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Enlace permanente de la investigaciónGut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis / Adriana Giraldo Villa
Título : Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis Tipo de documento : documento electrónico Autores : Adriana Giraldo Villa, Fecha de publicación : 2020 Títulos uniformes : Gut Microbes Idioma : Inglés (eng) Palabras clave : Intestinal microbiota antibiotics critically ill patient intensive care unit sepsis Resumen : Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients. Mención de responsabilidad : Gloria M Agudelo-Ochoa, Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Alfonso Benítez-Paéz Referencia : Gut Microbes. 2020 Nov 9;12(1):1707610. DOI (Digital Object Identifier) : 10.1080/19490976.2019.1707610 PMID : 31924126 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1707610 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5072 Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis [documento electrónico] / Adriana Giraldo Villa, . - 2020.
Obra : Gut Microbes
Idioma : Inglés (eng)
Palabras clave : Intestinal microbiota antibiotics critically ill patient intensive care unit sepsis Resumen : Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients. Mención de responsabilidad : Gloria M Agudelo-Ochoa, Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Alfonso Benítez-Paéz Referencia : Gut Microbes. 2020 Nov 9;12(1):1707610. DOI (Digital Object Identifier) : 10.1080/19490976.2019.1707610 PMID : 31924126 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1707610 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5072 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001302 AC-2020-006 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : Stool short-chain fatty acids in critically ill patients with sepsis Tipo de documento : documento electrónico Autores : Adriana Giraldo Villa, Fecha de publicación : 2020 Títulos uniformes : Journal of the American College of Nutrition Idioma : Inglés (eng) Palabras clave : Short-chain fatty acids critically ill patient sepsis acetic propionic butyric intensive care unit Resumen : Objective: To determine the concentration of stool short-chain fatty acids (SCFAs) in critically ill patients with sepsis and to compare the results between the critically ill patient and the control group. Methods: This descriptive, multicenter, observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients with sepsis who were admitted to the intensive care unit (ICU) and met the inclusion criteria were enrolled, and a control, paired by age and sex, was recruited for each patient. A spontaneous stool sample was collected from each participant and a gas chromatograph coupled to a mass spectrometer (Agilent 7890/MSD 5975 C) was used to measure the concentrations SCFAs. Results: The final sample included 44 patients and 45 controls. There were no differences in the age and sex distributions between the groups (p > 0.05). According to body mass index (BMI), undernutrition was more prevalent among critically ill patients, and BMI in control subjects was most frequently classified as overweight (p = 0.024). Propionic acid, acetic acid, butyric acid, and isobutyric acid concentrations were significantly lower in the critically ill patient group than in the control group (p = 0.000). No association with outcome variables (complications, ICU stay, and discharge condition) was found in the patients, and patients diagnosed with infection on ICU admission showed significant decreases in butyric and isobutyric acid concentrations with respect to other diagnostic criteria (p Mención de responsabilidad : Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Carlos J Barrera-Causil, Gloria M Agudelo-Ochoa Referencia : J Am Coll Nutr. Nov-Dec 2020;39(8):706-712. DOI (Digital Object Identifier) : 10.1080/07315724.2020.1727379 PMID : 32163012 En línea : https://www.tandfonline.com/doi/full/10.1080/07315724.2020.1727379 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5084 Stool short-chain fatty acids in critically ill patients with sepsis [documento electrónico] / Adriana Giraldo Villa, . - 2020.
