults. They require early recognition because delay diagnosis and initiation of treatment may have catastrophic consequences. Despite improvements in prenatal screening, vaccine safety, and antibiotics, infections of the central nervous system remain an important cause of neurological disabilities worldwide. This article reviews the most common congenital infections and their imaging findings. Mención de responsabilidad : Andres Arbelaez, Feliza Restrepo, Jorge Davila, Mauricio Castillo Referencia : Top Magn Reson Imaging.2014;23 (3): 165–72. DOI (Digital Object Identifier) : 10.1097/RMR.0000000000000024 PMID : 24887693 En línea : https://journals.lww.com/topicsinmri/Abstract/2014/06000/Congenital_Brain_Infect [...] Enlace permanente : ./index.php?lvl=notice_display&id=3777 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000352 AC-2014-018 Archivo digital Publicaciones HPTU Artículos científicos Disponible
Título : Spinal infections: clinical and imaging features Tipo de documento : documento electrónico Autores : Feliza Restrepo Restrepo, Autor asociado al HPTU ; Andrés Ignacio Arbeláez Medina, Autor asociado al HPTU Fecha de publicación : 2014 Títulos uniformes : Topics in Magnetic Resonance Imaging: TMRI Idioma : Inglés (eng) Palabras clave : Spinal spinal cord infections spondylitis discitis epidural abscess myelitis Resumen : Spinal infections represent a group of rare conditions affecting vertebral bodies, intervertebral discs, paraspinal soft tissues, epidural space, meninges, and spinal cord. The causal factors, clinical presentations, and imaging features are a challenge because the difficulty to differentiate them from other conditions, such as degenerative and inflammatory disorders and spinal neoplasm. They require early recognition because delay diagnosis, imaging, and intervention may have devastating consequences especially in children and the elderly. This article reviews the most common spinal infections, their pathophysiologic, clinical manifestation, and their imaging findings. Mención de responsabilidad : Andres Arbelaez, Feliza Restrepo, Mauricio Castillo Referencia : Top Magn Reson Imaging. 2014 Oct;23(5):303-14. DOI (Digital Object Identifier) : 10.1097/RMR.0000000000000032 PMID : 25296275 En línea : https://journals.lww.com/topicsinmri/Abstract/2014/10000/Spinal_Infections___Cli [...] Enlace permanente : ./index.php?lvl=notice_display&id=3779 Spinal infections: clinical and imaging features [documento electrónico] / Feliza Restrepo Restrepo, Autor asociado al HPTU ; Andrés Ignacio Arbeláez Medina, Autor asociado al HPTU . - 2014.
Obra : Topics in Magnetic Resonance Imaging: TMRI
Idioma : Inglés (eng)
Palabras clave : Spinal spinal cord infections spondylitis discitis epidural abscess myelitis Resumen : Spinal infections represent a group of rare conditions affecting vertebral bodies, intervertebral discs, paraspinal soft tissues, epidural space, meninges, and spinal cord. The causal factors, clinical presentations, and imaging features are a challenge because the difficulty to differentiate them from other conditions, such as degenerative and inflammatory disorders and spinal neoplasm. They require early recognition because delay diagnosis, imaging, and intervention may have devastating consequences especially in children and the elderly. This article reviews the most common spinal infections, their pathophysiologic, clinical manifestation, and their imaging findings. Mención de responsabilidad : Andres Arbelaez, Feliza Restrepo, Mauricio Castillo Referencia : Top Magn Reson Imaging. 2014 Oct;23(5):303-14. DOI (Digital Object Identifier) : 10.1097/RMR.0000000000000032 PMID : 25296275 En línea : https://journals.lww.com/topicsinmri/Abstract/2014/10000/Spinal_Infections___Cli [...] Enlace permanente : ./index.php?lvl=notice_display&id=3779 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000354 AC-2014-020 Archivo digital Publicaciones HPTU Artículos científicos Disponible
