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A Serous Cystic Tumor and a Pancreatic Neuroendocrine Tumor in the Same Patient: A Case Report and Literature Review / Vanessa García Gómez ; Aguilar Sr, Alexander ; Ortiz, Santiago ; Vélez Garcés, Sara
Título : A Serous Cystic Tumor and a Pancreatic Neuroendocrine Tumor in the Same Patient: A Case Report and Literature Review Tipo de documento : documento electrónico Autores : Vanessa García Gómez, Autor ; Aguilar Sr, Alexander, Autor ; Ortiz, Santiago, Autor ; Vélez Garcés, Sara, Autor Fecha de publicación : 2024 Títulos uniformes : Cureus Idioma : Inglés (eng) Palabras clave : pancreatic cyst magnetic resonance imaging serous neoplasms pancreatic neoplasms neuroendocrine tumors Resumen : A serous cystic tumor is a rare entity that has a benign course. Its imaging characteristics, such as the presence of multiple cysts with or without nodular enhancement, can simulate other cystic or solid lesions of the pancreas. Identification of the enhancing scar with punctate calcifications on computed tomography (CT) or magnetic resonance imaging (MRI) may be a distinctive finding suggesting this diagnosis. Neuroendocrine tumors of the pancreas are a different and also rare entity. In images, they have early arterial enhancement. In MRI, they are hyperintense on T2 and hypointense on T1, with avid contrast enhancement. A case of a patient with two focal lesions in the pancreas is presented and the importance of integrating clinical findings, semiology in diagnostic images and, if applicable, the histopathological result for the optimal management of pancreatic tumors is illustrated, highlighting the crucial role of a radiologist in this process. Mención de responsabilidad : Alexander Aguilar Sr. , Vanessa García Gómez , Santiago Ortiz , Sara Vélez Garcés Referencia : Cureus. 2024 May 27;16(5):e61159 DOI (Digital Object Identifier) : 10.7759/cureus.61159 PMID : 38933621 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11202097/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis A Serous Cystic Tumor and a Pancreatic Neuroendocrine Tumor in the Same Patient: A Case Report and Literature Review [documento electrónico] / Vanessa García Gómez, Autor ; Aguilar Sr, Alexander, Autor ; Ortiz, Santiago, Autor ; Vélez Garcés, Sara, Autor . - 2024.
Obra : Cureus
Idioma : Inglés (eng)
Palabras clave : pancreatic cyst magnetic resonance imaging serous neoplasms pancreatic neoplasms neuroendocrine tumors Resumen : A serous cystic tumor is a rare entity that has a benign course. Its imaging characteristics, such as the presence of multiple cysts with or without nodular enhancement, can simulate other cystic or solid lesions of the pancreas. Identification of the enhancing scar with punctate calcifications on computed tomography (CT) or magnetic resonance imaging (MRI) may be a distinctive finding suggesting this diagnosis. Neuroendocrine tumors of the pancreas are a different and also rare entity. In images, they have early arterial enhancement. In MRI, they are hyperintense on T2 and hypointense on T1, with avid contrast enhancement. A case of a patient with two focal lesions in the pancreas is presented and the importance of integrating clinical findings, semiology in diagnostic images and, if applicable, the histopathological result for the optimal management of pancreatic tumors is illustrated, highlighting the crucial role of a radiologist in this process. Mención de responsabilidad : Alexander Aguilar Sr. , Vanessa García Gómez , Santiago Ortiz , Sara Vélez Garcés Referencia : Cureus. 2024 May 27;16(5):e61159 DOI (Digital Object Identifier) : 10.7759/cureus.61159 PMID : 38933621 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11202097/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002202 AC-2024-055 Archivo digital Producción Científica Artículos científicos Disponible 
Título : A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Fecha de publicación : 2022 Títulos uniformes : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : Alzheimer’s disease amyloid antibody data sharing magnetic resonance imaging positron emission tomography presenilin 1 primary prevention secondary prevention Resumen : Introduction: The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease (API ADAD) Trial evaluated the anti-oligomeric amyloid beta (Aβ) antibody therapy crenezumab in cognitively unimpaired members of the Colombian presenilin 1 (PSEN1) E280A kindred. We report availability, methods employed to protect confidentiality and anonymity of participants, and process for requesting and accessing baseline data. Methods: We developed mechanisms to share baseline data from the API ADAD Trial in consultation with experts and other groups sharing data from Alzheimer's disease (AD) prevention trials, balancing the need to protect anonymity and trial integrity with making data broadly available to