Obra : Journal of the American College of Nutrition
Idioma : Inglés (eng)
Palabras clave : Short-chain fatty acids critically ill patient sepsis acetic propionic butyric intensive care unit Resumen : Objective: To determine the concentration of stool short-chain fatty acids (SCFAs) in critically ill patients with sepsis and to compare the results between the critically ill patient and the control group. Methods: This descriptive, multicenter, observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients with sepsis who were admitted to the intensive care unit (ICU) and met the inclusion criteria were enrolled, and a control, paired by age and sex, was recruited for each patient. A spontaneous stool sample was collected from each participant and a gas chromatograph coupled to a mass spectrometer (Agilent 7890/MSD 5975 C) was used to measure the concentrations SCFAs. Results: The final sample included 44 patients and 45 controls. There were no differences in the age and sex distributions between the groups (p > 0.05). According to body mass index (BMI), undernutrition was more prevalent among critically ill patients, and BMI in control subjects was most frequently classified as overweight (p = 0.024). Propionic acid, acetic acid, butyric acid, and isobutyric acid concentrations were significantly lower in the critically ill patient group than in the control group (p = 0.000). No association with outcome variables (complications, ICU stay, and discharge condition) was found in the patients, and patients diagnosed with infection on ICU admission showed significant decreases in butyric and isobutyric acid concentrations with respect to other diagnostic criteria (p Mención de responsabilidad : Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Carlos J Barrera-Causil, Gloria M Agudelo-Ochoa Referencia : J Am Coll Nutr. Nov-Dec 2020;39(8):706-712. DOI (Digital Object Identifier) : 10.1080/07315724.2020.1727379 PMID : 32163012 En línea : https://www.tandfonline.com/doi/full/10.1080/07315724.2020.1727379 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5084 Reserva
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Título : Development of a predictive model for Extubation Failure in weaning from mechanical ventilation: A retrospective cohort study Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2017 Títulos uniformes : Trends in Anaesthesia and Critical Care Idioma : Inglés (eng) Palabras clave : Respiratory insufficiency Weaning Endotracheal intubation Extubation failure Mechanical ventilation Intensive care unit Resumen : Introduction: Extubation failure (EF) occurs in 2–25% of ICU patients. Our objective was to develop an EF predictive model. Methods: We performed a retrospective cohort study in a medical-surgical ICU with 40 beds at a University Hospital. Were analyzed 1017 patients, from January 2010 to December 2014, all over 16 years old, undergoing invasive ventilation for more than 24 h, and successful spontaneous breathing test (SBT). Seventeen variables were evaluated; we utilized logistic regression analysis with an evaluation of discrimination and calibration based on the area under the ROC curve (AUC-ROC) and the Hosmer-Lemeshow's goodness-of-fit test (Chi2 H-L), respectively. Results: Extubation failure was present in 157 patients (15.4%); we developed a predictive model that included PaO2/FIO2 ratio ≤ 237.5, hemoglobin ≤9.5 g, accumulated fluid balance > 6022 ml, APACHE II > 16, blood urea nitrogen > 22.5 mg/dl and the presence of cardiopulmonary diagnostics. This model exhibited an AUC-ROC = 0.689 and a Chi2 H-L, p = 0.579. Conclusion: This study presents a risk score with an estimated probability of EF based on a multivariate predictive model. Due to the strong limitation of our retrospective study, however, it is necessary for an independent prospective cohort to improve discrimination and to prove the model applicability. Mención de responsabilidad : Jorge Eliécer Sará-Ochoa, Olga Helena Hernández Ortíz y Fabián Alberto Jaimes DOI (Digital Object Identifier) : 10.1016/j.tacc.2017.10.060 En línea : https://linkinghub.elsevier.com/retrieve/pii/S2210844017301144 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4673 Development of a predictive model for Extubation Failure in weaning from mechanical ventilation: A retrospective cohort study [documento electrónico] / Fabián Alberto Jaimes Barragán, . - 2017.
Obra : Trends in Anaesthesia and Critical Care
Idioma : Inglés (eng)
