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Submicroscopic infection of placenta by Plasmodium produces Th1/Th2 cytokine imbalance, inflammation and hypoxia in women from north-west Colombia / Beatriz Helena Aristizábal Bernal
Título : Submicroscopic infection of placenta by Plasmodium produces Th1/Th2 cytokine imbalance, inflammation and hypoxia in women from north-west Colombia Tipo de documento : documento electrónico Autores : Beatriz Helena Aristizábal Bernal, Fecha de publicación : 2014 Títulos uniformes : Malaria Journal Idioma : Inglés (eng) Palabras clave : Submicroscopic Placental malaria Plasmodium Cytokine Inflammation Hypoxia Resumen : Background: A large-scale study was set up in order to study the epidemiology, clinical aspects, and immunopathology of gestational and placental malaria in north-west Colombia. In this region, recent reports using a qPCR technique, confirmed frequencies of infection, by Plasmodium falciparum or Plasmodium vivax, up to 45%. Given the high rates of infection observed both in mother and placenta, a first exploratory study was proposed in order to characterize the effect on the inflammation status, tissue damage and hypoxia in Plasmodium spp. infected placentas.Methods: A descriptive, prospective, cross-sectional design was applied to pregnant women with (PM+) and without (PM-) placental malaria. Messenger RNA expression of Fas, FasL; COX-1, COX-2, HIF, VEGF, and the cytokines IL-2, IL-4, IL-10, IFN-γ and TNF, were measured in peripheral and placental blood using a quantitative PCR. The percentage of apoptotic cells was determined with a TUNEL assay. Results: In total 50 placentas were studied: 25 were positive for submicroscopic infection and 25 were negative for Plasmodium infection. Expression of IL-4 and IL-10 was observed high in placental tissue of PM+, while IL-2 was high in peripheral blood of the same group. Expression of TNF and IFNγ in peripheral blood of the PM + group was high. Similarly, the apoptotic index and Fas expression were significantly high in PM+. However, FasL expression was observed low in PM + compared to PM-. Inflammation markers (HIF, VEGF) and hypoxia markers (COX-1, COX-2) were high in the PM + group. Conclusion: During placental malaria expression of some pro-inflammatory cytokines is up-regulated and markers of hypoxia and tissue damage are increased in cases of submicroscopic infection. Mención de responsabilidad : Olga M Agudelo, Beatriz H Aristizabal, Stephanie K Yanow, Eliana Arango, Jaime Carmona-Fonseca, Amanda Maestre Referencia : Malar J. 2014 Mar 27;13:122. DOI (Digital Object Identifier) : 10.1186/1475-2875-13-122 PMID : 24673747 Derechos de uso : CC BY En línea : https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-122 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3807 Submicroscopic infection of placenta by Plasmodium produces Th1/Th2 cytokine imbalance, inflammation and hypoxia in women from north-west Colombia [documento electrónico] / Beatriz Helena Aristizábal Bernal, . - 2014.
