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Biomarkers of pituitary carcinomas / Luis Vicente Syro Moreno  

Público ISBD Título : Biomarkers of pituitary carcinomas Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2016 Títulos uniformes : Expert Review of Endocrinology and Metabolism Idioma : Inglés (eng) Palabras clave : Angiogenesis  Galectin-3  HIF-1  H-ras  Ki-67  microRNA  P27/KIP1  P53  pituitary carcinoma  telomerase Resumen : Pituitary carcinoma is a rare tumor originating from adenohypophyseal cells. Currently, diverse pathogenetic mechanisms, i.e. de novo versus malignant transformation from pituitary adenoma, remain obscure and require further investigation. During the last two decades, scientific research added new horizons not only in regards to general tumor concepts but also in next generation biomarker armamentarium that sheds light on alternate pathways in carcinogenesis. Areas covered: In this review, the impact of apoptotic and proliferative markers, angiogenesis, telomerase activity, H-ras, HIF-1, HER-2/neu, Rb gene, and microRNAs in pathogenetic mechanisms of pituitary carcinomas were revised. Expert commentary: It is becoming increasingly important for the need of standardization of new biomarkers but also for better comprehension of the diverse pathways in tumorigenesis. This can only be accomplished by tapping into the continuously expanding spectrum of new biomarkers. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V Syro, Antonio Di Ieva, Michael D Cusimano, Kalman Kovacs Referencia : Expert Rev Endocrinol Metab. 2016 May;11(3):253-261. DOI (Digital Object Identifier) : 10.1080/17446651.2016.1179110 PMID : 30058931 En línea : https://www.tandfonline.com/doi/abs/10.1080/17446651.2016.1179110 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4611 Biomarkers of pituitary carcinomas [documento electrónico] / Luis Vicente Syro Moreno,  . - 2016. Obra : Expert Review of Endocrinology and Metabolism Idioma : Inglés (eng) Palabras clave : Angiogenesis  Galectin-3  HIF-1  H-ras  Ki-67  microRNA  P27/KIP1  P53  pituitary carcinoma  telomerase Resumen : Pituitary carcinoma is a rare tumor originating from adenohypophyseal cells. Currently, diverse pathogenetic mechanisms, i.e. de novo versus malignant transformation from pituitary adenoma, remain obscure and require further investigation. During the last two decades, scientific research added new horizons not only in regards to general tumor concepts but also in next generation biomarker armamentarium that sheds light on alternate pathways in carcinogenesis. Areas covered: In this review, the impact of apoptotic and proliferative markers, angiogenesis, telomerase activity, H-ras, HIF-1, HER-2/neu, Rb gene, and microRNAs in pathogenetic mechanisms of pituitary carcinomas were revised. Expert commentary: It is becoming increasingly important for the need of standardization of new biomarkers but also for better comprehension of the diverse pathways in tumorigenesis. This can only be accomplished by tapping into the continuously expanding spectrum of new biomarkers. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V Syro, Antonio Di Ieva, Michael D Cusimano, Kalman Kovacs Referencia : Expert Rev Endocrinol Metab. 2016 May;11(3):253-261. DOI (Digital Object Identifier) : 10.1080/17446651.2016.1179110 PMID : 30058931 En línea : https://www.tandfonline.com/doi/abs/10.1080/17446651.2016.1179110 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4611

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD001109	AC-2016-090	Archivo digital	Producción Científica	Artículos científicos	Disponible

Biomarkers of pituitary neoplasms / Luis Vicente Syro Moreno  

Público ISBD Título : Biomarkers of pituitary neoplasms Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2012 Títulos uniformes : Anticancer Research Idioma : Inglés (eng) Palabras clave : Angiogenesis  apoptosis  p53  p27  cox-2  folliculostellate cells  galectin-3  hif-1alpha  inflammation and tumor  matrix metalloproteinases (MMPS)  microarray  microenvironment  microvessel density (MVD)  pituitary stem cells  proliferative marker (ki-67)  pituitary tumor-transforming gene (PTTG)  topoisomerase-2-alpha  tumor heterogeneity  VEGF  review Resumen : In a wide spectrum of tumors, cell proliferation, vascularity, apoptosis, cell adhesion, and cell-cycle progression may indicate tumor progression. In this review article, the literature regarding apoptotic markers and p53, as well as cyclooxygenase-2, galectin-3, and pituitary tumor transforming factor, proliferative markers, angiogenesis, including vascular endothelial growth factor and its receptor, pituitary tumor-transforming gene, microarrays, stem cells, and microenvironment and tumor heterogeneity are presented. Only a particular group of selected biomarkers show promise in differentiating pituitary tumors which will behave in an aggressive manner. Therefore, the most common and promising biomarkers and terms were analyzed, proposing the need for uniform design and application of methods and standardized criteria for the interpretation of results. The new spectrum of biomarkers may shed light upon the pathogenetic mechanisms and also may serve as standardized diagnostic tool for daily pathologic practice. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V. Syro, Bernd W. Scheithauer, and Kalman Kovacs Referencia : Anticancer Res. 2012; 32:(11)4639-54. En línea : http://ar.iiarjournals.org/content/32/11/4639.abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3635 Biomarkers of pituitary neoplasms [documento electrónico] / Luis Vicente Syro Moreno,  . - 2012. Obra : Anticancer Research Idioma : Inglés (eng) Palabras clave : Angiogenesis  apoptosis  p53  p27  cox-2  folliculostellate cells  galectin-3  hif-1alpha  inflammation and tumor  matrix metalloproteinases (MMPS)  microarray  microenvironment  microvessel density (MVD)  pituitary stem cells  proliferative marker (ki-67)  pituitary tumor-transforming gene (PTTG)  topoisomerase-2-alpha  tumor heterogeneity  VEGF  review Resumen : In a wide spectrum of tumors, cell proliferation, vascularity, apoptosis, cell adhesion, and cell-cycle progression may indicate tumor progression. In this review article, the literature regarding apoptotic markers and p53, as well as cyclooxygenase-2, galectin-3, and pituitary tumor transforming factor, proliferative markers, angiogenesis, including vascular endothelial growth factor and its receptor, pituitary tumor-transforming gene, microarrays, stem cells, and microenvironment and tumor heterogeneity are presented. Only a particular group of selected biomarkers show promise in differentiating pituitary tumors which will behave in an aggressive manner. Therefore, the most common and promising biomarkers and terms were analyzed, proposing the need for uniform design and application of methods and standardized criteria for the interpretation of results. The new spectrum of biomarkers may shed light upon the pathogenetic mechanisms and also may serve as standardized diagnostic tool for daily pathologic practice. Mención de responsabilidad : Aydin Sav, Fabio Rotondo, Luis V. Syro, Bernd W. Scheithauer, and Kalman Kovacs Referencia : Anticancer Res. 2012; 32:(11)4639-54. En línea : http://ar.iiarjournals.org/content/32/11/4639.abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3635

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD000206	AC-2012-046	Archivo digital	Producción Científica	Artículos científicos	Disponible