Palabras clave : Respiratory insufficiency Weaning Endotracheal intubation Extubation failure Mechanical ventilation Intensive care unit Resumen : Introduction: Extubation failure (EF) occurs in 2–25% of ICU patients. Our objective was to develop an EF predictive model. Methods: We performed a retrospective cohort study in a medical-surgical ICU with 40 beds at a University Hospital. Were analyzed 1017 patients, from January 2010 to December 2014, all over 16 years old, undergoing invasive ventilation for more than 24 h, and successful spontaneous breathing test (SBT). Seventeen variables were evaluated; we utilized logistic regression analysis with an evaluation of discrimination and calibration based on the area under the ROC curve (AUC-ROC) and the Hosmer-Lemeshow's goodness-of-fit test (Chi2 H-L), respectively. Results: Extubation failure was present in 157 patients (15.4%); we developed a predictive model that included PaO2/FIO2 ratio ≤ 237.5, hemoglobin ≤9.5 g, accumulated fluid balance > 6022 ml, APACHE II > 16, blood urea nitrogen > 22.5 mg/dl and the presence of cardiopulmonary diagnostics. This model exhibited an AUC-ROC = 0.689 and a Chi2 H-L, p = 0.579. Conclusion: This study presents a risk score with an estimated probability of EF based on a multivariate predictive model. Due to the strong limitation of our retrospective study, however, it is necessary for an independent prospective cohort to improve discrimination and to prove the model applicability. Mención de responsabilidad : Jorge Eliécer Sará-Ochoa, Olga Helena Hernández Ortíz y Fabián Alberto Jaimes DOI (Digital Object Identifier) : 10.1016/j.tacc.2017.10.060 En línea : https://linkinghub.elsevier.com/retrieve/pii/S2210844017301144 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4673 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001153 AC-2017-107 Archivo digital Producción Científica Artículos científicos Disponible
Título : StatNet electroencephalogram: a fast and reliable option to diagnose nonconvulsive status epilepticus in emergency setting Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2015 Títulos uniformes : Canadian Journal of Neurological Sciences Idioma : Inglés (eng) Palabras clave : disposable EEG electrodes emergency department emergent EEG intensive care unit nonconvulsive status epilepticus stat EEG Resumen : Background: The StatNet electrode set is a system that can be applied by a non-electroencephalogram (EEG) technologist after minimal training. The primary objectives of this study are to assess the quality and reliability of the StatNet recordings in comparison to the conventional EEG. Methods: Over 10 months, 19 patients with suspected nonconvulsive status epilepticus were included from university hospital emergency settings. Each patient received a StatNet EEG by a trained epilepsy fellow and a conventional EEG by registered technologists. We compared the studies in a blinded fashion, for the timeframe from EEG order to the setup time, start of acquisition, amount of artifact, and detection of abnormalities. The nonparametric Mann-Whitney two-sample t test was used for comparisons. The kappa score was used to assess reliability. Results: Mean age of patients was 61±16.3 (25-93) years. The inter-observer agreement for detection of abnormal findings was 0.83 for StatNet and 0.75 for conventional EEG. Nonconvulsive status epilepticus was detected in 10% (2/19) in both studies. The delay from the time of EEG requisition to acquisition was shorter in the StatNet (22.4±2.5 minutes) than the conventional EEG (217.7±44.6 minutes; p Mención de responsabilidad : Lady Diana Ladino, Alexandra Voll, Dianne Dash, Wes Sutherland, Lizbeth Hernández-Ronquillo, Jose Francisco Téllez-Zenteno, Farzad Moien-Afshari Referencia : Can J Neurol Sci. 2016 Mar;43(2):254-60. DOI (Digital Object Identifier) : 10.1017/cjn.2015.391 PMID : 26864547 En línea : https://www.cambridge.org/core/journals/canadian-journal-of-neurological-science [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4580 StatNet electroencephalogram: a fast and reliable option to diagnose nonconvulsive status epilepticus in emergency setting [documento electrónico] / Lady Diana Ladino Malagón, . - 2015.
Obra : Canadian Journal of Neurological Sciences
Idioma : Inglés (eng)
Palabras clave : disposable EEG electrodes emergency department emergent EEG intensive care unit nonconvulsive status epilepticus stat EEG Resumen : Background: The StatNet electrode set is a system that can be applied by a non-electroencephalogram (EEG) technologist after minimal training. The primary objectives of this study are to assess the quality and reliability of the StatNet recordings in comparison to the conventional EEG. Methods: Over 10 months, 19 patients with suspected nonconvulsive status epilepticus were included from university hospital emergency settings. Each patient received a StatNet EEG by a trained epilepsy fellow and a conventional EEG by registered technologists. We compared the studies in a blinded fashion, for the timeframe from EEG order to the setup time, start of acquisition, amount of artifact, and detection of abnormalities. The nonparametric Mann-Whitney two-sample t test was used for comparisons. The kappa score was used to assess reliability. Results: Mean age of patients was 61±16.3 (25-93) years. The inter-observer agreement for detection of abnormal findings was 0.83 for StatNet and 0.75 for conventional EEG. Nonconvulsive status epilepticus was detected in 10% (2/19) in both studies. The delay from the time of EEG requisition to acquisition was shorter in the StatNet (22.4±2.5 minutes) than the conventional EEG (217.7±44.6 minutes; p Mención de responsabilidad : Lady Diana Ladino, Alexandra Voll, Dianne Dash, Wes Sutherland, Lizbeth Hernández-Ronquillo, Jose Francisco Téllez-Zenteno, Farzad Moien-Afshari Referencia : Can J Neurol Sci. 2016 Mar;43(2):254-60. DOI (Digital Object Identifier) : 10.1017/cjn.2015.391 PMID : 26864547 En línea : https://www.cambridge.org/core/journals/canadian-journal-of-neurological-science [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4580 Reserva
