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Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity / Iván Martínez Forero
Título : Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity Tipo de documento : documento electrónico Autores : Iván Martínez Forero, Fecha de publicación : 2013 Títulos uniformes : BMC Systems Biology Idioma : Inglés (eng) Palabras clave : T cells effector regulatory B cells dynamics autoimmunity multiple sclerosis systems biology immunotherapy anti-CD20 Resumen : Background: Multiple Sclerosis (MS) is considered a T-cell-mediated autoimmune disease with a prototypical oscillatory behavior, as evidenced by the presence of clinical relapses. Understanding the dynamics of immune cells governing the course of MS, therefore, has many implications for immunotherapy. Here, we used flow cytometry to analyze the time-dependent behavior of antigen-specific effector (Teff) and regulatory (Treg) T cells and microglia in mice model of MS, Experimental Autoimmune Encephalomyelitis (EAE), and compared the observations with a mathematical cross-regulation model of T-cell dynamics in autoimmune disease. Results: We found that Teff and Treg cells specific to myelin olygodendrocyte glycoprotein (MOG) developed coupled oscillatory dynamics with a 4- to 5-day period and decreasing amplitude that was always higher for the Teff populations, in agreement with the mathematical model. Microglia activation followed the oscillations of MOG specific Teff cells in the secondary lymphoid organs, but they were activated before MOG-specific T-cell peaks in the CNS. Finally, we assessed the role of B-cell depletion induced by anti-CD20 therapy in the dynamics of T cells in anEAE model with more severe disease after therapy. We observed that B-cell depletion decreases Teff expansion, although its oscillatory behavior persists. However, the effect of B cell depletion was more significant in the Treg opulation within the CNS, which matched with activation of microglia and worsening of the disease. Mathematical modeling of T-cell cross-regulation after anti-CD20 therapy suggests that B-cell depletion maY influence the dynamics of T cells by fine-tuning their activation. Conclusions: The oscillatory dynamics of T-cells have an intrinsic origin in the physiological regulation of the adaptive immune response, which influences both disease phenotype and response to immunotherapy. Mención de responsabilidad : Sara Martinez-Pasamar, Elena Abad, Beatriz Moreno, Nieves Velez de Mendizabal, Ivan Martinez-Forero, Jordi Garcia-Ojalvo, Pablo Villoslada Referencia : BMC Syst Biol. 2013 Apr 26;7:34. DOI (Digital Object Identifier) : 10.1186/1752-0509-7-34|| PMID : 23618467 Derechos de uso : CC BY En línea : https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-7-34 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3671 Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity [documento electrónico] / Iván Martínez Forero, . - 2013.
Obra : BMC Systems Biology
Idioma : Inglés (eng)
Palabras clave : T cells effector regulatory B cells dynamics autoimmunity multiple sclerosis systems biology immunotherapy anti-CD20 Resumen : Background: Multiple Sclerosis (MS) is considered a T-cell-mediated autoimmune disease with a prototypical oscillatory behavior, as evidenced by the presence of clinical relapses. Understanding the dynamics of immune cells governing the course of MS, therefore, has many implications for immunotherapy. Here, we used flow cytometry to analyze the time-dependent behavior of antigen-specific effector (Teff) and regulatory (Treg) T cells and microglia in mice model of MS, Experimental Autoimmune Encephalomyelitis (EAE), and compared the observations with a mathematical cross-regulation model of T-cell dynamics in autoimmune disease. Results: We found that Teff and Treg cells specific to myelin olygodendrocyte glycoprotein (MOG) developed coupled oscillatory dynamics with a 4- to 5-day period and decreasing amplitude that was always higher for the Teff populations, in agreement with the mathematical model. Microglia activation followed the oscillations of MOG specific Teff cells in the secondary lymphoid organs, but they were activated before MOG-specific T-cell peaks in the CNS. Finally, we assessed the role of B-cell depletion induced by anti-CD20 therapy in the dynamics of T cells in anEAE model with more severe disease after therapy. We observed that B-cell depletion decreases Teff expansion, although its oscillatory behavior persists. However, the effect of B cell depletion was more significant in the Treg opulation within the CNS, which matched with activation of microglia and worsening of the disease. Mathematical modeling of T-cell cross-regulation after anti-CD20 therapy suggests that B-cell depletion maY influence the dynamics of T cells by fine-tuning their activation. Conclusions: The oscillatory dynamics of T-cells have an intrinsic origin in the physiological regulation of the adaptive immune response, which influences both disease phenotype and response to immunotherapy. Mención de responsabilidad : Sara Martinez-Pasamar, Elena Abad, Beatriz Moreno, Nieves Velez de Mendizabal, Ivan Martinez-Forero, Jordi Garcia-Ojalvo, Pablo Villoslada Referencia : BMC Syst Biol. 2013 Apr 26;7:34. DOI (Digital Object Identifier) : 10.1186/1752-0509-7-34|| PMID : 23618467 Derechos de uso : CC BY En línea : https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-7-34 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3671 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000244 AC-2013-012 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2013-012.pdfAdobe Acrobat PDF ¿The cognitive impairment can be considered as part of clinically isolated syndrome? / Basilio Vagner Ramírez
Título : ¿The cognitive impairment can be considered as part of clinically isolated syndrome? Tipo de documento : documento electrónico Autores : Basilio Vagner Ramírez, Fecha de publicación : 2012 Títulos uniformes : International Research Journal of Humanities Idioma : Inglés (eng) Palabras clave : clinically isolated syndrome cognitive deficit multiple sclerosis Resumen : The cognitive deficit in multiple sclerosis is considered one of the most frequent and early symptoms, however, in very few occasions is analyzed as a single entity. One of the objectives of the paper is to consider changes in the cognitive domain in the context of what is now called clinically isolated syndrome. Giving equal or greater importance in relation to the diagnosis and treatment, before the presentation of other symptoms most obvious clinically as motor, sensitive or Sensory. Mención de responsabilidad : Basilio Vagner R, Sebastian Roldan Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4919 ¿The cognitive impairment can be considered as part of clinically isolated syndrome? [documento electrónico] / Basilio Vagner Ramírez, . - 2012.
Obra : International Research Journal of Humanities
Idioma : Inglés (eng)
Palabras clave : clinically isolated syndrome cognitive deficit multiple sclerosis Resumen : The cognitive deficit in multiple sclerosis is considered one of the most frequent and early symptoms, however, in very few occasions is analyzed as a single entity. One of the objectives of the paper is to consider changes in the cognitive domain in the context of what is now called clinically isolated syndrome. Giving equal or greater importance in relation to the diagnosis and treatment, before the presentation of other symptoms most obvious clinically as motor, sensitive or Sensory. Mención de responsabilidad : Basilio Vagner R, Sebastian Roldan Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4919 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001509 AC-2012-131 Archivo digital Producción Científica Artículos científicos Disponible