accelerate progress in the field. We pressure-tested deliberate and inadvertent potential threats under specific assumptions, employed a system to suppress or mask both direct and indirect identifying variables, limited and firewalled data managers, and put forth specific principles requisite to receive data. Results: Baseline demographic, PSEN1 E280A and apolipoprotein E genotypes, florbetapir and fluorodeoxyglucose positron emission tomography, magnetic resonance imaging, clinical, and cognitive data can now be requested by interested researchers. Discussion: Baseline data are publicly available; treatment data and biological samples, including baseline and treatment-related blood-based biomarker data will become available in accordance with our original trial agreement and subsequently developed Collaboration for Alzheimer's Prevention principles. Sharing of these data will allow exploration of important questions including the differential effects of initiating an investigational AD prevention therapy both before as well as after measurable Aβ plaque deposition. Mención de responsabilidad : Eric M. Reiman, Jeremy J. Pruzin, Silvia Rios-Romenets, Chris Brown, Margarita Giraldo, Natalia Acosta-Baena, Carlos Tobon, Nan Hu, Yinghua Chen, Valentina Ghisays, Jessica Enos, Dhruman D. Goradia, Wendy Lee, Ji Luo, Michael Malek-Ahmadi, Hillary Protas, Ronald G. Thomas, Kewei Chen, Yi Su, Connie Boker, Diego Mastroeni, Sergio Alvarez, Yakeel T. Quiroz, Jessica B. Langbaum, Kaycee M. Sink, Francisco Lopera, Pierre N. Tariot, and the API ADAD Colombia Trial Group Referencia : Alzheimers Dement. 2022 Nov 14. DOI (Digital Object Identifier) : 10.1002/alz.12843 PMID : 36373344 Derechos de uso : CC BY-NC En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12843 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial [documento electrónico] / Sergio Álvarez Vallejo, . - 2022.
Obra : Alzheimer's & Dementia
Idioma : Inglés (eng)
Palabras clave : Alzheimer’s disease amyloid antibody data sharing magnetic resonance imaging positron emission tomography presenilin 1 primary prevention secondary prevention Resumen : Introduction: The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease (API ADAD) Trial evaluated the anti-oligomeric amyloid beta (Aβ) antibody therapy crenezumab in cognitively unimpaired members of the Colombian presenilin 1 (PSEN1) E280A kindred. We report availability, methods employed to protect confidentiality and anonymity of participants, and process for requesting and accessing baseline data. Methods: We developed mechanisms to share baseline data from the API ADAD Trial in consultation with experts and other groups sharing data from Alzheimer's disease (AD) prevention trials, balancing the need to protect anonymity and trial integrity with making data broadly available to accelerate progress in the field. We pressure-tested deliberate and inadvertent potential threats under specific assumptions, employed a system to suppress or mask both direct and indirect identifying variables, limited and firewalled data managers, and put forth specific principles requisite to receive data. Results: Baseline demographic, PSEN1 E280A and apolipoprotein E genotypes, florbetapir and fluorodeoxyglucose positron emission tomography, magnetic resonance imaging, clinical, and cognitive data can now be requested by interested researchers. Discussion: Baseline data are publicly available; treatment data and biological samples, including baseline and treatment-related blood-based biomarker data will become available in accordance with our original trial agreement and subsequently developed Collaboration for Alzheimer's Prevention principles. Sharing of these data will allow exploration of important questions including the differential effects of initiating an investigational AD prevention therapy both before as well as after measurable Aβ plaque deposition. Mención de responsabilidad : Eric M. Reiman, Jeremy J. Pruzin, Silvia Rios-Romenets, Chris Brown, Margarita Giraldo, Natalia Acosta-Baena, Carlos Tobon, Nan Hu, Yinghua Chen, Valentina Ghisays, Jessica Enos, Dhruman D. Goradia, Wendy Lee, Ji Luo, Michael Malek-Ahmadi, Hillary Protas, Ronald G. Thomas, Kewei Chen, Yi Su, Connie Boker, Diego Mastroeni, Sergio Alvarez, Yakeel T. Quiroz, Jessica B. Langbaum, Kaycee M. Sink, Francisco Lopera, Pierre N. Tariot, and the API ADAD Colombia Trial Group Referencia : Alzheimers Dement. 2022 Nov 14. DOI (Digital Object Identifier) : 10.1002/alz.12843 PMID : 36373344 Derechos de uso : CC BY-NC En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12843 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001948 AC-2022-109 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Autosomal dominant Alzheimer’s disease CADASIL cardiovascular risk factors cerebral small vessel disease cognition magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, . - 2021.