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Título : Prescription of antibiotics in intensive care units in Latin America: An observational study Tipo de documento : documento electrónico Autores : Franco Eduardo Montúfar Andrade, Fecha de publicación : 2009 Títulos uniformes : Journal of Chemotherapy Idioma : Inglés (eng) Palabras clave : intensive care unit antibiotics carbapenems resistance Resumen : A one-day point prevalence study to investigate the patterns of antibiotic use was undertaken in 43 Latin American (LA) intensive care units. Of 510 patients admitted, 231 received antibiotic treatment on the day of the study (45%); in 125 cases (54%) due to nosocomial-acquired infections. The most frequent infection reported was nosocomial pneumonia (43%). Only in 122 patients (53%) were cultures performed before starting antibiotic treatment. 33% of the isolated microorganisms were Enterobacteriaceae (40% extended-spectrum β-lactamase-producing), 23% methicillin-resistant Staphylococcus aureus and 17% carbapenems-resistant non-fermentative Gram-negatives. The antibiotics most frequently prescribed were carbapenems (99/231, 43%);alone (60/99, 60%) or in combination with vancomycin (39/99, 40%). “Restricted” antibiotics (carbapenems, vancomycin, piperacillin-tazobactam, broad-spectrum cephalosporins, tigecycline, polymixins and linezolid) were most frequently indicated inseverely ill patients (APACHE II score at admission ≥15, p=0.0007 and, SOFA scoreat the beginning of the antibiotic treatment ≥3, p=0.0000). Only 36% of antibiotictreatments were cultured-directed. Our findings help explain the high rates of multidrug-resistant pathogens in LA settings (i.e. ESBL-producing Gram-negatives) and the severity of the registered patients' illnesses. Mención de responsabilidad : D Curcio, A Alí, A Duarte, A Defilippi Pauta, C Ibáñez-Guzmán, M Chung Sang, E Valencia, F Plano, F Paredes Oña, F Arancibia, F Montufar Andrade, F Morales Alava, G Cañarte Bermudez, G La Fuente Zerain, V Alanis Mirones, J Rojas Suarez, J Guzmán Torrico, J Silva, J Vergara Centeno, J C Medina, K Marín, L A Caero, L Durán Crespo, M Gómez Duque, M Játiva, R Belloni, R Romero, R Aguilera Perrogón, R Camacho Alarcón, R Camargo, S Cevallos, V Intriago Cedeño, Z Urbina Contreras, Latin American Antibiotic Use in Intensive Care Unit Group Referencia : J Chemother. 2009 Nov;21(5):527-34. DOI (Digital Object Identifier) : 10.1179/joc.2009.21.5.527 PMID : 19933044 En línea : https://www.tandfonline.com/doi/abs/10.1179/joc.2009.21.5.527 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4457 Prescription of antibiotics in intensive care units in Latin America: An observational study [documento electrónico] / Franco Eduardo Montúfar Andrade, . - 2009.
Obra : Journal of Chemotherapy
Idioma : Inglés (eng)
Palabras clave : intensive care unit antibiotics carbapenems resistance Resumen : A one-day point prevalence study to investigate the patterns of antibiotic use was undertaken in 43 Latin American (LA) intensive care units. Of 510 patients admitted, 231 received antibiotic treatment on the day of the study (45%); in 125 cases (54%) due to nosocomial-acquired infections. The most frequent infection reported was nosocomial pneumonia (43%). Only in 122 patients (53%) were cultures performed before starting antibiotic treatment. 33% of the isolated microorganisms were Enterobacteriaceae (40% extended-spectrum β-lactamase-producing), 23% methicillin-resistant Staphylococcus aureus and 17% carbapenems-resistant non-fermentative Gram-negatives. The antibiotics most frequently prescribed were carbapenems (99/231, 43%);alone (60/99, 60%) or in combination with vancomycin (39/99, 40%). “Restricted” antibiotics (carbapenems, vancomycin, piperacillin-tazobactam, broad-spectrum cephalosporins, tigecycline, polymixins and linezolid) were most frequently indicated inseverely ill patients (APACHE II score at admission ≥15, p=0.0007 and, SOFA scoreat the beginning of the antibiotic treatment ≥3, p=0.0000). Only 36% of antibiotictreatments were cultured-directed. Our findings help explain the high rates of multidrug-resistant pathogens in LA settings (i.e. ESBL-producing Gram-negatives) and the severity of the registered patients' illnesses. Mención de responsabilidad : D Curcio, A Alí, A Duarte, A Defilippi Pauta, C Ibáñez-Guzmán, M Chung Sang, E Valencia, F Plano, F Paredes Oña, F Arancibia, F Montufar Andrade, F Morales Alava, G Cañarte Bermudez, G La Fuente Zerain, V Alanis Mirones, J Rojas Suarez, J Guzmán Torrico, J Silva, J Vergara Centeno, J C Medina, K Marín, L A Caero, L Durán Crespo, M Gómez Duque, M Játiva, R Belloni, R Romero, R Aguilera Perrogón, R Camacho Alarcón, R Camargo, S Cevallos, V Intriago Cedeño, Z Urbina Contreras, Latin American Antibiotic Use in Intensive Care Unit Group Referencia : J Chemother. 2009 Nov;21(5):527-34. DOI (Digital Object Identifier) : 10.1179/joc.2009.21.5.527 PMID : 19933044 En línea : https://www.tandfonline.com/doi/abs/10.1179/joc.2009.21.5.527 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4457 Reserva
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