Obra : Malaria Journal
Idioma : Inglés (eng)
Palabras clave : Submicroscopic Placental malaria Plasmodium Cytokine Inflammation Hypoxia Resumen : Background: A large-scale study was set up in order to study the epidemiology, clinical aspects, and immunopathology of gestational and placental malaria in north-west Colombia. In this region, recent reports using a qPCR technique, confirmed frequencies of infection, by Plasmodium falciparum or Plasmodium vivax, up to 45%. Given the high rates of infection observed both in mother and placenta, a first exploratory study was proposed in order to characterize the effect on the inflammation status, tissue damage and hypoxia in Plasmodium spp. infected placentas.Methods: A descriptive, prospective, cross-sectional design was applied to pregnant women with (PM+) and without (PM-) placental malaria. Messenger RNA expression of Fas, FasL; COX-1, COX-2, HIF, VEGF, and the cytokines IL-2, IL-4, IL-10, IFN-γ and TNF, were measured in peripheral and placental blood using a quantitative PCR. The percentage of apoptotic cells was determined with a TUNEL assay. Results: In total 50 placentas were studied: 25 were positive for submicroscopic infection and 25 were negative for Plasmodium infection. Expression of IL-4 and IL-10 was observed high in placental tissue of PM+, while IL-2 was high in peripheral blood of the same group. Expression of TNF and IFNγ in peripheral blood of the PM + group was high. Similarly, the apoptotic index and Fas expression were significantly high in PM+. However, FasL expression was observed low in PM + compared to PM-. Inflammation markers (HIF, VEGF) and hypoxia markers (COX-1, COX-2) were high in the PM + group. Conclusion: During placental malaria expression of some pro-inflammatory cytokines is up-regulated and markers of hypoxia and tissue damage are increased in cases of submicroscopic infection. Mención de responsabilidad : Olga M Agudelo, Beatriz H Aristizabal, Stephanie K Yanow, Eliana Arango, Jaime Carmona-Fonseca, Amanda Maestre Referencia : Malar J. 2014 Mar 27;13:122. DOI (Digital Object Identifier) : 10.1186/1475-2875-13-122 PMID : 24673747 Derechos de uso : CC BY En línea : https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-122 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3807 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000382 AC-2014-048 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : Inflammatory pseudotumor of the pituitary: Case report Tipo de documento : documento electrónico Fecha de publicación : 2004 Títulos uniformes : Surgical Neurology Idioma : Inglés (eng) Palabras clave : Immunohistochemistry inflammation panhypopituitarism pituitary pseudotumor ultrastructure Resumen : Background: Inflammatory pseudotumor of the pituitary is a very rare nonneoplastic lesion. We describe a case of a patient with past history of lymphocytic meningitis. Case description: A 32-year-old man presented with polyuria, polydipsia, anorexia, abdominal discomfort, and panhypopituitarism. He had 2 episodes of lymphocytic meningitis in the last two years. Magnetic resonance image (MRI) disclosed a sellar and suprasellar mass with extension to the pituitary stalk. The patient underwent transnasal-transsphenoidal surgery to remove the lesion. Histopathological findings revealed mixed inflammatory cells composed mainly of lymphocytes, macrophages and extensive fibrosis. Conclusions: Inflammatory pseudotumor of the pituitary, although rare, should be included in the differential diagnosis of a sellar and suprasellar mass. Mención de responsabilidad : Mubarak Al-Shraim, Luis V Syro, Kalman Kovacs, Hernan Estrada, Humberto Uribe, Mubarak Al-Gahtany Referencia : Surg Neurol. 2004 Sep;62(3):264-7; discussion 267. DOI (Digital Object Identifier) : 10.1016/j.surneu.2003.09.037 PMID : 15336877 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0090301903007869 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4404 Inflammatory pseudotumor of the pituitary: Case report [documento electrónico] . - 2004.
Obra : Surgical Neurology
Idioma : Inglés (eng)
Palabras clave : Immunohistochemistry inflammation panhypopituitarism pituitary pseudotumor ultrastructure Resumen : Background: Inflammatory pseudotumor of the pituitary is a very rare nonneoplastic lesion. We describe a case of a patient with past history of lymphocytic meningitis. Case description: A 32-year-old man presented with polyuria, polydipsia, anorexia, abdominal discomfort, and panhypopituitarism. He had 2 episodes of lymphocytic meningitis in the last two years. Magnetic resonance image (MRI) disclosed a sellar and suprasellar mass with extension to the pituitary stalk. The patient underwent transnasal-transsphenoidal surgery to remove the lesion. Histopathological findings revealed mixed inflammatory cells composed mainly of lymphocytes, macrophages and extensive fibrosis. Conclusions: Inflammatory pseudotumor of the pituitary, although rare, should be included in the differential diagnosis of a sellar and suprasellar mass. Mención de responsabilidad : Mubarak Al-Shraim, Luis V Syro, Kalman Kovacs, Hernan Estrada, Humberto Uribe, Mubarak Al-Gahtany Referencia : Surg Neurol. 2004 Sep;62(3):264-7; discussion 267. DOI (Digital Object Identifier) : 10.1016/j.surneu.2003.09.037 PMID : 15336877 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0090301903007869 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4404 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000904 AC-2004-007 Archivo digital Producción Científica Artículos científicos Disponible