Obra : Journal of Alzheimer's Disease
Idioma : Inglés (eng)
Palabras clave : Autosomal dominant Alzheimer’s disease CADASIL cardiovascular risk factors cerebral small vessel disease cognition magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001810 AC-2021-122 Archivo digital Producción Científica Artículos científicos Disponible
Título : Distal insertional anatomy of the triceps brachii muscle: MRI assessment in cadaveric specimens Employing Histologic Correlation and Play-doh ® Models of the Anatomic Findings Tipo de documento : documento electrónico Autores : Francisco Alejandro Ramírez Ruiz, Fecha de publicación : 2020 Títulos uniformes : Skeletal Radiology Idioma : Inglés (eng) Palabras clave : Cadavers Insertion anatomy Magnetic resonance imaging Triceps brachii tendon Resumen : Objectives: Assess the insertional anatomy of the distal aspect of the triceps brachii muscle using magnetic resonance imaging (MRI) in cadavers with histologic correlation and Play-doh® models of the anatomic findings. Materials: Elbows were obtained from twelve cadaveric arm specimens by transverse sectioning through the proximal portion of the humerus and the midportion of the radius and ulna. MRI was performed in all elbows. Two of the elbow specimens were then dissected while ten were studied histologically. Subsequently, Play-doh® models of the anatomic findings of the distal attachment sites of the triceps brachii muscle were prepared. Results: MRI showed a dual partitioned appearance of the distal attachment sites into the olecranon in all specimens. In the deeper tissue planes, the medial head muscle insertion was clearly identified while superficially, the terminal portion of the long and lateral heads appeared as a conjoined tendon. Histologic analysis, however, showed continuous tissue rather than separate structures attaching to the olecranon. Conclusion: Although MRI appeared to reveal separate and distinct attachments of the triceps brachii muscle into the olecranon, histologic analysis delineated complex but continuous tissue related to the attachments of the three heads of this muscle. The Play-doh® models were helpful for the comprehension of this complex anatomy and might serve as a valuable educational tool when applied to the analysis of other musculoskeletal regions. Mención de responsabilidad : José Renato Negrão, Roberto Mogami, Francisco Alejandro Ramirez Ruiz, Felipe Victora Wagner, Parviz Haghighi, Samuel R Ward, Donald L Resnick Referencia : Skeletal Radiol. 2020 Jul;49(7):1057-1067. DOI (Digital Object Identifier) : 10.1007/s00256-020-03382-3 PMID : 31993688 En línea : https://link.springer.com/article/10.1007%2Fs00256-020-03382-3 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Distal insertional anatomy of the triceps brachii muscle: MRI assessment in cadaveric specimens Employing Histologic Correlation and Play-doh ® Models of the Anatomic Findings [documento electrónico] / Francisco Alejandro Ramírez Ruiz, . - 2020.
Obra : Skeletal Radiology
Idioma : Inglés (eng)
Palabras clave : Cadavers Insertion anatomy Magnetic resonance imaging Triceps brachii tendon Resumen : Objectives: Assess the insertional anatomy of the distal aspect of the triceps brachii muscle using magnetic resonance imaging (MRI) in cadavers with histologic correlation and Play-doh® models of the anatomic findings. Materials: Elbows were obtained from twelve cadaveric arm specimens by transverse sectioning through the proximal portion of the humerus and the midportion of the radius and ulna. MRI was performed in all elbows. Two of the elbow specimens were then dissected while ten were studied histologically. Subsequently, Play-doh® models of the anatomic findings of the distal attachment sites of the triceps brachii muscle were prepared. Results: MRI showed a dual partitioned appearance of the distal attachment sites into the olecranon in all specimens. In the deeper tissue planes, the medial head muscle insertion was clearly identified while superficially, the terminal portion of the long and lateral heads appeared as a conjoined tendon. Histologic analysis, however, showed continuous tissue rather than separate structures attaching to the olecranon. Conclusion: Although MRI appeared to reveal separate and distinct attachments of the triceps brachii muscle into the olecranon, histologic analysis delineated complex but continuous tissue related to the attachments of the three heads of this muscle. The Play-doh® models were helpful for the comprehension of this complex anatomy and might serve as a valuable educational tool when applied to the analysis of other musculoskeletal regions. Mención de responsabilidad : José Renato Negrão, Roberto Mogami, Francisco Alejandro Ramirez Ruiz, Felipe Victora Wagner, Parviz Haghighi, Samuel R Ward, Donald L Resnick Referencia : Skeletal Radiol. 2020 Jul;49(7):1057-1067. DOI (Digital Object Identifier) : 10.1007/s00256-020-03382-3 PMID : 31993688 En línea : https://link.springer.com/article/10.1007%2Fs00256-020-03382-3 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001299 AC-2020-003 Archivo digital Producción Científica Artículos científicos Disponible
Título : Clinical Benefit of 3 Tesla Magnetic Resonance Imaging Rescanning in Patients With Focal Epilepsy and Negative 1.5 Tesla Magnetic Resonance Imaging Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2016 Títulos uniformes : Revista de Investigación Clínica Idioma : Inglés (eng) Palabras clave : Epilepsy surgery lesional epilepsy magnetic resonance imaging partial epilepsy refractory epilepsy 3 Tesla Resumen : Background: Magnetic resonance imaging is an essential tool in the pre-surgical evaluation of patients with drug-resistant epilepsy. Objective: Our aim was to assess the value of re-imaging patients with focal drug-resistant epilepsy. Methods: Thirty patients with negative or non-conclusive 1.5 Tesla magnetic resonance imaging were rescanned with 1.5T and 3T. All of them had previous 1.5 scans with no seizure protocol in a non-specialized center. Two neuroradiologists who were blinded to prior imaging results randomly reviewed the magnetic resonance images. Kappa score was used to assess the reliability. Results: Mean age of patients was 30 (SD ± 11) years. The intra-observer agreement for the first radiologist was 0.74 for 1.5T and 0.71 for 3T. In the second radiologist it was 0.82 and 0.66, respectively. Three lesions (10%) were identified by general radiologists in non-specialized centers using a 1.5T standard protocol. In our center a consensus between two neuroradiologists using epilepsy protocol identified seven lesions (23%) using 1.5T and 10 (33%) using 3T (p Mención de responsabilidad : Lady D Ladino, Pedro Balaguera, Simon Rascovsky, Jorge Delgado, Juan Llano, Lizbeth Hernández-Ronquillo, Bety Gómez-Arias, José F Téllez-Zenteno Referencia : Rev Invest Clin. 2016 May-Jun;68(3):112-8. PMID : 27408997 En línea : http://clinicalandtranslationalinvestigation.com/abstract.php?id=86 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Clinical Benefit of 3 Tesla Magnetic Resonance Imaging Rescanning in Patients With Focal Epilepsy and Negative 1.5 Tesla Magnetic Resonance Imaging [documento electrónico] / Lady Diana Ladino Malagón, . - 2016.
Obra : Revista de Investigación Clínica
Idioma : Inglés (eng)
Palabras clave : Epilepsy surgery lesional epilepsy magnetic resonance imaging partial epilepsy refractory epilepsy 3 Tesla Resumen : Background: Magnetic resonance imaging is an essential tool in the pre-surgical evaluation of patients with drug-resistant epilepsy. Objective: Our aim was to assess the value of re-imaging patients with focal drug-resistant epilepsy. Methods: Thirty patients with negative or non-conclusive 1.5 Tesla magnetic resonance imaging were rescanned with 1.5T and 3T. All of them had previous 1.5 scans with no seizure protocol in a non-specialized center. Two neuroradiologists who were blinded to prior imaging results randomly reviewed the magnetic resonance images. Kappa score was used to assess the reliability. Results: Mean age of patients was 30 (SD ± 11) years. The intra-observer agreement for the first radiologist was 0.74 for 1.5T and 0.71 for 3T. In the second radiologist it was 0.82 and 0.66, respectively. Three lesions (10%) were identified by general radiologists in non-specialized centers using a 1.5T standard protocol. In our center a consensus between two neuroradiologists using epilepsy protocol identified seven lesions (23%) using 1.5T and 10 (33%) using 3T (p Mención de responsabilidad : Lady D Ladino, Pedro Balaguera, Simon Rascovsky, Jorge Delgado, Juan Llano, Lizbeth Hernández-Ronquillo, Bety Gómez-Arias, José F Téllez-Zenteno Referencia : Rev Invest Clin. 2016 May-Jun;68(3):112-8. PMID : 27408997 En línea : http://clinicalandtranslationalinvestigation.com/abstract.php?id=86 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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